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| 1 | Copper ions influence the toxicity of β-amyloid(1-42) in a concen-tration-dependent manner in a Caenorhabditis elegans model of Alzheimer’s disease显示文摘β-amyloid (Aβ) and copper play important roles in the pathogenesis of Alzheimer’s disease (AD).However,the behavioral correlativity and molecular mechanisms of Aβ and copper toxicity have been investigated less often.In the present study,we investigated the interaction and toxicity of Aβ1-42 and copper in the Aβ1-42 transgenic Caenorhabditis elegans worm model CL2006.Our data show that the paralysis behavior of CL2006 worms significantly deteriorated after exposure to 10-3 mol L-1 copper ions.However,the paralysis behavior was dramatically attenuated with exposure to 10-4 mol L-1 copper ions.The exogenous copper treatment also partially changed the homeostatic balance of zinc,manganese,and iron.Our data suggest that the accumulation of reactive oxygen species (ROS) was responsible for the paralysis induced by Aβ and copper in CL2006.The ROS generation induced by Aβ and copper appear to be through sod-1,prdx-2,skn-1,hsp-60 and hsp-16.2 genes. | LUO YunFeng ZHANG Jie LIU NianQing LUO Yuan ZHAO BaoLu | 2011 | Science China(Life Sciences)2011，54，6： | 26 |
| 2 | COVID-19: Challenges to GIS with Big Data显示文摘The outbreak of the 2019 novel coronavirus disease(COVID-19)has caused more than 100,000 people infected and thousands of deaths.Currently,the number of infections and deaths is still increasing rapidly.COVID-19 seriously threatens human health,production,life,social functioning and international relations.In the fight against COVID-19,Geographic Information Systems(GIS)and big data technologies have played an important role in many aspects,including the rapid aggregation of multi-source big data,rapid visualization of epidemic information,spatial tracking of confirmed cases,prediction of regional transmission,spatial segmentation of the epidemic risk and prevention level,balancing and management of the supply and demand of material resources,and socialemotional guidance and panic elimination,which provided solid spatial information support for decision-making,measures formulation,and effectiveness assessment of COVID-19 prevention and control.GIS has developed and matured relatively quickly and has a complete technological route for data preparation,platform construction,model construction,and map production.However,for the struggle against the widespread epidemic,the main challenge is finding strategies to adjust traditional technical methods and improve speed and accuracy of information provision for social management.At the data level,in the era of big data,data no longer come mainly from the government but are gathered from more diverse enterprises.As a result,the use of GIS faces difficulties in data acquisition and the integration of heterogeneous data,which requires governments,businesses,and academic institutions to jointly promote the formulation of relevant policies.At the technical level,spatial analysis methods for big data are in the ascendancy.Currently and for a long time in the future,the development of GIS should be strengthened to form a data-driven system for rapid knowledge acquisition,which signifies ts that GIS should be used to reinforce the social operation parameterization of models and methods,especially when providing support for social management. | Chenghu Zhou Fenzhen Su Tao Pei An Zhang Yunyan Du Bin Luo Zhidong Cao Juanle Wang Wen Yuan Yunqiang Zhu Ci Song Jie Chen Jun Xu Fujia Li Ting Ma Lili Jiang Fengqin Yan Jiawei Yi Yunfeng Hu Yilan Liao Han Xiao | 2020 | Geography and Sustainability2020，1，1： | 13 |
| 3 | Criteria for hypersonic airbreathing propulsion and its experimental verification显示文摘Hypersonic airbreathing propulsion is one of the top techniques for future aerospace flight, but there are still no practical engines after seventy years’ development. Two critical issues are identified to be the barriers for the ramjet-based engine that has been taken as the most potential concept of the hypersonic propulsion for decades. One issue is the upstream-traveling shock wave that develops from spontaneous waves resulting from continuous heat releases in combustors and can induce unsteady combustion that may lead to engine surging during scramjet engine operation.The other is the scramjet combustion mode that cannot satisfy thrust needs of hypersonic vehicles since its thermos-efficiency decreases as the flight Mach number increases. The two criteria are proposed for the ramjet-based hypersonic propulsion to identify combustion modes and avoid thermal choking. A standing oblique detonation ramjet(Sodramjet) engine concept is proposed based on the criteria by replacing diffusive combustion with an oblique detonation that is a unique pressure-gain phenomenon in nature. The Sodramjet engine model is developed with several flow control techniques, and tested successfully with the hypersonic flight-duplicated shock tunnel.The experimental data show that the Sodramjet engine model works steadily, and an oblique detonation can be made stationary in the engine combustor and is controllable. This research demonstrates the Sodramjet engine is a promising concept and can be operated stably with high thermal efficiency at hypersonic flow conditions. | Zonglin JIANG Zijian ZHANG Yunfeng LIU Chun WANG Changtong LUO | 2021 | Chinese Journal of Aeronautics2021，34，3： | 9 |
| 4 | Reduced Graphene Oxide Mediated SnO_2 Nanocrystals for Enhanced Gas-sensing Properties显示文摘SnO2 ereduced graphene oxide (SnO2-rGO) composites were prepared via a hydro-thermal reaction of graphene oxide (GO) and SnCl2·2H2O in the mixed solvent of ethylene glycol and water. During the redox reaction, GO was reduced to rGO while Sn2+ was oxidized to SnO2, uniformly depositing on the surface of rGO sheets. The composites were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), infrared spectra analysis (IR) and transmission electron microscopy (TEM), respectively, and their gas sensing properties were further investigated. Compared with pure SnO2 nanoparticles, the as-prepared SnO2-rGO gas sensor showed much better gas sensing behavior in sensitivity and response-recovery time to ethanol and H2S at low concentrations. Overall, the highly sensitive, quickresponding and low cost SnO2-rGO gas sensor could be potentially applied in environmental monitoring area. | Yanhong Chang Yunfeng Yao Bin Wang Hui Luo Tianyi Li Linjie Zhi | 2013 | Journal of Materials Science & Technology2013，29，2： | 7 |
| 5 | Characteristics of atmospheric aerosol optical depth variation over China in recent 30 years显示文摘This note retrieves the annual and monthly mean 0.75 urn aerosol optical depth (AOD) by using the daily direct solar radiation and sunshine duration data of 47 solar stations from 1961 to 1990. The characteristic of AOD variation over China in recent 30 years was analyzed. The results indicate that AOD increased obviously over China from 1961 to 1990. AOD increased most rapidly over the east part of Southwest China, the middle-and-lower reaches of the Yangtze River and the Tibetan Plateau. The increasing trend of AOD is also relatively distinct in North China, the Shandong Peninsula, east part of Qinghai Province, and coastal areas of Guangdong Province. However, in most parts of Northwest China and Northeast China, the increase of AOD is less significant, while in the west part of the Xinjiang Uygur Autonomous Region and some parts of Yunnan Province, AOD shows decreasing tendency. Generally, AOD reaches its maximum in spring and the minimum appears in summer. As to the linear trend, the maximum | LUO Yunfeng LU Daren HE Qing LI Weiliang ZHOU Xiuji | 2000 | Chinese Science Bulletin2000，45，14： | 6 |
| 6 | Aerodynamic force and moment measurement of 10°half-angle cone in JF12 shock tunnel显示文摘An aerodynamic force and moment measurement was conducted in JF12 long-testduration detonation-driven shock tunnel of Institute of Mechanics,Chinese Academy of Sciences.The test duration of JF12 is 100–130 ms.The nominal Mach number is 7.0 and the exit diameter of the contoured nozzle is 2.5 m.The total enthalpy is 2.5 MJ/kg which duplicates the hypersonic flight conditions of Mach number 7.0 at 35 km altitude.The test model is the standard aerodynamic force model of 10° half-angle sharp cone.The length of the test model is 1500 mm and the weight is 57 kg.The aerodynamic forces were measured with a six-component strain balance.The angles of attack were set to be à5°,0°,5°,10° and 14°,respectively.The experimental results show that in the 100–130 ms test duration,the signals of strain balance have 3–4 complete vibration cycles.So,the aerodynamic forces and moments can be obtained directly by averaging the signals of balance without acceleration compensation.The force measurement error of repeatability of JF12 is less than 2%.The aerodynamic force coefficients of JF12 are in good agreement with those of conventional hypersonic wind tunnels.For this test model at Mach number 7.0 and total enthalpy of 2.5 MJ/kg,the real-gas effects on aerodynamic force characteristics are not very evident. | Yunfeng LIU Yunpeng WANG Chaokai YUAN Changtong LUO Zonglin JIANG | 2017 | Chinese Journal of Aeronautics2017，30，3： | 5 |
| 7 | Transient deformation during the Milashan Tunnel construction in northern Sangri-Cuona Rift,southern Tibet,China observed by Sentinel-1 satellites显示文摘Using 3-year Sentinel-1 C-band synthetic aperture radar(SAR) data, we observed prominent ground subsidence around the construction site of the Milashan Tunnel, which is on top of the northern SangriCuona Rift(SCR) in southern Tibet. The most deformed area extends ~7 km in the north-south direction and ~6 km in the east-west direction, with a peak subsidence rate of over 10 mm/a in the line of sight direction of both the descending and ascending satellites. Aside from the long-term ground subsidence arising directly from underground water outflow and rock excavation, a regional aseismic fault slip episode is also evident. The aseismic slip event began in May 2016 and ended in July 2016. The surface aseismic displacements can be explained by normal faulting with mainly down-dip movement and a modest right-lateral strike-slip component on a nearly north-south trending fault. The aseismic deformation triggered by the Milashan Tunnel construction demonstrates the sensitive response of crustal-scale tectonics to human activity, which poses high seismic hazards for the heavily populated region. | Yunfeng Tian Jing Liu-Zeng Yi Luo Yongsheng Li Yingshun Hu Bin Gong Lizheng Liu Ping Guo Jingfa Zhang | 2018 | Science Bulletin2018，63，21： | 3 |
| 8 | Dietary calcium requirements of broilers fed a conventional corn-soybean meal diet from 1 to 21 days of age显示文摘Background:The current calcium(Ca)recommendation for broilers is primarily based on studies conducted more than 30 years ago with birds of markedly different productive potentials from those which exist today.And the response indicators in these studies are mainly growth performance and bone ash percentage.Therefore,the present study was carried out to investigate the effect of dietary Ca level on growth performance,serum parameters,bone characteristics and Ca metabolism-related gene expressions,so as to estimate dietary Ca requirements of broilers fed a conventional corn-soybean meal diet from 1 to 21 days of age.Methods:A total of 4201-day-old Arbor Acres male broilers were randomly assigned to 1 of 7 treatments with 6 replicates(10 birds per cage)and fed the corn-soybean meal diets containing 0.60%,0.70%,0.80%,0.90%,1.00%,1.10%or 1.20%Ca for 21 days.Each diet contained the constant non-phytate phosphorus content of about 0.39%.Results:The average daily gain decreased linearly(P<0.001)as dietary Ca level increased.The serum and tibia alkaline phosphatase(ALP)activities,tibia bone mineral density(BMD),middle toe BMD,tibia ash percentage,tibia breaking strength,and tibia ALP protein expression level were affected(P<0.05)by dietary Ca level,and showed significant quadratic responses(P<0.02)to dietary Ca levels.The estimates of dietary Ca requirements were 0.80 to 1.00%based on the best fitted broken-line or quadratic models(P<0.03)of the above serum and bone parameters,respectively.Conclusions:The results from the present study indicate that the Ca requirements would be about 0.60%to obtain the best growth rate,and 1.00%to meet all of the Ca metabolisms and bone development of broilers fed a conventional corn-soybean meal diet from 1 to 21 days of age. | Shiping Bai Yunfeng Yang Xuelian Ma Xiudong Liao Runlian Wang Liyang Zhang Sufen Li Xugang Luo Lin Lu | 2022 | Journal of Animal Science and Biotechnology2022，13，4： | 2 |
| 9 | Concurrent topology optimization design of stiffener layout and cross-section for thin-walled structures显示文摘Stiffened plates or shells are widely used in engineering structures as primary or secondary load-bearing components.How to design the layout and sizes of the stiffeners is of great significance for structural lightweight.In this work,a new topology optimization method for simultaneously optimizing the layout and cross-section topology of the stiffeners is developed to solve this issue.The stilfeners and base plates are modeled by the beam and shell elements,respectively,significantly reducing the computational cost.The Giavotto beam theory,instead of the widely employed Euler or Timoshenko beam theory,is applied to model the stiffeners for considering the warping deformation in evaluating the section stiffness of the beam.A multi-scale topology optimization model is established by simultaneously optimizing the layout of the beam and the topology of the cross-section.The design space is significantly expanded by optimizing these two types of design variables.Several numerical examples are applied to illustrate the validity and effectiveness of the proposed method.The results show that the proposed two-scale optimization approach can generate better designs than the single-scale method. | Quhao Li Yongxin Qu Yunfeng Luo Shutian Liu | 2021 | Acta Mechanica Sinica2021，37，3： | 2 |
| 10 | Schwann-like mesenchymal stem cells within vein graft facilitate facial nerve regeneration and remyelination显示文摘 | Xuemei Wang En Luo Yunfeng Li Jing Hu | 2011 | Brain Research2011，，： | 1 |
| 11 | Effect of temperature and cyclic hydrothermal aging on the interlaminar shear strength of carbon fiber/bismaleimide (BMI) composite显示文摘 | Pei Sun Yan Zhao Yunfeng Luo Lili Sun | 2011 | Materials and De- sign2011，32，： | 1 |
| 12 | The utility of amplitude-integrated EEG and NIRS measurements as indices of hypoxic ischaemia in the newborn pig显示文摘 | Dandan Zhang Xinlin Hou Yunfeng Liu Congle Zhou Yuejia Luo Haiyan Ding | 2011 | Clinical Neurophysiology2011，，8： | 1 |
| 13 | Mechanistic analysis for the origin of diverse diterpenes in Tripterygium wilfordii显示文摘Tripterygium wilfordii is a valuable medicinal plant rich in biologically active diterpenoids,but there are few studies on the origins of these diterpenoids in its secondary metabolism.Here,we identified three regions containing tandemly duplicated diterpene synthase genes on chromosomes(Chr) 17 and 21 of T. wilfordii and obtained 11 diterpene synthases with different functions.We farther revealed that these diterpene synthases underwent duplication and rearrangement at approximately 2.3-23.7 million years ago(MYA) by whole-genome triplication(WGT),transposon mediation,and tandem duplication,followed by functional divergence.We first demonstrated that four key amino acids in the sequences of TwCPS3,TwCPS5,and TwCPSS were altered during evolution,leading to their functional divergence and the formation of diterpene secondary metabolites.Then,we demonstrated that the functional divergence of three TwKSLs was driven by mutations in two key amino acids.Finally,we discovered the mechanisms of evolution and pseudogenization of miltiradiene synthases in T.wilfordii and elucidated that the new function in TwMS1/2 from the terpene synthase(TPS)-b subfamily was caused by progressive changes in multiple amino acids after the WGT event.Our results provide key evidence for the formation of diverse diterpenoids during the evolution of secondary metabolites in T.wilfordii. | Lichan Tu Xinbo Cai Yifeng Zhang Yuru Tong Jian Wang Ping Su Yun Lu Tianyuan Hu Yunfeng Luo Xiaoyi Wu Dan Li Luqi Huang Wei Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 1 |
| 14 | Modification of Nafion membrane using interfacial polymerization for vanadium redox flow battery applications显示文摘 | Qingtao Luo Huaming Zhang Jian Chen Peng Qian Yunfeng Zhai | 2007 | Journal of Membrane Science2007，，1： | 1 |
| 15 | A competition model of oligopolists affected by emission taxes and regulation显示文摘 | Xiao Jiangwen Luo Yunfeng Zhao Yong | 2001 | Advances in Systems Science and Applications2001，2，： | 1 |
| 16 | Effect of temperature and cyclic hygrothermal aging on the interlaminar shear strength of carbon fiber/bismaleimide (BMI) composite显示文摘 | Pei Sun Yan Zhao Yunfeng Luo Lili Sun | 2011 | Materials and Design2011，，8： | 1 |
| 17 | Surface and wettability property analysis of CCF300 carbon fibers with different sizing or without sizing显示文摘 | Yunfeng Luo Yan Zhao Yuexin Duan Shanyi Du | 2010 | Materials and Design2010，，2： | 1 |
| 18 | Inorganic nitrogen dynamics in sequencing batch reactors using biofloc technology to treat aquaculture sludge显示文摘 | Luo Guozhi Avnimelech Y Pan Yunfeng | 2013 | Aquaculture Engineering2013，52，： | 1 |
| 19 | The reinforcing mechanism of carbon fiber in composite adhesive for bonding carbon/carbon composites 显示文摘 | ZHANG Yunfeng LUO Ruiying ZHANG Jiangsong | 2011 | J Mater Process Tech2011，211，2： | 1 |
| 20 | Effect of temperature and cyclic hygrothermal aging on the in- terlaminar shear strength of carbon fiber bismaleim- ide (BMI) composite 显示文摘 | Sun Pei Zhao Yan Luo Yunfeng | 2011 | Materials and Design2011，32，89： | 1 |
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