|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Linear Quadratic Differential Game Strategies with Two-pursuit Versus Single-evader显示文摘In order to intercept the future targets that are characterized by high maneuverability, multiple interceptors may be launched and aimed at single target. The scenario of two missiles P and Q intercepting a single target is modeled as a two-pursuit single-evader non-zero-sum linear quadratic differential game. The intercept space is decomposed into three subspaces which are mutually disjoint and their union covers the entire intercept space. The effect of adding the second interceptor arises in the intercept space of both P and Q (PQ-intercept space). A guidance law is derived from the Nash equilibrium strategy set (NESS) of the game. Simulation studies are focused on the PQ-intercept space. It is indicated that 1) increasing the target's maneuverability will enlarge PQ-intercept space; 2) the handover conditions will be released if the initial zero-effort-miss (ZEM) of both interceptors has opposite sign; 3) overvaluation of the target's maneuverability by choosing a small weight coefficient will generate robust performance with respect to the target maneuvering command switch time and decrease the fuel requirement; and 4) cooperation between interceptors increases the interception probability. | LIU Yanfang QI Naiming TANG Zhiwei | 2012 | Chinese Journal of Aeronautics2012，25，6： | 19 |
| 2 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
| 3 | Description and Evaluation Approach for Uncertainty of RS Images Classi- fication显示文摘与关于遥感图象的分类质量的研究的开发,研究人员们认为不确定性是影响分类质量的主要因素。这研究提出一条途径到不确定性表示,它从二个方面被开发:形式化的描述和全面评估。首先,我们用模糊监视途径完成分类,作为对分类不确定性的形式化的描述拿它。然后,我们为分类不确定性评估介绍一个混合的熵模型,它能满足几不确定性的全面思考的要求,当与对每个象素的错误率的不同贡献的完整的考虑从象素规模构造评估索引时。最后,一个应用程序例子将被学习检验新方法。结果证明评估结果充分反映分类质量,当与常规评估相比从单一的不确定性和范畴构造模型的方法可伸缩时。 | LAN Zeying LIU Yanfang TANG Xiangyun LIU Yang | 2009 | Geo-Spatial Information Science2009，12，1： | 3 |
| 4 | Effect of degradation of PLGA and PLGA/β-TCP scaffolds on the growth of osteoblasts显示文摘Osteoblasts were cultured on porous scaffolds of poly(L-lactide-co-glycolide) (PLGA) and PLGA/β-tricalcium phosphate (β-TCP) to evaluate their cytocompatibility.The proliferation of the cells on both scaffolds was examined before and after in vitro degradation for 4,8 and 12 weeks under static (shaking water bath) and dynamic (cyclic loading) conditions.Results indicate that porous PLGA and PLGA/β-TCP scaffolds have good biocompatibility and can be used as effective templates for guiding the growth of osteoblasts.The degradation of the scaffolds affects the proliferation of osteoblasts and the cell viability decreased with the degradation time. | YANG YanFang TANG GongWen ZHAO YunHui ZHANG Yang LI XiuLan YUAN XiaoYan | 2011 | Chinese Science Bulletin2011，56，10： | 2 |
| 5 | Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes显示文摘Severe fever with thrombocytopenia syndrome virus(SFTSV),the causative agent of a febrile human disease,was first identified from central and eastern provinces in China,and later in Japan and South Korea.Hubei Province is one of the major SFTS epidemic areas in the central part of China.This study reported the isolation of 11 new SFTSV strains from patients in Hubei Province collected in 2017.Extensive phylogenetic analyses were conducted based on the complete coding sequences of SFTSV segments including the new strains.It was suggested that five different SFTSV genotypes were circulating in Hubei,and 15 reassortment patterns and migration pathways correlated with each genotype were identified,which was more than previously recognized.Hubei Province was more involved in the evolutionary events of SFTSV than that previously thought in which the evolutionary events of SFTSV were reported to be independent from those in other epidemic regions.Further divergence of SFTSV strains was suggested by pairwise comparison of SFTSV sequences from each genotype and sequence identity normalized to representative strain in genotype C1.Subsequently,amino acid variations specific for genotype(s),strain(s),or cluster(s)were inspected,which may be related to differential biological activity of SFTSV strains/genotypes.In conclusion,we analyzed the current status of SFTSV phylogeny in Hubei Province and discussed the possible events correlated to SFTSV evolution.It provided an in-depth insight into SFTSV evolution,raising concerns for the use of proper SFTSV strains in future studies. | Xiaoli Wu Mingyue Li Yanfang Zhang Boyun Liang Junming Shi Yaohui Fang Zhengyuan Su Mengmeng Li Wenjing Zhang Ling Xu Jun Wang Qiaoli Wu Shuang Tang Hualin Wang Tao Zhang Cheng Peng Xin Zheng Fei Deng Shu Shen | 2021 | Virologica Sinica2021，36，2： | 2 |
| 6 | Physicochemical characterization of a high molecular weight bioactive β -D-glucan from the fruiting bodies of Gcmoderma Itzcidum显示文摘 | LIU Yanfang ZHANG Jingsong TANG Qingjiu | 2014 | Carbohydrate Polymers2014，101，： | 1 |
| 7 | Extracellular vesicles as novel biomarkers and pharmaceutic targets of diseases显示文摘 | Yanfang CHEN Yaoliang TANG Guo-Chang FAN Dayue Darrel DUAN | 2018 | Acta Pharmacologica Sinica2018，39，4： | 1 |
| 8 | RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities显示文摘RING finger protein 152(RNF152)is a novel RING finger protein and has not been well characterized.We report here that RNF152 is a canonical RING finger protein and has E3 ligase activity.It is polyubiqitinated partly through Lys-48-linked ubiquitin chains in vivo and this phenomenon is dependent on its RING finger domain and transmembrane domain.RNF152 is localized in lysosomes and co-localized with LAMP3,a lysosome marker.Moreover,over-expression of RNF152 in Hela cells induces apoptosis.These results suggest that RNF152 is a lysosome localized E3 ligase with pro-apoptotic activities.It is the first E3 ligase identified so far that is involved in lysosome-related apoptosis. | Songling Zhang Wei Wu Yanfang Wu Jiyan Zheng Talin Suo Hong Tang Jie Tang | 2010 | Protein & Cell2010，1，7： | 1 |
| 9 | Gradually modulating the three parts of D-π-A type polymers for high-performance organic solar cells显示文摘Organic solar cells(OSCs)have received great attention for the prominent advantage of low-cost,light-weight and potential for fabricating flexible and semi-transparent device via roll-to-roll printing toward making better use of inexhaustible renewable clean energy during the past years[1-4]. | Jialing Zhou Peiqing Cong Lie Chen Bao Zhanga Yanfang Geng Ailing Tang Erjun Zhou | 2021 | Journal of Energy Chemistry2021，30，11： | 1 |
| 10 | In vitro degradation of porous poly( L-lactide-co-glycol- ide)/β-tricalciumphosphate ( PLGA/β-TCP ) scaffolds under dynamic and static conditions显示文摘 | Yanfang Yang Yunhui Zhao Gongwen Tang | 2008 | Polymer Degradation and Stability2008，93，： | 1 |
| 11 | Existence of a periodic solutions for subquadratic second order discrete Hamiltonian systems 显示文摘 | Xue Yanfang Tang Chunlei | 2007 | Nonlinear Anal2007，67，7： | 1 |
| 12 | Identification of a key G-protein coupled receptor in mediating appressorium formation and fungal virulence against insects显示文摘Fungal G-protein coupled receptors(GPCRs)play essential roles in sensing environmental cues including host signals.The study of GPCR in mediating fungus-insect interactions is still limited.Here we report the evolution of GPCR genes encoded in the entomopathogenic Metarhizium species and found the expansion of Pth11-like GPCRs in the generalist species with a wide host range.By deletion of ten candidate genes MrGpr1–MrGpr10 selected from the six obtained subfamilies in the generalist M.robertsii,we found that each of them played a varied level of roles in mediating appressorium formation.In particular,deletion of MrGpr8 resulted in the failure of appressorium formation on different substrates and the loss of virulence during topical infection of insects but not during injection assays when compared with the wild-type(WT)strain.Further analysis revealed that disruption of MrGpr8 substantially impaired the nucleus translocation of the mitogen-activated protein kinase(MAPK)Mero-Fus3 but not the MAPK Mero-Slt2 during appressorium formation.We also found that the defect ofΔMrGpr8 could not be rescued with the addition of cyclic AMP for appressorium formation.Relative to the WT,differential expression of the selected genes have also been detected inΔMrGpr8.The results of this study may benefit the understanding of fungus-interactions mediated by GPCRs. | Junmei Shang Yanfang Shang Guirong Tang Chengshu Wang | 2021 | Science China(Life Sciences)2021，64，3： | 1 |
| 13 | Excitatory effects of motilin in the hippocampus on gastric motility in rats显示文摘 | Yanfang Guan Ming Tang Zhengyao Jiang Theo L Peeters | 2003 | Brain Research2003，，1： | 1 |
| 14 | A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment显示文摘Harlequin ichthyosis (HI) is a severe genetic skin disorder and caused by mutation in the ATP-binding cassette A12 (ABCA12) gene. The retinoid administration has dramatically improved long-term survival of HI, but improvements are still needed. However, the ABCA12 null mice failed to respond to retinoid treatment, which impedes the development of novel cure strategies for HI. Here we generated an ethylnitrosourea mutagenic HI pig model (named Z9), which carries a novel deep intronic mutation IVS49-727 A>G in the ABCA12 gene, resulting in abnormal mRNA splicing and truncated protein production. Z9 pigs exhibit significant clinical symptom as human patients with HI. Most importantly, systemic retinoid treatment significantly prolonged the life span of the mutant pigs via improving epidermal maturation, decreasing epidermal apoptosis, and triggering the expression of ABCA6. Taken together, this pig model perfectly resembles the clinical symptom and molecular pathology of patients with HI and will be useful for understanding mechanistic insight and developing therapeutic strategies. | Xiao Wang Chunwei Cao Yongshun Li Tang Hai Qitao Jia Ying Zhang Qiantao Zheng Jing Yao Guosong Qin Hongyong Zhang Ruigao Song Yanfang Wang Guanghou Shui Sin Man Lam Zhonghua Liu Hong Wei Anming Meng Qi Zhou Jianguo Zhao | 2019 | Journal of Molecular Cell Biology2019，11，12： | 1 |
| 15 | In Vitro Degradation of Porous Poly(L-lactide-co-glycolide)/β-tricalcium Phosphate(PLGA/p-TCP)Scaffolds under Dynamic and Static Conditions显示文摘 | Yanfang Yang Yunhui Zhao Gongwen Tang | 2008 | Polymer Degradation and Stability2008，93，： | 1 |
| 16 | Microstructure and Mechanical Properties of Ti–Ta Composites Prepared Through Cold Spray Additive Manufacturing显示文摘In this study, an innovative approach was used to fabricate Ti–Ta composite biomaterials through cold spray additive manufacturing followed by a diff usion treatment. The microstructure and mechanical properties of the composites were investigated in detail using field emission scanning electron microscopy, electron backscatter diff raction, 3D X-ray computed tomography, tensile test, nanohardness test and resonance vibration test. The obtained results indicated that the prepared composites have inhomogeneity in their microstructure and composition. A unique microstructure, composed of Ti-rich, Ta-rich and diff usion regions, was evolved in the composites due to incomplete diff usion between Ti and Ta splats. Further, Kirkendall pores were formed in the composites due to uneven diff usion of the two phases(of Ti and Ta) during high-temperature heat treatment. The prepared composites simultaneously showed low elastic modulus and high tensile strength which is required for a good biomaterial. Low elastic modulus was associated with the residual pores and the alloying eff ect of Ta in Ti, while high tensile strength was related to the solid solution strengthening eff ects. The obtained results indicated that the prepared Ti–Ta composites have a great potential to become a new candidate for biomedical applications. | Junrong Tang Naeem ul Haq Tariq Zhipo Zhao Mingxiao Guo Hanhui Liu Yupeng Ren Xinyu Cui Yanfang Shen Jiqiang Wang Tianying Xiong | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，9： | 1 |
| 17 | Structural elucidation of a neutral fucogalactan from the mycelium of Coprinus comatus显示文摘 | Fan Junmin Zhang Jingsong Tang Qingjiu Liu Yanfang Zhang Anqiang Pan Yingjie | 2006 | Carbohydrate Research2006，341，9： | 1 |
| 18 | Separation and structural elucidation of a polysaccharide CC30w-1 from the fruiting body of Coprinus comatus显示文摘 | Zhou Shuai Liu Yanfang Yang Yan Jia Wei Tang Qingjiu Tang Chuanhong Feng Na Zhang Jingsong | 2013 | Bioactive Carbohydrates and Dietary Fibre2013，1，2： | 1 |
| 19 | Structural characteristics and hypoglycemic activity of polysaccharides from Coprinus comatus显示文摘 | Liu Yanfang Zhao Yuan Yang Yan Tang Qingjiu Zhou Shuai Wu di Zhang Jingsong | 2013 | Bioactive Carbohydrates and Dietary Fibre2013，2，2： | 1 |
| 20 | 近取诸身,远取诸物: Chinese Idioms from an Epistemological Perspective显示文摘 | Tang Yanfang | 2000 | Journal of Chinese Language Teachers Association2000，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员