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| 1 | The cessation and detoxification effect of tea filters on cigarette smoke显示文摘To treat tobacco addiction,a tea filter was developed and studied for smoking cessation.This work reports the smoking cessation effect of tea when it was used as a component of cigarette filters.In one trial it was found that after using the tea filters for 2 months,the volunteer smokers decreased their cigarette consumption by 56.5%,and 31.7% of them stopped smoking.This work identified a new method and material,tea filter and theanine,which inhibit tobacco and nicotine addiction and provide an effective strategy for treating tobacco addiction. | YAN JingQi1,2,DI XiaoJing1,4,LIU CaiYi3,ZHANG HuiMin3,HUANG XiouQin3,ZHANG JunJing1,2,ZHAO Yan5,ZHANG LongZe1,CHANG YanZhong4,LIANG YongLin2$,TAO Ran3 & ZHAO BaoLu1,21 State Key Laboratory of Brain and Cognitive Science,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 2 Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China 3 Addiction Branch,Beijing Military Region General Hospital,Beijing 100700,China 4 Institute of Molecular Neurobiology,Hebei Normal University,Shijiazhuang 050016,China 5 Department of Food Sciences and Technology,Harbin Institute of Technology at Weihai,Weihai 264209,China | 2010 | Science China(Life Sciences)2010，53，5： | 8 |
| 2 | Short exposure to paclitaxel induces multipolar spindle formation and aneuploidy through promotion of acentrosomal pole assembly显示文摘Paclitaxel is a widely used microtubule drug and cancer medicine. Here we report that by short exposure to paclitaxel at a low dose, multipolar spindles were induced in mitotic cells without centrosome amplification. Both TPX2 depletion and Aurora-A overexpression antagonized the multipolarity. Live cell imaging showed that some paclitaxel-treated cells accomplished multipolar cell division and a portion of the daughter cells went on to the next round of mitosis. The surviving cells grew into clones with varied genome content. The results indicated that an aneuploidy population could be induced by short exposure to paclitaxel at a low dose, implicating potential side effects of paclitaxel. | BIAN MingLei1, FU JingYan1, YAN Yan1, CHEN Qiang1, YANG Chao2, SHI QingHua2,JIANG Qing1 & ZHANG ChuanMao1 1MOE Key Laboratory of Cell Proliferation and Differentiation and the State Key Laboratory of Bio-membrane and Membrane Bio-engineering, College of Life Sciences, Peking University, Beijing 100871, China 2Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230026, China | 2010 | Science China(Life Sciences)2010，53，11： | 3 |
| 3 | Multi-locus association study of schizophrenia susceptibility genes with a posterior probability method显示文摘Schizophrenia is a serious neuropsychiatric illness affecting about 1% of the world’s population. It is considered a complex inheritance disorder. A number of genes are involved in combination in the etiology of the disorder. Evidence implicates the altered dopaminergic trans- mission in schizophrenia. In the present study, in order to identify susceptibility genes for schizophrenia in dopaminergic metabolism, we analyzed 59 single nucleotide polymorphisms (SNPs) in 24 genes of the dopaminergic pathway among 82 unrelated patients with schizophre- nia and 108 matched normal controls. Considering that traditional single-locus association stud- ies ignore the multigenic nature of complex diseases and do not take into account possible in- teractions between susceptibility genes, we proposed a multi-locus analysis method, using the posterior probability of morbidity as a measure of absolute disease risk for a multi-locus genotype combination, and developed an algorithm based on perturbation and average to detect the sus- ceptibility multi-locus genotype combinations, as well as to repress noise and avoid false positive results at our best. A three-locus SNP genotype combination involved in the interactions of COMT and ALDH3B1 genes was detected to be significantly susceptible to schizophrenia. | SUN Xiangqing 1* , JIA Yanbin 2* , ZHANG Xuegong 1 , XU Qi 2 , SHEN Yan 2 & LI Yanda 1 1. Ministry of Education (MOE) Key Laboratory of Bioinformatics at Tsinghua University Department of Automation, Tsinghua University, Beijing 100084, China 2. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China | 2005 | Science China(Life Sciences)2005，48，3： | 2 |
| 4 | In-hospital revascularization and one-year outcome of acute coronary syndrome patients stratified by the GRACE risk score显示文摘 | Yan AT Yan RT Tan M | 2005 | Am J Cardiol2005，96，7： | 1 |
| 5 | Risk scores for risk stratification in acute coronary syndromes:useful but simpler is not necessarily better显示文摘 | Yan AT Yan RT Tan M | | 0，，09： | 1 |
| 6 | The expanded global registry of acute coronary events:baseline characteristics,management practices,and hospital outcomes of patients w ith acute coronary syndromes显示文摘 | Goodman SG Huang W Yan AT | 2009 | Am Heart J2009，158，2： | 1 |
| 7 | Systematic review and meta-analysis of randomized and nonrandomized trims on safety and efficacy of video-assisted thoracic surgery lobectomy for early-stage non-small-cell lung cancer 显示文摘 | Yan TD Black D Bannon PG et at | 2009 | J Clin Oncol2009，27，15： | 1 |
| 8 | Risk scores for risk stratification inacute coronary syndromes: useful but simpler is not necessarily better显示文摘 | Yan AT Yan RT Tan M | 2007 | Eur Heart J2007，28，9： | 1 |
| 9 | Understanding physicians' risk stratification of acute coronary syndromes: insights from the Canadian ACS 2 Registry 显示文摘 | Yan AT Yan RT Huynh T | 2009 | Arch Intern Med2009，169，4： | 1 |
| 10 | Design of integrated passive component for a 1 MHz 1 kW half - bridge LLC reso- nant converter 显示文摘 | Liang Yan Liu Wenduo Lu Bing et at | 2005 | IEEE Conference Recordias Meeting2005，，： | 1 |
| 11 | Toll-like receptor 4-mydoid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice显示文摘 | Li H Su X Yan X et at | | 0，，03： | 1 |
| 12 | Characterization of CTX-M- type extended-spectrum beta-lactamase in clinical chines of Escherichia coil in Southwest China显示文摘 | Zhao WD Yan P Guan HN et at | 2014 | J Basic Miernbiol2014，54，3： | 1 |
| 13 | The expanded Global Registry of Acute Coronary Events : baseline characteristics, management practices, and hospital outcomes of patients with acute coronary syndromes 显示文摘 | Goodman SG Huang W Yan AT | 2009 | Am Heart J2009，158，2： | 1 |
| 14 | Characterization of the Peri-Infarct Zone by Contrast-Enhanced Cardiac MRI is a Powerful Predictor of Post-Myocardial Infarction Mortality显示文摘 | Shayne AJ Brown KA | 2006 | Circulation2006，114，1： | 1 |
| 15 | Management patterns in relation to risk stratification among patients with non-ST elevation acute coronary syndromes显示文摘 | Yan AT Yan RT Tan M | | 0，，10： | 1 |
| 16 | Contemporary management of dyslipidemia in high-risk patients: Targets still not met显示文摘 | Yan AT Yah RT Tan M | 2006 | Am J Med2006，119，8： | 1 |
| 17 | 7M NaCl solution显示文摘 | Yan Gao and Alfonso Mucci Acid base reactions phosphate and arsenate complexation and their competitive adsorption at the surface of goethite in 0 | 2001 | Geachimica et Casmochimica Acta2001，65，14： | 1 |
| 18 | The role of continuous positive airway pressure in the treatment of congestive heart failure显示文摘 | Yan AT Bradley D Liu PP | 2001 | Chest2001，120，： | 1 |
| 19 | In-hospital revascularization and one-year outcome of acute coronary syndrome patients stratified by the GRACE risk score显示文摘 | Yah AT Yan RT Tan M | 2005 | Am J Cardiol2005，96，7： | 1 |
| 20 | Fibrinogen and left ventricular myocardial systolic function: The Multi-Ethnic Study of Atherosclerosis (MESA)显示文摘 | Yan RT Fernandes V Yan AT | 2010 | Am HeartJ2010，160，3： | 1 |
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