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| 1 | Dual function of Arabidopsis A TAF1 in abiotic and biotic stress responses显示文摘NAC 家庭基因编码涉及多样的生物过程的植物特定的抄写因素。在这研究, Arabidopsis NAC 基因 ATAF1 被发现被干旱导致,高咸度, abscisic 酸(骆驼毛的织物) ,甲基 jasmonate,机械伤害,并且 Botrytis cinerea 感染。ATAF1 的重要正式就职在受到干旱或高咸度的骆驼毛的织物缺乏的变异的 aba2 被发现,揭示表示的骆驼毛的织物无关的机制。Arabidopsis ATAF1-overexpression 线显示了许多改变的显型,包括侏儒症和短主要的根。而且,在 vivo,实验显示 ATAF1 是真正的管理者 modulating 植物对许多不能生活的压力和 necrotrophic 病原体感染的回答。在 Arabidopsis 的 ATAF1 的 Overexpression 增加了植物敏感到骆驼毛的织物,盐,和氧化压力。特别, ATAF1 overexpression 种,然而并非异种排队显示出的显著地提高的植物忍耐到干旱。另外, ATAF1 overexpression 提高了植物危险性到 necrotrophic 病原体 B。cinerea,但是没改变 P 的无毒害或剧毒的紧张引起的疾病症状。syringae pv 西红柿 DC3000。转基因的植物 overexpressing ATAF1 对氧化应力过分敏感,建议反应的氧中介可能与响应病原体和不能生活的压力的调停 ATAF1 的发信号有关。 | Yaorong Wu Zhiyong Deng Jianbin Lai Yiyue Zhang Cuiping Yang Bojiao Yin Qingzhen Zhao Ling Zhang Yin Li Chengwei Yang Qi Xie | 2009 | Cell Research2009，19，11： | 56 |
| 2 | Mechanism and control of lake eutrophication显示文摘A review about lake naturally eutrophi- cating, the internal loading of nutrients from lake sediment as well as the mechanism of algal blooms and the control practices was made, especially the eutrophication problem of shallow lakes since sev- enty percent of fresh water lakes in China are shallow lakes. It was found that shallow lakes are apt toward eutrophication than deep lakes. Without any influ- ences of human activity, shallow lakes in the middle and lower reaches of Yangtze River are still easily eutrophicated, which may be owing to the effects of flood in this area. In shallow lakes, sediments are frequently disturbed by wind-wave and resuspended, which result in huge nutrients release to overlying water. This may be the major reason for higher in- ternal loading of nutrients in shallow lakes than in deep lakes. Algal bloom is an extreme response of lake ecosystem to the eutrophication. Appearance of algal blooms is related to physical condition of lakes, such as underwater radiation (or transparency), temperature, and hydrodynamic conditions, or related to geochemical conditions of lakes, like concentra- tions of nutrients and ratio of nitrogen to phosphorus, as well as the physiological advantage of cyanobac- teria such as vacuole for moving towards the radiant energy-rich zone and the mycosporine-like amino acids (MAAs) for resisting the harm of ultraviolet ra- diation. In shallow lakes, these advantages of cyanobacteria are favorable in the competition than in deep lakes. Also being the shallowness, it is more difficult to reduce nutrient loading and to control algae blooms in shallow lakes. For the control of eutrophi- cation, people should follow the sequence from pollution sources control, ecological restoration tocatchment management. To control the internal nu- trient release, physical, chemical, biological tech- niques, and even bionic techniques could be selected. The idea of ecological restoration for a eutrophic lake is to shift the ecosystem from phytoplankton-domi- nant state to macrophyte-dominant state. To realize the shift of ecosystem state, environmental condition improvement is the fundamental work. Nowadays, we should do more work on environmental condition improvement than on planting of macrophytes since we are lack of the knowledge about the relationship between macrophyte and lake ecosystem. Empha- sizing the macrophyte planting, therefore, has blind- ness at present. Because all lakes have different characteristics of environment and ecosystem, ap- plicable lake harness techniques should be selected based on the distinct ecosystem types and environ- mental problems. | QIN Boqiang YANG Liuyan CHEN Feizhou ZHU Guangwei ZHANG Lu CHEN Yiyu | 2006 | Chinese Science Bulletin2006，51，19： | 38 |
| 3 | CRISPR/Cas9-mediated base-editing system efficiently generates gain-of-function mutations in Arabidopsis显示文摘Dear Editor,The CRISPR/Cas9(clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9)system is revolutionizing genome editing due to its high efficiency,low cost,design simplicity and versatility.However,introduction of a point mutation at a desired position remains a great challenge in plant genome engineering.Currently,point mutation in plants was achieved by incorporating | Yiyu Chen Zhiping Wang Hanwen Ni Yong Xu Qijun Chen Linjian Jiang | 2017 | Science China(Life Sciences)2017，60，5： | 40 |
| 4 | Three Perspectives of Granular Computing显示文摘As an emerging field of study, granular computing has received much attention. Many models, frameworks, methods and techniques have been proposed and studied. It is perhaps the time to seek for a general and unified view so that fundamental issues can be examined and clarified.This paper examines granular computing from three perspectives.By viewing granular computing as a way of structured thinking,we focus on its philosophical foundations in modeling human perception of the reality.By viewing granular computing as a method of structured problem solving,we examine its theoretical and methodological foundations in solving a wide range of real-world problems.By viewing granular computing as a paradigm of information processing,we turn our attention to its more concrete techniques. The three perspectives together offer a holistic view of granular computing. | Yiyu (Y.Y.) Yao | 2006 | 南昌工程学院学报2006，25，2： | 18 |
| 5 | Applications of Orlicz-Hardy spaces associated with operators satisfying Poisson estimates显示文摘Let L be a linear operator in L2 (Rn) and generate an analytic semigroup {e-tL } t 0 with kernel satisfying an upper bound estimate of Poisson type,whose decay is measured by θ(L) ∈ (0,∞).Let Φ be a positive,continuous and strictly increasing function on (0,∞),which is of strictly critical lower type p Φ∈ (n/(n + θ(L)),1].Denote by H Φ,L (Rn) the Orlicz-Hardy space introduced in Jiang,Yang and Zhou's paper in 2009.If Φ is additionally of upper type 1 and subadditive,the authors then show that the Littlewood-Paley g-function g L maps H Φ,L (Rn) continuously into L Φ (Rn) and,moreover,the authors characterize H Φ,L (Rn) in terms of the Littlewood-Paley g λ-function with λ∈ (n(2/p Φ + 1),∞).If Φ is further slightly strengthened to be concave,the authors show that a generalized Riesz transform associated with L is bounded from H Φ,L (Rn) to the Orlicz space L Φ (Rn) or the Orlicz-Hardy space H Φ (Rn);moreover,the authors establish a new subtle molecular characterization of H Φ,L (Rn) associated with L and,as applications,the authors then show that the corresponding fractional integral L-γ for certain γ∈ (0,∞) maps H Φ,L (Rn) continuously into H Φ,L (Rn),where Φ satisfies the same properties as Φ and is determined by Φ and γ,and also that L has a bounded holomorphic functional calculus in H Φ,L (Rn).All these results are new even when Φ(t) ≡ tp for all t ∈ (0,∞) and p ∈ (n/(n + θ(L)),1]. | LIANG YiYu YANG DaChun YANG SiBei | 2011 | Science China Mathematics2011，54，11： | 11 |
| 6 | A closed-form solution for moving source localization using LBI changing rate of phase difference only显示文摘Due to the deficiencies in the conventional multiple-receiver localization systems based on direction of arrival(DOA) such as system complexity of interferometer or array and amplitude/phase unbalance between multiple receiving channels and constraint on antenna configuration,a new radiated source localization method using the changing rate of phase difference(CRPD)measured by a long baseline interferometer(LBI) only is studied. To solve the strictly nonlinear problem, a two-stage closed-form solution is proposed. In the first stage, the DOA and its changing rate are estimated from the CRPD of each observer by the pseudolinear least square(PLS) method,and then in the second stage, the source position and velocity are found by another PLS minimization. The bias of the algorithm caused by the correlation between the measurement matrix and the noise in the second stage is analyzed. To reduce this bias, an instrumental variable(IV) method is derived. A weighted IV estimator is given in order to reduce the estimation variance. The proposed method does not need any initial guess and the computation is small. The Cramer–Rao lower bound(CRLB) and mean square error(MSE) are also analyzed. Simulation results show that the proposed method can be close to the CRLB with moderate Gaussian measurement noise. | Zhang Min Guo Fucheng Zhou Yiyu | 2014 | Chinese Journal of Aeronautics2014，27，2： | 10 |
| 7 | Underdetermined DOA estimation and blind separation of non-disjoint sources in time-frequency domain based on sparse representation method显示文摘This paper deals with the blind separation of nonstationary sources and directionofarrival(DOA) estimation in the underdetermined case, when there are more sources than sensors. We assume the sources to be timefrequency(TF) disjoint to a certain extent. In particular, the number of sources presented at any TF neighborhood is strictly less than that of sensors. We can identify the real number of active sources and achieve separation in any TF neighborhood by the sparse representation method. Compared with the subspacebased algorithm under the same sparseness assumption, which suffers from the extra noise effect since it cannot estimate the true number of active sources, the proposed algorithm can estimate the number of active sources and their corresponding TF values in any TF neighborhood simultaneously. Another contribution of this paper is a new estimation procedure for the DOA of sources in the underdetermined case, which combines the TF sparseness of sources and the clustering technique. Simulation results demonstrate the validity and high performance of the proposed algorithm in both blind source separation(BSS) and DOA estimation. | Xiang Wang Zhitao Huang Yiyu Zhou | 2014 | Journal of Systems Engineering and Electronics2014，25，1： | 9 |
| 8 | Apoptosis of human gastric cancer SGC-7901 cells induced by mitomycin combined with sulindac显示文摘AIM: To investigate the effects of mitomycin (MMC)combined with sulindac on cell viability, apoptotic induction and expression of apoptosis-related gene Bcl-2 and cyclooxygenase-2 (COX-2)in gastric cancer SGC-7901cells.METHODS: Human gastric cancer SGC-7901 cells were divided into three treatment groups,namely sulindac treatment group, MMC treatment group and combined sulindac with MMC treatment group. After being treated with drugs, cell viability was examined by MTr assay.Flow cytometry was used to evaluate the cell cycle distribution and apoptotic rates. Morphology of the cells was observed under light microscope and interactive laser microscope. Expression of COX-2 and Bcl-2 was determined by immunocytochemical method.RESULTS: After exposure for 12 h to three kinds of drugs,gastric cancer SGC-7901 cells presented some morphological features of apoptosis, including cell shrinkage, nuclear condensation, DNA fragmentation and formation of apoptotic bodies. Growth inhibition was more obvious in combined sulindac with MMC treatment group and sulindac treatment group than in MMC treatment group. The apoptotic rates in co-treated cells and MMC-treated cells 24 h after treatment were 12.0% and 7.2%, respectively.After exposure for 24 h to MMC, the expression of COX-2and Bcl-2 protein was up-regulated, COX-2 levels were down-regulated but Bcl-2 gene expression was not changed significantly in combined treatment group.CONCLUSION: MMC-induced apoptosis is reduced by up-regulating the expression of COX-2 and Bcl-2 genes.MMC combined with sulindac can suppress the growth of gastric cancer cells through induction of apoptosis mediated by down-regulation of apoptosis-related Bcl-2and COX-2 gene. | LiMa Yong-LeXie YiYu Qiu-NingZhang | 2005 | World Journal of Gastroenterology2005，11，12： | 8 |
| 9 | Influence of overnight orthokeratology lens fitting decentration on corneal topography reshaping显示文摘Background:This retrospective study was designed to investigate the sole influence of orthokeratology(OK)lens fitting decentration on the Zernike coefficients of the reshaped anterior corneal surface.Methods:This study comprised a review of 106 right eyes and measurements of corneal topography both before OK and at 1-month follow-up visit.A routine was designed to calculate local corneal surface astigmatism and assist the determination of OK lens fitting decentration from pupil center.The pupil-centered corneal Zernike coefficients of baseline(PCCB)and post-treatment(PCCP)were calculated.Meanwhile,the OK-lens-centered corneal Zernike coefficients of post-treatment(OCCP)were also calculated and considered as the presumptive ideal fitting group without decentration.Relationships between lens fitting decentration and the change of Zernike coefficients including(PCCP−PCCB)and(PCCP−OCCP)were analyzed.Results:Patients with a mean age of 11±2.36 years old had an average spherical equivalent refractive error of−3.52±1.06 D before OK.One month after treatment,OK lens fitting decentration from pupil center was 0.68±0.35 mm.RMS of 3rd-order(P<0.05),RMS of 4th-order(P<0.001)and RMS of total high order(P<0.001)corneal Zernike coefficients were increased in PCCP by comparing with OCCP,which was solely caused by lens fitting decentration.Nevertheless,no significant difference was observed in C^(0)_(2)(P>0.05).For the high order corneal Zernike coefficients in(PCCP–OCCP),radial distance of decentration was correlated with C^(−1)_(3)(r=−0.296,P<0.05),C^(1)_(3)(r=−0.396,P<0.001),and C^(0)_(4)(r=0.449,P<0.001),horizontal decentration was significantly correlated with C^(1)_(3)(r=0.901,P<0.001)and C^(1)_(5)(r=0.340,P<0.001),and vertical decentration was significantly correlated with C^(−1)_(3)(r=0.904,P<0.001).Conclusions:OK lens fitting decentration within 1.5 mm hardly influenced the change of corneal spherical power for myopia correction,but significantly induced additional corneal high order Zernike coefficients including C^(−1)_(3),C^(1)_(3),C^(0)_(4),and C^(1)_(5). | Jiaojie Chen Wei Huang Rong Zhu Jun Jiang Yiyu Li | 2018 | Eye and Vision2018，5，1： | 8 |
| 10 | Recent progresses in application of functionalized graphene sheets显示文摘Graphene,a rapidly rising star on the horizon of material science,has a unique two-dimensional nanostructure as well as exceptional mechanical and electronic properties.Despite its short history,graphene has exhibited great potential in various applications.In order to implement the potential applications,functionalization of graphene is necessary to obtain uniform dispersions for good processability.Two kinds are dominant for functionalization such as covalent and non-covalent methods.The former is based on the formation of covalent bonds,and the latter the interaction among molecules.In this review,we summarized briefly the recent progress of functionalized graphene sheets (FGs) in different fields,such as optoelectronic materials,sensors,energy storage materials,catalytic,reinforcing components and so on,and also prospected the development trend of FGs in the future. | Lü Peng,FENG YiYu,ZHANG XueQuan,LI Yu & FENG Wei School of Materials Science and Engineering,Tianjin University,Tianjin 300072,China | 2010 | Science China(Technological Sciences)2010，53，9： | 7 |
| 11 | Physiological responses of Populus euphratica Oliv. to groundwater table variations in the lower reaches of Heihe River, Northwest China显示文摘Riparian vegetation in the lower reaches of Heihe River serves important ecological functions. However, the riparian ecosystems have been constantly deteriorating in the past 30 years simply due to water interception for oasis agricultural irrigation in the middle reaches of the river. This study pays a particular attention to Populus euphratica Oliv. forest because it is a dominant component of the riparian ecosystem in the lower reaches of Heihe River where the depth of groundwater table is the controlling factor in sustaining riparian ecosystems. To reveal leaf-related physiological responses of Populus euphratica Oliv. forest to groundwater table variations, we analyzed the relationships between the depth of groundwater table (DG) and three leaf-related parameters, i.e. leaf stomatal density (SD), specific leaf area (SLA), and stable carbon isotopic composition (δ 13 C). Our results show that the relationship between DG and leaf SD is a bi-mode one shaped by both salt stress and water stress. That is, salt stress appeared in shallow groundwater conditions and water stress happened in deep groundwater conditions, and the thin layer around 2.7 m of DG is a stress-free layer. Leaf SD fluctuated according to the DG variation, first decreased with increasing DG, then increased at depths ranging 2.7-3.7 m, and after a relatively stable plateau of SD at depths ranging 3.7-5.2 m, decreased again with increasing DG. Our results also show that SLA decreased exponentially with increasing DG and foliar δ 13 C values are also strongly dependent on DG, further demonstrating that these two parameters are sensitive indicators of water stress. The exponential curve suggests that SLA is more sensitive to DG when groundwater table is shallow and 3 m seems to be a threshold beyond which SLA becomes less sensitive to DG. Foliar δ 13 C becomes more sensitive when the groundwater table is deep and 7 m seems to be a threshold below which the δ 13 C signature becomes more sensitive to DG. These findings should be helpful in monitoring the growth and development of Populus euphratica Oliv. forests and also in providing protection measures (i.e. DG related) for Heihe River riparian forests. | Yang ZHAO ChuanYan ZHAO ZhongLin XU YiYue LIU Yao WANG Chao WANG HuanHua PENG XiangLin ZHENG | 2012 | Journal of Arid Land2012，4，3： | 6 |
| 12 | Vertical distribution of aerosol optical properties based on aircraft measurements over the Loess Plateau in China显示文摘Vertical distributions of aerosol optical properties based on aircraft measurements over the Loess Plateau were measured for the first time during a summertime aircraft campaign, 2013 in Shanxi, China. Data from four flights were analyzed. The vertical distributions of aerosol optical properties including aerosol scattering coefficients(σsc), absorption coefficients(σab),Angstr?m exponent(α), single scattering albedo(ω), backscattering ratio(βsc), aerosol mass scattering proficiency(Q sc) and aerosol surface scattering proficiency(Q sc′) were obtained. The mean statistical values of σsc were 77.45 Mm-1(at 450 nm), 50.72 Mm-1(at 550 nm), and32.02 Mm-1(at 700 nm). The mean value of σab was 7.62 Mm-1(at 550 nm). The mean values ofα, βsc and ω were 1.93, 0.15, and 0.91, respectively. Aerosol concentration decreased with altitude. Most effective diameters(ED) of aerosols were less than 0.8 μm. The vertical profiles of σsc,, α, βsc, Q sc and Q sc′ showed that the aerosol scattering properties at lower levels contributed the most to the total aerosol radiative forcing. Both α and βsc had relatively large values, suggesting that most aerosols in the observational region were small particles. The mean values of σsc, α, βsc, Q sc, Q sc′, σab and ω at different height ranges showed that most of the parameters decreased with altitude. The forty-eight hour backward trajectories of air masses during the observation days indicated that the majority of aerosols in the lower level contributed the most to the total aerosol loading, and most of these particles originated from local or regional pollution emissions. | Junxia Li Xingang Liu Liang Yuan Yan Yin Zhanqing Li Peiren Li Gang Ren Lijun Jin Runjun Li Zipeng Dong Yiyu Li Junmei Yang | 2015 | Journal of Environmental Sciences2015，27，8： | 6 |
| 13 | Azobenzene/graphene hybrid for high-density solar thermal storage by optimizing molecular structure显示文摘A large capacity storing solar energy as latent heat in a close-cycle is essentially important for solar thermal fuels. This paper presents a solar thermal molecule model of a photo-isomerizable azobenzene(Azo) molecule covalently bound to graphene. The storage capacity of the Azo depending on isomerization enthalpy(ΔH) is calculated based on density functional theory. The result indicates that the ΔH of Azo molecules on the graphene can be tuned by electronic interaction, steric hindrance and molecular hydrogen bonds(H-bonds). Azo with the withdrawing group on the ortho-position of the free benzene shows a relatively high ΔH due to resonance effect. Moreover, the H-bonds on the trans-isomer largely increase ΔH because they stabilize the trans-isomer at a low energy. 2-hydroxy-4-carboxyl-2′,6′,-dimethylamino-Azo/graphene shows the maximum ΔH up to 1.871 e V(107.14 Wh kg^(-1)), which is 125.4% higher than Azo without functional groups. The Azo/graphene model can be used for developing high-density solar thermal storage materials by controlling molecular interaction. | LI Man FENG YiYu LIU EnZuo QIN ChengQun FENG Wei | 2016 | Science China(Technological Sciences)2016，59，9： | 6 |
| 14 | An overview of chronic myeloid leukemia and its animal models显示文摘Chronic myeloid leukemia(CML) is a form of leukemia characterized by the presence of clonal bone marrow stem cells with the proliferation of mature granulocytes(neutrophils, eosinophils, and basophils) and their precursors. CML is a type of myeloproliferative disease associated with a characteristic chromosomal translocation called the Philadelphia(Ph) chromosome or t(9;22) translocation(BCR-ABL). CML is now usually treated with targeted drugs called tyrosine kinase inhibitors(TKIs). The mechanism and natural history of CML is still unclear. Here, we summarize the present CML animal disease models and compare them with each other. Meanwhile, we propose that it is a very wise choice to establish zebrafish(Danio rerio) CML model mimics clinical CML. This model could be used to learn more about the mechanism of CML, and to aid in the development of new drugs to treat CML. | MA WeiXu MA Ning CHEN XiaoHui ZHANG YiYue ZHANG WenQing | 2015 | Science China(Life Sciences)2015，58，12： | 6 |
| 15 | Inferring the Tree of Life of the order Cypriniformes, the earth's most diverse clade of freshwater fishes: Implications of varied taxon and character sampling显示文摘The phylogenetic relationships of species are fundamental to any biological investigation, including all evolutionary studies. Accurate inferences of sister group relationships provide the researcher with an historical framework within which the attributes or geographic origin of species (or supraspecific groups) evolved. Taken out of this phylogenetic context, interpretations of evolutionary processes or origins, geographic distributions, or speciation rates and mechanisms, are subject to nothing less than a biological experiment without controls. Cypriniformes is the most diverse clade of freshwater fishes with estimates of diversity of nearly 3,500 species. These fishes display an amazing array of morphological, ecological, behavioral, and geographic diversity and offer a tremendous opportunity to enhance our understanding of the biotic and abiotic factors associated with diversification and adaptation to environments. Given the nearly global distribution of these fishes, they serve as an important model group for a plethora of biological investigations, including indicator species for future cli-matic changes. The occurrence of the zebrafish, Danio rerio, in this order makes this clade a critical component in understanding and predicting the relationship between mutagenesis and phenotypic expressions in vertebrates, including humans. With the tremendous diversity in Cypriniformes, our understanding of their phylogenetic relationships has not proceeded at an acceptable rate, despite a plethora of morphological and more recent mo-lecular studies. Most studies are pre-Hennigian in origin or include relatively small numbers of taxa. Given that analyses of small numbers of taxa for molecular characters can be compromised by peculiarities of long-branch attraction and nodal-density effect, it is critical that significant progress in our understanding of the relationships of these important fishes occurs with increasing sampling of species to mitigate these potential problems. The recent Cypriniformes Tree of Life initiative is an effort to achieve this goal with morphological and molecular (mitochondrial and nuclear) data. In this early synthesis of our understanding of the phylogenetic relationships of these fishes, all types of data have contributed historically to improving our understanding, but not all analyses are complementary in taxon sampling, thus precluding direct understanding of the impact of taxon sampling on achieving accurate phylogenetic inferences. However, recent molecular studies do provide some insight and in some instances taxon sampling can be implicated as a variable that can influence sister group relationships. Other instances may also exist but without inclusion of more taxa for both mitochondrial and nuclear genes, one cannot distinguish between inferences being dictated by taxon sampling or the origins of the molecular data. | Richard L. MAYDEN Kevin L. TANG Robert M. WOOD Wei-Jen CHEN Mary K. AGNEW Kevin W. CONWAY Lei YANG Andrew M. SIMONS Henry L. BART Phillip M. HARRIS Junbing LI Xuzhen WANG Kenji SAITOH Shunping HE Huanzhang LIU Yiyu CHEN Mutstmi NISHIDA Masaki MIYA | 2008 | 植物分类学报2008，46，3： | 5 |
| 16 | Sequences of cytochrome b gene for primitive cyprinid fishes in East Asia and their phylogenetic concerning显示文摘1140 bp of cytochrome b gene were amplified and sequenced from 14 species of primitive cyprinid fishes in East Asia. Aligned with other ten cytochrome b gene sequences of cyprinid fish from Europe and North America retrieved from Gene bank, we obtained a matrix of 24 DNA sequences. A cladogram was generated by the method of Maximum likelihood for the primitive cyprinid fishes. The result indicated that subfamily Leuciscinae and Danioninae do not form a monophyletic group. In the subfamily Danioninae, Opsariichthys biden and Zacco platypus are very primitive and form a natural group and located at the root. But the genera in subfamily Danioninae are included in different groups and have not direct relationship. Among them, Aphyocypris chinensis and Yaoshanicus arcus form a monophyletic group. Tanichthys albonubes and Gobiocypris rarus have a close relation to Gobioninae. The genus Danio is far from other genera in Danioninae. In our cladogram, the genera in Leuciscinae were divided into two groups that | HE Shunping CHEN Yiyu Nakajiama Tsuneo | 2001 | Chinese Science Bulletin2001，46，8： | 5 |
| 17 | A new method of combined rock drilling显示文摘Based on the technologies of traditionally mechanical drilling and water jet,we propose a new method of abrasive water jet in combination with rock drilling,and establish a combined rock drilling system for the gas pre-drainage.This study chose the common sandstone and silicon limestone as the rock sample.A series of experiments were completed in the case of dry drilling,existing technology drilling,combined drilling with high pressure water jet and combined drilling with abrasive water jet,respectively.The drilling efficiency and performance were contrasted and analyzed in detail.The results indicate that it is better to choose the method of combined drilling with the high-pressure water jet for soft rocks.The method of combined drilling with abrasive water jet is feasible for the hard rock drilling and has higher drilling efficiency and performance.In this paper,compared with the existing technology,the drilling depth has increased by about 65%,the axial force and torque have reduced by about 14%and 17%,respectively,and the drill wear reduces obviously in the same conditions. | Tang Jiren Lu Yiyu Ge Zhaolong Xia Binwei Sun Huijuan Du Peng | 2014 | International Journal of Mining Science and Technology2014，24，1： | 5 |
| 18 | Comparative expression analysis of three genes from the Arabidopsis vacuolar Na^+/H^+ antiporter (AtNHX) family in relation to abiotic stresses显示文摘Na^+/H^+ antiporters (NHX) are ubiquitous transmembrane proteins that play a key role in salt tolerance of plants. In this study, the sequence of 3 Arabidopsis NHX gene (AtNHX2―4) were compared with other AtNHX members. Putative cis-elements analysis identified elements that have been associated with stress responses. The activities of the promoters AtNHX2―4 were studied in transgenic plants carrying corresponding promoter-β-glucuronidase (GUS) fusions. The AtNHX2 promoter-GUS analysis indicated that AtNHX2 was expressed in constitutive pattern with high GUS activity in roots and leaves. AtNHX2 promoter activity was not up-regulated by NaCl or abscisic acid (ABA), in contrast to the AtNHX1 promoter which was previously studied. The AtNHX3 and AtNHX4 promoters showed tissue-specific activities. Strong GUS activity was detected in roots and vascular bundles of the stele in plants carry-ing an AtNHX4 promoter-GUS fusion, and GUS activity increased under salt stress suggesting a func-tion related to salt tolerance. Transgenic plants carrying the AtNHX3 promoter-GUS fusion showed strong GUS activity in petals, stamens and tops of siliques, suggesting a possible role of AtNHX3 in flower and seed development. Results of histochemical analysis suggested that AtNHX2―4 are involved in divergent functions and are differentially regulated under abiotic stress. The structure of AtNHX4 was predicted to include 12 transmembrane regions and a NHX domain. Overexpression of AtNHX4 in Arabidopsis transgenic lines confers greater salt tolerance than in wild type plants. These results suggest that AtNHX4 may encode a putative vacuolar NHX that plays an important role in salt tolerance. | WANG WeiQuan LI Yin ZHANG YiYue YANG CuiPing ZHENG NuoYan XIE Qi | 2007 | Chinese Science Bulletin2007，52，13： | 5 |
| 19 | Multimodal Identification by Transcriptomics and Multiscale Bioassays of Active Components in Xuanfeibaidu Formula to Suppress Macrophage-Mediated Immune Response显示文摘Xuanfeibaidu Formula (XFBD) is a Chinese medicine used in the clinical treatment of coronavirus disease 2019 (COVID-19) patients. Although XFBD has exhibited significant therapeutic efficacy in clinical practice, its underlying pharmacological mechanism remains unclear. Here, we combine a comprehensive research approach that includes network pharmacology, transcriptomics, and bioassays in multiple model systems to investigate the pharmacological mechanism of XFBD and its bioactive substances. High-resolution mass spectrometry was combined with molecular networking to profile the major active substances in XFBD. A total of 104 compounds were identified or tentatively characterized, including flavonoids, terpenes, carboxylic acids, and other types of constituents. Based on the chemical composition of XFBD, a network pharmacology-based analysis identified inflammation-related pathways as primary targets. Thus, we examined the anti-inflammation activity of XFBD in a lipopolysaccharide-induced acute inflammation mice model. XFBD significantly alleviated pulmonary inflammation and decreased the level of serum proinflammatory cytokines. Transcriptomic profiling suggested that genes related to macrophage function were differently expressed after XFBD treatment. Consequently, the effects of XFBD on macrophage activation and mobilization were investigated in a macrophage cell line and a zebrafish wounding model. XFBD exerts strong inhibitory effects on both macrophage activation and migration. Moreover, through multimodal screening, we further identified the major components and compounds from the different herbs of XFBD that mediate its anti-inflammation function. Active components from XFBD, including Polygoni cuspidati Rhizoma, Phragmitis Rhizoma, and Citri grandis Exocarpium rubrum, were then found to strongly downregulate macrophage activation, and polydatin, isoliquiritin, and acteoside were identified as active compounds. Components of Artemisiae annuae Herba and Ephedrae Herba were found to substantially inhibit endogenous macrophage migration, while the presence of ephedrine, atractylenolide I, and kaempferol was attributed to these effects. In summary, our study explores the pharmacological mechanism and effective components of XFBD in inflammation regulation via multimodal approaches, and thereby provides a biological illustration of the clinical efficacy of XFBD. | Lu Zhao Hao Liu Yingchao Wang Shufang Wang Dejin Xun Yi Wang Yiyu Cheng Boli Zhang | 2023 | Engineering2023，，1： | 5 |
| 20 | Application of the multi-cycle estimator of Doppler and TDOA to passively locating targets exploiting non-cooperative transmitters显示文摘By exploiting the cyclostationary property of non cooperative source signals, the problem of joint time difference of arrival (TDOA) and Doppler estimation is discussed, and the multi cycle estimator is developed by generalizing the single cycle estimator. Utilizing a special commercial FM radio as a non cooperative transmitter, some practical experiments are carried out. The right estimates of TDOA and Doppler of a particular airplane can really be obtained by processing the measurements with the multi cycle estimation algorithm. Through adding some slowly time variant white Gaussian noise to the original measurements, some independent Monte Carlo simulations are performed, and the simulation results reveal that the multi cycle estimator is really superior to the single cycle estimator and the conventional cross correlation method. | HUANG Zhitao, JIANG Wenli and ZHOU Yiyu(School of Electronic Science and Engineering, National University of Defense Technology, Changsha 410073, China) | 2003 | Progress in Natural Science:Materials International2003，13，10： | 5 |
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