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| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 3 | 强化与标准降压治疗对脑卒中亚型的影响显示文摘在收缩压干预试验(systolic blood pressure intervention trial, SPRINT)中,各治疗组的脑卒中发生比例差异无统计学意义,但脑卒中亚型的病因不同,可能对强化降压治疗的反应不同。SPRINT纳入患者(n=9 361)随机分为目标收缩压<120 mm Hg(1 mm Hg=0.133 kPa)的强化治疗与目标收缩压<140 mm Hg的标准治疗组。 | Wright CB Auchus AP Lerner A Ambrosius WT Ay H Bates JT Chen J Meschia JF Pancholi S Papademetriou V Rastogi A Sweeney M Willard JJ Yee J Oparil S 赵狄(摘译) 郑武洪(审校) | 2021 | 中华高血压杂志2021，29，3： | 2 |
| 4 | Three-dimensional imaging system显示文摘 | Yee S R Griffin P M | 1994 | Opt Eng1994，33，6： | 1 |
| 5 | IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response 显示文摘 | Li Y Bleakley M Yee C | 2005 | J Immtmol2005，175，4： | 1 |
| 6 | NKIAMRE, a novel conserved CDC2 related kinase with features of both mitogen- activated protein kinases and cyclin-dependent kinases显示文摘 | Yee KW Moore SJ Midmer M | 2003 | Biochem Biophys Res Commun2003，308，4： | 1 |
| 7 | Mechanics of toughening brittle polymers显示文摘 | Thouless M D Du J Yee A F | 2000 | ACS Symposium Series2000，759，5： | 1 |
| 8 | The stomach and intestines aparoxysm is tiny to encroach upon the surgery显示文摘 | Lauence F Yee M D Sean J | 1996 | Current Diagnosis&Treatment in Gastroentetology1996，196，： | 1 |
| 9 | Reduced maternal expression of adrenomedullin disrupts fertility, placcntation , and fetal growth in mice 显示文摘 | Li M Yee D Magnuson TR | 2006 | J Clin Invest2006，116，10： | 1 |
| 10 | The evaluation of a fluorogenic polymerase chain reaction assay for the detection of Salmonella species in food commodities显示文摘 | Chen S Yee A Griffiths M | 1997 | Int J Food Microbiol1997，35，3： | 1 |
| 11 | TANMEI/EMB2757 encodes a WD repeat protein required for embryo development in Arabidopsis显示文摘 | YAMAGISHI K NAGATA N YEE K M | | Plant Physiol0，139，1： | 1 |
| 12 | Cleavage of corneal basement membrane components by ethanol exposure in laser-assisted subepithelial keratectomy 显示文摘 | Espana EM Grueterich M Mateo A Romano AC Yee SB Yee RW | 2003 | J Cataract Refract Surg2003，29，6： | 1 |
| 13 | Neoadjuvant chemotherapy with CPT-11 and cisplatin downstages locally advanced gastric cancer显示文摘 | Newman E Marcus SG Potmesil M Sewak S Yee H Sorich J | 2002 | J Gastrointest Surg2002，6，22： | 1 |
| 14 | Porphyromonas gingivalis stimu- lates IL-18 secretion in human monocytic THP-1 cells 显示文摘 | Yee M Kim A Alpagot T | 2012 | Mi- crobes Infect2012，14，9： | 1 |
| 15 | Progress in the in situ recovery of heavy oils and bitumen 显示文摘 | BUTLER R M YEE C T | 2000 | Journal of Canadian Petroleum Technology2000，41，1： | 1 |
| 16 | Improving the catalytic activity of a thermophilic enzyme at low temperatures 显示文摘 | MERZ A YEE M C SZADKOWSKI H | 2000 | Biochemistry2000，39，5： | 1 |
| 17 | Zinc and carbon co-limitation of marine phytoplankton显示文摘 | Morel F M M Reinfelder J R Roberts S B Chamberlain C P Lee J G Yee D | 1994 | Nature1994，369，6483： | 1 |
| 18 | Food safety: building consumer trust in livestock farmers for potential purchase behavior 显示文摘 | Yee W M S Yeung R M W Morris J | 2005 | British Food Journal2005，107，11： | 1 |
| 19 | Metabotropic glutamate receptor 5(mGluR5)antagonists attenuate cocaine priming-and cue -induced reinstatement of cocaine seeking显示文摘 | Kumaresan V Yuan M Yee J | | 0，，02： | 1 |
| 20 | NKIAMRE, a novel conserved CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases显示文摘 | Yee KW Moore S J Midmer M | 2003 | Biochem Biophys Res Commun2003，308，： | 1 |
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