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| 1 | Scale-up of a high shear wet granulation process using a nucleation regime map approach显示文摘 | Gan Luo Bing Xu Yi Zhang Xianglong Cui Jianyu Li Xinyuan Shi Yanjiang Qiao | 2017 | Particuology2017，15，2： | 7 |
| 2 | Preclinical evaluation and pilot clinical study of [^(18)F]AlF-labeled FAPI-tracer for PET imaging of cancer associated fibroblasts显示文摘In recent years,fibroblast activation protein(FAP)has emerged as an attractive target for the diagnosis and radiotherapy of cancers using FAP-specific radioligands.Herein,we aimed to design a novel^(18)Flabeled FAP tracer([^(18)F]Al F-P-FAPI)for FAP imaging and evaluated its potential for clinical application.The[^(18)F]Al F-P-FAPI novel tracer was prepared in an automated manner within 42 min with a non-decay corrected radiochemical yield of 32±6%(n=8).Among A549-FAP cells,[^(18)F]Al F-P-FAPI demonstrated specific uptake,rapid internalization,and low cellular efflux.Compared to the patent tracer[^(18)F]FAPI-42,[^(18)F]Al F-P-FAPI exhibited lower levels of cellular efflux in the A549-FAP cells and higher stability in vivo.Micro-PET imaging in the A549-FAP tumor model indicated higher specific tumor uptake of[^(18)F]Al F-P-FAPI(7.0±1.0%ID/g)compared to patent tracers[^(18)F]FAPI-42(3.2±0.6%ID/g)and[68 Ga]Ga-FAPI-04(2.7±0.5%ID/g).Furthermore,in an initial diagnostic application in a patient with nasopharyngeal cancer,[^(18)F]Al F-P-FAPI and[^(18)F]FDG PET/CT showed comparable results for both primary tumors and lymph node metastases.These results suggest that[^(18)F]Al F-P-FAPI can be conveniently prepared,with promising characteristics in the preclinical evaluation.The feasibility of FAP imaging was demonstrated using PET studies. | Kongzhen Hu Junqi Li Lijuan Wang Yong Huang Li Li Shimin Ye Yanjiang Han Shun Huang Hubing Wu Jin Su Ganghua Tang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 3 | Property theory of Chinese materia medica: Clinical pharmacodynamics of traditional Chinese medicine显示文摘The property theory of Chinese materia medica is one of the foundations of traditional Chinese medicine.The property of Chinese materia medica(PCMM)is a multi-dimensional expression of the effect of Chinese materia medica(CMM),and it is related to the clinical prescription that fully reflects the clinical effect evaluation of CMM in a holistic,systematic,and scientific way.This paper discusses the source,development,and application of the PCMM by considering not only the five dimensions that constitute the PCMM but also the recognition of the human body and disease as given in traditional Chinese medicine.This paper aims to provide theoretical guidance for the rational use and development of CMM. | Yanjiang Qiao Yanling Zhang Sha Peng Mengqi Huo Jing Li Yanfeng Cao Zhao Chen | 2022 | Journal of Traditional Chinese Medical Sciences2022，9，1： | 2 |
| 4 | Identification of berbamine dihydrochloride from barberry as an anti-adipogenic agent by high-content imaging assay显示文摘Objective:Lipid droplet(LD)deposition in adipose tissue is a critical factor leading to metabolic dysfunction.Various herbal medicines in traditional Chinese medicine(TCM)are used to treat hyperlipidemia,type 2 diabetes,obesity,and other diseases.The objective of this study was to identify potential anti-adipogenic agents from TCM herbal compounds.Methods:One hundred and twenty compounds were evaluated in terms of their effect on adipocyte differentiation through image-based high content screening.Anti-adipogenic effects of identified hits were further confirmed at various concentrations.In addition,drug-induced liver injury assay was performed with HepG2 cells to test the hepatotoxicity of hit compounds.Results:Berbamine(BBM),a chemical isolated from barberry,and a derivative of BBM,berbamine dihydrochloride(BBMD),reduced LDs formation by more than 50%.Dose-dependent effects were observed and the IC50 values of the two hits,BBM and BBMD,were determined as 1.88 mM and 0.95 mM,respectively.Moreover,BBM induced mild HepG2 cell injury,while its dihydrochloridedBBMD did not exhibit hepatotoxicity within 40 mM.Conclusion:This study demonstrates that BBMD may be a potential therapeutic candidate for disorders associated with elevated LDs accumulation. | Shifeng Wang Qiao Zhang Yuxin Zhang Yanling Zhang Qinghua Wu Shiyou Li Yanjiang Qiao | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，2： | 2 |
| 5 | Seismic tes ting of a long-span concrete filled steel tubular arch bridge显示文摘 | Yan Weiming Li Yong Chen Yanjiang | 2011 | Key Engineering Material2011，456，： | 1 |
| 6 | Natural frequency analysis of fluid conveying pipeline with different boundary conditions显示文摘 | Huang Yimin Liu Yongshou Li Baohui Li Yanjiang Yue Zhufeng | 2010 | Nuclear Engineering and Design2010，240，： | 1 |
| 7 | Chronic hypoperfusion due to intracranial large artery stenosis is not associated with cerebralβ-amyloid deposition and brain atrophy显示文摘Background:Insufficient cerebral perfusion is suggested to play a role in the development of Alzheimer disease(AD).However,there is a lack of direct evidence indicating whether hypoperfusion causes or aggravates AD pathology.We investigated the effect of chronic cerebral hypoperfusion on AD-related pathology in humans.Methods:We enrolled a group of cognitively normal patients(median age:64 years)with unilateral chronic cerebral hypoperfusion.Regions of interest with the most pronounced hypoperfusion changes were chosen in the hypoperfused region and were then mirrored in the contralateral hemisphere to create a control region with normal perfusion.11C-Pittsburgh compound-positron emission tomography standard uptake ratios and brain atrophy indices were calculated from the computed tomography images of each patient.Results:The median age of the 10 participants,consisting of 4 males and 6 females,was 64 years(47-76 years).We found that there were no differences in standard uptake ratios of the cortex(volume of interest[VOI]:P=0.721,region of interest[ROI]:P=0.241)and grey/white ratio(VOI:P=0.333,ROI:P=0.445)and brain atrophy indices(Bicaudate,Bifrontal,Evans,Cella,Cella media,and Ventricular index,P>0.05)between the hypoperfused regions and contralateral normally perfused regions in patients with unilateral chronic cerebral hypoperfusion.Conclusion:Our findings suggest that chronic hypoperfusion due to large vessel stenosis may not directly induce cerebralβ-amyloid deposition and neurodegeneration in humans. | Dongyu Fan Huiyun Li Dongwan Chen Yang Chen Xu Yi Heng Yang Qianqian Shi Fangyang Jiao Yi Tang Qiming Li Fangyang Wang Shunan Wang Rongbing Jin Fan Zeng Yanjiang Wang | 2022 | Chinese Medical Journal2022，，5： | 1 |
| 8 | Preparation and Microwave Absorption Properties of Ni-B alloy-coated Fe3O4 Particles 显示文摘 | Xueai Li Xijiang Han Yanjiang Tan | 2008 | Journal of Alloys and Compounds2008，464，： | 1 |
| 9 | Fatigue Life Prediction for Some Metallic Materials under Constant Am- plitude Multiaxial Loading显示文摘 | LI Jing LI Chunwang QIAO Yanjiang | 2014 | International Journal of Fa tigue2014，38，6： | 1 |
| 10 | Typical diseases of a long-span concrete-filled steel tubular arch bridge and their effects on vehicle-induced dynamic response显示文摘A long-span concrete-filled steel tubular(CFST)arch bridge suffers severe vehicle-induced dynamic responses during its service life.However,few quantitative studies have been reported on the typical diseases suffered by such bridges and their effects on vehicle-induced dynamic response.Thus,a series of field tests and theoretical analyses were conducted to study the effects of typical diseases on the vehicle-induced dynamic response of a typical CFST arch bridge.The results show that a support void results in a height difference between both sides of the expansion joint,thus increasing the effect of vehicle impact on the main girder and suspenders.The impact factor of the displacement response of the main girder exceeds the design value.The variation of the suspender force is significant,and the diseases are found to have a greater effect on a shorter suspender.The theoretical analysis results also show that the support void causes an obvious longitudinal displacement of the main girder that is almost as large as the vertical displacement.The support void can also cause significant changes in the vehicle-induced acceleration response,particularly when the supports and steel box girder continue to collide with each other under the vehicle load. | Jianling HOU Weibing XU Yanjiang CHEN Kaida ZHANG Hang SUN Yan LI | 2020 | Frontiers of Structural and Civil Engineering2020，14，4： | 1 |
| 11 | Pinacol coupling of aromatic aldehydes and ketones using magnesium in aqueous Ammonium Chloride under ultrasound 显示文摘 | LI Jitai BIAN Yanjiang ZANG Hongjun | 2002 | Synth Commun2002，32，4： | 1 |
| 12 | Pinacol coupling of aromatic aldehydes and ketones using aluminum under ultrasound 显示文摘 | BIAN Yanjiang LIU Shuming LI Jitai | 2002 | Synth Commun2002，32，8： | 1 |
| 13 | Magnesium-induced pinacol coupling of aromatic aldehydes and ketones in water under ultrasound 显示文摘 | LI Jitai BIAN Yanjiang LIU Shuming | 2004 | Indian Journal of Chemistry2004，43，： | 1 |
| 14 | Reductive coupling of aromatic aldehydes to pinacols using active manga- nese under ultrasound irradiation 显示文摘 | BIAN Yanjiang LIU Shuming LI Jitai | 2005 | Indian Journal of Chemistry2005，44，8： | 1 |
| 15 | Preparation and microwave absorption properties of Ni-B alloy - coated Fe3O4 particles 显示文摘 | Li Xueai Han Xijiang Tan Yanjiang | 2008 | Journal of Alloys and Compounds2008，464，12： | 1 |
| 16 | Data-driven engineering framework with AI algorithm of Ginkgo Folium tablets manufacturing显示文摘Smart manufacturing still remains critical challenges for pharmaceutical manufacturing.Here,an original data-driven engineering framework was proposed to tackle the challenges.Firstly,from sporadic indicators to five kinds of systematic quality characteristics,nearly 2,000,000 real-world data points were successively characterized from Ginkgo Folium tablet manufacturing.Then,from simplex to the multivariate system,the digital process capability diagnosis strategy was proposed by multivariate C_(pk)integrated Bootstrap-t.The C_(pk)of Ginkgo Folium extracts,granules,and tablets were discovered,which was 0.59,0.42,and 0.78,respectively,indicating a relatively weak process capability,especially in granulating.Furthermore,the quality traceability was discovered from unit to end-to-end analysis,which decreased from 2.17 to 1.73.This further proved that attention should be paid to granulating to improve the quality characteristic.In conclusion,this paper provided a data-driven engineering strategy empowering industrial innovation to face the challenge of smart pharmaceutical manufacturing. | Lijuan Ma Jing Zhang Ling Lin Tuanjie Wang Chaofu Ma Xiaomeng Wang Mingshuang Li Yanjiang Qiao Yongxiang Wang Guimin Zhang Zhisheng Wu | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 1 |
| 17 | Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis:a multi-omics study with drug exploration显示文摘Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics,and currently used drugs cannot reverse the disease progress.Worse still,there are still challenges to be addressed to fully decipher the intricated pathogenesis.Thus,specifying the essential mechanisms and targets in silicosis progression then exploring anti-silicosis pharmacuticals are desperately needed.In this work,multi-omics atlas was constructed to depict the pivotal abnormalities of silicosis and develop targeted agents.By utilizing an unbiased and time-resolved analysis of the transcriptome,proteome and phosphoproteome of a silicosis mouse model,we have verified the significant differences in transcript,protein,kinase activity and signaling pathway level during silicosis progression,in which the importance of essential biological processes such as macrophage activation,chemotaxis,immune cell recruitment and chronic inflammation were emphasized.Notably,the phosphorylation of EGFR(p-EGFR)and SYK(pSYK)were identified as potential therapeutic targets in the progression of silicosis.To inhibit and validate these targets,we tested fostamatinib(targeting SYK)and Gefitinib(targeting EGFR),and both drugs effectively ameliorated pulmonary dysfunction and inhibited the progression of inflammation and fibrosis.Overall,our drug discovery with multi-omics approach provides novel and viable therapeutic strategies for the treatment of silicosis. | Mingyao Wang Zhe Zhang Jiangfeng Liu Meiyue Song Tiantian Zhang Yiling Chen Huiyuan Hu Peiran Yang Bolun Li Xiaomin Song Junling Pang Yanjiang Xing Zhujie Cao Wenjun Guo Hao Yang Jing Wang Juntao Yang Chen Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 1 |
| 18 | Dual active sites over Cu-ZnO-ZrO_(2) catalysts for carbon dioxide hydrogenation to methanol显示文摘CO_(2) hydrogenation to methanol is a significant approach to tackle the problem of global warming and simultaneously meet the demand for the portable fuel.Cu-ZnO catalysts with various kinds of promoters have received wide attention.However,the role of promoter and the form of active sites in CO_(2) hydrogenation are still in debate.Here,various molar ratios of ZrO_(2) were added into the Cu-ZnO catalysts to tune the distributions of Cu^(0) and Cu+species.A volcano-like trend between the ratio of Cu+/(Cu++Cu^(0))and the amount of ZrO_(2) is presented,among which the CuZn10Zr(the molar ratio of ZrO_(2) is 10%)catalyst reaches the highest value.Correspondingly,the maximum value of space-time yield to methanol with 0.65 gMeOH/(gcat·hr)is obtained on CuZn10Zr at reaction conditions of 220°C and 3 MPa.Detailed characterizations demonstrate that dual active sites are proposed during CO_(2) hydrogenation over CuZn10Zr catalyst.The exposed Cu^(0) takes participate in the activation of H_(2),while on the Cu^(+) species,the intermediate of formate from the co-adsorption of CO_(2) and H_(2) prefers to be further hydrogenated to CH_(3)OH than decomposing into the by-product of CO,yielding a high selectivity of methanol. | Xiucheng Sun Yifei Jin Zaizhe Cheng Guojun Lan Xiaolong Wang Yiyang Qiu Yanjiang Wang Huazhang Liu Ying Li | 2023 | Journal of Environmental Sciences2023，，9： | 1 |
| 19 | ERG–SOX4 interaction promotes epithelial–mesenchymal transition in prostate cancer cells显示文摘 | Lin Wang Yanjiang Li Xiaoqing Yang Huiqing Yuan Xiangzhi Li Mei Qi Yannicca W.Y. Chang Chunni Wang WeiWei Fu Muyi Yang Juan Zhang Bo Han | 2014 | Prostate2014，，6： | 1 |
| 20 | Effect of high cholesterol diet on spatial learning and memory in a rat model of Alzheimer’s disease显示文摘BACKGROUND: Recently study indicates a potentially important link between cholesterol, Aβ deposit, and clinicopathological manifestation of Alzheimer’s disease (AD). OBJECTIVE: To study the effect of high cholesterol diet on cognitive function and neuronal loss of hippocampal dentate gyrus in AD model rats. DESIGN, TIME AND SETTING: A randomized controlled animal study, which was performed in the Laboratory of Stem Cells, Department of Pathology, Third Military Medical University of Chinese PLA from February 2006 to March 2007. MATERIALS: Twenty healthy, male, Wistar rats, aged 3-4 months and weighing (300 ± 20) g, were selected for this study. Aβ1-40 was provided by Sigma Company, USA. Standard diet and high cholesterol diet mixed with cholesterol (5%), sodium hypocholic acid (1%), lard (10%), and ordinary rat food (84%) were provided by Experimental Animal Center, Institute of Field Surgery, Daping Hospital, Third Military Medical University of Chinese PLA. METHODS: Rats were fed on high cholesterol diet or standard diet for eight successive weeks. Then, rats were randomly divided into cholesterol diet +Aβ, high cholesterol diet + phosphate buffered saline(PBS), standard diet + Aβ, and standard diet + PBS group, with five rats in each group. AD rat models were established by local injection of Aβ1-40 solution (10 μL) into the hippocampal dentate gyrus. Rats in the control group were injected with the same volume of PBS. After injection, rat were fed for two weeks MAIN OUTCOME MEASURES: Neuronal cells in the hippocampal dentate gyrus were detected by Nissl staining; spatial navigation and spatial probe were detected by Morris water maze to reflect learning and memory. RESULTS: Twenty rats were included in the final analysis, without any loss. (1) Neuronal numbers: neuronal loss in the high cholesterol diet + Aβ and standard diet + Aβ groups was significantly higher than in the PBS groups (P < 0.01). In particular, loss of pyramidal cells in the high cholesterol diet + Aβ group was significantly higher than in the standard diet + Aβ group (P < 0.01). (2) Average escape latency: average escape latency was ranked as follows: cholesterol diet + Aβ group > standard diet + Aβ group > high cholesterol diet + PBS group > standard diet + PBS group. Moreover, the number of occasions on which the platform was passed—as well as percentage of swimming distance between two quadrants within two minutes—negatively correlated with average escape latency. CONCLUSION: High cholesterol diet may accelerate neuronal loss in the hippocampal dentate gyrus and aggravate cognitive impairment in AD rats. | Chuanqin Fang Huadong Zhou Jingcheng Li Jing Li Meng Zhang Yanjiang Wang ChangyueGao Juan Deng | 2008 | Neural Regeneration Research2008，3，5： | 0 |
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