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| 1 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 2 | Vitamin C alleviates aging defects in a stem cell model for Werner syndrome显示文摘沃纳症候群(WS ) 是主要影响从中层导出的纸巾的早衰混乱。我们最近用 WRN 缺乏的人的间充质的干细胞(MSC ) 开发了一个新奇人的 WS 模型。这个模型概括 WS 的许多 phenotypic 特征。基于很多化学药品的一幅屏幕,这里,我们发现维生素 C 在出现在WRN缺乏的 MSC 的早衰为许多特征施加很有效的营救包括细胞生长拘捕,增加了反应的氧种层次, telomere 摩擦,煽动性的因素的过多的分泌物,象原子薄板和 heterochromatin 的组织的破坏一样。而且,维生素 C 在一个老鼠模型在 vivo 恢复 MSC 的生存能力。定序分析的 RNA 显示维生素 C 改变涉及染色质冷凝作用,房间周期规定, DNA 复制,和 DNA 损坏的一系列基因的表示在 WRN 缺乏的 MSC 的修理小径。我们的结果为 WS MSC 作为一个恢复因素识别维生素 C,它保持作为 WS 的处理的一种新奇类型被使用的潜力。 | Ying Li Weizhou Zhang Liang Chang Yan Han Liang Sun Xiaojun Gong Hong Tang Zunpeng Liu Huichao Deng Yanxia Ye Yu Wang Jian Li Jie Qiao Jing Qu Weiqi Zhang Guang-Hui Liu | 2016 | Protein & Cell2016，7，7： | 10 |
| 3 | B cells biology in systemic lupus erythematosus—from bench to bedside显示文摘Systemic lupus erythematosus(SLE) is a debilitating autoimmune disease that can involve multi-organs. B cells play a central role in the immunopathogenesis via antibody-dependent and antibody-independent ways. Excessive autoantibodies production, hyperresponsiveness and prolonged survival of autoreactive B cells are characteristics of SLE. In this article, mechanisms of self-tolerance loss of B cells and promising B cell-targeting therapies in lupus are reviewed and discussed. | ZHAO LiDan YE YanXia ZHANG Xuan | 2015 | Science China(Life Sciences)2015，58，11： | 7 |
| 4 | Functional characterization of RelBE toxin-antitoxin system in probiotic Bifidobacterium Iongum JDM301显示文摘毒素抗毒素(TA ) 系统在细菌和 archaea 是普遍的。然而,在细菌的生理学的 chromosomally 编码的 TA 系统的角色仍然是开的辩论。在这研究, ? TA ? 在 Bifidobacterium longum JDM301 的 module-relBE (relBE Bif ) 被识别,它在压力反应的功能被评估。JDM301 的整个染色体序列的生物信息学分析揭示了编码一个象 RelBE 一样 TA 系统的一双连接基因(RelBE Bif ) 。我们的结果揭示了 relBE 在 JDM301 的 Bif 。RelE Bif 在 Escherichia coli 上有有毒的效果,它能被它的血缘的抗毒素的合作表示抵销, RelB Bif 。我们的数据也表明了那 RelE Bif 是 mRNA interferase 并且 RelE Bif 能被 RelB Bif 。这些结果建议那 RelE Bif 是通过 mRNA 降级逮捕细胞生长的有毒的核酸酶,并且 RelE Bif 能被 RelB Bif 。另外,我们也发现 RelBE Bif 在渗透的应力期间被增加,建议那 RelBE Bif 在这个不利条件下面被激活。我们的结果暗示 RelBE Bif TA 模块可以代表帮助 B 的一个房间生长调节的人。longum 将处理渗透的应力。 | Yanxia Wei Lu Ye Yang Li Fan Yang Dianbin Liu Xiaokui Guo Renxian Tang Chang Liu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，8： | 1 |
| 5 | GROWTH OF DIAMOND-LIKE FILMS BY DC PLASMA CHEMICAL VAPOR DEPOSITION显示文摘Diamond-like films have been deposited by dc plasma chemical vapor deposition(CVD).During deposition,the characteristics of the plasma have been measured by means of the Langmuir single probe.The structure of the deposits has been studied by X-ray diffraction,Raman spectroscopy and Fourier transform infrared spectroscopy. | ZHAN Rujuan GAO Kelin ZOU Zuping WANG Yanxia LIU Jiezhou XIANG Zhilin LIU Hongtu WU Zhiqiang YE Jian ZHOU Guien WANG Changsui | 1990 | Chinese Physics Letters1990，7，10： | 1 |
| 6 | Characteristics of secondary droplets produced by the impact of drops onto a smooth surface显示文摘This work investigates the splashing behaviors of droplets impacting on solid surfaces and mainly focuses on the characteristics of secondary droplets.According to the experimental results,two different splashing patterns,corona splash and levitating-lamella breakup,are observed.A new breakup mode,named rimsegmenting,is found during the levitating-lamella breakup.In particular,the detailed information of the splashing secondary droplets,including the size,velocity,angle,and total volume of the splashing secondary droplets is obtained from the experimental data.The size distribution of the splashing secondary droplets obeys the gamma distribution function.The average diameter and splashing angle of the secondary droplets are mainly related to the Reynolds number Re,and can be expressed as functions of Re.High impact velocity and liquid viscosity will result in a wider size distribution range of splashing secondary droplets.We also put forward an empirical model to predict the total splashing volume,which is consistent with the experimental data both in this work and previous studies.This work is believed to provide insights on the prediction of the characteristics of splashing secondary droplets. | Haixiang Zhang Ye Gao Xiwen Zhang Xian Yi Yanxia Du Feng He Zheyan Jin Pengfei Hao | 2021 | Advances in Aerodynamics2021，3，1： | 1 |
| 7 | Synergistic effects of AAGL and anti-PD-1 on hepatocellular carcinoma through lymphocyte recruitment to the liver显示文摘Objective:Therapy for hepatocellular carcinoma(HCC)is a major challenge,and targeted therapies provide only a modest benefit in terms of overall survival.Treatment with antibodies to programmed cell death protein 1(PD-1)/PD-L1 can restore the functions of tumor-infiltrating T cells in HCC and has shown clinical efficacy in 20%of patients with advanced HCC.Novel approaches are urgently needed to treat HCC and to augment the efficacy of immunotherapy.Methods:Tumor-bearing mice were treated with Agrocybe aegerita galectin(AAGL)alone or in combination with anti-PD-1,and the tumor sizes and lifespans of mice were determined.Transcriptome analysis,cytokine analysis,flow cytometry analysis of the number and proportion of immune cell subsets in the liver and spleen,and molecular and cellular analyses of tumors were used to define the underlying mechanisms.Results:AAGL significantly inhibited the growth of liver tumors in a dose-dependent manner.Furthermore,AAGL increased the expression of multiple cytokines and chemokines in tumor-bearing mouse livers;this effect was associated with the activation and migration of T cells and macrophages,in agreement with the in vitro results.Importantly,the aggregation of T cells and macrophages induced by AAGL in tumor-bearing mouse livers clearly enhanced the response to PD-1 blockade immunotherapy.Conclusions:The results showed that AAGL induced the activation and migration of lymphocytes to the liver,and that the combination of AAGL and anti-PD-1 may be a promising strategy for HCC treatment. | Xiangdong Ye Xueqing Wang Wenhui Yu Qing Yang Yan Li Yanxia Jin Yanting Su Jiaqi Song Bo Xu Hui Sun | 2021 | Cancer Biology & Medicine2021，18，4： | 0 |
| 8 | Single-nucleus transcriptomics reveals a gatekeeper role for FoxP1 in primate cardiac aging显示文摘Aging poses a major risk factor for cardiovascular diseases,the leading cause of death in the aged population.However,the cell type-specific changes underlying cardiac aging are far from being clear.Here,we performed single-nucleus RNA-sequencing analysis of left ventricles from young and aged cynomolgus monkeys to define cell composition changes and transcriptomic alterations across different cell types associated with age.We found that aged cardiomyocytes underwent a dramatic loss in cell numbers and profound fluctuations in transcriptional profles.Via transcription regulatory network analysis,we identified FOxP1,a core transcription factor in organ development,as a key downregulated factor in aged cardiomyocytes,concomitant with the dysregulation of FoxP1 target genes associated with heart function and cardiac diseases.Consistently,the deficiency of FOxP1 led to hypertrophic and senescent phenotypes in human embryonic stem cell-derived cardiomyocytes.Altogether,our findings depict the celiular and molecular landscape of ventricular aging at the single-cell resolution,and identify drivers for primate cardiac aging and potential targets for intervention against cardiac aging and associated diseases. | Yiyuan Zhang Yandong Zheng Si Wang Yanling Fan Yanxia Ye Yaobin Jing Zunpeng Liu Shanshan Yang Muzhao Xiong Kuan Yang Jinghao Hu Shanshan Che Qun Chu Moshi Song Guang-Hui Liu Weiqi Zhang Shuai Ma Jing Qu | 2023 | Protein & Cell2023，14，4： | 0 |
| 9 | Preparation and characteriza-tion of a novel composite mi-croporous polymer electrolyte for Li-ion batteries显示文摘A novel composite microporous polymer elec- trolyte composed of poly(vinylidene fluoride-co-hexafluorop- ropylene) (PVdF-HFP) and mesoporous SBA-15 was pre- pared. The composite solid polymer electrolyte (CSPE) ex- hibits ionic conductivity as high as 0.30 mS·cm?1 with a composition of SBA-15︰PVdF-HFP=3︰8 at room tem- perature. Infrared transmission spectroscopic results sug- gested that the mechanism of micropore formation is similar to that of the phase inversion. X-ray diffraction (XRD) results demonstrated that the addition of SBA-15 inhibits the crys- tallization of PVdF-HFP, while the SBA-15 preserves well its ordered mesoporous structure during the course of prepara- tion. The Li/CSPE/MCF of half-cell was assembled, and it showed a good electrochemical and cyclability performance during charge-discharge cycles. | CHEN Zuofeng JIANG Yanxia ZHUANG Quanchao DONG Quanfeng WANG Ye SUN Shigang | 2005 | Chinese Science Bulletin2005，50，14： | 0 |
| 10 | Effect of Ti Incorporation on the Microstructure and Properties of the a-C:H Films Deposited by Magnetron Sputtering Technique显示文摘Amorphous hydrogenated carbon(a-C:H)and Ti-incorporated a-C:H(Ti/a-C:H)films were deposited by magnetron sputtering with a mixture gas of CH4 and Ar.The effect of the Ti incorporation on the chemical composition,microstructure and properties of the as-deposited and the annealed films were investigated by various techniques.It has been shown that the bonding structure and the internal stress were sensitive to the incorporation of the Ti atoms.The results of the XPS revealed that the concentration of Ti atom on the surface of the film increased when the Ti/a-C:H film annealed at 300oC.The tribologcial properties of the(Ti/)a-C:H films changed greatly after annealed,due to the graphitization,oxidation of carbon,and so forth.It compared and discussed in detail the change of the microstructure and properties of the a-C:H and Ti/a-C:H films before and after | Wang Yongxia Ye Yinping Li Hongxuan Ji Li Wang Yongjun Wu Yanxia Liu Xiaohong Chen Jianmin Zhou Huidi | 2012 | 稀有金属材料与工程2012，41，S1： | 0 |
| 11 | Discussion on Construction and Mechanism of Practice Bases for Professional Degree Postgraduates Based on the Integration of Production and Education in Local Universities显示文摘Under the background of emerging agricultural education,practice bases are an important place to train profession talented person that match social needs,so it is very important to build stable and long-term practice bases.At present,the main problems in the construction of practice bases for postgraduates in local colleges and universities are mainly focusing on construction and neglecting management,imperfect cooperation mechanism and lack of teaching management effectively.It is of great significance to build a long-term management mechanism to ensure the education quality of practice bases.Therefore,constructing the mode of'double integration and double promotion of production and education'with practice bases as the carrier and realizing the organic combination of industrial needs and postgraduate projects is an important idea for local colleges and universities to train professional degree postgraduates to'know agriculture,love agriculture,strengthen agriculture and promote agriculture',and it also provides a reference for the mechanism construction of postgraduate bases. | Dabing XIANG Yu FAN Xueling YE Changying LIU Liangzhen JIANG Yan WAN Yuehua WANG Yanxia SUN | 2023 | Agricultural Biotechnology2023，12，5： | 0 |
| 12 | Boosted photocatalytic efficiency of GQDs sensitized(BiO)_(2)CO_(3)/β-Bi_(2)O_(3)heterojunction via enhanced interfacial charge transfer显示文摘The NO gas is easily oxidized to form toxic by-products(NO_(2))during the oxidation process,which are adsorbed on the catalyst surface and inhibit the subsequent reaction.For photocatalytic NO removal,a significant challenge is to achieve catalytic stability while maintaining high conversion efficiency.Here,we fabricated a(BiO)_(2)CO_(3)/β-Bi_(2)O_(3)heterostructure that enables efficient charge transfer and promotes the NO removal.We propose that the catalytic stability depends on the heterojunction structure,which is able to generate interfacial charge transfer channels.In addition,we further introduce graphene quantum dots on the heterojunction structure,which further strengthens the interfacial charge transfer dynamics and finally realizes that the NO_(2)byproduct could gain electrons and convert to the final product(nitrite or nitrate).This composite structure not only exhibits high activity for NO removal but also maintains long-term stability under visible light. | Yanxia Wang Jianping Sheng Xiaoli Zhao Ye He Fan Dong Yanjuan Sun | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 13 | Transcriptome-wide association analysis identified candidate susceptibility genes for nasopharyngeal carcinoma显示文摘Dear Editor,Nasopharyngeal carcinoma(NPC)is a common malignancy in East and Southeast Asia,especially in South China.The etiology of NPC has been linked to genetic susceptibility,Epstein-Barr virus(EBV)infection,and environmental factors.Accumulated evidence including multiple genome-wide association studies(GWASs)has revealed robust genetic predisposition of NPC.However,GWAS-identified genetic variants collectively account for only 8.2%of NPC heritability[1].The underlying inherited predisposition is largely undetermined.The strongest genetic signal for NPC consistently hits the human leukocyte antigen(HLA)region on 6p21[2].However,the highly polymorphic nature and complicated long-range linkage disequilibrium(LD)in the HLA region particularly obscure the causal variants driving the association.In addition,most genetic variants located in introns or intergenic regions.The causal genes mediating genetic effects on NPC risk have rarely been ascertained by GWAS alone. | Yong-Qiao He Wen-Qiong Xue Dan-Hua Li Tong-Min Wang Zhi-Ming Mai Da-Wei Yang Chang-Mi Deng Ying Liao Wen-Li Zhang Ruo-Wen Xiao Luting Luo Hua Diao Xiating Tong Yanxia Wu Jiang-Bo Zhang Ting Zhou Xi-Zhao Li Pei-Fen Zhang Xiao-Hui Zheng Shao-Dan Zhang Ye-Zhu Hu Minzhong Tang Yuming Zheng Yonglin Cai Ellen T.Chang Zhe Zhang Guangwu Huang Su-Mei Cao Qing Liu Lin Feng Ying Sun Maria Li Lung Hans-Olov Adami Weimin Ye Tai-Hing Lam Wei-Hua Jia | 2022 | Cancer Communications2022，42，9： | 0 |
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