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| 1 | Precise fabrication of single-atom alloy co-catalyst with optimal charge state for enhanced photocatalysis显示文摘While the surface charge state of co-catalysts plays a critical role for boosting photocatalysis,studies on surface charge regulation via their precise structure control remain extremely rare.Herein,metal-organic framework(MOF)stabilized bimetallic Pd@Pt nanoparticles,which feature adjustable Pt coordination environment and a controlled structure from core-shell to single-atom alloy(SAA),have been fabricated.Significantly,apart from the formation of a Mott-Schottky junction in a conventional way,we elucidate that Pt surface charge regulation can be alternatively achieved by changing its coordination environment and the structure of the Pd@Pt co-catalyst,where the charge between Pd and Pt is redistributed.As a result,the optimized Pd10@Pt1/MOF composite,which involves an unprecedented SAA co-catalyst,exhibits exceptionally high photocatalytic hydrogen production activity,far surpassing its corresponding counterparts. | Yating Pan Yunyang Qian Xusheng Zheng Sheng-Qi Chu Yijun Yang Chunmei Ding Xi Wang Shu-Hong Yu Hai-Long Jiang | 2021 | National Science Review2021，8，1： | 4 |
| 2 | Simultaneous density and magnetic field fluctuation measurements by far-infrared interferometry and polarimetry in MST显示文摘 | Yates T F Ding W X Carter T A | 2008 | Review of Scientific Instruments2008，79，10： | 1 |
| 3 | Environment-friendly antisolvent tert-amyl alcohol modified hybrid perovskite photodetector with high responsivity显示文摘The preparation of high-quality perovskite films with optimal morphologies is important for achieving highperformance perovskite photodetectors(PPDs). An effective strategy to optimize the morphologies is to add antisolvents during the spin-coating steps. In this work, a novel environment-friendly antisolvent tert-amyl alcohol(TAA) is employed first to improve the quality of perovskite films, which can effectively regulate the formation of an intermediate phase staged in between a liquid precursor phase and a solid perovskite phase due to its moderate polarity and further promote the homogeneous nucleation and crystal growth, thus leading to the formation of high-quality perovskite films and enhanced photodetector performance. As a result, the responsivity of the PPD reaches 1.56 A/W under the illumination of 532 nm laser with the power density of 6.37 μW=cm^(2) at a bias voltage of -2 V, which is good responsivity for PPDs with the vertical structure and only CH_(3)NH_(3)PbI_(3) perovskite as the photosensitive material. The corresponding detectivity reaches 1.47×10^(12) Jones, while the linear dynamic range reaches 110 dB. These results demonstrate that our developed green antisolvent TAA has remarkable advantages for the fabrication of high-performance PPDs and can provide a reference for similar research work. | TENGTENG LI QINGYAN LI XIN TANG ZHILIANG CHEN YIFAN LI HONGLIANG ZHAO SILEI WANG XIN DING YATING ZHANG JIANQUAN YAO | 2021 | Photonics Research2021，9，5： | 1 |
| 4 | Mapping of individual sensory nerve axons from digits to spinal cord with the transparent embedding solvent system显示文摘Achieving uniform optical resolution for a large tissue sample is a major challenge for deep imaging.For conventional tissue clearing methods,loss of resolution and quality in deep regions is inevitable due to limited transparency.Here we describe the Transparent Embedding Solvent System(TESOS)method,which combines tissue clearing,transparent embedding,sectioning and block-face imaging.We used TESOS to acquire volumetric images of uniform resolution for an adult mouse whole-body sample.The TESOS method is highly versatile and can be combined with different microscopy systems to achieve uniformly high resolution.With a light sheet microscope,we imaged the whole body of an adult mouse,including skin,at a uniform 0.8×0.8×3.5μm^(3) voxel resolution within 120 h.With a confocal microscope and a 40×/1.3 numerical aperture objective,we achieved a uniform sub-micron resolution in the whole sample to reveal a complete projection of individual nerve axons within the central or peripheral nervous system.Furthermore,TESOS allowed the first mesoscale connectome mapping of individual sensory neuron axons spanning 5 cm from adult mouse digits to the spinal cord at a uniform sub-micron resolution. | Yating Yi Youqi Li Shiwen Zhang Yi Men Yuhong Wang Dian Jing Jiayi Ding Qingjie Zhu Zexi Chen Xingjun Chen Jun-Liszt Li Yilong Wang Jun Wang Hanchuan Peng Li Zhang Wenjing Luo Jian Q.Feng Yongwen He Woo-Ping Ge Hu Zhao | 2024 | Cell Research2024，34，2： | 0 |
| 5 | A NIR ratiometric fluorescent biosensor for sensitive detection and imaging of α-L-fucosidase in living cells and HCC tumor-bearing mice显示文摘Detection and imaging of α-L-fucosidase(AFU)is of great value to understand its roles in hepatocellular carcinoma(HCC)and tumor early diagnosis,but ideal assays are still lacking.Herein,a near-infrared(NIR)fluorescent biosensor(α-Fuc-DCM)was elaborately designed and synthesized for rapid and ratiometric detection of AFU activity in cells and HCC tumor mouse models.In the presence of AFU,this biosensor shows an enhancement in NIR emission in a ratiometric manner,which significantly improves the detection accuracy with the limit of detection as low as 4.8 mU/mL.Taking advantage of these merits,the activity of AFU in lysosomes could be visualized using ratiometric and NIR dual modality in living cells.Furthermore,its remarkable application for monitoring of endogenous AFU activity in HCC tumor-bearing mouse model is also demonstrated with bright fluorescence signal,which indicated that the biosensor could clearly monitor the liver tumor in the early stage.Importantly,the α-Fuc-DCM probe can be utilized to detect the AFU in serum from HCC patients.This strategy offers a promising biosensor system for early diagnosis of HCC and studying the roles of AFU in cancers. | Guo-Qiang Zhang Weiwei Feng Zhiyuan Gao Gao-Lan Zhang Xinying Wu Yating Xiao Xun Li Lei Zheng Dan Ding Jianshuang Guo Bo Situ | 2023 | Aggregate2023，4，2： | 0 |
| 6 | Engineering the thermostability of D-lyxose isomerase from Caldanaerobius polysaccharolyticus via multiple computer-aided rational design for efficient synthesis of D-mannose显示文摘D-Mannose is an attractive functional sugar that exhibits many physiological benefits on human health.The demand for low-calorie sugars and sweeteners in foods are increasingly available on the market.Some sugar isomerases,such as D-lyxose isomerase(D-LIase),can achieve an isomerization reaction between D-mannose and D-fructose.However,the weak thermostability of D-LIase limits its efficient conversion from D-fructose to D-mannose.Nonetheless,few studies are available that have investigated the molecular modification of D-LIase to improve its thermal stability.In this study,computer-aided tools including FireProt,PROSS,and Consensus Finder were employed to jointly design D-LIase mutants with improved thermostability for the first time.Finally,the obtained five-point mutant M5(N21G/E78P/V58Y/C119Y/K170P)showed high thermal stability and cat-alytic activity.The half-life of M5 at 65◦C was 10.22 fold,and the catalytic efficiency towards 600 g/L of D-fructose was 2.6 times to that of the wild type enzyme,respectively.Molecular dynamics simulation and intramolecular forces analysis revealed a thermostability mechanism of highly rigidity conformation,newly formed hydrogen bonds andπ-cation interaction between and within protein domains,and redistributed surface electrostatic charges for the mutant M5.This research provided a promising D-LIase mutant for the industrial production of D-mannose from D-fructose. | Hao Wu Ming Yi Xiaoyi Wu Yating Ding Minghui Pu Li Wen Yunhui Cheng Wenli Zhang Wanmeng Mu | 2023 | Synthetic and Systems Biotechnology2023，8，2： | 0 |
| 7 | Effects of two strategies on afterglow behavior of Lu_(2)O_(3):Eu single crystal scintillator:Co-doping with Pr^(3+)and solid solution with Sc_(2)O_(3)显示文摘In this paper,effect of two strategies on afterglow behavior of Lu_(2)O_(3):Eu single crystal scintillato r,Pr^(3+)codoping and solid solution with Sc_(2)O_(3),were studied systematically.Two groups of Lu_(2)O_(3):5 at%Eu,x at%Pr(x=0,0.2,0.5,1,2 and 5)and(Lu1-yScy)_(2)O_(3):5 at%Eu(y=0,20 at%,50 at%and 70 at%)single crystals were grown by floating zone(FZ)method in air atmosphere.The structures of as-grown crystals were determined by X-ray diffraction(XRD).The scintillation,photoluminescence properties and carrier trap states were investigated through afterglow,X-ray excitation luminescence(XEL),transmittance,photoluminescence excitation(PLE)and photoluminescence(PL),PL decay and thermal stimulated luminescence(TSL)curves.It is found that with the increase of Pr^(3+)concentration,the afterglow level of the system decreases at the expense of scintillation luminescence efficiency.Meanwhile,although Sc_(2)O_(3):Eu presents much lower afterglow intensity than Lu_(2)O_(3):Eu,the addition of Sc_(2)O_(3)will just increase the afterglow level of the(Lu1-yScy)_(2)O_(3):5 at%Eu single crystal system.Possible mechanisms for above phenomena are discussed based on experimental results. | Zhongjun Xue Dongzhou Ding Yating Sima Zuyao Zhou Hanrui Dong Shuwen Zhao He Feng | 2023 | Journal of Rare Earths2023，41，5： | 0 |
| 8 | A Predictive Nomogram for Predicting Improved Clinical Outcome Probability in Patients with COVID-19 in Zhejiang Province,China显示文摘The aim of this research was to develop a quantitative method for clinicians to predict the probability of improved prognosis in patients with coronavirus disease 2019(COVID-19).Data on 104 patients admitted to hospital with laboratory-confirmed COVID-19 infection from 10 January 2020 to 26 February 2020 were collected.Clinical information and laboratory findings were collected and compared between the outcomes of improved patients and non-improved patients.The least absolute shrinkage and selection operator(LASSO)logistics regression model and two-way stepwise strategy in the multivariate logistics regression model were used to select prognostic factors for predicting clinical outcomes in COVID-19 patients.The concordance index(C-index)was used to assess the discrimination of the model,and internal validation was performed through bootstrap resampling.A novel predictive nomogram was constructed by incorporating these features.Of the 104 patients included in the study(median age 55 years),75(72.1%)had improved short-term outcomes,while 29(27.9%)showed no signs of improvement.There were numerous differences in clinical characteristics and laboratory findings between patients with improved outcomes and patients without improved outcomes.After a multi-step screening process,prognostic factors were selected and incorporated into the nomogram construction,including immunoglobulin A(IgA),C-reactive protein(CRP),creatine kinase(CK),acute physiology and chronic health evaluation II(APACHE II),and interaction between CK and APACHE II.The C-index of our model was 0.962(95%confidence interval(CI),0.931-0.993)and still reached a high value of 0.948 through bootstrapping validation.A predictive nomogram we further established showed close performance compared with the ideal model on the calibration plot and was clinically practical according to the decision curve and clinical impact curve.The nomogram we constructed is useful for clinicians to predict improved clinical outcome probability for each COVID-19 patient,which may facilitate personalized counselling and treatment. | Jiaojiao Xie Ding Shi Mingyang Bao Xiaoyi Hu Wenrui Wu Jifang Sheng Kaijin Xu Qing Wang Jingjing Wu Kaicen Wang Daiqiong Fang Yating Li Lanjuan Li | 2022 | Engineering2022，8，1： | 0 |
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