| 1 | 中药性味辨识的研究进展显示文摘中药的性味包括四气五味(四气即寒、热、温、凉;五味即酸、苦、甘、辛、咸),是药物性能的重要标志之一。中药性味的辨识与确定是正确指导中医药性实践的重要步骤,同时也是一个长期的、综合的、不断完善的过程。传统上主要通过口尝、取象比类、以药物效应反推等方法辨识中药四气五味,现代中医药工作者在传统方法的基础上结合现代药物研究方法和技术进行创新,从不同侧面对四气五味药性规律进行探讨,为揭示中药药性本质提供了新视角。该文通过梳理中药性味理论的起源、发展历程、中药性味辨识的研究方法及研究思路,总结归纳中药性味的辨识方法,为继承和发展中药药性理论提供新方法,为促进中医药现代化提供参考。 | 许曼文 施钧瀚 王艳丽 桂新景 姚静 张璐 李学林 刘瑞新 | 2023 | 医药导报2023，42，5： | 1 |
| 2 | Identification of the material basis of the medicinal properties in Curcuma Longa L. to enhance targeted clinical application显示文摘Objective:To identify the relationship between the active compounds in turmeric(Curcuma Longa L.,C.Longa)and their medicinal properties,and clarify the chemical material basis of the medicinal properties in C.Longa.Methods:High throughput screening models of the thermo-transient receptor potentials(thermo-TRPs)and human taste type 2 receptors(hTAS2Rs)were established to evaluate the activity of the active compounds in C.Longa.The biological processes and distributions of the related targets of the active compounds were acquired by data mining.The above results were then used as basic data to comprehensively analyze the material basis of the medicinal properties of turmeric.Results:Curcumin inhibited TRPV1,TRPV2,TRPV3,and TRPA1,while demethoxycurcumin(DMC)inhibited TRPV3,TRPA1,and TRPM8.In terms of the 21 hTAS2Rs,the response values of hTAS2R38,hTAS2R16,and hTAS2R44 intervened by curcumin were ranked top three;the response values of hTAS2R3,hTAS2R1,and hTAS2R9 by DMC were in top three;the response values of hTAS2R47,hTAS2R39,and hTAS2R43 by bisdemethoxycurcumin(BDMC)were in top three.The biological processes related to active compounds primarily involved blood circulation,ossification,and regulation of the inflammatory response.Conclusion:Curcumin,DMC,and BDMC were identified as the material basis of the property of Chinese materia medica of C.Longa.Among these,curcumin and DMC may contribute to its warming effect in the four qi.Curcumin,DMC,and BDMC may lead to its bitter flavor,and the three active compounds were consistent with the meridian entry of C.Longa.Although different compounds play diverse roles in the four qi,five flavors,and meridian entry,they all were relevant to the efficacy of C.Longa.It is helpful to further understand the important role of the property of Chinese materia medica for the clinical application of traditional Chinese medicine. | Sha Peng Jing Li Mengqi Huo Yanfeng Cao Zhao Chen Yanling Zhang Yanjiang Qiao | 2022 | Journal of Traditional Chinese Medical Sciences2022，9，4： | 0 |
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