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| 1 | Midbrain enkephalin expression in a rat migraine model following intragastric scorpion powder administration显示文摘Scorpion has strong analgesic effects,but its analgesic mechanisms remain unclear.This study investigated the effects of scorpion powder on enkephalin expression in the midbrain of rats with nitroglycerin-induced migraine at mRNA and protein levels.Results confirmed that migraine rat abnormal behavior was significantly improved,and proenkephalin mRNA expression was significantly increased following treatment with scorpion.The number of methionine-enkephalin-positive cells in the migraine rats following treatment with scorpion was significantly increased,but no significant difference in the number of leucine-enkephalin-positive cells was detectable compared with migraine and normal rats.Taken together,these results show that scorpion exerts potentially beneficial effects by promoting enkephalin expression in nitroglycerin-induced migraine rats. | Gang Yao Xiangdan Luo Dihui Ma Tingmin Yu | 2011 | Neural Regeneration Research2011，6，12： | 9 |
| 2 | Hierarchically nanostructured porous TiO_2(B) with superior photocatalytic CO_2 reduction activity显示文摘Hierarchically nanostructured, porous TiO_2(B) microspheres were synthesized by a microwave-assisted solvothermal method combined with subsequent heat treatment in air. The materials were carefully characterized by scanning and transmission electron microscopy, X-ray diffraction, CO_2 adsorption, and a range of spectroscopies, including Raman, infrared, X-ray photoelectron and UV-Vis spectroscopy. The hierarchical TiO_2(B) particles are constructed by ultrathin nanosheets and possess large specific surface area, which provided many active sites for CO_2 adsorption as well as CO_2 conversion. The TiO_2(B)nanostructures exhibited marked photocatalytic activity for CO_2 reduction to methane and methanol. Anatase TiO_2 and P25 were used as the reference photocatalysts. Transient photocurrent measurement also proved the higher photoactivity of TiO_2(B) than that of anatase TiO_2. In-situ infrared spectrum was measured to identify the intermediates and deduce the conversion process of CO_2 under illumination over TiO_2(B) photocatalyst. | Tingmin Di Jinfeng Zhang Bei Cheng Jiaguo Yu Jingsan Xu | 2018 | Science China Chemistry2018，61，3： | 8 |
| 3 | Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine显示文摘The present study utilized a nitroglycerin-induced rat model of migraine to detect the effects of rizatriptan benzoate on proenkephalin and substance P gene expression in the midbrain using real-time quantitative polymerase chain reaction and investigate whether rizatriptan benzoate can regulate the endogenous pain modulatory system. The results showed that rizatriptan benzoate significantly reduced expression of the mRNAs for proenkephalin and substance P. Rizatriptan benzoate may inhibit the analgesic effect of the endogenous pain modulatory system. | Gang Yao Yuhong Man Xiangdan Luo Tingmin Yu Lin Ji | 2012 | Neural Regeneration Research2012，7，2： | 7 |
| 4 | Effects of Toutongning capsule on enkephalin expression in a rat migraine headache model显示文摘Toutongning capsule is used for the treatment of migraine headaches,and has yielded therapeutically beneficial effects.However,whether Toutongning capsule exerts its effects via endogenous opioid peptides remains poorly understood.This study investigated the effects of Toutongning capsule on enkephalin expression in the midbrain of rats with nitroglycerin-induced migraine headache at the mRNA and protein levels.Results confirmed that proenkephalin mRNA levels were significantly upregulated following treatment with Toutongning capsule.The numbers of methionine-enkephalin and leucine-enkephalin-positive cells were significantly greater in the migraine headache rats following treatment with Toutongning capsule compared with the model group.Taken together,these results show that Toutongning capsule exerts potentially beneficial effects by promoting enkephalin expression in nitroglycerin-induced migraine headache rats. | Gang Yao Yuhong Man Jingjing Qi Tingmin Yu Dihui Ma | 2011 | Neural Regeneration Research2011，6，9： | 7 |
| 5 | Magnesium effects on behavior and substance P mRNA expression in the midbrain of a rat migraine model显示文摘BACKGROUND:Substance P participates in pain transmission and modulation,suggesting a close association with migraine headaches.The clinical application of magnesium has been effective in treating migraines,and the action mechanisms underlying migraines correlate with substance P expression. OBJECTIVE:To analyze different magnesium doses on behavior and substance P mRNA expression in the midbrain of a rat migraine model,and to determine the action pathway of migraine treatment using magnesium. DESIGN,TIME AND SETTING:A completely randomized,controlled,animal experiment was performed at the Experimental Animal Center and Central Laboratory in the Second Hospital of Jilin University between 2007 and 2008. MATERIALS:Magnesium sulfate(25%) was supplied by Tianjin Pharmaceutical Jiaozuo,China. Nitroglycerin was provided by Shanxi Kangbao Biological,China.Substance P primer sequence was synthesized by TaKaRa Biotechnology(Dalian),China. METHODS:A total of 36 healthy,adult,Wistar rats were randomly assigned to 6 groups:control, migraine,low- and high-dose magnesium sulfate treated,and low- and high-dose magnesium sulfate control,with 6 rats in each group.Migraines were induced by subcutaneous injection of 10 mg/kg nitroglycerin in the migraine and low- and high-dose magnesium sulfate treated groups, and 2 mL/kg physiological saline was administered to rats in the control and low- and high-dose of magnesium sulfate control groups.Five minutes following administration,rats in low-dose groups were intraperitoneally injected with 100 mg/kg magnesium sulfate,while those in high-dose groups were injected with 300 mg/kg magnesium sulfate.No interventions were administered to the control and migraine groups. MAIN OUTCOME MEASURES:At 2 hours after nitroglycerin injection,substance P mRNA expression in the rat midbrain was measured by real-time quantitative polymerase chain reaction.At 60-90 minutes after nitroglycerin injection,behavioral changes of pain were analyzed in the experimental rats. RESULTS:The migraine group exhibited significantly lower levels of substance P mRNA expression compared with the control group(P<0.05).Following magnesium sulfate injection,substance P mRNA expression increased,compared with the migraine and control groups(P<0.05).In the low-and high-dose magnesium sulfate treated groups,pain behavior was remarkably ameliorated, compared with the migraine group(P<0.05),particularly with the high-dose injection(P<0.05). CONCLUSION:Magnesium relieved pain behaviors in a rat migraine model in a dose-dependent manner,and the therapeutic effect was achieved in conjunction with increased substance P expression in the midbrain. | Tingmin Yu Gang Yao Liping Zhang | 2009 | Neural Regeneration Research2009，4，11： | 6 |
| 6 | Therapeutic effects and safety of olcegepant and telcagepant for migraine A meta-analysis显示文摘OBJECTIVE: To evaluate the therapeutic effects and adverse reactions of olcegepant and telcagepant for the treatment of migraine. DATA RETRIEVAL: We identified studies using Medline (1966-01/2012-06), PubMed (1966-01/2012-06), Scopus (1980-01/2012-06), Cochrane Central Register of Controlled Trials (1980-01/2012-06) and China National Knowledge Infrastructure (1980-01/2012-06). SELECTION CRITERIA: The included studies were double-blind, randomized and placebo-controlled trials of olcegepant or telcagepant for the treatment of single acute migraine in patients with or without aura. Adverse reaction data were also included. Two independent investigators performed quality evaluation and data extraction using Jadad scoring. Meta-analyses were undertaken using RevMan 5.0.25 software. MAIN OUTCOME MEASURES: Pain relief rate, pain-free rate, and incidence of adverse reactions were measured in patients 2 and 24 hours after injection of olcegepant and oral telcagepant. RESULTS: Six randomized, controlled trials were included. Meta-analysis demonstrated that compared with placebo, the pain relief rate (odds ratio, OR = 5.21, 95% confidence interval, CI: 1.91-14.2, P < 0.01) and pain-free rate (OR = 31.11, 95% CI: 3.80-254.98, P < 0.01) significantly increased 2 hours after 2.5 mg/d olcegepant treatment. Pain relief rate and pain-free rate 2 and 24 hours after treatment with telcagepant 150 mg/d and 300 mg/d were superior to placebo (P < 0.01). Moreover, the remission rate of unrelenting headache was higher after 24 hours of 300 mg/d telcagepant treatment compared with 150 mg/d (OR = 0.78, 95% CI: 0.62-0.97, P < 0.05). The incidence of adverse reactions with olcegepant was not significantly greater than placebo (P = 0.28), but within 48 hours of administration of telcagepant 300 mg/d, the incidence of adverse reactions was higher than placebo (OR = 1.21, 95% CI: 1.04-1.42, P < 0.01). Few studies have compared the therapeutic effects of olcegepant and telcagepant. CONCLUSION: The calcitonin-gene-related peptide receptor antagonists olcegepant and telcagepant have shown good therapeutic effects in the treatment of migraine. Moreover, the incidence of adverse reactions compares favorably with placebo, although liver transaminases may become elevated after long-term use. | Gang Yao Tingmin Yu Ximei Han Xijing Mao Bo Li | 2013 | Neural Regeneration Research2013，8，10： | 5 |
| 7 | CdS nanosheets decorated with Ni@graphene core-shell cocatalyst for superior photocatalytic H_(2) production显示文摘A novel cocatalyst,i.e.metallic nickel nanoparticles encapsulated in few-layer graphene(Ni@C),is obtained by carbonization of metal–organic frameworks(MOF)and leaching treatment of hydrochloric acid.It is selected as the cocatalyst for CdS nanosheets,forming CdS-Ni@C nanocomposites.It remarkably improves the photocatalytic activities of CdS nanosheets due to the synergistic effect of Ni nanoparticles and graphene layers.In addition,the Ni nanoparticles encapsulated by graphene layers effectively isolate Ni from the ambient,which avoids contamination and curbs corrosion.The larger work function of Ni@C and outstanding conductivity of graphene promote the electron transfer from CdS to Ni@C,suppressing the recombination of photogenerated carriers and facilitating the separation of photogenerated electronhole pairs.This strategy by adopting this novel cocatalyst provides a new solution to the improvement of the photocatalytic hydrogen production. | Tingmin Di Liuyang Zhang Bei Cheng Jiaguo Yu Jiajie Fan | 2020 | Journal of Materials Science & Technology2020，56，21： | 1 |
| 8 | A case of thalamic hemorrhage-induced diaschisis显示文摘Diaschisis refers to a disturbance (inhibition or facilitation) of function in an area remote from the site of a primary brain lesion.Previous studies have confirmed that regional cerebral blood flow and metabolism are noticeably decreased in an infarct region.Transient excessive perfusion appears in the ischemic penumbra,and diaschisis occurs in an area remote from the lesion site,showing decreased regional cerebral blood flow and metabolism.Mirror diaschisis refers to a decrease in oxygen metabolism and blood flow in the 'mirror image area' to the infarct regions in the contralateral hemisphere.In this study,a patient with right thalamic hemorrhage was affected with right arm and leg numbness.At 4 months before onset,magnetic resonance imaging of the head demonstrated lacunar infarcts in the left thalamus;therefore the right arm and leg numbness was not associated with lacunar infarcts in the left thalamus.At 8 days following onset,magnetic resonance imaging reexamination did not reveal the focus that could induce right arm and leg numbness and weakness.Thus,it is suggested in this study that the onset of this disease can be explained by mirror diaschisis.That is,right thalamic hemorrhage leads to decreased blood flow and metabolic disturbance in the contralateral thalamus,resulting in right arm and leg numbness. | Gang Yao Yuhong Man Xijing Mao Tingmin YU | 2011 | Neural Regeneration Research2011，6，23： | 0 |
| 9 | Meta-analysis of efficacy of topiramate in migraine prophylaxis显示文摘OBJECTIVE:To evaluate the treatment effects and safety of topiramate in migraine prophylaxis. DATA RETRIEVAL:We searched the Medline database,EMbase,Cochrane Library and China National Knowledge Infrastructure database for articles published between January 1995 and May 2011,using the key words'migraine','topiramate',and'prophylaxis'. SELECTION CRITERIA:We selected randomized controlled trials of migraine patients,in which the experimental group was orally administered topiramate,and the control group was given placebo. Odds ratios(ORs)and mean differences(MDs)were calculated using a fixed effects model/random effects model.Quality evaluation and data extraction were performed independently by two researchers utilizing RevMan 5.0 software. MAIN OUTCOME MEASURES:Efficacy was recorded as the responder rate(response defined as at least a 50%reduction in average monthly migraine frequency)and change in mean monthly number of migraine days.Adverse events were recorded as the number of subjects exhibiting at least one adverse event. RESULTS:Eight randomized controlled trials were found to be appropriate,and had available data. The meta-analysis results revealed that topiramate(100 or 200 mg/d)was more effective than placebo in responder rate(OR=2.97,95%confidence interval(CI):2.17-4.08,P<0.01;OR=2.35, 95%CI:1.77-3.12,P<0.01).Topiramate(100 mg/d)was more effective than placebo in terms of the change in mean monthly migraine days(MD:-1.14,95%CI:-1.69 to-0.59,P<0.01).The total incidence rate of adverse events for topiramate was higher than in the placebo group(P<0.01),but most adverse events were mild to moderate. CONCLUSION:Overall,topiramate obtained good outcomes and safety in migraine prophylaxis. | Yiyi Guo Ximei Han Tingmin Yu Gang Yao | 2012 | Neural Regeneration Research2012，7，23： | 0 |
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