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| 1 | Effects of L-lactic acid and D,L-lactic acid on viability and osteogenic differentiation of mesenchymal stem cells显示文摘Poly(lactic acid) (PLA) and other aliphatic polyesters containing the unit of lactic acid are very popular biodegradable materials. While the degradation products, lactic acids, have been worried to bring with negative influence on biocompatibility, the focused experimental studies are less reported. This study is aimed at an in vitro examination of cytotoxicity of both L-lactic acid and D,L-lactic acid. Mesenchymal stem cells (MSCs) derived from rat bone marrow are employed to test the cytotoxicity of the lactic acids. Considering that the addition of lactic acids not only introduces lactate groups but also alters medium pH and ion strength, these three candidate effects are examined in a decoupled way by setting different comparison groups. The results confirm that the change of medium pH is the predominant factor. It has also been found that D-lactate is more cytotoxic than L-lactate at high concentrations. Yet, either L-or D,L-lactic acids seem acceptable in most of medical applications, because the cytotoxicity is significant only when the concentrations are as high as 20 mmol/L for both of them. | HE Yao WANG WeiRan DING JianDong | 2013 | Chinese Science Bulletin2013，58，20： | 5 |
| 2 | 纳米TCP颗粒在骨修复用复合材料中分散性的研究进展显示文摘运用骨组织工程技术修复骨缺损是近年来研究的热点,其中对骨组织工程技术中关键要素之一的骨修复材料的研究最为深入。纳米TCP(nano-TCP)/可吸收高聚物复合材料因其优良的骨传导性、骨生成性及骨诱导性而备受关注,但由于nano-TCP颗粒团聚而引起的复合材料性能的恶化仍然是当下研究的难点。本文从nano-TCP颗粒分散性的研究意义、团聚原理以及改善分散性的方法3个方面进行文献综述与讨论,期望为进一步改善nano-TCP/可吸收高聚物复合材料的应用性能提供参考。 | 刘来俊 张天添 丁雯 王富军 王璐 | 2019 | 生物骨科材料与临床研究2019，16，3： | 1 |
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