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| 1 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 2 | Fabrication of poly(vinylidene fluoride) membrane via thermally induced phase separation using ionic liquid as green diluent显示文摘Ionic liquid(IL),1-butyl-3-methylimidazolium hexafluorophosphate([BMIM]PF6)as a new and environmentally friendly diluent was introduced to prepare poly(vinylidene fluoride)(PVDF)membranes via thermally induced phase separation(TIPS).Phase diagram of PVDF/[BMIM]PF6 was measured.The effects of polymer concentration and quenching temperature on the morphologies,properties,and performances of the PVDF membranes were investigated.When the polymer concentration was 15 wt%,the pure water flux of the fabricated membrane was up to nearly 2000 L·m-2·h-1,along with adequate mechanical strength.With the increasing of PVDF concentration and quenching temperature,mean pore size and water permeability of the membrane decreased.SEM results showed that PVDF membranes manufactured by ionic liquid(BMIm PF6)presented spherulite structure.And the PVDF membranes were represented asβphase by XRD and FTIR characterization.It provides a new way to prepare PVDF membranes with piezoelectric properties. | Xiaozu Wang Xiaogang Li Juan Yue Yangming Cheng Ke Xu Qian Wang Fan Fan Zhaohui Wang Zhaoliang Cui | 2020 | Chinese Journal of Chemical Engineering2020，28，5： | 4 |
| 3 | Urban-rural disparities in mild cognitive impairment and its functional subtypes among community- dwelling older residents in central China显示文摘background Substantial variations in the prevalence of mild cognitive impairment(MCI)and its subtypes have been reported,although mostly in geographically defined developed countries and regions.Less is known about MCI and its subtypes in rural areas of less developed central China.Aims The study aimed to compare the prevalence of MCI and its subtypes in residents aged 65 years or older in urban and rural areas of Hubei Province,China.Methods Participants aged 65 years or older were recruited between 2018 and 2019.Inperson structured interviews and clinical and neuropsychological assessments were performed at city health community centres and township hospitals.results Among 2644 participants without dementia,735 had MCI,resulting in a prevalence of 27.8%for total MCI,20.9%for amnestic MCI(aMCI)and 6.9%for non-amnestic MCI(naMCI).The prevalence of MCI in urban and rural areas was 20.2%and 44.1%,respectively.After adjusting for demographic factors,the prevalence of total MCI,aMCI and naMCI differed significantly between rural and urban areas(adjusted odds ratio(OR)2.10,1.44 and 3.76,respectively).Subgroup analysis revealed an association between rural socioeconomic and lifestyle disadvantage and MCI and its subtypes.Conclusions Our findings suggest that the prevalence of MCI among urban residents in central China is consistent with that in other metropolis areas,such as Shanghai,but the prevalence in rural areas is twice that in urban areas.Prospective studies and dementia prevention in China should focus on rural areas. | Dan Liu Lin Li Lina An Guirong Cheng Cong Chen Mingjun Zou Bo Zhang Xuguang Gan Lang Xu Yangming Ou Qingming Wu Ru Wang Yan Zeng | 2021 | General Psychiatry2021，34，5： | 3 |
| 4 | Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia显示文摘Hepatic cholesterol accumulation is an important contributor to hypercholesterolemia,which results in atherosclerosis and cardiovascular disease(CVD).ATP-citrate lyase(ACLY)is a key lipogenic enzyme that converts cytosolic citrate derived from tricarboxylic acid cycle(TCA cycle)to acetyl-CoA in the cytoplasm.Therefore,ACLY represents a link between mitochondria oxidative phosphorylation and cytosolic de novo lipogenesis.In this study,we developed the small molecule 326E with an enedioic acid structural moiety as a novel ACLY inhibitor,and its CoA-conjugated form 326E-CoA inhibited ACLY activity with an IC_(50)=5.31±1.2μmol/L in vitro.326E treatment reduced de novo lipogenesis,and increased cholesterol efflux in vitro and in vivo.326E was rapidly absorbed after oral administration,exhibited a higher blood exposure than that of the approved ACLY inhibitor bempedoic acid(BA)used for hypercholesterolemia.Chronic 326E treatment in hamsters and rhesus monkeys resulted in remarkable improvement of hyperlipidemia.Once daily oral administration of 326E for 24 weeks prevented the occurrence of atherosclerosis in ApoE^(-/-)mice to a greater extent than that of BA treatment.Taken together,our data suggest that inhibition of ACLY by 326E represents a promising strategy for the treatment of hypercholesterolemia. | Zhifu Xie Mei Zhang Qian Song Long Cheng Xinwen Zhang Gaolei Song Xinyu Sun Min Gu Chendong Zhou Yangming Zhang Kexin Zhu Jianpeng Yin Xiaoyan Chen Jingya Li Fajun Nan | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 5 | Quantitative study of dimensional stability mechanism and microstructure evolution during precipitation process of 2024Al alloy显示文摘In this paper,we were devoted to quantitatively analyzing the dimensional change of 2024 Al alloy during the aging process.Types of precipitates have been defined and the corresponding volume fraction has been measured with Transmission Electron Microscopy(TEM)and Three-Dimensional Atom Probe Tomography(3 D-APT).Guinier-Preston-Bagaryatsky(GPB)zone(0.86 vol.%)was found after aging for 8 h.GPB zone(0.17 vol.%)and S'phase(1.02 vol.%)was found after aging for 24 h.The reduced dimensional change was attributed to the reduction of matrix lattice parameter.Relative to the initial supersaturated solid solution state,the lattice strain of-2.79×10^(-5)and-5.16×10^(-5)was produced after 8 h and 24 h aging respectively.The difference of the lattice parameters between the precipitates and matrix was also considered.A model was established to quantitatively describe the relationship between the precipitation process and dimensional change of 2024 Al alloy. | Youfang Cao Longtao Jiang Deng Gong Guoqin Chen Ziyang Xiu Yangming Cheng Xiufang Wang Gaohui Wua | 2021 | Journal of Materials Science & Technology2021，，31： | 1 |
| 6 | Contouring accuracy improvement using cross-coupled control and position error compensator显示文摘 | SU Kehan CHENG Yangming | | 0，，12： | 1 |
| 7 | Ultra-high-linearity integrated lithium niobate electro-optic modulators显示文摘Integrated lithium niobate(LN)photonics is a promising platform for future chip-scale microwave photonics systems owing to its unique electro-optic properties,low optical loss,and excellent scalability.A key enabler for such systems is a highly linear electro-optic modulator that could faithfully convert analog electrical signals into optical signals.In this work,we demonstrate a monolithic integrated LN modulator with an ultra-high spurious-free dynamic range(SFDR)of 120.04 dB·Hz^(4/5)at 1 GHz,using a ring-assisted Mach–Zehnder interferometer configuration.The excellent synergy between the intrinsically linear electro-optic response of LN and an optimized linearization strategy allows us to fully suppress the cubic terms of third-order intermodulation distortions(IMD3)without active feedback controls,leading to∼20 dB improvement over previous results in the thin-film LN platform.Our ultra-high-linearity LN modulators could become a core building block for future large-scale functional microwave photonic integrated circuits by further integration with other high-performance components like low-loss delay lines,tunable filters,and phase shifters available on the LN platform. | HANKE FENG KE ZHANG WENZHAO SUN YANGMING REN YIWEN ZHANG WENFU ZHANG CHENG WANG | 2022 | Photonics Research2022，10，10： | 0 |
| 8 | Berry texture QTL and candidate gene analysis in grape(Vitis vinifera L.)显示文摘Berry texture is a noteworthy economic trait for grape;however,the genetic bases and the complex gene expression and regulatory mechanism for the diverse changes in berry texture are still poorly understood.In this study,the results suggest that it is difficult to obtain high-mesocarp firmness(MesF)and high-pericarp puncture hardness(PPH)grape cultivars with high pericarp brittleness(PerB).The high-density linkage map was constructed using whole-genome resequencing based on 151 F1 individuals originating from intraspecific hybridization between the firm-flesh cultivar‘Red Globe’and soft-flesh cultivar‘Muscat Hamburg’.The total length of the consensus map was 1613.17 cM,with a mean genetic distance between adjacent bin markers of 0.59 cM.Twenty-seven quantitative trait loci(QTLs)for berry MesF,PPH,and PerB were identified in linkage groups(LGs)1,3,4,6,8,9,10,11,14,16,and 17,including twelve QTLs that were firstly detected in LGs 6,11,and 14.Fourteen promising candidate genes were identified from the stable QTL regions in LGs 10,11,14,and 17.In particular,VvWARK2 and VvWARK8 refer to chromosome 17 and are two promising candidate genes for MesF and PPH,as the VvWARK8 gene may increase pectin residue binding with WARK for high berry firmness maintenance and the allele for VvWARK2 carrying the‘CC’and‘GA’genotypes at Chr17:1836764 and Chr17:1836770 may be associated with non-hard texture grape cultivars.In addition,real-time quantitative polymerase chain reaction(RT-qPCR)verification revealed that the promising candidate transcription factor genes VvMYB4-like,VvERF113,VvWRKY31,VvWRKY1,and VvNAC83 may regulate cell wall metabolism candidate gene expression for grape berry texture changes. | Hong Lin Li Ma Qiuyu Guo Cheng Liu Yangming Hou Zhendong Liu Yuhui Zhao Changyue Jiang Xiuwu Guo Yinshan Guo | 2023 | Horticulture Research2023，10，12： | 0 |
| 9 | A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery显示文摘Coronaviruses(Co Vs)have brought serious threats to humans,particularly severe acute respiratory syndrome coronavirus 2(SARS-Co V-2),which continually evolves into multiple variants.These variants,especially Omicron,reportedly escape therapeutic antibodies and vaccines,indicating an urgent need for new antivirals with pan-SARS-Co V-2 inhibitory activity.We previously reported that a peptide fusion inhibitor,P3,targeting heptad repeated-1(HR1)of SARS-Co V-2 spike(S)protein,could inhibit viral infections.Here,we further designed multiple derivatives of the P3 based on structural analysis and found that one derivative,the P315V3,showed the most efficient antiviral activity against SARS-Co V-2 variants and several other sarbecoviruses,as well as other human-Co Vs(HCo Vs).P315V3 also exhibited effective prophylactic efficacy against the SARS-Co V-2 Delta and Omicron variants in mice via intranasal administration.These results suggest that P315V3,which is in PhaseⅡclinical trial,is promising for further development as a nasal pan-SARS-Co V-2 or pan-Co Vs inhibitor to prevent or treat CoV diseases. | Lili Wu Anqi Zheng Yangming Tang Yan Chai Jiantao Chen Lin Cheng Yu Hu Jing Qu Wenwen Lei William Jun Liu Guizhen Wu Shaogui Zeng Hang Yang Qihui Wang George Fu Gao | 2023 | Science China(Life Sciences)2023，66，10： | 0 |
| 10 | Exploring the psychological impact of the 2022 SARS-CoV-2 Omicron variant outbreak in China显示文摘To the editor:The impact of the coronavirus disease 2019(COVID-19)pandemic in 2020 on mental health was substantialin Chinai2and various other countries.34 Beyond the direct consequences of COVID-19,the pandemic created an environment in which many determinants of mental health were affected.Issues associated with the pandemic,such as loss of livelihood,limited access to medical services,reduced social interactions,and economic downturn,could potentially have adverse effects on the population's mental well-being.5 In November 2021,the World Health Organization(WHO)designated the new variant of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),variant B.1.1.529,as a variant of concern and named it Omicron;its rapid mutation and spread raised a new global health concern. | Gangbin Han Guirong Cheng Feifei Hu Chunli Li Dan Liu Juan Zhou Jing Liu Linya Huang Xiaochang Liu Qianqian Nie Dan Song Deyang Zeng Lang Xu Jinquan Li Yushan Chen Zhen Wei Qiong Wu Xiaoming He Qingming Wu Wei Tan Yufei Mei Xingxing Chen Yangming Ou Jingjing ZhangYafu Yu Mengliu Yang Pengfei Lian Fukai Zhou Renjia Fan Hong Wan Chenlu Hu Yidi Fu Shiyue Li Junyi Wang Cheng Cai Mengdie Pei Yuyang Cui Wanying Cai Yiqing Li Shiyao Pan Chang Chen Yan He Zhaoxia Wu Liu Hu Liang Tao Hongyan Xiao Xinyan Xie Yan Zeng | 2023 | General Psychiatry2023，36，6： | 0 |
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