4篇
您的检索式：作者名="Yangming Tang"
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| 1 | Compression Deformation Behavior of AZ91D Magnesium Alloy in Semi-solid State显示文摘 | YANGM B PAN F S TANG LW | 2007 | Material Science Forum2007，，： | 1 |
| 2 | Densification of Al2OTi2La particles in rapidly soidified Al-Ti-La alloy 显示文摘 | YangM S Shen N F Tang Y L | 1995 | J Mater Sci Letters1995，，14： | 1 |
| 3 | Efficient inhibition of SARS-CoV-2 emerging EG.5,EG.5.1 and BA.2.86 variants by fusion inhibitor HY3000 peptide显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to pose a significant threat to the world,as it continually evolves and gives rise to multiple variants and sub-variants.Recently,the Omicron EG.5 linage,which was first detected in Indonesia on 17 February 2023,has raised concerns due to its increased prevalence and extended immune escape properties,according to the risk analysis by the World Health Organization(WHO)[1].As of 3 October 2023,EG.5 and its sub-linages have been reported in 83 countries with shared 49,008 genome sequences in GISAID database(http://gffzz25fa773688d24fb7sqwqc06nw5ou96kbc.ffgz.tsg.suse.edu.cn/hcov19-variants/).EG.5 has become the dominant strain in the United States according to Centers for Disease Control and Prevention(CDC),accounting for 29.4%of SARS-CoV-2 infections(http://gffzz7e25867c50ea4228sqwqc06nw5ou96kbc.ffgz.tsg.suse.edu.cn/covid-data-tracker/#variant-proportions). | Lili Wu Anqi Zheng Yangming Tang Xiaoyun Wang Yue Gao Wenwen Lei Guizhen Wu Qihui Wang George Fu Gao | 2024 | hLife2024，2，1： | 0 |
| 4 | A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery显示文摘Coronaviruses(Co Vs)have brought serious threats to humans,particularly severe acute respiratory syndrome coronavirus 2(SARS-Co V-2),which continually evolves into multiple variants.These variants,especially Omicron,reportedly escape therapeutic antibodies and vaccines,indicating an urgent need for new antivirals with pan-SARS-Co V-2 inhibitory activity.We previously reported that a peptide fusion inhibitor,P3,targeting heptad repeated-1(HR1)of SARS-Co V-2 spike(S)protein,could inhibit viral infections.Here,we further designed multiple derivatives of the P3 based on structural analysis and found that one derivative,the P315V3,showed the most efficient antiviral activity against SARS-Co V-2 variants and several other sarbecoviruses,as well as other human-Co Vs(HCo Vs).P315V3 also exhibited effective prophylactic efficacy against the SARS-Co V-2 Delta and Omicron variants in mice via intranasal administration.These results suggest that P315V3,which is in PhaseⅡclinical trial,is promising for further development as a nasal pan-SARS-Co V-2 or pan-Co Vs inhibitor to prevent or treat CoV diseases. | Lili Wu Anqi Zheng Yangming Tang Yan Chai Jiantao Chen Lin Cheng Yu Hu Jing Qu Wenwen Lei William Jun Liu Guizhen Wu Shaogui Zeng Hang Yang Qihui Wang George Fu Gao | 2023 | Science China(Life Sciences)2023，66，10： | 0 |
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