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| 1 | Influence of ginsenoside Rg1, a panaxatriol saponin from Panax notoginseng, on renal fibrosis in rats with unilateral ureteral obstruction显示文摘Total saponins of Panax notoginseng (PNS) have been shown to ameliorate renal interstitial fibrosis. Ginsenoside Rg1, a panaxatriol saponin, is one of the major active molecules from PNS. The present study was undertaken to investigate the effect of ginsenoside Rg1 on renal fibrosis in rats with unilateral ureteral obstruction (UUO). The rats were randomly divided into 3 groups: sham-operation (n=15), UUO (n=15) and UUO with ginsenoside Rg1 treatment (n=15, 50 mg per kg body weight, intraperito- neally (i.p.) injected). The rats were sacrificed on Days 7 and 14 after the surgery. Histological examination demonstrated that ginsenoside Rg1 significantly inhibited interstitial fibrosis including tubular injury as well as collagen deposition. α-smooth muscle actin (α-SMA) and E-cadherin are two markers of tubular epithelial-myofibroblast transition (TEMT). Interestingly, ginsenoside Rg1 notably decreased α-SMA expression and simultaneously enhanced E-cadherin expression. The messenger RNA (mRNA) of transforming growth factor-β1 (TGF-β1), a key mediator to regulate TEMT, in the obstructed kidney increased dra- matically, but was found to decrease significantly after administration of ginsenoside Rg1. Further study showed that ginsenoside Rg1 considerably decreased the levels of both active TGF-β1 and phosphorylated Smad2 (pSmad2). Moreover, ginsenoside Rg1 substantially suppressed the expression of thrombospondin-1 (TSP-1), a cytokine which can promote the transcription of TGF-β1 mRNA and the activation of latent TGF-β1. These results suggest that ginsenoside Rg1 inhibits renal interstitial fibrosis in rats with UUO. The mechanism might be partly related to the blocking of TEMT via suppressing the expression of TSP-1. | Xi-sheng XIE Man YANG Heng-cuang LIU Chuan ZUO Zi LI Yao DENG Jun-ming FAN | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，11： | 34 |
| 2 | Size distribution of chemical elements and their source apportionment in ambient coarse, fine, and ultrafine particles in Shanghai urban summer atmosphere显示文摘Ambient coarse particles (diameter 1.8-10 μm), fine particles (diameter 0.1-1.8 μm), and ultrafine particles (diameter < 0.1 μm) in the atmosphere of the city of Shanghai were sampled during the summer of 2008 (from Aug 27 to Sep 08). Microscopic characterization of the particles was investigated by scanning electron microscopy coupled with energy dispersive X-ray spectroscopy (SEM/EDX). Mass concentrations of Si, P, S, Cl, K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, As, Se, Br, Rb, Sr, and Pb in the size-resolved particles were quantified by using synchrotron radiation X-ray fluorescence (SRXRF). Source apportionment of the chemical elements was analyzed by means of an enrichment factor method. Our results showed that the average mass concentrations of coarse particles, fine particles and ultrafine particles in the summer air were 9.38 ± 2.18, 8.82 ± 3.52, and 2.02 ± 0.41 μg/m3, respectively. The mass percentage of the fine particles accounted for 51.47% in the total mass of PM10, indicating that fine particles are the major component in the Shanghai ambient particles. SEM/EDX results showed that the coarse particles were dominated by minerals, fine particles by soot aggregates and fly ashes, and ultrafine particles by soot particles and unidentified particles. SRXRF results demonstrated that crustal elements were mainly distributed in the coarse particles, while heavy metals were in higher proportions in the fine particles. Source apportionment revealed that Si, K, Ca, Fe, Mn, Rb, and Sr were from crustal sources, and S, Cl, Cu, Zn, As, Se, Br, and Pb from anthropogenic sources. Levels of P, V, Cr, and Ni in particles might be contributed from multi-sources, and need further investigation. | Senlin Lu Rui Zhang Zhenkun Yao Fei Yi Jingjing Ren Minghong Wu Man Feng Qingyue Wang | 2012 | Journal of Environmental Sciences2012，24，5： | 22 |
| 3 | Mechanical properties and corrosion behavior of selective laser melted 316L stainless steel after different heat treatment processes显示文摘Irregular grains, high interfacial stresses and anisotropic properties widely exist in 3D-printed metallic materials, and this paper investigated the effects of heat treatment on the microstructural, mechanical and corrosion properties of 316 L stainless steel fabricated by selective laser melting. Sub-grains and low-angle boundaries exist in the as-received selective laser melted(SLMed) 316 L stainless steel. After heat treatment at 1050℃, the sub-grains and low-angle boundaries changed slightly, and the stress state and strength decreased to some extent due to the decrease of dislocation density. After heat treatment at 1200℃, the grains became uniform, and the dislocation cells vanished, which led to a sharp decline in the hardness and strength. However, the ductility was improved after recrystallization heat treatment.The passive film thickness and corrosion potential of the SLMed 316 L stainless steel decreased after heat treatment, and the pitting potential also decreased due to the accelerated transition from metastable to steady-state pitting;this accelerated transition was caused by the presence of weak passive films at the enlarged pores after heat treatment, especially for an adequate solid solution treatment. | Decheng Kong Chaofang Dong Xiaoqing Ni Liang Zhang Jizheng Yao Cheng Man Xuequn Cheng Kui Xiao Xiaogang Li | 2019 | Journal of Materials Science & Technology2019，35，7： | 23 |
| 4 | Investigation of quality of life in patients with lung cancer by the EORTC QLQ-C30(V3.0) Chinese version显示文摘Objective To explore quality of life(QOL) and its influencing factors in patients with lung cancer.Methods A QOL questionnaire(European Organization for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire-Core 30 [QLQ-C30] Chinese version) was used with 138 patients with lung cancer participating in the study. A statistical description of the general characteristics of the patients with lung cancer was performed. The patients' QLQ-C30 scores were compared with the reference value for each dimension. To analyze the influence of QOL in different genders, age groups, and cancer stages, ttests and rank sum tests were used to compare the differences in QOL using a 5% significance level. Results The QLQ-C30 function scores in PF(physical functioning), EF(emotional functioning), SF(social functioning), and GH(global functioning), and symptom scales in NV(nausea and vomiting), DY(dyspnea), SL(insomnia), and FI(financial difficulties) were significantly different(P < 0.05) in comparison to the reference values. Female patients were worse than males(P < 0.05) in EF, NV, and DI(diarrhea). The later the stage of lung cancer, the worse the quality of life became; the functional scales in RF(role functioning), EF, CF, SF, and GH, and symptom scales in PA(pain), AP(appetite), and SL differences were statistically significant(P < 0.05). Conclusion This study aids understanding of the status of the quality of life of Chinese patients with cancer and might be useful for clinical work, theory research, and health policymakers. | Jun Li Xiaoguang Xiao Yao Wei Yang Li Man Zou Shiying Yu Yuan Chen Qian Chu | 2015 | Oncology and Translational Medicine2015，1，3： | 18 |
| 5 | High levels of serum interleukin-6 increase mortality of hepatitis B virus-associated acute-on-chronic liver failure显示文摘BACKGROUND Patients with hepatitis B virus-associated acute-on-chronic liver failure(HBVACLF)present a complex and poor prognosis.Systemic inflammation plays an important role in its pathogenesis,and interleukin-6(IL-6)as a pro-inflammatory cytokine is related with severe liver impairment and also plays a role in promoting liver regeneration.Whether serum IL-6 influences HBV-ACLF prognosis has not been studied.AIM To determine the impact of serum IL-6 on outcome of patients with HBV-ACLF.METHODS We performed a retrospective study of 412 HBV-ACLF patients.The findings were analyzed with regard to mortality and the serum IL-6 level at baseline,as well as dynamic changes of serum IL-6 within 4 wk.RESULTS The serum IL-6 level was associated with mortality.Within 4 wk,deceased patients had significantly higher levels of IL-6 at baseline than surviving patients[17.9(7.3-57.6)vs 10.4(4.7-22.3),P=0.011].Patients with high IL-6 levels(>11.8 pg/mL)had a higher mortality within 4 wk than those with low IL-6 levels(≤11.8 pg/mL)(24.2%vs 13.2%,P=0.004).The odds ratios calculated using univariate and multivariate logistic regression were 2.10(95%confidence interval[CI]:1.26-3.51,P=0.005)and 2.11(95%CI:1.15-3.90,P=0.017),respectively.The mortality between weeks 5 and 8 in patients with high IL-6 levels at 4 wk was 15.0%,which was significantly higher than the 6.6%mortality rate in patients with low IL-6 levels at 4 wk(hazard ratio=2.39,95%CI:1.05-5.41,P=0.037).The mortality was 5.0%in patients with high IL-6 levels at baseline and low IL-6 levels at 4 wk,7.5%in patients with low IL-6 levels both at baseline and at 4 wk,11.5%in patients with low IL-6 levels at baseline and high IL-6 levels at 4 wk,and 16.7%in patients with high IL-6 levels both at baseline and at 4 wk.The increasing trend of the mortality rate with the dynamic changes of IL-6 was significant(P for trend=0.023).CONCLUSION A high level of serum IL-6 is an independent risk factor for mortality in patients with HBV-ACLF.Furthermore,a sustained high level or dynamic elevated level of serum IL-6 indicates a higher mortality. | Chao Zhou Ning Zhang Ting-Ting He Yao Wang Li-Fu Wang Yong-Qiang Sun Jing Jing Jing-Jing Zhang Shuang-Nan Fu Xuan Wang Xiao-Xiao Liang Xin Li Man Gong Jun Li | 2020 | World Journal of Gastroenterology2020，26，30： | 15 |
| 6 | Development of fractures in soft rock surrounding a roadway and their control显示文摘As the excavation of roadway,new fractures will be formed and the pre-existing fractures extend with the redistribution of stress in surrounding rocks.Eventually,fracture zone and bed separation are formed in rocks because of the developed fractures.Therefore,mastering the fracture evolution of surrounding rocks is very important to maintain the stability of roadway.The surrounding rocks of main haulage roadway in a certain coal mine is so broken and loose that the supporting is very difficult.Based on comprehensive analysis of the engineering geological conditions,a sight instrument was used to observe the fractures of internal surrounding rocks.Four indices,i.e.,the width of fracture zone W,the number of fractures n,the width of fractures d and rock fracture designation RFD,are put forward to evaluate the fracture development.According to the evolution rules of the soft rock roadway from this paper,control principles by stages and by regions are presented through the research.At the same time,the best time of grouting reinforcement is determined on the basis of fracture saturation.Field practice shows that the roadway can satisfy normal production during service periods by suitable first support and grouting reinforcement. | Li Xuehua Yao Qiangling Man Jiankang Chen Chaoqun He Lihui | 2011 | Mining Science and Technology2011，21，4： | 12 |
| 7 | USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA显示文摘圈套(也作为 MITA 知道) 调停天生的抗病毒的发信号和圈套的 ubiquitination 对它的功能关键。然而,圈套的 deubiquitination 过程是不清楚的。这里,我们报导那 USP18 成员 USP20 到连接 K48 的 ubiquitination 从圈套锁住并且支持的 deconjugate 圈套和类型的表示的稳定性我在 DNA 病毒感染以后的 IFN 和 proinflammatory cytokines。USP18 缺乏或 USP20 击倒导致了提高的连接 K48 的 ubiquitination 并且加速了圈套的降级,并且与 DNA 病毒 HSV-1 或各种各样的 DNA ligands 的 transfection 在感染以后损害了下游的基因的 IRF3 和 NF-B 以及正式就职的激活。另外, Usp18 / 老鼠与野类型的同窝出生的人相比更产生 HSV-1 感染。USP18 deubiquitinate 没在 vitro 叮,但是便于 USP20 在 USP18 的酶的活动的一个方式独立人士催化圈套的 deubiquitination。另外,进 Usp18 / MEF 的圈套的宪法恢复了下游的基因和细胞的抗病毒的回答的 HSV-1-induced 表示。我们的调查结果因此以前揭开在调停的 USP18 和 USP20 的 uncharacterized 角色被触发病毒的发信号并且贡献天生的抗病毒的回答的复杂规章的系统的理解。 | Man Zhang Meng-Xin Zhang Qiang Zhang Gao-Feng Zhu Lei Yuan Dong-Er Zhang Qiyun Zhu Jing Yao Hong-Bing Shu Bo Zhong | 2016 | Cell Research2016，26，12： | 12 |
| 8 | Influence of Al-Ti-B addition on the microstructure and mechanical properties of A356 alloys显示文摘The mechanical properties (σb,σ0.2,and δ) and fracture behavior of tensile specimens of the refined A356 alloys were investigated as a function of the addition level of Al-Ti-B master alloy under both as-cast and T6 heat-treated conditions. The results show that as the addition level of Al-5Ti-1B master alloy increases from 0.1 wt.% to 5.0 wt.%,the mechanical properties of refined A356 alloys improve steadily and then decrease slightly under both as-cast and T6 heat-treated conditions. Also,they display excellent mechanical properties with σb = 231.30-258.30 MPa,σ0.2 =134.00-155.50 MPa,and δ = 8.5%-11.75% at T6 heat-treated state. The excellent mechanical properties of refined A356 alloys are ascribed to the formation of α-Al equiaxed dendrites,the improvement of eutectic structure from needle/plate-like to short-lathy/block-shaped,and the Mg2Si aging precipitation phase after T6 heat treatment. The fracture surface examined by SEM exhibits a mixed fracture mode of refined A356 alloys at as-cast state,while it reveals a ductile fracture mode after T6 heat treatment. | Zhu Man Yang Gencang Yao Lijuan Cheng Suling Zhou Yaohe | 2009 | Rare Metals2009，28，2： | 11 |
| 9 | Temperature distribution and dynamic control of secondary cooling in slab continuous casting显示文摘To predict and optimize the temperature distribution of slab continuous casting in steady operational state, a three-dimensional model (named 'offline model') based on the heat transfer and solidification theories was developed. Both heat transfer and flux distribution characteristics of the nozzle sprays on the slab were considered, and the complicated boundary condi-tions, such as spray cooling, natural convection, thermal radiation as well as contact cooling of individual rolls were involved in the model. By using the calibrated caster dependent model factors, the calculated temperature and shell thickness accorded well with the measured. Furthermore, a dynamic secondary water cooling control system was also developed on the basis of a two-dimensional transient heat transfer model (named 'online model') and incremental PID control algorithm to reduce slab surface temperature fluctuation in unsteady state. Compared with the traditional spray table control method, the present online model and dynamic PID con-trol demonstrate a higher capability and flexibility to adjust cooling water flowrate and reduce slab surface temperature fluctuation when the casting speed is changed. | Liang-hang Guo Yong Tian Man Yao Hou-fa Shen | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，6： | 9 |
| 10 | Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine显示文摘The present study utilized a nitroglycerin-induced rat model of migraine to detect the effects of rizatriptan benzoate on proenkephalin and substance P gene expression in the midbrain using real-time quantitative polymerase chain reaction and investigate whether rizatriptan benzoate can regulate the endogenous pain modulatory system. The results showed that rizatriptan benzoate significantly reduced expression of the mRNAs for proenkephalin and substance P. Rizatriptan benzoate may inhibit the analgesic effect of the endogenous pain modulatory system. | Gang Yao Yuhong Man Xiangdan Luo Tingmin Yu Lin Ji | 2012 | Neural Regeneration Research2012，7，2： | 7 |
| 11 | Ultrasound screening of fetal structural abnormalities by standard ultrasound views during the first trimester显示文摘In China,ultrasound screening of fetal abnormalities is usually performed at 20 to 24 weeks of gestation.Recent data suggest that many fetal abnormalities can be detected as early as 11 to 14 weeks of gestation.1 In this study,we applied standard ultrasound views to screen for fetal structural abnormalities during the first trimester and investigated the effectiveness of the standard ultrasound views in the detection of fetal abnormalities. | WANG Li WU Qing-qing CHEN Yan MA Yu-qing YAO Ling LI Man | 2013 | Chinese Medical Journal2013，，5： | 7 |
| 12 | Effects of Toutongning capsule on enkephalin expression in a rat migraine headache model显示文摘Toutongning capsule is used for the treatment of migraine headaches,and has yielded therapeutically beneficial effects.However,whether Toutongning capsule exerts its effects via endogenous opioid peptides remains poorly understood.This study investigated the effects of Toutongning capsule on enkephalin expression in the midbrain of rats with nitroglycerin-induced migraine headache at the mRNA and protein levels.Results confirmed that proenkephalin mRNA levels were significantly upregulated following treatment with Toutongning capsule.The numbers of methionine-enkephalin and leucine-enkephalin-positive cells were significantly greater in the migraine headache rats following treatment with Toutongning capsule compared with the model group.Taken together,these results show that Toutongning capsule exerts potentially beneficial effects by promoting enkephalin expression in nitroglycerin-induced migraine headache rats. | Gang Yao Yuhong Man Jingjing Qi Tingmin Yu Dihui Ma | 2011 | Neural Regeneration Research2011，6，9： | 7 |
| 13 | miR-145 improves metabolic inflammatory disease through multiple pathways显示文摘Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes,yet the mechanisms are not completely understood.Here,we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control.miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics.LPS repressed the transcription of miR-143/145 cluster and decreased miR-145 levels.Attenuation of miR-145 activity by anti-miR-145 triggered liver inflammation and increased serum chemokines in C57BL/6 J mice.Conversely,lentivirus-mediated miR-145 overexpression inhibited macrophage infiltration,reduced body weight,and improved glucose metabolism in db/db mice.And miR-145 overexpression markedly reduced plaque size in the aorta in ApoE−/−mice.Both OPG and KLF5 were targets of miR-145.miR-145 repressed cell proliferation and induced apoptosis partially by targeting OPG and KLF5.miR-145 also suppressed NF-κB activation by targeting OPG and KLF5.Our findings provide an association of the environment with the progress of metabolic disorders.Increasing miR-145 may be a new potential therapeutic strategy in preventing and treating metabolic diseases such as type 2 diabetes and atherosclerosis. | Min He Nan Wu Man Cheong Leong Weiwei Zhang Zi Ye Rumei Li Jinyang Huang Zhaoyun Zhang Lianxi Li Xiao Yao Wenbai Zhou Naijia Liu Zhihong Yang Xuehong Dong Yintao Li Lili Chen Qin Li Xuanchun Wang Jie Wen Xiaolong Zhao Bin Lu Yehong Yang Qinghua Wang Renming Hu | 2020 | Journal of Molecular Cell Biology2020，12，2： | 7 |
| 14 | Spider web-like carbonized bacterial cellulose/MoSe_(2) nanocomposite with enhanced microwave attenuation performance and tunable absorption bands显示文摘It is essential to manufacture microwave absorbers with strong absorption as well as tunable absorption bands at a low filler content.However,it remains challenging for pure biomass material to reach this goal without loading other components.MoSe_(2),as a transition metal chalcogenide with semiconductor properties,has emerged as a potential microwave absorber filler.Herein,bacterial cellulose(BC)-derived carbon nanofibers/MoSe_(2) nanocomposite was fabricated and phosphoric acid was used to dope phosphorus in BC,in which MoSe_(2) microspheres were dropped on the BC network like a dew-covered spider web.This unique network structure enhances conductive loss and multiple reflections of the incident wave.The collocation of BC and MoSe_(2) is helpful to impedance match and introduces interfacial/dipolar polarization loss;moreover,the P-doping of BC helps to tune the absorption bands.Overall,the optimal reflection loss of undoped one reaches−53.33 dB with only 20 wt.%filler content,whose main absorption peaks focus on X-band.Interestingly,after the P-doping of BC,the main absorption peaks move to Ku-band and the optimal reflection loss gets stronger(−66.84 dB)with the same filler loading.Strong absorption and tunable absorption bands can be realized,and thus wide frequency range is covered.This work is expected to enlighten future exploration of biomass carbon materials on high-performance microwave absorption materials. | Zhengjian Xu Man He Yuming Zhou Shuangxi Nie Yongjuan Wang Yao Huo Yifan Kang Ruili Wang Ran Xu Hao Peng Xi Chen | 2021 | Nano Research2021，14，3： | 6 |
| 15 | The anatomy of the skin of the Chinese tree shrew is very similar to that of human skin显示文摘DEAR EDITOR,The Chinese tree shrew(Tupaia belangeri chinensis)is a small mammal closely related to primates.It has a small body size,low maintenance cost,and a relatively short reproductive cycle,all of which has made it the ideal model for the study of a variety of human diseases.In this study,we compared the anatomy of the skin of the Chinese tree shrew with that of the rhesus macaque,mouse and human,with the intention of providing the basic data required for the creation of skin disease models using this animal.Paraffin sections,hematoxylin-eosin(H&E)staining,masson staining and immunohistochemical techniques were used to examine the dorsal skin structure of the Chinese tree shrew.The epidermis was shown to be composed of 1–2 layers of cells.There were hair follicles,sebaceous glands and sweat glands in the dermis and the subcutaneous tissue,with apocrine glands being more common than eccrine glands.Both Keratin5(KRT5)and Keratin10(KRT10)were expressed in the skin of the Chinese tree shrew,with a localization in the cytoplasm.Overall,the skin morphology and histology of the Chinese tree shrew was basically the same as that of the human.We propose that the Chinese tree shrew has a strong potential to be used for creating animal models to help elucidate the molecular mechanisms underlying a variety of skin diseases. | Jing Zhang Rong-Can Luo Xiao-Yong Man Long-Bao Lv Yong-Gang Yao Min Zheng | 2020 | Zoological Research2020，41，2： | 5 |
| 16 | Comparable effects of Jiedu Granule, a compound Chinese herbal medicine, and sorafenib for advanced hepatocellular carcinoma: A prospective multicenter cohort study显示文摘Objective:Sorafenib has been extensively used for the treatment of advanced hepatocellular carcinoma(HCC),and Chinese herbal medicine has also been used to manage advanced HCC.The present work evaluates the effectiveness and safety of Jiedu(JD)Granule,a compound of traditional Chinese herbal medicine,side-by-side with sorafenib for the treatment of advance HCC.Methods:Patients with advanced HCC receiving treatment with JD Granule or sorafenib were enrolled from December 2014 to March 2018.The primary endpoint was overall survival(OS).The secondary endpoints were progression-free survival(PFS)and safety.Propensity score matching(PSM)analysis was used to control for possible selection bias from the study group allocation process.Results:Of the 325 patients included,161 received JD Granule and 164 received sorafenib.No significant differences were found in OS or PFS among patients receiving JD Granule compared to sorafenib(P>0.05).Median OS of the two study groups was 6.83 months(95%confidence interval[CI]:5.83–9.47)in the group receiving JD Granule and 8 months(95%CI:6.67–9.80)in the group receiving sorafenib,with half-,1-and 2-year survival rates of 53.6%,31.2%and 13.2%vs 60.1%,35.5%and 14.2%,respectively.Even after PSM,the median survival time did not differ between the JD Granule group(9.03 months;95%CI:6.37–14.2)and the sorafenib group(7.93 months;95%CI:6.5–9.97),with comparable half-,1-and 2-year survival rates.The most common adverse events(AEs)were diarrhea(13.7%)and fatigue(5.6%)in the JD Granule group,and hand-foot skin reaction(46.3%)and diarrhea(36.6%)in the sorafenib group.The JD Granule was more cost-effective than sorafenib treatment for advanced HCC.Conclusion:Compared to sorafenib,JD Granule was more cost-effective and caused fewer AEs for the treatment of Chinese patients with advanced HCC. | He-tong Zhao Yong-bin Meng Xiao-feng Zhai Bin-bin Cheng Sha-sha Yu Man Yao Hui-xia Yin Xu-ying Wan Yun-ke Yang Hui Liu Feng Shen Chang-quan Ling | 2020 | Journal of Integrative Medicine2020，18，4： | 5 |
| 17 | Effectiveness and safety of Chinese herbal medicines for hepatitis B virus-related acute-on-chronic liver failure:study protocol for a multicenter randomized controlled trial显示文摘OBJECTIVE:To conduct a multicenter randomized controlled trial of the efficacy of standardized Chinese herbal medicines(CHMs)against acuteon-chronic liver failure(ACLF)and provide reproducible and high-level evidence for clinical practice.METHODS:This is a prospective,multicenter,centrally randomized controlled trial.Patients diagnosed with hepatitis B virus-related ACLF(n=510)will be allocated to the standard medical therapy or CHM group at a 1∶1 ratio.Two CHMs will be used on the basis of the traditional Chinese medicine syndrome:Liangxue Jiedu granules for excess syndromes and Yiqi Jiedu granules for deficiency syndromes.The primary outcome is transplant-free survival at week 12.The secondary outcomes are(a)transplant-free survival at week 24,(b)liver function as assessed using the model for end-stage liver disease score at week 12,(c)liver function as assessed using the Child-Pugh score at week 12,and(d)the incidence of complications at week 12.DISCUSSION:The effectiveness and safety of CHM formulations will be assessed following treatment for ACLF.TRIAL REGISTRATION:The trial was registered at Clinical Trials.gov(NCT03577938)on June 24,2018. | Zhang Ning Zhou Chao Wang Lifu He Tingting Wang Yao Wang Yan Bai Yunfeng Li Jun Xiao Xiaohe Gong Man | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 5 |
| 18 | Comprehensive model for a slag bath in electroslag remelting process with a current-conductive mould显示文摘A mathematical model was developed to describe the interaction of multiple physical fields in a slag bath during electroslag remelting (ESR) process with a current-conductive mould. The distributions of current density, magnetic induction intensity, electromagnetic force, Joule heating, fluid flow and temperature were simulated. The model was verified by temperature measurements during remelting 12CrMoVG steel with a slag of 50wt%-70wt% CaF2, 20wt%-30wt% CaO, 10wt%-20wt% Al2O3, and ≤10wt% SiO2 in a 600 mm diameter current-conductive mould. There is a good agreement between the calculated temperature results and the measured data in the slag bath. The calculated results show that the maximum values of current density, electromagnetic force and Joule heating are in the region between the corner electrodes and the conductivity element. The characteristics of current density distribution, magnetic induction intensity, electromag-netic force, Joule heating, velocity patterns and temperature profiles in the slag bath during ESR process with current-conductive mould were analyzed. | Fu-bin Liu Xi-min Zang Zhou-hua Jiang Xin Geng Man Yao | 2012 | International Journal of Minerals,Metallurgy and Materials2012，19，4： | 5 |
| 19 | 4epatic cytochrome P450s play a major role in monocrotaline-induced renal toxicity in mice显示文摘 | Jun YAO Cheng-gang LI Li-kun GONG Chen-chen FENG Chun-zhu LI Man GAO Yang LUAN Xin-ming Qi Jin REN | 2014 | Acta Pharmacologica Sinica2014，35，2： | 4 |
| 20 | Association between Fine Particulate Air Pollution and Outpatient Visits for Eczema in Beijing, China: A Time-series Analysis显示文摘Eczema is a very common inflammatory skin disease characterized by patches of erythematous,itchy, cracked, and scaly skin.According to the 2010 Global Burden of Disease Study, the global prevalence of eczema is 3.33% and the leading cause of skin condition-based disability-adjusted life years is eczema[1].The large health burden brought about by eczema suggests high direct medical costs and health care utilization[2].Thus, eczema prevention is of great importance in efforts to eliminate the public health burden of the disease. | WANG Xiao Wen TIAN Yao Hua CAO Ya Ying SONG Jing LI Man WU Yao WANG Meng Ying HUANG Zhe HU Yong Hua | 2019 | Biomedical and Environmental Sciences2019，32，8： | 4 |
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