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	题名	作者	年代	出处	被引量
1	Effects of transforming growth factor beta 1 on the growth of rhabdomyosarcoma cell line RD显示文摘Backgroud Transforming growth factor-β (TGF-β) can inhibit the growth of most epithelial and endothelial cells. The growth regulative role of TGF-β on soft tissue sarcoma was seldom reported. Here we examined TGF-β1 effects on the growth of human rhabdomyosarcoma cell RD and searched the relative molecular mechanism. Methods The viability of RD was examined by [ 3H]-thymidine incorporation and [3-(4,5-dimethylthiazol-z-yl)-2,5-diphenyltetraz olium bromide] (MTT) assay. RD cell cycle was analysed by flow cytometry. The protein and mRNA of cell cycle regulative factors in RD were detected by Western blot and reverse transcription-polymerase chain reation (RT-PCR), respectively. The kinase activity of cdk2 or cdk4 was examined by immunoprecipitation and kinase assay. Immunofluorescent staining was used to detect the location of cell cycle regulative factors in RD by laser scanning confocal microscope.Results TGF-β1 inhibits RD proliferation by G1-arrest in cell cycle progression. TGF-β1 can prominently up-regulate P27 of RD, then augment P27 to bind cyclinE-cdk2 complexes, which effectively suppress cdk2 kinase activity. P21 increased and c-myc decreased in RD due to TGF-β1. Both P15 and cdk4 have not been involved in the growth inhibitory event. TGF-β1 treatment induced P27 to congregate around nucleus. P21 pervaded from nucleus to both nucleus and cytoplasm by TGF-β1 treatment.Conclusion TGF-β1 inhibits the proliferation of human rhabdomyosarcoma cell line RD and induces RD G1-arrest. This course is accomplished by TGF-β1 up-regulating P27 to suppress cdk2 kinase activity. The induction of P21 and down-regulation of C-myc might participate in the growth-arrest event.	YELü ZHANGHong-ying WANGHua YANGGuang-hua BUHong ZHANGLi WANGShou-li	2005	Chinese Medical Journal2005，，8：	7
2	Dynamics of circulating microparticles in chronic kidney disease and transplantation:Is it really reliable marker?显示文摘The deterioration of endothelial structure plays a very important role in the development of vascular diseases. It is believed that endothelial dysfunction starts in the early stage of kidney disease and is a risk factor of an unfavorable cardiovascular prognosis. Because a direct assessment of biological states in endothelial cells is not applicable, the measurement of endothelial microparticles(EMPs) detached from endothelium during activation or apoptosis is thought to be a marker of early vascular disease and endothelial dysfunction in children with chronic kidney disease(CKD). Few studies have shown increased circulating EMPs and its relationship with cardiovascular risk factors in patients with CKD.MPs contain membrane proteins and cytosolic material derived from the cell from which they originate. EMPs having CD144, CD 146, CD31+/CD41-, CD51 and CD105 may be used to evaluate the vascular endothelial cell damage and determine asymptomatic patients who might be at higher risk of developing cardiovascular disease in CKD and renal transplant.	Ismail Dursun Sibel Yel Emel Unsur	2015	World Journal of Transplantation2015，5，4：	3
3	Serum Adipocyte Fatty Acid-Binding Protein Levels Are Associated With Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients显示文摘	Koh Jang Hyun Shin Young Goo Nam Soo Min Lee Mi Young Chung Choon Hee Shin Jang Yel	2009	Diabetes Care2009，，1：	1
4	Studies on the antibiotic activity and its stability of chitosan显示文摘	YeL(叶磊) HeLQ(何立千) GaoTZ(高天洲) etal		北京联合大学学报自科版0，，：	1
5	Surfactant interac- tions with P ( AM-AA-BPAM ) hydrophobically modified polyelectmlytes 显示文摘	Yel L Huang Ronghua Hoffman H	2003	Journal of Applied Polymer Science2003，89，10：	1
6	Tobacco use among adults in Cambodia:evidence for a tobacco epidemic among women 显示文摘	Singh PN Yel D Sin S	2009	Bull World Health Organ2009，87，12：	1
7	IL - 1β and TNF -α induce neurotoxicity through glutamate production: a potential role for neu- renal glutaminase 显示文摘	YeL HuangY Zhao L	2013	J Neurechem2013，125，：	1
8	Biochemical and molecular basis of thimerosal-induced apoptosis in T cells: a major role of mitochondrial pathway 显示文摘	Makani S Gollapudi S Yel L	2003	Genes Immun2003，22，53：	1
9	Elevated serum γ-glutamyltransferase levels are independently associated with insulin resistance in non-diabetic subjects显示文摘	Jang Yel Shin Sei Jin Chang Young Goo Shin Kwang-Seok Seo Choon Hee Chung	2009	Diabetes Research and Clinical Practice2009，，2：	1
10	Mutations in the mu heavy-chain gene in patients with agammaglobulinemia显示文摘	Yel L Minegishi Y Smith EC	1996	N Eng J Med1996，35，20：	1
11	Arsenic trioxide induces apoptosis inperipheral blood T lymphocyte subsets by inducing oxidative stress:arole of Bcl-2显示文摘	Gupta S Yel L Kim D	2003	Mol Cancer Ther2003，2，8：	1
12	Studyon the morphology of the novel hydrophobically associative acrylamide-based terpolymer in aqueous solution by AFM measurements 显示文摘	ZHONG C R HUANG R H YEL	2006	Journal of Applied Polymer Science2006，101，6：	1
13	Biochemical and molecular basis of thimerosal- induced apoptosis in T cells: a major role of mitochondrial pathway显示文摘	Makani S Gollapudi S Yel L	2002	Genes Immun2002，3，5：	1
14	Direct proinflammatory effect of C-reactive protein on human endothelial cells 显示文摘	Pasceri V Willerson JT Yel ETH	2000	Circulation2000，102，：	1
15	The effectiveness of a dia- betes nurse clinic in treating older patients with type 2 diabetes for their glyeaemic control 显示文摘	Chan MF Yee ASW Leung YEL	2006	Journal of Clinical Nursing2006，15，6：	1
16	Healing rate and post- obturation pain of single-versus multiple visit endodon tic treatment for infected root canals: a system review 显示文摘	Su YY Wang CL YeL	2011	Endod2011，37，2：	1
17	Detection of circulating cancer cells by nested reverse transcription -polymerase chain reaction of cytokeratin-19 posssible clinical significance in advanced gastric cancer显示文摘	Chen YC Yeh SH etal	1998	J Anticancer Res1998，18，2：	1
18	Selective molecular adsorption using electrospun nanofiber affinity membranes显示文摘	Yoshimatsu K YeL Lindberg J Chronak is I S		0，，07：	1
19	VEGF induces phosphorylation of STAT3 through binding VEGFR2 in ovarian carcinoma cells in vitro显示文摘	Lu W Chen H Yel F	2006	Eur J Gynaecol Oncol2006，27，4：	1
20	Beigeadipocytesareadistincttypeofthermogenicfatcellinmouseandhuman显示文摘	WuJ BostrmP SparksLM YeL ChoiJH GiangAH etal	2012	Cell2012，150，36：	1

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