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| 1 | Application of a microseismic monitoring system in deep mining显示文摘A microseismic monitoring system was used in the Donggua Shan underground copper mine, and its application was intro- duced. The spacial distribution of the seismic event was monitored effectively during mining with this system. The distribution of the seismic intensity in different time periods and in the different mining districts was obtained via the clustering analysis of the monitored results, and the different intensity concentration districts of seismicity were compartmentalized. The various characteristics and wave- forms of different vibrations in the underground mine were revealed with the help of the micro-seismic monitoring system. It was proved that the construction and application of the micro-seismic monitoring system in the mine not only realized the continuous monitoring of seismicity in the deep mine, but also settled an important foundation for further studies on hazard prediction, based on this system. | Chengxiang Yang Zhouquan Luo Guobin Hu Xiaoming Liu | 2007 | Journal of University of Science and Technology Beijing2007，14，1： | 14 |
| 2 | Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source. | Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang | 2020 | Cell Research2020，30，1： | 7 |
| 3 | A novel true triaxial test system for microwave-induced fracturing of hard rocks显示文摘This study introduces a test system for microwave-induced fracturing of hard rocks under true triaxial stress.The test system comprises a true triaxial stress loading system,an open-ended microwaveinduced fracturing system,a data acquisition system,an acoustic emission(AE)monitoring system,and an auxiliary specimen loading system.Microwave-induced surface and borehole fracturing tests under true triaxial stress were fulfilled for the first time,which overcomes the problem of microwave leakage in the coupling loading of true triaxial stress and microwave.By developing the dynamic monitoring system,the thermal response and fracture evolution were obtained during microwave irradiation.The monitoring system includes the infrared thermometry technique for monitoring rock surface temperature,the distributed optic fiber sensing technique for monitoring temperature in borehole in rock,the AE technique and two-dimensional digital speckle correlation technique for monitoring the evolution of thermal damage and the rock fracturing process.To validate the advantages of the test system and investigate the characteristics of microwave-induced fracturing of hard rocks,the study demonstrates the experimental methods and results for microwave-induced surface and borehole fracturing under true triaxial stress.The results show that thermal cracking presented intermittent characteristics(calm eactiveecalm)during microwave-induced surface and borehole fracturing of basalt.In addition,true triaxial stress can inhibit the development and distribution of thermal cracks during microwave-induced surface fracturing.When microwave-induced borehole fracturing occurs,it promotes the distribution of thermal cracks in rock,but inhibits the width of cracks.The results also prove the reliability of the test system. | Xia-Ting Feng Jiuyu Zhang Chengxiang Yang Jun Tian Feng Lin Shiping Li Xiangxin Su | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，5： | 5 |
| 4 | Experimental investigation on fracturing process of marble under biaxial compression显示文摘In this study,servo-controlled biaxial compression tests were conducted on marble specimens to investigate their failure characteristics and fracturing process.The complete stressestrain curves were obtained,and the three-dimensional(3D)features of the failure surfaces were acquired by 3D laser scanning.Acoustic emission(AE)monitoring and moment tensor(MT)analysis were used in combination to better understand the fracturing mechanism of marble under biaxial compression.It was noted that a type of 3D stepwise cracking behaviour occurred on the fracturing surfaces of the examined specimens.The stress dropped multiple times,and a repeated fracturing mode corresponding to the repeated stress drops in the post-peak regime was observed.Three substages,i.e.stress stabilisation,stress decrease and stress increase,were identified for a single fracturing mode.Then quantitative and statistical analyses of the fracturing process at each substage were discussed.Based on the testing results,it was found that at the stress stabilisation substage,the proportion of mixed-mode fractures increased.At the stress decrease substage,the proportion of mixed-mode fractures decreased,and the tensile or shear fractures increased.At the stress increase substage,the proportion of mixed-mode or tensile fractures decreased,and the shear fractures increased.Finally,a conceptual model for the stepwise crack formation was proposed. | Zhaofeng Wang Xia-Ting Feng Chengxiang Yang Yangyi Zhou Hong Xu Qiang Han Yaohui Gao | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，5： | 3 |
| 5 | Neighbor-Aware Multiple Access Protocol for 5G m MTC Applications显示文摘In order to support massive Machine Type Communication(mMTC) applications in future Fifth Generation(5G) systems,a key technical challenge is to design a highly effective multiple access protocol for massive connection requests and huge traffic load from all kinds of smart devices,e.g.bike,watch,phone,ring,glasses,shoes,etc..To solve this hard problem in distributed scenarios with massive competing devices,this paper proposes and evaluates a Neighbor-Aware Multiple Access(NAMA) protocol,which is scalable and adaptive to different connectivity size and traffic load.By exploiting acknowledgement signals broadcasted from the neighboring devices with successful packet transmissions,NAMA is able to turn itself from a contention-based random access protocol to become a contention-free deterministic access protocol with particular transmission schedules for all neighboring devices after a short transition period.The performance of NAMA is fully evaluated from random state to deterministic state through extensive computer simulations under different network sizes and Contention Window(CW)settings.Compared with traditional IEEE802.11 Distributed Coordination Function(DCF),for a crowded network with 50 devices,NAMA can greatly improve system throughput and energy efficiency by more than 110%and210%,respectively,while reducing average access delay by 53%in the deterministic state. | Yang Yang Guannan Song Wuxiong Zhang Xiaohu Ge Chengxiang Wang | 2016 | China Communications2016，13，S2： | 2 |
| 6 | Sevoflurane inhibits invasion and migration of lung cancer cells by inactivating the p38 MAPK signaling pathway显示文摘 | Hua Liang Miaoning Gu Chengxiang Yang Hanbing Wang Xianjie Wen Qiaoling Zhou | 2012 | Journal of Anesthesia2012，，3： | 1 |
| 7 | Genetic evolution of nonlinear material constitutive models显示文摘 | Feng Xiating Yang Chengxiang | 2001 | Computers Methods in Applied Mechanics and Engineering2001，190，45： | 1 |
| 8 | Photocatalytic degradation of gaseous toluene on Fe-TiO 2 under visible light irradiation: A study on the structure, activity and deactivation mechanism显示文摘 | Song Sun Jianjun Ding Jun Bao Chen Gao Zeming Qi Xiaoyan Yang Bo He Chengxiang Li | 2012 | Applied Surface Science2012，，12： | 1 |
| 9 | Thixotropic composite hydrogels based on agarose and inorganic hybrid gellants显示文摘Water can be used as oxidant in conjunction with metal particles to form metal-water propellant to increase the energy of propellant.For this application,water needs to be stored in form of solid and capable of becoming liquid when use.Stable and thixotropic hydrogel has good potential as water-retaining material and oxidant of metal-based propellant.In this study,we prepared organic/inorganic composite hydrogels by combining inorganic gellants hectorite and fumed silica with organic gellant agarose,respectively.The total content of the gellants can be reduced to less than 2%by adding agarose.The influence of agarose on water content,phase transition temperature,centrifugal stability and other basic physical properties of composite hydrogels were discussed.The results show that the composite hydrogels have better thixotropy and stability than pure inorganic hydrogels,and the gel-sol transformation can be realized by applying shear force or heating to the phase transition temperature.The composite hydrogels have good shear thinning ability and improved mechanical stability.Fumed silica/agarose hydrogels have better physical stability,while the thixotropy and shear thinning ability of hectorite/agarose hydrogels are better. | Hongzhi Zhang Huiyan Guo Yang Liu Chengxiang Shi Lun Pan Xiangwen Zhang Ji-Jun Zou | 2023 | Chinese Journal of Chemical Engineering2023，54，2： | 1 |
| 10 | Conversion of lignin oil and hemicellulose derivative into high-density jet fuel显示文摘Synthesizing high-density fuel from lignocellulose can not only achieve green and low-carbon development,but also expand the feedstock source of hydrocarbon fuel.Here,we reported a route of producing high-density fuel from lignin oil and hemicellulose derivative cyclopentanol through alkylation and hydrodeoxygenation,HY with SiO_(2)/Al_(2)O_(3) molar ratio of 5.3 was screened as the alkylation catalyst in the reaction of model phenolic compounds and mixtures,and the reaction conditions were optimized to achieve conversion of phenolic compounds higher than 87%and selectivity of bicyclic and tricyclic products higher than 99%.Then two phenolic pools simulating the composition of two typic lignin oils were studied to validate the alkylation and analyze the competition mechanism of phenolic compounds in mixture system.Finally,real lignin oil from depolymerized of beech powder was tested,and notably80%of phenolic monomers in the oil were converted into fuel precursor.After hydrodeoxygenation,the alkylated product was converted to fuel blend with a density of 0.91 g/mL at 20℃and a freezing point lower than-60℃,very promising as high density fuel.This work provides a facile and energyefficient way of synthesizing high-performance jet fuel directly from lignocellulosic derivatives,which decreases processing energy consumption and improve the utilization rate of feedstock. | Sichao Yang Chengxiang Shi Zhensheng Shen Lun Pan Zhenfeng Huang Xiangwen Zhang Ji-Jun Zou | 2023 | Journal of Energy Chemistry2023，，2： | 1 |
| 11 | Identification of visco-elastic models for rocks usinggenetic programming coupled with the modified particle swarm optimization algorithm显示文摘 | Feng Xiating Chen Bingrui Yang Chengxiang | 2006 | International Journal of Rock Mechanics & Mining Sciences2006，43，3： | 1 |
| 12 | Identification of visco-elastic models for rocks using genetic programming coupled with the modified particle swarm optimization algorithm 显示文摘 | Feng Xiating Chen Bingrui Yang Chengxiang | 2006 | International Journal of Rock Mechanics & Mining Sciences2006，43，5： | 1 |
| 13 | The interaction between oxidative stress and mast cell activation plays a role in acute lung injuries induced by intestinal ischemia–reperfusion显示文摘 | Weicheng Zhao Xiaoliang Gan Guangjie Su Gao Wanling Shangrong Li Ziqing Hei Chengxiang Yang Hanbing Wang | 2013 | Journal of Surgical Research2013，，： | 1 |
| 14 | Progress and perspectives on two-dimensional silicon anodes for lithium-ion batteries显示文摘Silicon(Si)anodes with extremely high theoretical capacities are considered indispensable for next-generation high-energy lithium-ion batteries(LIBs).However,several intractable problems,including pulverization,poor electrical contact,and continuous side reactions caused by the large volume change of Si during lithia-tion/delithiation,lead to a short cycle life and poor rate capability,thus hindering the commercial use of Si anodes in LIBs.Two-dimensional(2D)Si with a unique graphene-like structure has a short ion diffusion path-way,small volume change during lithiation,and efficient redox site utilization,making it more promising than bulk Si or Si with other versatile structures for use in LIBs.Theoretical analysis demonstrated that the low energy barrier on the surface of 2D Si accelerates the transport of Li+.However,the issues surrounding 2D Si,includ-ing the tedious and user-unfriendly synthesis,ease of restacking,and atmospheric sensitivity,limit its practical applications,which are discussed in this review.Furthermore,possible solutions to these remaining challenges and new directions are provided,with the aim of designing practical and high-performance 2D Si anodes for next-generation LIBs. | Han Zhao Fan Yang Chongxing Li Tong Li Shuxian Zhang Chengxiang Wang Zhiwei Zhang Rutao Wang | 2023 | ChemPhysMater2023，2，1： | 1 |
| 15 | Senescent bone marrow microenvironment promotes Nras-mutant leukemia显示文摘Dear Editor,In recent years,there is growing interest regarding the roles of senescent bone marrow(BM)microenvironment in the initiation of leukemia.Aged mice transplanted with AML1-ETO(AML1-ETO fusion protein)-positive hematopoietic stem cells(HSCs)present with a significant increase in the frequency of AMLETO-positive early progenitor cells in BM as well as an in crease of immature myeloid cells compared to young recipients(Vas et aL,2012).BM mesenchymal stem cells(MSCs)from myelodysplastic syndromes(MDS)animal models and MDS patients exhibit impaired proliferation and differentiation potentials,abnormal cytoki ne secretion,and dysregulated gene expression profile(Lopez-Villar et al.,2009;Geyh et al.,2013;Mattiucci et al.,2018).However,the causal relationship between senes・cent BM microenvironment and leukemia development is unclear.Whether senes・cent BM microenvironment initiates or accelerates leukemia development remains unknown. | Peiqing Zhou Chengxiang Xia Tongjie Wang Yong Dong Qitong Weng Xiaofei Liu Yang Geng Jinyong Wang Juan Du | 2021 | Journal of Molecular Cell Biology2021，13，1： | 1 |
| 16 | Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors显示文摘Regeneration of functional B lymphopoiesis from pluripotent stem cells(PSCs)is challenging,and reliable methods have not been developed.Here,we unveiled the guiding role of three essential factors,Lhx2,Hoxa9,and Runx1,the simultaneous expression of which preferentially drives B lineage fate commitment and in vivo B lymphopoiesis using PSCs as a cell source.In the presence of Lhx2,Hoxa9,and Runx1 expression,PSC-derived induced hematopoietic progenitors(iHPCs)immediately gave rise to pro/pre-B cells in recipient bone marrow,which were able to further differentiate into entire B cell lineages,including innate B-1a,B-1b,and marginal zone B cells,as well as adaptive follicular B cells.In particular,the regenerative B cells produced adaptive humoral immune responses,sustained antigen-specific antibody production,and formed immune memory in response to antigen challenges.The regenerative B cells showed natural B cell development patterns of immunoglobulin chain switching and hypermutation via cross-talk with host T follicular helper cells,which eventually formed T cell-dependent humoral responses.This study exhibits de novo evidence that B lymphopoiesis can be regenerated from PSCs via an HSC-independent approach,which provides insights into treating B cell-related deficiencies using PSCs as an unlimited cell resource. | Qi Zhang Bingyan Wu Qitong Weng Fangxiao Hu Yunqing Lin Chengxiang Xia Huan Peng Yao Wang Xiaofei Liu Lijuan Liu Jiapin Xiong Yang Geng Yalan Zhao Mengyun Zhang Juan Du Jinyong Wang | 2022 | Cellular & Molecular Immunology2022，19，4： | 0 |
| 17 | A robust interface enabled by electrospun membrane with optimal resistance in lithium metal batteries显示文摘A uniform diffusion layer is essential for non-dendritic deposition of lithium in high-density lithium batteries.However,natural pristine solid electrolyte interface(SEI)is always porous and inhomogeneous because of repeated breakdown and repair cycles,whereas ideal materials with excellent mechanical property for artificial SEIs remain a challenge.Herein,a robust and stable interface is achieved by spinning soft polymer associated with few MoO_(3) into fibers,and thus mechanical property of fibers other than materials determines mechanical performance of the interface which can be optimized by adjusting parameters.Furthermore,lithium deposited underneath the layer is enabled by constructing an optimal resistance to make the membrane serve as an artificial SEI rather than lithium host.As a result,dendritefree lithium was observed underneath the membrane,and stable interface for long-term cycling was also indicated by EIS measurements.The lithium iron phosphate(LiFePO_(4))full-cell with coated electrode demonstrated an initial capacity of 155.2 m Ah g^(-1),and 80%of its original capacity was retained after 500 cycles at 2.0℃ without any additive in carbonate-based electrolyte. | Chen Dong Zhenkang Lin Yuxin Yin Yaoxuan Qiao Wei Wang Qibing Wu Chengxiang Yang David Rooney Cheng Fan Kening Sun | 2021 | Journal of Energy Chemistry2021，30，4： | 0 |
| 18 | Microwave response characteristics and influencing factors of ores based on dielectric properties of synthetic samples显示文摘In order to understand the influence of different factors on the microwave response characteristics of ores,the effects of electrical conductivity,metal mineral content,compactness,metal mineral distribution,microwave frequency and temperature on the dielectric properties of synthetic ores(metal mineral and quartz)were studied.Microwave heating tests were carried out on three types of natural ores(Hongtoushan copper ore,Sishanling iron ore and Dandong gold ore)with significant differences in metal mineral contents.The test results showed that under microwave irradiation,the stronger the electrical conductivity of the metal minerals,the smaller the penetration depth in synthetic ore.For those metal minerals with lower electrical conductivity,the microwave absorption coefficient of the synthetic samples increases with increasing metal mineral content.For those metal minerals with higher electrical conductivity,the microwave absorption coefficient of the samples first increases and then decreases as the metal mineral content increases.When the metal minerals are distributed in layers,the penetration depth is much less than that given a uniform distribution.The penetration depth in the sample at microwave frequency of 915 MHz is greater than that at 2.45 GHz.The higher the electrical conductivity of metal minerals used in synthetic ores,the higher the high-temperature sensitivity of electromagnetic shielding coefficient(0.C-500.C).The Hongtoushan copper ore with high metal mineral content exhibits obvious size effect.The effects of ore structure and crystal particle size on the distribution characteristics of microcracks were discussed.Based on the test results,a quantitative prediction model of microwave sensitivity of ore was proposed,which provides guidance for the prediction of ore heating effect and the selection of microwave heating sequence of ore. | Feng Lin Xia-Ting Feng Chengxiang Yang Shiping Li Jiuyu Zhang Xiangxin Su Tianyang Tong | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，2： | 0 |
| 19 | An open-end high-power microwave-induced fracturing system for hard rock显示文摘Microwave pre-treatment is considered as a promising technique for alleviating cutter wear. This paper introduces a high-power microwave-induced fracturing system for hard rock. The test system consists of a high-power microwave subsystem (100 kW), a true triaxial testing machine, a dynamic monitoring subsystem, and an electromagnetic shielding subsystem. It can realize rapid microwave-induced fracturing, intelligent tuning of impedance, dynamic feedback under strong microwave fields, and active control of microwave parameters by addressing the following issues: the instability and insecurity of the system, the discharge breakdown between coaxial lines during high-power microwave output, and a lack of feedback of rock-microwave response. In this study, microwave-induced surface and borehole fracturing tests under true triaxial stress were carried out. Experimental comparisons imply that high-power microwave irradiation can reduce the fracturing time of hard rock and that the fracture range (160 mm) of a 915-MHz microwave source is about three times that of 2.45 GHz. After microwave-induced borehole fracturing, many tensile cracks occur on the rock surface and in the borehole: the maximum reduction of the P-wave velocity is 12.8%. The test results show that a high-power microwave source of 915 MHz is more conducive to assisting mechanical rock breaking and destressing. The system can promote the development of microwave-assisted rock breaking equipment. | Xia-Ting Feng Jiuyu Zhang Feng Lin Chengxiang Yang Shiping Li Tianyang Tong Xiangxin Su | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，12： | 0 |
| 20 | Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis显示文摘Mesenchymal stem cells(MSCs)experience substantial viability issues in the stroke infarct region,limiting their therapeutic efficacy and clinical translation.High levels of deadly reactive oxygen radicals(ROS)and proinflammatory cytokines(PC)in the infarct milieu kill transplanted MSCs,whereas low levels of beneficial ROS and PC stimulate and improve engrafted MSCs’viability.Based on the intrinsic hormesis effects in cellular biology,we built a microglia-inspired MSC bioengineering system to transform detrimental high-level ROS and PC into vitality enhancers for strengthening MSC therapy.This system is achieved by bioorthogonally arming metabolic glycoengineered MSCs with microglial membrane-coated nanoparticles and an antioxidative extracellular protective layer.In this system,extracellular ROSscavenging and PC-absorbing layers effectively buffer the deleterious effects and establish a microlivable niche at the level of a single MSC for transplantation.Meanwhile,the infarct’s inanimate milieu is transformed at the tissue level into a new living niche to facilitate healing.The engineered MSCs achieved viability five times higher than natural MSCs at seven days after transplantation and exhibited a superior therapeutic effect for stroke recovery up to 28 days.This vitality-augmented system demonstrates the potential to accelerate the clinical translation of MSC treatment and boost stroke recovery. | Jianpei Xu Yinzhe Sun Yang You Yuwen Zhang Dan Huang Songlei Zhou Yipu Liu Shiqiang Tong Fenfen Ma Qingxiang Song Chengxiang Dai Suke Li Jigang Lei Zhihua Wang Xiaoling Gao Jun Chen | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
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