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590篇 您的检索式:作者名="YAMAMOTO O"
    题名 作者 年代 出处 被引量
1Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy显示文摘IgG 的 Fc 区域的 Glycosylation 在安全和治疗学的抗体的临床的功效上有深刻影响。当复杂类型的 oligosaccharide 纳入了 Fc 的 Asn297 的 biantennary 为抗体受动器功能是必要的时,海藻糖和外部手臂的糖属于核心 heptasaccharide 产生结构的异质(glycoforms ) 展出唯一的生物活动。因此,有效、量的 glycan 分析技术为治疗学的抗体的发展和质量控制是日益重要的,并且 Fc 的 glycan 侧面作为批评优秀属性被认出。在过去的十年,我们 IgG-Fc 的结构 / 功能上的 glycosylation 的影响的理解通过 X 光检查结晶、原子的磁性的回声研究很快成长了,它为新奇抗体治疗学的设计提供可能性。而且,用基于 endoglycosidase 的 glycosynthases 的 chemoenzymatic glycoengineering 途径可以作为下一代的治疗学的抗体与理想的功能便于同类的 IgG glycoforms 的发展。因此, Fc glycans 是在精确药的时代的治疗学的 IgG 抗体的安全,功能,和功效的改进的肥沃的地面。Yusuke Mimura Toshihiko Katoh Radka Saldova Roisin O'Flaherty Tomonori Izumi Yuka Mimura-Kimura Toshiaki Utsunomiya Yoichi Mizukami Kenji Yamamoto Tsuneo Matsumoto Pauline M. Rudd 2018Protein & Cell2018,9,1:2
2Denitrification with Methane as External Carbon Source显示文摘MODIN O FUKUSHI K YAMAMOTO K 2007Water Res2007,41,12:1
3Bisphenol A in hazardous waste landfill leachates 显示文摘Yamamoto T Yasuhara A Shiraishi H Yamamoto A Yasuhara H Shiraishi H Nakasugi O 2001Chemosphere2001,42,:1
4J Power Sources显示文摘Matsuoka O Hiwara A Omi T Toriida M Hayashi T Tanaka C Saito Y Ishida T Tan H Ono S S Yamamoto S 2002108:1282002,108,:1
5Master-equation model of a single-quantum-dot microsphere laser显示文摘Benson O Yamamoto Y 1999Phys Rev A1999,59,6:1
6Anharmonicity and the equation of state for gold显示文摘Anderson O L Isaak D G Yamamoto S 1989J Appl Phys1989,65,:1
7Electron microscopic study of Langerhans cell histiocytosis 显示文摘Kobayashi M Yamamoto O Suenaga Y 2000J Dermatol2000,27,7:1
8Analgesic effects of nonsteroidal antiinflammatory drugs, acetaminophen, and morphine in a mouse model of bone cancer pain 显示文摘Saito O Aoe T Yamamoto T 2005J Anesth2005,19,3:1
9Surfactant protein gene expressions for detection of lung carcinoma cells in peripheral blood显示文摘Yamamoto O Takahashi H Hirasawa M 2005Respir Med2005,99,9:1
10Improving withstand vol- tage by roughening the surface of an insulating spacer used in vacuum显示文摘Yamamoto O Takuma T Fukuda M 2003IEEE Transactions on Dielectrics and Electrical Insulation2003,10,4:1
11FIGO Staging system for endometrial cancer: added benefits of MR imaging 显示文摘Beddy P O'Neill AC Yamamoto AK 2012Radiograph- ics2012,32,1:1
12The DSCI channel, encoded by the smi60E locus, contributes to odor-guided behavior in Drosophila mel(mogaster显示文摘KULKARNI N H YAMAMOTO A H ROBINSON K O et ol 2002Genet- ics2002,161,4:1
13Identification and Analysis of Cytochrome P450IID6 Antigenic Sites Recognized by Anti-liver-kidney Microsome Type-1 Antibodies(LKMI)显示文摘Yamamoto AM Cresteil D Boniface O 1993European Journal of Immunology1993,23,5:1
14Purification and properties of L-galactono-1,4-lactone dehydrogenase,a key enzyme for ascorbic acid biosynthesis,from sweet potato root显示文摘(O)ba K Ishikawa S Nishikawa M Mizuno H Yamamoto T 0,,:1
15Early retropancreatic dissection during pancreaticoduodenectomy 显示文摘Varty PP Yamamoto H Farges O 2005Am J Surg2005,189,4:1
16Difference in the reactivity of acetaldehyde intermediates in the dehydrogenation of ethanol over supported Pd catalysts显示文摘ISAWA N YAMAMOTO O TAMURA R 1999Catal Lett1999,62,:1
17Modelling of a transmission tower for lightning-surge analysis 显示文摘Hara T Yamamoto O 1996IEE Proceedings Generation Transmission and Distribution1996,143,3:1
18Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia显示文摘Jonsson KB Zahradnik R Larsson T White KE Sugimoto T Imanishi Y Yamamoto T Hampson G Koshiyama H Ljunggren O Oba K Yang IM Miyauchi A Econs MJ Lavigne J Juppner H 0,,:1
19查看详情显示文摘Pashkin Y A Yamamoto T Astafiev O Nakamara Y Averin D V Tsai J S 0,,:1
20Preparation ofcarbon material with SiC-concentration gradient by silicon im- pregnation and its oxidation behaviour显示文摘Yamamoto O Imai K Sasamoto T 1993Journal of the Eu- ropean Ceramic Society1993,12,6:1
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