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| 1 | Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway显示文摘Non-alcoholic steatohepatitis(NASH) is a chronic metabolic syndrome and the CFLAR-JNK pathway can reverse the process of NASH. Although silibinin is used for the treatment of NASH in clinical, its effect on CFLAR-JNK pathway in NASH remains unclear. This study aimed to investigate the effect of silibinin on CFLAR-JNK pathway in NASH models both in vivo and in vitro. The in vivo study was performed using male C57 BL/6 mice fed with methionine– choline-deficient diet and simultaneously treated with silibinin for 6 weeks. The in vitro study was performed by using mouse NCTC-1469 cells which were respectively pretreated with oleic acid plus palmitic acid, and adenovirus-down Cflar for 24 h,then treated with silibinin for 24 h. After the drug treatment, the key indicators involved in CFLAR-JNK pathway including hepatic injury, lipid metabolism and oxidative stress were determined. Silibininsignificantly activated CFLAR and inhibited the phosphorylation of JNK, up-regulated the mRNA expression of Pparα, Fabp5, Cpt1α, Acox, Scd-1, Gpat and Mttp, reduced the activities of serum ALT and AST and the contents of hepatic TG, TC and MDA, increased the expression of NRF2 and the activities of CAT, GSH-Px and HO-1, and decreased the activities and expression of CYP2 E1 and CYP4 A in vivo.These effects were confirmed by the in vitro experiments. Silibinin prevented NASH by regulating CFLAR-JNK pathway, and thereby on one hand promoting the β-oxidation and efflux of fatty acids in liver to relieve lipid accumulation, and on the other hand inducing antioxidase activity(CAT, GSH-Px and HO-1) and inhibiting pro-oxidase activity(CYP2 E1 and CYP4 A) to relieve oxidative stress. | Yayun Liu Wei Xu Ting Zhai Jiaojiao You Yong Chen | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 12 |
| 2 | Grey GM(1,1) Model with Function-Transfer Method for Wear Trend Prediction and its Application显示文摘Trend forecasting is an important aspect in fault diagnosis and work state supervision. The principle, where Grey theory is applied in fault forecasting, is that the forecast system is considered as a Grey system; the existing known information is used to infer the unknown information’s character, state and development trend in a fault pattern, and to make possible forecasting and decisions for future development. It involves the whitenization of a Grey process. But the traditional equal time interval Grey GM (1,1) model requires equal interval data and needs to bring about accumulating addition generation and reversion calculations. Its calculation is very complex. However, the non equal interval Grey GM (1,1) model decreases the condition of the primitive data when establishing a model, but its requirement is still higher and the data were pre processed. The abrasion primitive data of plant could not always satisfy these modeling requirements. Therefore, it establishes a division method suited for general data modeling and estimating parameters of GM (1,1), the standard error coefficient that was applied to judge accuracy height of the model was put forward; further, the function transform to forecast plant abrasion trend and assess GM (1,1) parameter was established. These two models need not pre process the primitive data. It is not only suited for equal interval data modeling, but also for non equal interval data modeling. Its calculation is simple and convenient to use. The oil spectrum analysis acted as an example. The two GM (1,1) models put forward in this paper and the new information model and its comprehensive usage were investigated. The example shows that the two models are simple and practical, and worth expanding and applying in plant fault diagnosis. | LUO You xin 1 , PENG Zhu 2 , ZHANG Long ting 1 , GUO Hui xin 1 , CAI An hui 1 1Department of Mechanical Engineering, Changde Teachers University, Changde 415003, P.R. China 2 Engineering Technology Board, Changsha Cigare | 2001 | International Journal of Plant Engineering and Management2001，6，4： | 11 |
| 3 | Effects of Wei Chang An on expression of multiple genes in human gastric cancer grafted onto nude mice显示文摘AIM:To investigate the expression of multiple genes in Chinese jianpi herbal recipe Wei Chang An (WCA) in human gastric cancer cell line SGC-7901. METHODS:A human gastric adenocarcinoma cell line SGC-7901 grafted onto nude mice was used as the animal model. The mice were randomly divided into 3 groups, one control and the two representing experimental conditions. Animals in the two experimental groups received either WCA over a 34-d period or 5-fluorouracil (5-FU) over 6-d period starting at 8th d after grafting. Control animals received saline on an identical schedule. Animals were killed 41 d after being grafted. The expression profiles in paired WCA treated gastric cancer samples and the N.S. control samples were studied by using a cDNA array representing 14 181 cDNA clusters. The alterations in gene expression levels were confirmed by Real-time Quantitative polymerase chain reaction (qPCR). RESULTS:When compared with controls, the average tumor inhibitory rate in WCA group was 44.32% ± 5.67% and 5-FU 47.04% ± 11.33% (P < 0.01, respectively). The average labeling index (LI) for PCNA in WCA group and 5-FU group was significantly decreased compared with the control group. Apoptotic index (AI) was significantly increased to 9.72% ± 4.51% using the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate fluorescence nick end labeling (TUNEL) method in WCA group compared with the controls 2.45% ± 1.37%. 5-FU group was also found to have a significantly increased AI compared with the controls. The expression of cleaved Caspase-3 in WCA group and 5-FU group was significantly increased compared with the control group respectively. There were 45 different expressed sequence tags (ESTs) among the control sample pool and WCA sample pool. There were 24 ESTs up-regulated in WCA samples and 21 ESTs down-regulated. By using qPCR, the expression level of Stat3, rap2 interacting protein x (RIPX), regulator of differentiation 1 (ROD1) and Bcl-2 was lower in WCA group than that in control group respectively. By using SP immunohistochemical method the expression of Phospho-Stat3 (Tyr705) and Bcl-2 in WCA group and 5-FU group was significantly decreased compared with the control group respectively. | Ai-Guang Zhao Ting Li Sheng-Fu You Hai-Lei Zhao Ying Gu Lai-Di Tang Jin-Kun Yang | 2008 | World Journal of Gastroenterology2008，14，5： | 11 |
| 4 | Plasma metabolomic and lipidomic alterations associated with COVID-19显示文摘The pandemic of the coronavirus disease 2019(COVID-19)has become a global public health crisis.The symptoms of COVID-19 range from mild to severe,but the physiological changes associated with COVID-19 are barely understood.In this study,we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms.We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients,indicating that the development of COVID-19 affected their whole-body metabolism.In particular,malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction,respectively.It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms.And,more importantly,guanosine monophosphate(GMP),which is mediated not only by GMP synthase but also by CD39 and CD73,is significantly changed between healthy subjects and patients with COVID-19,as well as between the mild and fatal cases.In addition,dyslipidemia was observed in patients with COVID-19.Overall,the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19.This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets,as well as an important resource for further studies of the pathogenesis of COVID-19. | Di Wu Ting Shu Xiaobo Yang Jian-Xin Song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang Yuan Yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang Yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-Yu Zhang You Shang Xi Zhou | 2020 | National Science Review2020，7，7： | 9 |
| 5 | Chitinase-3 like-protein-1 function and its role in diseases显示文摘Non-enzymatic chitinase-3 like-protein-1(CHI3L1)belongs to glycoside hydrolase family 18.It binds to chitin,heparin,and hyaluronic acid,and is regulated by extracellular matrix changes,cytokines,growth factors,drugs,and stress.CHI3L1 is synthesized and secreted by a multitude of cells including macrophages,neutrophils,synoviocytes,chondrocytes,fibroblast-like cells,smooth muscle cells,and tumor cells.It plays a major role in tissue injury,inflammation,tissue repair,and remodeling responses.CHI3L1 has been strongly associated with diseases including asthma,arthritis,sepsis,diabetes,liver fibrosis,and coronary artery disease.Moreover,following its initial identification in the culture supernatant of the MG63 osteosarcoma cell line,CHI3L1 has been shown to be overexpressed in a wealth of both human cancers and animal tumor models.To date,interleukin-13 receptor subunit alpha-2,transmembrane protein 219,galectin-3,chemo-attractant receptor-homologous 2,and CD44 have been identified as CHI3L1 receptors.CHI3L1 signaling plays a critical role in cancer cell growth,proliferation,invasion,metastasis,angiogenesis,activation of tumor-associated macrophages,and Th2 polarization of CD4+T cells.Interestingly,CHI3L1-based targeted therapy has been increasingly applied to the treatment of tumors including glioma and colon cancer as well as rheumatoid arthritis.This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis,then posits investigational strategies for targeted therapies. | Ting Zhao Zhongping Su Yingchang Li Xiaoren Zhang Qiang You | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 8 |
| 6 | Grey System Judgment on Reliability of Mechanical Equipment显示文摘The Grey system theory was applied in reliability analysis of mechanical equipment.It is a new theory and method in reliability engineering of mechanical engineering of mechanical equipment. Through the Grey forecast of reliability parameters and the reliability forecast of parts and systems, decisions were made in the real operative state of equipment in real time. It replaced the old method that required mathematics and physical statistics in a large base of test data to obtain a pre check, and it was used in a practical problem. Because of applying the data of practical operation state in real time, it could much more approach the real condition of equipment; it was applied to guide the procedure and had rather considerable economic and social benefits. | LUO You xin, GUO Hui xin, ZHANG Long ting, CAI An hui, PENG Zhu Department of Mechanical Engineering,Changde Teachers University, Changde 415003, P.R.China | 2001 | International Journal of Plant Engineering and Management2001，6，3： | 7 |
| 7 | Halogen Inhalation-Induced Lung Injury and Acute Respiratory Distress Syndrome显示文摘 | Ting Zhou Wei-Feng Song You Shang Shang-Long Yao Sadis Matalon | 2018 | Chinese Medical Journal2018，，10： | 6 |
| 8 | Research on dynamic performance of star tracker显示文摘This manuscript briefly summarizes the development trends and recent research focus of the star tracker.And the relevant technologies about dynamic performance of the star tracker are analyzed and discussed.These can provide reference for the star tracker and attitude measurement device researchers. | SUN Ting XING Fei YOU Zheng | 2015 | Instrumentation2015，2，1： | 6 |
| 9 | New Record of Palaeoscolecids from the Early Cambrian of Yunnan,China显示文摘摘要:新 palaeoscolecid, Guanduscolex 次要的胡,罗 et Fu 情报。et sp。nov,与内向的人和肠的保存软部分来自云南的更低的寒武纪的 Guanshan 动物志,华南。扫描电子显微镜学(SEM ) 揭示的表皮的微结构细节证明每个环忍受三排盘子,每个盘子忍受 910 边缘并且 45 个中央节点。这发现在关系和 palaeoscolecids 和另外的早 priapulids 的进化小径上打开新灯。 | HU Shixue LI Yong LUO Huilin FU Xiaoping YOU Ting PANG Jiyuan LIU Qi Michael STEINER | 2008 | Acta Geologica Sinica(English Edition)2008，82，2： | 6 |
| 10 | Effect and safety of acupotomy in treatment of knee osteoarthritis:a systematic review and Meta-analysis显示文摘OBJECTIVE: To evaluate the clinical efficacy and safety of acupotomy in treatment of knee osteoarthritis(OA).METHODS: Extensive literature searches were carried out in PubMed, EMBASE, Cochrane Library(Issue 5, 2017), Chinese Biomedical Literature Database, China National Knowledge Infrastructure Database, China Science and Technology Journal Database and Wanfang Database. All databases were retrieved from their inception until May 31, 2017.Randomized controlled trials incorporating acupotomy versus intra-articular sodium hyaluronate for knee osteoarthritis were included. According to Cochrane Reviews’ Handbook(5.2), two reviewers screened each article and extracted data independently and were blinded to the findings of each reviewer. Meta-analysis was performed by the Cochrane Collaboration’s RevMan 5.3 software.RESULTS: We identified 12 studies involving 1150 patients aged between 40 and 78 years old. The pooled analysis indicated that acupotomy showed a significant improvement for short-term effect[cure rate: odds ratio(OR) = 2.04, 95% confidence interval(CI)(1.46, 2.85), P < 0.01;total effective rate:OR = 2.25, 95% CI(1.55, 3.28), P < 0.01;pain score:standard mean difference(SMD) =-1.02;95% CI(-1.72,-0.31);P = 0.005;Western Ontario and McMaster Universities Questionnaire(WOMAC) score:SMD =-0.74;95% CI(-1.11,-0.37);P < 0.01];and also for long-term effect [total effective rate:OR = 2.99, 95%CI(1.88, 4.76), Z = 4.64, P < 0.01;pain score: SMD =-1.68;95% CI(-2.14,-1.22);P <0.001;WOMAC score: SMD =-0.91;95% CI(-1.40,-0.41);P < 0.001]. In addition, there was no obvious difference between acupotomy group and control group in adverse events [OR = 2.13, 95% CI(0.14, 32.28), P = 0.58].CONCLUSION: Acupotomy is a safe and effective treatment for KOA. However, due to the methodological deficiency of the included studies, well-designed randomized controlled trials are required to further confirm the findings. | Fang Ting Li Qi Zhou Fanyuan Liu Fushui Liu Zhongyong Zhao Meimei Chen Mei You Jianyu Jin Yuli Xie Jinmei | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 6 |
| 11 | Superior in vitro anticancer effect of biomimetic paclitaxel and triptolide co-delivery system in gastric cancer显示文摘As a well-known anticancer drug,paclitaxel(PTX),a first-line chemotherapeutic agent,remains unsatisfactory for gastric cancer therapy.It is reported that triptolide(TPL)could enhance the anti-gastric cancer effect of PTX.Considering the poor solubility of both drugs,we developed a red blood cell membrane-biomimetic nanosystem,an emerging tool in drug delivery,to co-load paclitaxel and triptolide(red blood cell membrane coated PTX and TPL co-loaded poly(lactic-co-glycolic acid)[PLGA]nanoparticles,RP(P/T)).The successful preparation was confirmed in terms of particle size,morphology,and surface markers assays.This biomimetic system could prolong circulation and escape immune surveillance.And these properties were verified by stability,in vitro drug release,and cellular uptake assays.Moreover,the MTT and colony formation assays demonstrated the superior anti-proliferation effect of the RP(P/T)to free drugs.The enhanced antitumor effects of RP(P/T)on migration and invasion were also evaluated by wound-healing and transwell assays.Overall,the bionic co-delivery nanoplatform with improved efficacy in vitro is a promising therapy for gastric cancer. | Siwan Wang Hui Jiang Jia Wang Haisi Wu Ting Wu Mengnan Ni Qianqian Zhao You Ji Ziting Zhang Chunming Tang Huae Xu | 2021 | The Journal of Biomedical Research2021，35，4： | 5 |
| 12 | Space high-accuracy intelligence payload system with integrated attitude and position determination显示文摘recently,the requirements for space high resolution and high accuracy earth observation payloads are more urgent in many fields.However,traditional satellites mainly use the separation model of platform and payload.The precision of platform was unable to fulfill the requirements of high-precision imaging of payload.In addition,because traditional satellites mainly use the rigid connection between platform and payload,the precision of payload strongly depends on platform.They make satellite development and requirements increasingly difficult.To solve these disadvantages,in this paper,we introduce a Space High-accuracy integrated Intelligence Payload(SHIP) system with real-time attitude and position determination.SHIP can complete real time autonomous high accuracy attitude and position determination,high resolution remote sensing imaging,high-accuracy target position based on image,multi-mode motion imaging and target identification,tracking,self-recovery function of on orbit image,self-determination function of attitude and position,and so on. | LI Jin XING Fei SUN Ting LIU Zengyi YOU Zheng | 2015 | Instrumentation2015，2，1： | 5 |
| 13 | Unraveling a genetic roadmap for improved taste in the domesticated apple显示文摘Although taste is an important aspect of fruit quality, an understanding of its genetic control remains elusive in apple and other fruit crops. In this study, we conducted genomic sequence analysis of 497 Malus accessions and revealed erosion of genetic diversity caused by apple breeding and possible independent domestication events of dessert and cider apples. Signatures of selection for fruit acidity and size, but not for fruit sugar content, were detected during the processes of both domestication and improvement. Furthermore, we found that single mutations in major genes affecting fruit taste, including Ma1, MdTDT, and MdSOT2, dramatically decrease malate, citrate, and sorbitol accumulation, respectively, and correspond to important domestication events. Interestingly, Ma1 was identified to have pleiotropic effects on both organic acid content and sugar:acid ratio, suggesting that it plays a vital role in determining fruit taste. Fruit taste is unlikely to have been negatively affected by linkage drag associated with selection for larger fruit that resulted from the pyramiding of multiple genes with minor effects on fruit size. Collectively, our study provides new insights into the genetic basis of fruit quality and its evolutionary roadmap during apple domestication, pinpointing several candidate genes for genetic manipulation of fruit taste in apple. | Liao Liao Weihan Zhang Bo Zhang Ting Fang Xiao-Fei Wang Yarning Cai Collins Ogutu Lei Gao Gang Chen Xiaoqing Nie Jinsheng Xu Quanyan Zhang Yiran Ren Jianqiang Yu Chukun Wang Cecilia H.Deng Baiquan Ma Beibei Zheng Chun-Xiang You Da-Gang Hu Richard Espley Kui Lin-Wang Jia-Long Yao Andrew C.Allan Awais Khan Schuyler S.Korban Zhangjun Fei Ray Ming Yu-Jin Hao Li Li Yuepeng Han | 2021 | Molecular Plant2021，14，9： | 5 |
| 14 | A New Arthropod,Guangweicaris Luo,Fu et Hu gen. nov. from the Early Cambrian Guanshan Fauna,Kunming,China显示文摘The Guanshan Fauna is a soft-bodied fauna dominated by arthropods (including trilobites, trilobitoides, Tuzoia, Isoxys, and bradorids) in association with priapulids, brachiopods, anomalocaridids, vetulicoliids, sponges, chancellorids, and echinoderms. This paper reports and describes a new arthropod from the yellowish green mudstone at the lower part of the Wulongqing Formation, Canglangpuan Stage, Lower Cambrian in Kunming, Yunnan, China. The stratigraphic and geographic distribution, classification, fossil preservation, life style of this new arthropod and comparisons with other fossil arthropods are also discussed in details. The discovery and research of the non-mineralized arthropod, Guangweicaris Luo, Fu et Hu gen. nov. from the Guanshan Fauna adds new members to the taxonomic list and provides new information to the evolution of early arthropods. Furthermore, this study would shed new light into the “Cambrian Explosion” and the evolution of early life. | LUO Huilin FU Xiaoping HU Shixue LI Yong HOU Shuguang YOU Ting PANG Jiyuan LIU Qi | 2007 | Acta Geologica Sinica(English Edition)2007，81，1： | 5 |
| 15 | Combined Effect of Smoking and Obesity on Coronary Heart Disease Mortality in Male Veterans:A 30-year Cohort Study显示文摘Objective Evidence is lacking regarding the combined effects of smoking and obesity on mortality from coronary heart disease in male veterans.This study aimed to explore the combined effect of smoking and obesity on coronary heart disease mortality in male veterans in China.Methods A cohort of 1,268 male veterans from 22 veteran centers in Xi’an(Shaanxi Province,China)were followed up once every 2 years from February 1,1987 to October 30,2016.The endpoint was death from any cause.The hazard ratio(HR)of each risk factor and the 95%confidence interval(CI)were calculated using a multivariate Cox proportional hazard model.Results The total follow-up was 24394.21 person-years;each subject was followed up for a mean duration of 19.24 years.By the end of the study,of the 1,268 veterans,889 had died,363 were alive,and 16 were lost to follow-up.Cox regression analysis results revealed that current smoking(HR:1.552,95%CI:1.074–2.243),obesity(HR:1.625,95%CI:1.024–2.581),and the combined effect of the two factors(HR:2.828,95%CI:1.520–5.262)were associated with coronary heart disease mortality.Conclusion Our results suggest that obese veterans who smoke might be an important target population for coronary heart disease mortality control. | SAI Xiao Yong GAO Feng ZHANG Wen Yu GAO Meng YOU Jing SONG Yu Jian LUO Ting Gang SUN Yuan Yuan | 2021 | Biomedical and Environmental Sciences2021，34，3： | 5 |
| 16 | Fructus phyllanthi tannin fraction induces apoptosis and inhibits migration and invasion of human lung squamous carcinoma cells in vitro via MAPK/MMP pathways显示文摘目的: 从传统的西藏的药 Fructus phyllanthi 的 Fructus phyllanthi 丹宁部分(PTF ) 被发现了在老鼠禁止肺和肝癌。在这研究,我们在人的肺调查了 PTF 的 anticancer 机制在 vitro 的有鳞的癌房间。 | Hai-juan ZHAO Ting LIU Xin MAO Shu-xian HAN Ri-xin LIANG Lian-qiang HUI Chun-yu CAO Yun YOU Lan-zhen ZHANG | 2015 | Acta Pharmacologica Sinica2015，36，6： | 4 |
| 17 | Regional Meteorological Patterns for Heavy Pollution Events in Beijing显示文摘The present study investigates meteorological conditions for the day-to-day changes of particulate matter(PM)concentration in Beijing city during the period 2008–2015. The local relationship of PM concentration to surface air temperature, pressure, wind speed, and relative humidity displays seasonal changes and year-to-year variations. The average correlation coefficient with PM10 in spring, summer, fall, and winter is 0.45, 0.40, 0.38, and 0.30 for air temperature; –0.45, –0.05, –0.40, and –0.45 for pressure; 0.13, 0.04, 0.53, and 0.50 for relative humidity; and –0.18,–0.11, –0.45, and –0.33 for wind speed. A higher correlation with wind speed is obtained when wind speed leads by half a day. The heavily polluted and clean days, which are defined as the top and bottom 10% of the PM values, show obvious differences in the regional distribution of air temperature, pressure, and wind. Polluted days correspond to higher air temperature in all the four seasons, lower sea level pressure and anomalous southerly winds to the south and east of Beijing in spring, fall, and winter, and a northwest–southeast contrast in the pressure anomaly and anomalous southerly winds in summer. Higher relative humidity is observed on polluted days in fall and winter. The polluted days are preceded by an anomalous cyclone moving from the northwest, accompanied by lower pressure and higher air temperature, in all four seasons. This feature indicates the impacts of moving weather systems on local meteorological conditions for day-to-day air quality changes in Beijing. | ting you renguang wu gang huang guangzhou fan | 2017 | Journal of Meteorological Research2017，31，3： | 4 |
| 18 | Efficacy of water fraction from Dioscorea cirrhosa on oxidative stress and apoptosis in H9c2 cardiomyocytes induced by H2O2显示文摘OBJECTIVE:To investigate the efficacy of water fraction from Dioscorea cirrhosa(WF)on oxidative damage and apoptosis of cardiomyocytes induced by H2O2,and to study its mechanism.METHODS:Cell viability was measured by the MST assay kit.The content of malondialdehyde(MDA),release of lactate dehydrogenase(LDH)and activity of catalase(CAT)and superoxide dismutase(SOD)were detected by biochemical kit.The content of reactive oxygen species(ROS)was assessed by nonfluorescent probe 2′,7′-dichlorofluorescin diacetate(DCFH-DA).JC-1 was used to analyze the mitochondrial membrane potential(mtΔΨ)and Annexin-V-FITC/PI staining was applied to assess apoptosis of H9c2 by flow cytometry.Moreover,the expression of B-cell lymphoma-2(Bcl-2),Bcl-2-associated X(Bax),caspase-3,caspase-9,cleaved-caspase-3 and cleaved-caspase-9 proteins was determined by western blot analysis.RESULTS:WF increased cell viability and decreased LDH leakage in H9c2 cells exposed to H2O2.WF treatment decreased ROS and MDA level,enhanced SOD and CAT activities,improved mtΔΨand inhibited apoptosis.Western blot analysis demonstrated that the ratio of Bcl-2/Bax was increased and the expression cleaved-caspase-3,caspase-3,cleaved-caspase-9 and caspase-9 were decreased in group treated with WF.CONCLUSION:WF protects H9c2 myocardial cells on H2O2-induced oxidative stress and apoptosis by scavenging ROS,improving antioxidant capacity,protecting mitochondrial and regulating the proteins expression related to apoptosis. | LIU Chunhua PAN Jie WANG Aimin LAN Yanyu LI Yongjun LU Yuan SUN Jia WANG Yonglin LIU Ting LU Dingyan YOU Jingrui | 2021 | Journal of Traditional Chinese Medicine2021，41，1： | 4 |
| 19 | Endomorphin analogues with balanced affinity for bothμ- andδ-opioid receptors显示文摘在位置修改的 endomorphin 和 tripeptides 的类似物分别地, 4 和 3 与各种各样的本氨基丙酸类似物被综合,他们为 opioid 受体的亲密关系被评估。大多数肽展出了有势力受体亲密关系和选择,在他们之中,(Dmt-Pro-Tmp-Tmp-NH2 ) 化合物 7 展出了有势力亲密关系为 - 并且受体(Ki = 0.47 nmol/L, Ki = 1.63 nmol/L ) 。 | Liang Zhang Lei Chang Lei Lei Yu Jin Chun Liu Jia Jia Chen Xiao Wen Li Lawrence H. Lazarus Ting You Li | 2011 | Chinese Chemical Letters2011，22，8： | 4 |
| 20 | A new derivative of triterpene with anti-melanoma B16 activity from Conyza canadensis显示文摘A new derivative of triterpene named Erigeronol 1 was isolated from the EtOH extract of the aerial part of Conyza canadensis together with 15 known compounds for the first time from this plant.The structure of Erigeronol 1 was elucidated as 3-O-(hydroxyacetyl) -23,28-dihydroxy-β-amyrin by hydrolysis and spectroscopic analysis.Erigeronol 1 showed potent cytotoxic activity with IC_(50) value of 7.77±0.47μg/mL against melanoma B16 determined by the 3-(4,5-dimethylthiazo-2-yl)-2,5-diphenyltetrazolium bromide(MTT) method. | Ming Ming Yan Ting You Li Da Qing Zhao Shuai Shao Sheng Nan Bi | 2010 | Chinese Chemical Letters2010，21，7： | 4 |
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