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| 1 | Effects of transforming growth factor beta 1 on the growth of rhabdomyosarcoma cell line RD显示文摘Backgroud Transforming growth factor-β (TGF-β) can inhibit the growth of most epithelial and endothelial cells. The growth regulative role of TGF-β on soft tissue sarcoma was seldom reported. Here we examined TGF-β1 effects on the growth of human rhabdomyosarcoma cell RD and searched the relative molecular mechanism. Methods The viability of RD was examined by [ 3H]-thymidine incorporation and [3-(4,5-dimethylthiazol-z-yl)-2,5-diphenyltetraz olium bromide] (MTT) assay. RD cell cycle was analysed by flow cytometry. The protein and mRNA of cell cycle regulative factors in RD were detected by Western blot and reverse transcription-polymerase chain reation (RT-PCR), respectively. The kinase activity of cdk2 or cdk4 was examined by immunoprecipitation and kinase assay. Immunofluorescent staining was used to detect the location of cell cycle regulative factors in RD by laser scanning confocal microscope.Results TGF-β1 inhibits RD proliferation by G1-arrest in cell cycle progression. TGF-β1 can prominently up-regulate P27 of RD, then augment P27 to bind cyclinE-cdk2 complexes, which effectively suppress cdk2 kinase activity. P21 increased and c-myc decreased in RD due to TGF-β1. Both P15 and cdk4 have not been involved in the growth inhibitory event. TGF-β1 treatment induced P27 to congregate around nucleus. P21 pervaded from nucleus to both nucleus and cytoplasm by TGF-β1 treatment.Conclusion TGF-β1 inhibits the proliferation of human rhabdomyosarcoma cell line RD and induces RD G1-arrest. This course is accomplished by TGF-β1 up-regulating P27 to suppress cdk2 kinase activity. The induction of P21 and down-regulation of C-myc might participate in the growth-arrest event. | YELü ZHANGHong-ying WANGHua YANGGuang-hua BUHong ZHANGLi WANGShou-li | 2005 | Chinese Medical Journal2005，，8： | 7 |
| 2 | Security Enhancement of UAV Swarm Enabled Relaying Systems with Joint Beamforming and Resource Allocation显示文摘The high mobility of unmanned aerial vehicles(UAVs)could bring abundant degrees of freedom for the design of wireless communication systems,which results in that UAVs,especially UAV swarm,have attracted considerable attention.This paper considers a UAV Swarm enabled relaying communication system,where multiple UAV relays are organized via coordinated multiple points(CoMP)as a UAV swarm to enhance physical layer security of the system in the presence of an eavesdropper.In order to maximize achievable secrecy rate of downlink,we jointly optimize the beamforming vector of the virtual array shaped by the UAV swarm and bandwidth allocation on it for receiving and forwarding,and both amplify-and-forward(AF)and decode-andforward(DF)protocols are considered on the UAV swarm.Due to the non-convexity of the joint optimization problem,we propose an alternating optimization(AO)algorithm to decompose it into two subproblems utilizing block coordinate descent technique,then each subproblem is solved by successive convex optimization method.Simulation results demonstrate that DF has competitive performance advantage compared with AF and the superiority of the proposed secure transmission strategy with optimal beamforming and bandwidth allocation compared with benchmark strategies. | Runze Dong Buhong Wang Kunrui Cao | 2021 | China Communications2021，18，9： | 2 |
| 3 | Analysis of Internal Moisture Change of Camphor Seeds during Drying by Low-Field NMR显示文摘In this study,low-field nuclear magnetic resonance(LF-NMR)was used to collect the transverse relaxation signals of camphor seeds that had been dried at different temperatures and for different durations.The transverse relaxation time of the hydrogen nucleus was obtained by SIRT(Simultaneous Iterative Reconstruction Technique)inversion,and the correlation between the moisture content on dry basis and the amplitude of NMR signal of camphor seeds sampled at different drying stages was analyzed.The results showed that water existed in three main forms strongly bound water,weakly bound water and free water in camphor seeds.During the drying process,the peak position of strongly bound water remained unchanged,but the peak positions of weakly bound water and free water fluctuated.Drying rate increased with drying temperature increasing.In addition,there was a very significant linear relationship between the total NMR signal amplitude and moisture content on dry basis,and the correlation coefficient reached 0.984 4. | Yan XUAN Yilong XIANG Jing YANG Buhong GAO Ying TANG Feng LIN | 2019 | Agricultural Biotechnology2019，8，4： | 2 |
| 4 | Frequency-invariant pattern synthesis of conformal ar- ray with low cross-polarization显示文摘 | WANG Buhong GUO Ying and WANG Yongliang | 2008 | IET Microwaves Antennas & Propagation2008，2，5： | 1 |
| 5 | Decoupled 2D Direction of Arrival Estimation Using Compact Uniform Circular Arrays in the Presence of Elevation-Dependent Mutual Coupling 显示文摘 | Buhong W Hon T H Mook S L | 2010 | EEE Trans on AP2010，58，3： | 1 |
| 6 | Weighted spatial smoothing for direction-of-arrival estimation of coherent sig- nals显示文摘 | Wang Buhong Wang Yongliang ( hen Hui | 2002 | IEEE Antennas and Propagation Society International Symposium2002，，2： | 1 |
| 7 | Frequency-invariant pattern synthesis of con~ormal array with low cross-polarization 显示文摘 | WANG Buhong GUO Ying WANG Yongliang | 2008 | IET Micro- waves Antennas& Propagation2008，2，5： | 1 |
| 8 | Mobility measurement, transition matrices and statistical inference显示文摘 | John P. Formby W.James Smith Buhong Zheng | 2003 | Journal of Econometrics2003，，1： | 1 |
| 9 | Introduction to the Special Issue on Enhanced Photodynamic Therapy显示文摘Photodynamic therapy(PDT)utilizes photosensi-tizer(PS)together with irradiation light of specific wavelength interacting with oxygen to generate cytotoxic reactive oxygen species,which has been approved for the treatment of several maligr nant and non-malignant pathologies.Most recently,en-hanced PDT has been achieved by using novel nano-PSs,1 new light sources,2 oxygen supply,and synergistic therapy. | Buhong Li Lothar Lilge | 2022 | Journal of Innovative Optical Health Sciences2022，15，4： | 0 |
| 10 | Recent progress in medical photonics显示文摘The field of medical photonics is rapidly expanding, and a wide variety of optical technologies and instruments have recently been developed for diagnostic, therapeutic and basic science applications in medicine. This review presents the recent advances and application of medical photonics, and the obtained results from our laboratory are highlighted. Finally, the challenges and future prospects for the transition from technological exploration to clinical studies are discussed. | XIE ShuSen LI Hui LI BuHong | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，6： | 0 |
| 11 | Special issue on enhanced photodynamic therapy:Part Ⅱ显示文摘We welcome the readers to Part Ⅱ of the special issue on Enhanced Photodynamic Therapy(PDT),an issue dedicated to highlighting the latest developments in both fundamental mechanisms and clinical applications for enhanced PDT.Therst part of this special issue was published in July 2022 as Issue 4 of Volume 15,andve research articles were included.1 It is really exciting that we have an enthusiastic response from our colleagues that continuously contributed eight articles to produce Part II.We believe these two special issues will provide a better understanding of enhanced PDT. | Buhong Li Lothar Lilge | 2022 | Journal of Innovative Optical Health Sciences2022，15，6： | 0 |
| 12 | Cerium-based nanoparticles for cancer photodynamic therapy显示文摘Metal-and metal-oxide-based nanoparticles have been widely exploited in cancer photodynamic therapy(PDT).Among these materials,cerium-based nanoparticles have drawn extensive attention due to their superior biosafety and distinctive physicochemical properties,especially the reversible transition between the valence states of Ce(Ⅲ)and Ce(Ⅳ).In this review,the recent advances in the use of cerium-based nanoparticles as novel photosensitizers for cancer PDT are discussed,and the activation mechanisms for electron transfer to generate singlet oxygen are presented.In addition,the types of cerium-based nanoparticles used for PDT of cancer are summarized.Finally,the challenges and prospects of clinical translations of cerium-based nanoparticles are briefly addressed. | Hui Li Min Wei Xinyi Lv Yanling Hu Jinjun Shao Xuejiao Song Dongliang Yang Wenjun Wang Buhong Li Xiaochen Dong | 2022 | Journal of Innovative Optical Health Sciences2022，15，6： | 0 |
| 13 | Monitoring of time-resolved singlet oxygen luminescence at 1270 nm by an optical fiber detection system显示文摘Singlet oxygen(^(1)O_(2))is the main cytotoxic substance in Type II photodynamic therapy(PDT).The luminescence of ^(1)O_(2) at 1270nm is extremely weak with a low quantum yield,making the direct detection of'O2 at 1270 nm very challenging.In this study,a set of highly sensitive optical fiber detection system is built up to detect the luminescence of photosensitized ^(1)O_(2) We use this system to test the luminescence characteristics of ^(1)O_(2) in pig skin tissue ex vrivo and mouse auricle skin in vivo.The experimental results show that the designed system can quantitatively detect photosensitized ^(1)O_(2) luminescence.The ^(1)O_(2) luminescence signal at 1270 nm is successfully detected in pig skin exr vivo.Compared with RB in an aqueous solution,the lifetime of ^(1)O_(2) increases to 17.4±12pus in pig skin tissue ex vivo.Experiments on living mice suggest that an enhancement of ^(1)O_(2) intensity with the increase of the TMPyP concentration.When the dose is 25 mg/kg,the vasoconstriction can reach more than 80%。The results of this study hold the potential application for clinical PDT dose monitoring using an optical fiber detection system. | Cheng Zhang Hongxin Lin Ying Hu Jian Sui Lisheng Lin Buhong Li | 2022 | Journal of Innovative Optical Health Sciences2022，15，6： | 0 |
| 14 | SINGLET OXYGEN DETECTION DURING PHOTOSENSITIZATION显示文摘Singlet oxygen(^(1)O_(2))is a highly reactive oxygen species involved in numerous chemical and photochemical reactions in diferent biological systems and in particular,in photodynamic therapy(PDT).However,the quantifcation of^(1)O_(2) generation during in vitro and in vivo pho-tosensitization is still technically challenging.To address this problem,indirect and direct methods for^(1)O_(2)detection have been intensively studied.This review presents the available methods currently in use or under development for detecting and quantifying^(1)O_(2) generation during photosensitization.The advantages and limitations of each method will be presented.Moreover,the future trends in developing PDT-^(1)O_(2) dosimetry will be briefly discussed. | BUHONG LI HUIYUN LIN DEFU CHEN BRIAN C.WILSON YING GU | 2013 | Journal of Innovative Optical Health Sciences2013，6，1： | 0 |
| 15 | Editorial-Introduction to the Special Issue on Photodynamic Therapy显示文摘Photodynamic therapy(PDT)is a minimally invasive treatment for malignant and nonmalignant diseases that uses light-activated photosensitizers to destroy or modify cells or tissues.It has been approved by health agencies in several countries for cancers of different sites and stages,and for treatment of age related macular degeneration,various benign skin conditions and localized bacterial infections. | Buhong Li Brian C.Wilson | 2015 | Journal of Innovative Optical Health Sciences2015，8，1： | 0 |
| 16 | Correlation of in vivo tumor response and singlet oxygen luminescence detection in mTHPC-mediated photodynamic therapy显示文摘Excited-state singlet axygen(^(1)O_(2)),generated during photodynamic therapy(PDT),is believed to be the primary cytotoxic agent with a number of clinically approved photosensitizers.Its relative concentration in cells or tissues can be measured directly through its near-infrared(NIR)luminescence emission,which has correlated well with in vitro cell and in triro normal skin treatment responses.Here,its correlation with the response of tumor tiss1e in vito is examined,using the photosensitizer meso-tetralydroxyphenylchlorin(mTHPC)in an animal model comprising luciferase-and green fluorescent protein(GFP)-transduced gliosarcoma grown in a dorsal window chamber.The change in the bioluminescence signal,imaged pre-treatment and at 2,5 and 9 d post treatment,was used as a quantitative measure of the tumor response,which was classified in individual tumors as'non','moderate'and'strong'in order to reduce the variance in the data.Plotting the bioluminescence-based response vs the^(1)O_(2)counts demonstrated clear correlation,indicating tha^(1)O_(2)luminescence provides a valid do-simetric technique for PDT in tumor tissue. | Brian C.Wilson Michael S.Patterson Buhong Li Mark T.Jarvi | 2015 | Journal of Innovative Optical Health Sciences2015，8，1： | 0 |
| 17 | COMPLETE PARAMETER MEASUREMENT FOR MIMO BISTATIC RADAR WITHOUT SYNCHRONIZATION显示文摘In order to measure the range, angle, and Doppler frequency of the target without any synchronization in the bistatic radar, a novel complete parameter estimation method based on separability of a pair of Linear Frequency Modulation (LFM) signal is presented. The Doppler fre-quency is measured by the time difference between two peak positions corresponding to the positive and the negative LFM return signal respectively. Direction Of Departures (DODs) and Direction Of Arrivals (DOAs) of the target are estimated by constructing a special eigenmatrix in which the es-timated angles can be extracted from the eigenvalue or the eigenvector. The target position can be located in the presence of the estimated DODs, DOAs and the signal delay difference between the echo and the directive wave signal in Multiple Input Multiple Output (MIMO) bistatic radar without any synchronization. The correctness and effectiveness of the proposed method are verified by the computer simulation. | Zhang Yongshun Zhao Guoqing Guo Yiduo] Wang Buhong | 2010 | Journal of Electronics(China)2010，27，6： | 0 |
| 18 | Effects of pulse width and repetition rate of pulsed laser on kinetics and production of singlet oxygen luminescence显示文摘Pulsed and continuous-wave(CW)lasers have been widely used as the light sources for photodynamic therapy(PDT)treatment.Singlet oxygen(^(1)O_(2))is known to be a major cytotoxic agent in type-II PDT and can be directly detected by its near-infrared luminescence at 1270 nm.As compared to CW laser excitation,the effiects of pulse width and repetition rate of pulsed laser on the kinetics and production of^(1)O_(2)luminescence were quantitatively studied during photosensitization of Rose Bengal.Significant di®erence in kinetics of^(1)O_(2)luminescence was found under the excitation with various pulse widths of nanosecond,microsecond and CW irradiation with power of 20mW.The peak intensity and duration of^(1)O_(2)production varied with the pulse widths for pulsed laser excitation,while the^(1)O_(2)was generated continuously and its production reached a steady state with CW excitation.However,no significant di®erence(P>0:05)in integral^(1)O_(2)production was observed.The results suggest that the PDT efficacy using pulsed laser may be identical to the CW laser with the same wavelength and the same average°uence rate below a threshold in solution. | Defu Chen Ying Wang Buhong Li Huiyun Lin Xuechun Lin Ying Gu | 2016 | Journal of Innovative Optical Health Sciences2016，9，6： | 0 |
| 19 | Internal light source for deep photodynamic therapy显示文摘Photodynamic therapy(PDT)for deep-seated lesion is seriously hindered by the limited depth of visible light penetration.Most recently,researchers have designed a genetically-encoded NanoLuc-miniSOG with internal light source for self-excitation,which is highly beneficial for deep PDT. | Buhong Li Li Lin | 2022 | Light(Science & Applications)2022，11，5： | 0 |
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