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| 1 | Loss of YTHDF2-mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration显示文摘 | Hu Wang Hongna Zuo Jin Liu Fei Wen Yawei Gao Xudong Zhu Bo Liu Feng Xiao Wengong Wang Gang Huang Bin Shen Zhenyu JU | 2018 | Cell Research2018，28，10： | 16 |
| 2 | Exosomes Released from Rabies Virus-Infected Cells May be Involved in the Infection Process显示文摘Exosomes are cell-derived vesicles that are secreted by many eukaryotic cells. It has recently attracted attention as vehicles of intercellular communication. Virus-infected cells release exosomes, which contain viral proteins, RNA, and pathogenic molecules. However, the role of exosomes in virus infection process remains unclear and needs to be further investigated.In this study, we aimed to evaluate the effects of exosomes on rabies virus infection. OptiPrep^(TM) density gradient centrifugation was used to isolate exosomes from rabies virus-infected cell culture supernatants. A rabies virus G protein enzyme-linked immunosorbent assay and acetylcholinesterase activity assays were performed to verify the centrifugation fractions. Exosomes were then characterized using transmission electron microscopy and Western blotting. Our results showed that rabies virus infection increased the release of exosomes. Treatment with GW4869 and si-Rab27 a, two exosomal secretion inhibitors, inhibited exosome release. Furthermore, the inhibitors reduced the levels of extracellular and intracellular viral RNA. These data indicated that exosomes may participate in the viral infection process. Moreover, our results establish a basis for future research into the roles of exosomes in rabies virus infection and as potential targets for developing new antiviral strategies. | Jingyu Wang Fan Wu Chuntian Liu Wenwen Dai Yawei Teng Weiheng Su Wei Kong Feng Gao Linjun Cai Ali Hou Chunlai Jiang | 2019 | Virologica Sinica2019，34，1： | 3 |
| 3 | Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers显示文摘 | Chen Wu Yuanyuan Xie Feng Gao Yanan Wang Yawei Guo Huanna Tian Yanshuang Li Wufang Fan | 2013 | Gene2013，，1： | 2 |
| 4 | Self-powered electrochemical system by combining Fenton reaction and active chlorine geheration for organic contaminant treatment显示文摘Environmental deterioration,especially water pollution,is widely dispersed and could affect the quality of people's life at large.Though the sewage treatment plants are constructed to meet the demands of cities,distributed treatment units are still in request for the supplementary of centralized purification beyond the range of plants.Electrochemical degradation can reduce organic pollution to some degree,but it has to be powered.Triboelectric nanogenerator(TENG)is a newly-invented technology for low-frequency mechanical energy harvesting.Here,by integrating a rotary TENG(R-TENG)as electric power source with an electrochemical cell containing a modified graphite felt cathode for hydrogen peroxide(H2O2)along with hydroxyl radical(·OH)generation by Fenton reaction and a platinum sheet anode for active chlorine generation,a self-powered electrochemical system(SPECS)was constructed.Under the driven of mechanical energy or wind flow,such SPECS can efficiently degrade dyes after power management in neutral condition without any O2 aeration.This work not only provides a guideline for optimizing self-powered electrochemical reaction,but also displays a strategy based on the conversion from distributed mechanical energy to chemical energy for environmental remediation. | Yawei Feng Kai Han Tao Jiang Zhenfeng Bian Xi Liang Xia Cao Hexing Li Zhong Lin Wang | 2019 | Nano Research2019，12，11： | 2 |
| 5 | Introduction of porous structure:A feasible and promising method for improving thermoelectric performance of Bi_2Te_3 based bulks显示文摘The porous p-type Bi_(0.4)Sb_(1.6)Te_3 bulks containing irregularly and randomly oriented pores were obtained by artificially controlling the relative density of sintered samples during resistance pressing sintering process. It is demonstrated that the thermoelectric performances are significantly affected by the porous structure, especially for the electrical and thermal conductivity due to the enhanced carrier scattering and phonon scattering. The increasing porosity resulted in the obvious decrease in electrical and thermal conductivity, and little change in Seebeck coefficients. It is encouraging that the reduction of thermal conductivity can compensate for the deterioration of electrical performance, leading to the enhancement in thermoelectric figure of merit(ZT). The maximum ZT value of 1.0 was obtained for the sample with a relative density of 90% at 333 K. Unfortunately, the increase in porosity also brought in obvious degradations in Vickers hardness from 51.71 to 27.74 HV. It is worth mentioning that although the Vickers hardness of the sample with a relative density of 90% decreased to 40.12 HV, it was still about twice as high as that of the zone melting sample(21.25 HV). To summarize, introducing pores structure into bulks properly not only enhances the ZT value of Bi_2Te_3 based alloys, but also reduces the use of raw materials and saves production cost. | Jie Hu Xi’An Fan Chengpeng Jiang Bo Feng Qiusheng Xiang Guangqiang Li Zhu He Yawei Li | 2018 | Journal of Materials Science & Technology2018，34，12： | 1 |
| 6 | Spatiotemporal distribution pattern of cyanobacteria community and its relationship with the environmental factors in Hongze Lake, China显示文摘 | Ying Ren Haiyan Pei Wenrong Hu Chang Tian Daping Hao Jielin Wei Yawei Feng | 2014 | Environmental Monitoring and Assessment2014，，10： | 1 |
| 7 | Self-powered ammonia synthesis under ambient conditions via N_(2) discharge driven by Tesla turbine triboelectric nanogenerators显示文摘Ammonia synthesis using low-power consumption and eco-friendly methods has attracted increasing attention.Here,based on the Tesla turbine triboelectric nanogenerator(TENG),we designed a simple and effective self-powered ammonia synthesis system by N_(2) discharge.Under the driving of the simulated waste gas,the Tesla turbine TENG showed high rotation speed and high output.In addition,the performance of two Tesla turbine TENGs with different gas path connections was systematically investigated and discussed.A controllable series-parallel connection with the control of gas supply time was also proposed.Taking advantage of the intrinsic high voltage,corona discharge in a N_(2) atmosphere was simply realized by a Tesla turbine TENG.With the flow of N_(2),the generated high-energy plasma can immediately react with water molecules to directly produce ammonia.The self-powered system achieved a yield of 2.14μg h^(−1)(0.126μmol h^(−1))under ambient conditions,showing great potential for large-scale synthesis. | Kai Han Jianjun Luo Jian Chen Baodong Chen Liang Xu Yawei Feng Wei Tang Zhong Lin Wang | 2021 | Microsystems & Nanoengineering2021，7，1： | 1 |
| 8 | Treatment of refractory H.pylori by Chai Ping Decoction:two case reports显示文摘目的:幽门螺杆菌感染是最常见的感染之一,目前已经广泛应用了很多医学治疗措施,比如四联疗法和序贯疗法。但部分患者经多次治疗仍有感染。在幽门螺杆菌感染的治疗中,中药得到了广泛的应用。对于反复感染幽门螺杆菌的患者,中医治疗与抗生素治疗相结合是否有效尚需临床观察。方法:报告2例难治性幽门螺杆菌感染病例。一例是一名60岁的中国妇女,诊断为慢性萎缩性胃炎和幽门螺杆菌感染,胃部不适,食欲不振,情绪低落,排便不规律。另一例是一名46岁的越南妇女,已经腹痛11年。我们采用柴平汤联合序贯治疗两例患者。结果:两例患者治疗后均疼痛缓解,幽门螺杆菌被根除。结论:中药联合序贯治疗可能清除幽门螺杆菌感染。根据中医理论,患者出现腹部不适症状,为脾虚湿气证,可以被较好的治疗。 | Heqing Chen Yawei Du Xiaoyi Tang Shuo Feng Xiaoli Wang Xinyi Li Yeyin Hu Youping Li Guihua Tian Bo Li | 2018 | TMR Clinical Research2018，1，2： | 0 |
| 9 | Penile vascular anomalies:A retrospective single center study and cumulative analysis of studies from China显示文摘Objective Penile vascular anomalies(PVAs)or hemangioma can arouse patient concern about aesthetics and cause symptoms like bleeding and sexual dysfunction.However,its low incidence and the deficiency of large-volume studies hinder urologists from making informed decisions.This study aimed to investigate the clinical features and treatment experience of PVAs at the Seventh Medical Center of PLA General Hospital,Beijing,China.Furthermore,by systematically analysis of studies on PVAs in Chinese people,we aimed to provide novel insights on the management of this condition.Methods We retrospectively investigated clinical features and pathology of surgery-treated PVAs at our center.Moreover,by systemically reviewing the literature from PubMed and the three largest medical databases(China National Knowledge Infrastructure,Wan Fang,and Chinese Medical Journal Database)in China,we analyzed the clinical features and various therapies of PVAs in Chinese people.Results Between March 1,2018 and March 1,2023,a total of 356 cases with vascular anomalies were treated with surgery at out center.Only seven(2.0%)cases had lesions involving the perineum and external genitalia.All the seven cases were pathologically benign and demonstrated no recurrence over a follow-up period of 1-52 months(median 14 months).A total of 410 cases from 44 studies were selected in the cumulative analysis.Most patients(92.4%)diagnosed with PVAs were asymptomatic,and 68.8%of the patients were treated with sclerotherapy.As to the pathology,57.1%were venous malformation.Conclusion The most common PVA is venous malformation and the majority of patients are asymptomatic.Sclerotherapy and laser have emerged as viable options for treating small lesions.Surgery still has its role in treating large lesions and obtaining pathology.Although PVAs often relapse or demand multiple treatments,the prognosis is favorable. | Chong Ma Feng Gao Ran An Yawei Guan Jingfei Teng Xing Ai | 2023 | Asian Journal of Urology2023，10，4： | 0 |
| 10 | Co-activation for enhanced K-ion storage in battery anodes显示文摘The relative natural abundance of potassium and potentially high energy density has established potassium-ion batteries as a promising technology for future large-scale global energy storage.However,the anodes'low capacity and high dis charge platform lead to low energy density,which impedes their rapid development.Herein,we present a possible co-activation mechanism between bismuth(Bi)and tin(Sn)that enhances K-ion storage in battery anodes.The co-activated Bi-Sn anode delivered a high capacity of634 mAh g^(-1),with a discharge plateau as low as 0.35 V,and operated continuously for 500 cycles at a current density of 50 mA g^(-1),with a high Coulombic efficiency of 99.2%.This possible co-activation strategy for high potassium storage may be extended to other Na/Zn/Ca/Mg/Al ion battery technologies,thus providing insights into how to improve their energy storage ability. | Yanhong Feng Yawei Lv Hongwei Fu Mihir Parekh Apparao MRao He Wang Xiaolin Tai Xianhui Yi Yue Lin Jiang Zhou Bingan Lu | 2023 | National Science Review2023，10，7： | 0 |
| 11 | UTI: a double-function inhibitor isolated from naked flax seeds显示文摘Acute glucose fluctuation during the postprandial period causes a risk fo r type 2 diabetes m ellitus(T2DM).a-Glucosidase inhibitors have been approved as therapeutic agents fo r diabetes.In the present study,a protein w ith a-glucosidase inhibitory activity from Flax(Linum usitatissimum)seeds was isolated using a one-step purification w ith Q-Sepharose4B colum n,follow ed by Sephacryl S-200 size-exclusion chromatography.It was identified as a trypsin inhibitor,named L.usitatissimum trypsin inh ibito r(LUTI).The half maximal inhibitory concentration(IC50)of LUTI was 113.92 pM fo r a-glucosidase and 6.17 pM for trypsin.Lineweaver-Burk kinetic experim ent showed that the protein exhibited tw o distinct inhibitory modes,a com petitive inh ibito r type for a-glucosidase and a non-com petitive type fo r trypsin.The interaction between LUTI and aglucosidase was detected through gel filtration chromatography and dynam ic light scattering.Increased glucose consum ption and lactic acid production were also observed fo llo w in g LUTI treatm ent in Caco-2 and HepG2 cells.LUTI inhibits not only the activity of trypsin but also the activity of a-glucosidase.It is expected that LUTI w ill become an oral hypoglycem ic polypeptide drug fo r T2DM. | Lei Wang Yinglu Chen Feng Wu Shasha Wu Xiaojun Hu Yawei Shi | 2019 | Acta Biochimica et Biophysica Sinica2019，51，10： | 0 |
| 12 | Effects of Cr and Mo elements on the microstructures and compressive properties of the in situ (TiCxNy–TiB2)/Ni cermets显示文摘In-situ(TiCxNy–TiB2)/Ni cermets with 70 wt%TiCxNy–TiB2 were successfully fabricated by combustion synthesis and hot pressing sintering in Ni-Ti-B4C-BN powder systems.The microstructures,density,compressive properties,and hardness of the TiCxNy–TiB2/Ni cermets with the addition of 0–8 wt%Cr/Mo to the Ni-Ti-B4C-BN powder systems were compared and analysed.The results showed that the ceramic particles distributed uniformly in the cermets,and the size of the ceramic particles reduced with the Cr/Mo addition.Both Cr and Mo addition can improve the hardness,compressive properties,and fracture strains of the cermets.The hardness,compressive strength,and fracture strain of the(TiCxNy–TiB2)/(Ni+Cr)cermets increased from 1561 HV,2.94 GPa,and 2.9%to 1864 HV,3.65 GPa,and 3.4%,respectively when the Cr content increased to 5 wt%.The hardness and compressive strength of the(TiCxNy–TiB2)/(Ni+Mo)cermets increased from 1561 HV and 2.94 GPa to 1902 HV and 3.43 GPa,respectively when the Mo content increased to 8 wt%.The cermets with Cr had better compressive properties than the cermets with Mo. | Fang Chang Feng Qiu Chuanlu Li Yawei Wang Qichuan Jiang | 2019 | Progress in Natural Science:Materials International2019，29，1： | 0 |
| 13 | Low-frequency blue energy harvesting for sustainable and active anticorrosion显示文摘Engineering materials serving in marine surroundings are inevitably corroded.The corrosive marine conditions can also be utilized to harvest kinetic ocean wave energy to solve this problem.Leveraging water–solid triboelectrification to harvest lowfrequency wave energy for active anticorrosion is promising.Existing techniques are efficient in harnessing environmental energy with frequencies higher than 3 Hz,whereas the dominated ocean waves with optimal wave spectral density fluctuate from 0.45 to 1.5 Hz.Herein,we proposed a highly efficient and sustainable blue energy-powered cathodic protection(BECP)strategy by fusing water–solid triboelectric nanogenerators and cathodic protection technology.Leveraging the highly efficient triboelectrification between the moving water and hydrophobic fluorinated ethylene propylene tube,we developed the built-in power module,enabling the harvest of ocean wave energy lower than 1.5 Hz.The generated volumetric current density is 28.9 mA·m^(-3),5–20 times higher than the values of the reported devices.Moreover,the proposed BECP performs comparably to conventional cathodic protection in corrosion inhibition.Significantly,the proposed approach can be easily applied to ships,buoys,and other offshore platforms to simultaneously realize blue energy harvesting and engineering material protection,providing an alternative to traditional active protection technology. | Miaomiao Cui Yawei Feng Hao Wu Yuankai Jin Wanbo Li Zuankai Wang | 2023 | Nano Research2023，16，9： | 0 |
| 14 | Declines in Blood Lead Levels Among General Population-China,2000–2018显示文摘What is already known about this topic?Environmental and occupational lead exposure has generally declined in the past two decades.However,there is no large-scale monitoring of blood lead levels(BLLs)in the Chinese general population.What is added by this report?This nationally representative study showed declines of BLLs in all ages of participants;for children aged 3–5 years,down from 78.1μg/L to 16.9μg/L,corresponding to 78.4%decrease in the past two decades(2000–2018).What are the implications for public health practice?Recommendations for elevated BLLs on screening children at high risk now need to be revisited and updated from 100μg/L to 50μg/L in guidelines to conform with the substantial declines in China. | Yuebin Lyu Jing Chen Zheng Li Liang Ding Feng Zhao Yingli Qu Xulin Zheng Zheng Zhang Xiaojian Hu Saisai Ji Yifu Lu Yawei Li Yuanduo Zhu Yanwei Yang Yidan Qiu Haocan Song Wenli Zhang Bing Wu Jiayi Cai Miao Zhang Fangyu Li Ying Zhu Zhaojin Cao John Ji Xiaoyuan Yao Yuxin Zheng Xiaoming Shi | 2022 | China CDC weekly2022，4，50： | 0 |
| 15 | Manganese therapy for dyslipidemia and plaque reversal in murine models显示文摘Precise control of circulating lipid levels is vital in both health and disease.We recently uncovered that bulk lipids,transported by lipoproteins,enter the circulation initially via the coat protein complex II(COPII)in a condensation-dependent manner.Divalent manganese,acting as a signaling messenger,selectively controls COPII condensation to regulate lipid homeostasis in vivo.Here,we present evidence for a manganese-based therapy in murine models of hypolipidemia and hyperlipidemia. | Yawei Wang Xin Feng Wenjing Zhou Runze Huang Yating Hu Hui Hui Jie Tian Xiao Wang Xiao-Wei Chen | 2023 | Life Metabolism2023，2，6： | 0 |
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