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| 1 | Curative effect of warming kidney and fortifying spleen recipe on diarrhea-predominant irritable bowel syndrome显示文摘OBJECTIVE:To observe the curative effect of a recipe for warming the kidney and fortifying the spleen on diarrhea-predominant irritable bowel syndrome(IBS-D).METHODS:This multi-center,double-blind,randomized,and controlled trial included 240 patients that met the inclusion criterion and were then divided into two groups of 120.Patients in the treatment group(group A)took modified Sishen Wan orally for warming the kidney and fortifying the spleen and patients in the control group(group B)took a placebo,Chao Maiya,for 4 weeks.28 days after withdrawal,there was a 6-month follow-up to observe patient recurrence condition.The total effective rate,curative effect,and recurrence rate were evaluated after treatment.RESULTS:There was statistical difference(P<0.01)between the two groups in total effective rate(92.24%in the treatment group and 49.07%in the control group),in curative effect of TCM syndrome(90.52%and 47.22%,respectively),and in the recurrence rate(15.79%and 56.86%,respectively)within6 months after treatment.CONCLUSION:Modified Sishen Wan,for warming the kidney and fortifying the spleen,can effectively treat IBS-D and better control its recurrence. | Xiaolan Su Yanping Tang Jing Zhang Yuebin Dong Wei Wei Yibing Bai Yong Liu | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 22 |
| 2 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 3 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 4 | Oxidation behavior of Mo-Si-B alloys at medium-to-high temperatures显示文摘Continuous exploration of high-temperature structural materials is being driven by the needs of gasturbine engines capable of withstanding the high-temperature environment.Relatively low melting points of currently applied superalloys restrain the further improvement of service tempe ratures.With higher melting tempe ratures above 2000℃,Mo-Si-B alloys are regarded as a new generation of ultrahightemperature structural materials.However,oxidation is a concern for the industrial application of Mo-Si-B alloys.Therefore,an in-depth understanding of the oxidation mechanisms may contribute to solving this issue,whereas relevant reviews about their recent advances are lacking.In the current work,a comprehensively systematic review about the oxidation behaviors of Mo-Si-B alloys is described for this purpose. | Kunming Pan Yanping Yang Shizhong Wei Honghui Wu Zhili Dong Yuan Wu Shuize Wang Laiqi Zhang Junping Lin Xinping Mao | 2021 | Journal of Materials Science & Technology2021，，1： | 5 |
| 5 | Influence of Tip End-plate on Noise of Small Axial Fan显示文摘In this work, tip end-plate is used to improve the noise performance of small axial fans. Both numerical simulations and experimental methods were adopted to study the fluid flow and noise level of axial fans. Four modified models and the prototype are simulated. Influences of tip end-plate on static characteristics, internal flow field and noise of small axial fans are analyzed. The results show that on basis of the prototype, the model with the tip end-plate of 2 mm width and changed length achieved best noise performance. The overall sound pressure level of the model with the tip end-plate of 2 mm width and changed length is 2.4 dB less than that of the prototype at the monitoring point in specified far field. It is found that the mechanism of noise reduction is due to the decrease of vorticity variation on the surface of blades caused by the tip end-plate. Compared with the prototype, the static pressure of the model with the tip end-plate of 2 mm width and changed length at design flow rate decreases by 2 Pa and the efficiency decreases by 0.8%. It is concluded that the method of adding tip end-plate to impeller blades has a positive influence on reducing noise, but it may diminish the static characteristics of small axial fan to some extent. | MAO Hongya WANG Yanping LIN Peifeng JIN Yingzi Toshiaki Setoguchi Heuy Dong Kim | 2017 | Journal of Thermal Science2017，26，1： | 4 |
| 6 | A phenomenological constitutive equation for Rene 95 PM alloy and its application to isothermal forging process of turbine disk显示文摘The flow behavior of Rene 95 PM alloy was studied from 1050 to 1150℃with strain rate of 1€?10, 1€?10, 1€?10 and 1. At a given temperature and strain rate, flow curves exhibit a peak followed by flow softening up to a steady state. Moreover, at constant strain, flow stress increases with increasing strain rate and decreasing temperature. An equation relating hyperbolic sine of flow stress to hot working parameters, such as strain, strain rate and temperature, was established by using multiple nonlinear regression method. A very good agreement was found between predicted and experimental flow stress in all the strain range investigated. Application of the constitutive equation in predicting forming loads and flow behavior and temperature distribution in both upper and lower dies in an isothermal forging process of turbine disk of large dimension (about 630mm) by means of a finite element code was systematically analyzed. | Maicang Zhang, Jianxin Dong, Yanping Zeng, Xishan XieMaterials Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China | 2002 | Journal of University of Science and Technology Beijing2002，9，4： | 4 |
| 7 | Developing controllable hypermutable Clostridium cells through manipulating its methyl-directed mismatch repair system显示文摘Development of controllable hypermutable cells can greatly benefit understanding and harnessing microbial evolution.However,there have not been any similar sys-tems developed for Clostridium,an important bacterial genus.Here we report a novel two-step strategy for de-veloping controllable hypermutable cells of Clostridium acetobutylicum,an important and representative indus-trial strain.Firstly,the mutS/L operon essential for methyl-directed mismatch repair(MMR)activity was inactivated from the genome of C.acetobutylicum to generate hy-permutable cells with over 250-fold increased mutation rates.Secondly,a proofreading control system carrying an inducibly expressed mutS/L operon was constructed.The hypermutable cells and the proofreading control system were integrated to form a controllable hypermut-able system SMBMutC,of which the mutation rates can be regulated by the concentration of anhydrotetracycline(aTc).Duplication of the miniPthl-tetR module of the proof-reading control system further signifi cantly expanded the regulatory space of the mutation rates,demonstrating hypermutable Clostridium cells with controllable mutation rates are generated.The developed C.acetobutylicum strain SMBMutC2 showed higher survival capacities than the control strain facing butanol-stress,indicating greatly increased evolvability and adaptability of the controllable hypermutable cells under environmental challenges. | Guodong Luan Zhen Cai Fuyu Gong Hongjun Dong Zhao Lin Yanping Zhang Yin Li | 2013 | Protein & Cell2013，4，11： | 4 |
| 8 | Distribution and segregation of dissolved elements in pipeline slab显示文摘The chemical composition in a cross section of a high grade pipeline slab was measured point by point (in a scale of 1 μm) using original position statistic distribution analysis (OPA). The result indicated that negative segregation strips of Si, Mn, Mo, Ni, Cr, Nb, Cu, Ti, and V exist in the two sides 24 mm away from the central line, with a width of 8-12 mm, Negative segregation inside the central line is more severe than that outside the central line, and the highest positive segregation of the elements appears closely by the inner sides of the negative segregation strips. No obvious negative segregation strip of S and P is found. Segregation of the elements in the central area is higher than that in the outer and inner arc areas. The segregation of C, Ti, S, and P is high and that of Cr, Cu, Si, and Mn is low in the slab. | Jianhua Liu Yanping Bao Xian Dong Taiquan Li Yi Ren Shuai Zhang | 2007 | Journal of University of Science and Technology Beijing2007，14，3： | 3 |
| 9 | The miR-58 microRNA family is regulated by insulin signaling and contributes to lifespan regulation in Caenorhabditis elegans显示文摘microRNAs regulate diverse biological processes such as development and aging by promoting degradation or inhibiting translation of their target mRNAs. In this study, we have found that the miR-58 family microRNAs regulate lifespan in C.elegans. Intriguingly, members of the miR-58 family affect lifespan differently, sometimes in opposite directions, and have complex genetic interactions. The abundances of the miR-58 family miRNAs are up-regulated in the long-lived daf-2 mutant in a daf-16-dependent manner, indicating that these miRNAs are effectors of insulin signaling in C. elegans. We also found that miR-58 is regulated by insulin signaling and partially required for the lifespan extension mediated by reduced insulin signaling,germline ablation, dietary restriction, and mild mitochondrial dysfunction. We further identified the daf-21, ins-1, and isw-1 mRNAs as endogenous targets of miR-58. Our study shows that miRNAs function in multiple lifespan extension mechanisms,and that the seed sequence is not the dominant factor defining the role of a miRNA in lifespan regulation. | Yanping Zhang Wenhong Zhang Mengqiu Dong | 2018 | Science China(Life Sciences)2018，61，9： | 3 |
| 10 | Crack initiation and propagation induced by inclusions in a nickel-base P/M superalloy under fatigue load显示文摘In situ fatigue tests in special designed SEM were conducted to trace the whole process of crack initiation andpropagation till to fracture in nickel-base P/M superalloy seeded inclusions. The experimental results show that non-metallicinclusions can induce crack initiation. When the inclusion size is larger than the critical one, the crack can propagate as themain crack that induces the specimen to fracture. As a result, the LCF life of the specimen decreases. | ZENG Yanping ZHANG Maicang DONG Jianxin ZHANG Lina XIE Xishan | 2005 | Rare Metals2005，24，3： | 2 |
| 11 | Transmission and mortality risk assessment of severe fever with thrombocytopenia syndrome in China:results from 11-years’study显示文摘Background: The transmission and fatal risk of severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease first discovered in China in 2009, still needed further quantification. This research aimed to analyze the SFTS clusters and assess the transmission and mortality risk for SFTS.Methods: Both epidemiological investigation and case reports regarding SFTS clusters in China during 2011-2021 were obtained from the Public Health Emergency Information Management System of the Chinese Center for Disease Control and Prevention Information System. The transmission risk was evaluated by using the secondary attack rate (SAR) and relative risk (RR). Mortality risk factors were analyzed using a logistic regression model.Results: There were 35 SFTS clusters during 2011-2021 involving 118 patients with a fatality rate of 22.0%. The number of clusters annually increased seasonally from April to September. The clusters mainly occurred in Anhui (16 clusters) and Shandong provinces (8 clusters). The SAR through contact with blood or bloody fluids was much higher than that through contact with non-bloody fluids (50.6% vs 3.0%;χ^(2) = 210.97,P < 0.05), with anRR of 16.61 [95% confidence interval (CI): 10.23-26.97]. There was a statistically significant difference in the SAR between exposure to the blood of a deceased person during burial preparation and exposure to the living patients’ blood (66.7% vs 34.5%;χ^(2)= 6.40,P < 0.05), with anRR of 1.93 (95%CI: 1.11-3.37). The mortality risk factors were a long interval from onset to diagnosis [odds ratio (OR)= 1.385), 95%CI: 1.083-1.772,P= 0.009) and advanced age (OR: 1.095, 95%CI: 1.031-1.163,P= 0.01).Conclusions: The SFTS clusters showed a high mortality rate and resulted in a high SAR. Contact with a bleeding corpse was associated with a higher infection risk, compared with contacting the blood from living patients. It is important to promote early detection and appropriate case management of patients with SFTS, as well as improved handling of their corpses, to prevent further transmission and mortality. | Qiulan Chen Dong Yang Yanping Zhang Mantong Zhu Ning Chen Zainawudong Yushan | 2022 | Infectious Diseases of Poverty2022，11，5： | 2 |
| 12 | Simulation and Experiment Research of Aerodynamic Performance of Small Axial Fans with Struts显示文摘Interaction between rotor and struts has great effect on the performance of small axial fan systems.The small axial fan systems are selected as the studied objects in this paper,and four square struts are downstream of the rotor.The cross section of the struts is changed to the cylindrical shapes for the investigation:one is in the same hydraulic diameter as the square struts and another one is in the same cross section as the square struts.Influence of the shape of the struts on the static pressure characteristics,the internal flow and the sound emission of the small axial fans are studied.Standard K-ε turbulence model and SIMPLE algorithm are applied in the calculation of the steady fluid field,and the curves of the pressure rising against the flow rate are obtained,which demonstrates that the simulation results are in nice consistence with the experimental data.The steady calculation results are set as the initial field in the unsteady calculation.Large eddy simulation and PISO algorithm are used in the transient calculation,and the Ffowcs Williams-Hawkings model is introduced to predict the sound level at the eight monitoring points.The research results show that:the static pressure coefficients of the fan with cylindrical struts increase by about 25%compared to the fan with square struts,and the efficiencies increase by about 28.6%.The research provides a theoretical guide for shape optimization and noise reduction of small axial fan with struts. | CHU Wei LIN Peifeng ZHANG Li JIN Yingzi WANG Yanping Heuy Dong Kim Toshiaki Setoguchi | 2016 | Journal of Thermal Science2016，25，3： | 2 |
| 13 | High sensitivity SPR sensor for liquid phase sample with Ag/PbS/Graphene hybrid nanostructure显示文摘A surface plasmon resonance(SPR)sensor with Ag/PbS/GR hybrid nanostructure has been proposed for the diagnostics of liquid phase samples.Here Ag/PbS/GR hybrid nanostructure is designed as an asymmetric MIM waveguide for surface plasmon.Due to the guided wave SPR(GWSPR)modes,the index of the liquid phase samples can be measured more accurately than the conventional SPR sensors.Numerical simulation results show that the sensitivity of the sensor is about 5 times higher than the conventional SPR sensors.The origin of the enhancement mechanism is the combination of GWSPR in the Ag/PbS/GR hybrid nanostructure which enables the surface plasmon to spread along the PbS layer.In Ag/PbS/GR hybrid nanostructure,the electric field is concentrated mostly in the PbS layer,and the enhancement of the field intensity is nearly30%. | Kexiu Dong Yanping Ji Jiajia Mi Xiaotong Zhao Bin Wu Wangxia Huang Jianping Shi | 2017 | 光电工程2017，44，2： | 2 |
| 14 | Mesoporous carbon nanosheet-assembled flowers towards superior potassium storage显示文摘Potassium-ion batteries(PIBs)are attracted tremendous interest for large-scale energy storage systems(ESSs)owing to their economic merits.However,the main challenges of the PIBs are sluggish K-ion diffusion and large volume variations in the potassium repeated intercalation/deintercalation.Herein,mesoporous carbon nanosheet-assembled flowers(abbreviated as F-C)are designed as an original anode for superior-performance PIBs.Specifically,the F-C anode exhibits a high K-storage capacity(e.g.,381 mAh/g at 50 mA/g during the 2^(nd)cycle),excellent rate performance(e.g.,101 mAh/g at 2.0 A/g)and superior long cycle capability.Such excellent K-ion storage property is largely benefited from the large surface area(~141 m^(2)/g)and reasonable pore volume(0.465 cm^(3)/g),which not only stimulates rapid Kions diffusion and relieves the huge volume strain,but also exposes extensive active sites for K-ion capacitive storage. | Xianghua Zhang Dong Chen Yanping Zhou Dan Yang Weiling Liu Yuezhan Feng Xianhong Rui Yan Yu | 2021 | Chinese Chemical Letters2021，32，3： | 1 |
| 15 | Formic acid triggers the 'acid crash' of acetone-butanol-ethanol fermentation by Clostridium acetobutylicum显示文摘 | Wang Shaohua Zhang Yanping Dong Hongjun | 2011 | Applied and Environmental Microbiology2011，77，5： | 1 |
| 16 | Macroscopic Electromagnetic Cooperative Network‑Enhanced MXene/Ni Chains Aerogel‑Based Microwave Absorber with Ultra‑Low Matching Thickness显示文摘Electromagnetic cooperative strategy has been presented as a mainstream approach that can effectively optimize the matching thickness of dielectric loss dominant system.However,it is still challenging for dielectric–magnetic loss coexisting-type absorber to develop electromagnetic wave(EMW)performance with ultra-low matching thickness(≤1 mm).Breaking the limitation of traditional electromagnetic response at microscopic/mesoscopic scale,a ficus microcarpa-like magnetic aerogel with macroscopical electromagnetic cooperative effect was fabricated through highly oriented self-assembly engineering.The highly oriented Ni chains with unique macroscopic morphology(~1 cm in length)were achieved via a special magnetic field-induced growth.Strong magnetic coupling was observed in the Ni chains confirmed by the micromagnetic simulation.The deductive calculation validates that maintaining high value of electromagnetic parameters at high frequencies is the prerequisites of ultrathin absorber.The electromagnetic cooperative networks with uninterrupted and dual pathways spread through the entire aerogel skeleton,resulting in the impressive permittivity even at high frequencies.Consequently,the aerogel exhibits a remarkable EMW performance at an ultrathin thickness of 1 mm.Thus,based on the modulation of electromagnetic parameters,this work proposed a macroscopic ordered structure with the electromagnetic cooperative effect useful to develop a suitable strategy for achieving ultrathin EMW absorbers. | Fei Pan Yanping Rao Dan Batalu Lei Cai Yanyan Dong Xiaojie Zhu Yuyang Shi Zhong Shi Yaowen Liu Wei Lu | 2022 | Nano-Micro Letters2022，14，8： | 1 |
| 17 | Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study显示文摘 | HaiYing Chen Hui Yuan Rongbao Gao Jinxiang Zhang Dayan Wang Ying Xiong GuoYin Fan Fan Yang Xiaodan Li Jianfang Zhou Shumei Zou Lei Yang Tao Chen Libo Dong Hong Bo Xiang Zhao Ye Zhang Yu Lan Tian Bai Jie Dong Qun Li ShiWen Wang YanPing Zhang Hui Li Tian Go | 2014 | The Lancet2014，，： | 1 |
| 18 | Methadone maintenance treatment of heroin abuse in China 显示文摘 | Lu Lin Zhao Dong Bao Yanping | 2008 | Am J Drug Alcohol Abuse2008，34，2： | 1 |
| 19 | Two positive solutions for second order three point boundary value problems with sign changing nonlinearities 显示文摘 | GUO Yanping GE Weigao DONG Shijie | 2004 | Acta Math Appl Sin2004，27，3： | 1 |
| 20 | A New Next-Generation Sequencing-Based Assay for Concurrent Preimplantation Genetic Diagnosis of Charcot-Marie-Tooth Disease Type 1A and Aneuploidy Screening显示文摘Charcot-Marie-Tooth(CMT)disease is the most common hereditary neuropathy,with a population prevalence of 1 in2500.CMT disease type 1A(CMT1A),accounting for w70%of CMT1 cases and w50%of all CMT cases,is transmitted in an autosomal dominant manner.CMT1A maps to chromosome 17p11.2 and is caused,in the majority of cases,by a 1.4- | Baoheng Gui Pu Yang Zhongyuan Yao Yanping Li Donge Liu Nenghui Liu Sijia Lu Desheng Liang Lingqian Wu | 2016 | Journal of Genetics and Genomics2016，43，3： | 1 |
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