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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Malate transported from chloroplast to mitochondrion triggers production of ROS and PCD in Arabidopsis thaliana显示文摘规划房间死亡(PCD ) 是一个基本生物过程。在马赛克死亡 1 的缺乏(MOD1 ) ,质体局部性的 enoyl-ACP reductase,导致反应的氧种类(ROS ) 和 PCD 的累积,它能被 mitochondrial 建筑群压制我变化,从叶绿体显示一个信号到线粒体。然而,这个信号尚待被阐明。在这研究,通过克隆并且分析一系列 mod1 suppressors,我们揭示调整 mitochondrial ROS 和扳机 PCD 的产生的一条全面细胞器通讯小径。我们证明在 PLASTIDIAL NAD 依赖的 MALATE 脱氢酶(plNAD-MDH ) 的变化, chloroplastic DICARBOXYLATE TRANSPORTER 1 (DiT1 ) 并且(mMDH1 ) MITOCHONDRIAL MALATE 脱氢酶 1 能各在 mod1 救 ROS 累积和 PCD 显型,经由 malate 梭从叶绿体表明直接通讯到线粒体。进一步的研究证明这些元素在不同光周期条件下面在氧化还原作用动态平衡和植物生长起关键作用。而且,我们表明 ROS 水平和 PCD 显著地在房间,它能是戏剧性地稀释了由的对待 malate 的 HeLa 被增加人的基因 MDH2 击倒, Arabidopsis mMDH1 的 ortholog。这些结果揭开在植物和动物系统的一条保存导致 malate 的 PCD 小径,革命化我们在细胞器之间的通讯的理解。 | Yannan Zhao Lilan Luo Jiesi Xu Peiyong Xin Hongyan Guo Jian Wu Lin Bai Guodong Wang Jinfang Chu Jianru Zuo Hong Yu Xun Huang Jiayang Li | 2018 | Cell Research2018，28，4： | 24 |
| 3 | Intercropping with Solanum nigrum and Solanum photeinocarpum from Two Ecoclimatic Regions Promotes Growth and Reduces Cadmium Uptake of Eggplant Seedlings显示文摘Soil contamination by heavy metals is a serious environmental problem worldwide, and reduction of heavy metal accumulation in vegetables grown on contaminated land is a matter of urgency. A pot experiment was conducted to study the effects of intercropping with the Cd hyperaccumulators Solanum nigrum and Solanum photeinocarpum from two ecoclimatic regions, Ya'an and Chengdu,Sichuan Province, China, on the growth and cadmium(Cd) uptake of eggplant(Solanum melongena L.). The biomass, photosynthetic pigment contents, and activities of antioxidant enzymes of eggplant were enhanced by intercropping. The biomass of eggplant was the highest after intercropping with S. photeinocarpum from Ya'an, but did not differ significantly from that after intercropping with S. nigrum from Chengdu. The shoot Cd content of eggplant was significantly reduced by intercropping with the hyperaccumulators,which ranked as follows: S. nigrum from Chengdu > S. nigrum from Ya'an > S. photeinocarpum from Chengdu > S. photeinocarpum from Ya'an, with the decreases being 19.60%, 14.36%, 9.66%, and 6.42%, respectively, as compared with the control. The lowest shoot Cd content and translocation factor of eggplant were attained after intercropping with S. nigrum from Chengdu. Therefore, it was feasible to intercrop eggplant with S. nigrum and S. photeinocarpum on Cd-contaminated soil. | TANG Yi HE Juan YU Xuena XIE Yongdong LIN Lijin SUN Guochao LI Huanxiu LIAO Mingan LIANG Dong XIA Hui WANG Xun ZHANG Jing LIU Zejing TU Lihua LIU Li | 2017 | Pedosphere2017，27，3： | 17 |
| 4 | N-methyl-D-aspartic acid receptor 1 (NMDAR1) aggravates secondary inflammatory damage induced by hemin-NLRP3 pathway after intracerebral hemorrhage显示文摘 | Xun Weng Yan Tan Xiang Chu Xiao-Feng Wu Rui Liu Yue Tian Lin Li Feng Guo Qing Ouyang Lei Li | 2015 | Chinese Journal of Traumatology2015，18，5： | 12 |
| 5 | Comparison between different reconstruction routes in esophageal squamous cell carcinoma显示文摘AIM:To compare postoperative complications and prognosis of esophageal squamous cell carcinoma patients treated with different routes of reconstruction. METHODS:After obtaining approval from the Medical Ethics Committee of the Sun Yat-Sen University Cancer Center, we retrospectively reviewed data from 306 consecutive patients with histologically diagnosed esophageal squamous cell carcinoma who were treated between 2001 and 2011. All patients underwent radical McKeown-type esophagectomy with at least two-field lymphadenectomy. Regular follow-up was performed in our outpatient department. Postoperative complica-tions and long-term survival were analyzed by treatment modality, baseline patient characteristics, and operative procedure. Data from patients treated via the retrosternal and posterior mediastinal routes were compared. RESULTS:The posterior mediastinal and retrosternal reconstruction routes were employed in 120 and 186 patients, respectively. Pulmonary complications were the most common complications experienced during the postoperative period (46.1% of all patients; 141/306). Compared to the retrosternal route, the posterior mediastinal reconstruction route was associated with a lower incidence of anastomotic stricture (15.8% vs 27.4%, P = 0.018) and less surgical bleeding (242.8 ± 114.2 mL vs 308.2 ± 168.4 mL, P < 0.001). The median survival time was 26.8 mo (range:1.6-116.1 mo). Upon uni/multivariate analysis, a lower preoperative albumin level (P = 0.009) and a more advanced pathological stage (pT; P = 0.006; pN; P < 0.001) were identified as independent factors predicting poor prognosis. The reconstruction route did not influence prognosis (P = 0.477). CONCLUSION:The posterior mediastinal route of reconstruction reduces incidence of postoperative complications but does not affect survival. This route is recommended for resectable esophageal squamous cell carcinoma. | Yu-Zhen Zheng Shu-Qin Dai Wei Li Xun Cao Xin Wang Jian-Hua Fu Peng Lin Lan-Jun Zhang Bin Lu Jun-Ye Wang | 2012 | World Journal of Gastroenterology2012，18，39： | 10 |
| 6 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 7 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 8 | Renal-targeting triptolide-glucosamine conjugate exhibits lower toxicity and superior efficacy in attenuation of ischemia/reperfusion renal injury in rats显示文摘我们以前报导了新奇 triptolide (TP )-glucosamine 结合(TPG ) 那明确地在肾积累了并且保护了肾的功能免受尖锐 ischemia/reperfusion (I/R ) 的伤害在老鼠的损害。在这研究,我们进一步检验了位于 TPG.Methods 的 renoprotective 行动下面的分子的机制:TPG 肾指向被测量 TP 或 TPG 的房间举起在一根人的近似肾的管状的上皮的房间线(HK-2 ) 调查。房间周期分发和 HK-2 房间的 apoptosis 率上的 TP 或 TPG 的效果被估计,并且 caspase-3 和 caspase-9 的活动也被测量。SD 老鼠被暂时夹钳两根肾的小花梗受到双边的肾的局部缺血。老鼠是管理 TP (4.17 μ mol· kg −1·d−1, iv ) 或 TPG (4.17 μ mol· kg −1·d−1, iv ) 为在肾的外科前的 3 d。肾从外科在恢复的 24 h 以后被收获。在肾的氧化应力, proinflammatory cytokines,趋化性的 cytokines 和细胞内部的粘附分子的层次是 examined.Results:在 HK-2 房间的 TPG 的举起比在测试的集中的 TP 的高是 2-3 时间。而且,指向近似小管的 TPG 通过和 megalin 受体的相互作用被调停。TP (40-160 nmol/L ) concentration-dependently 在 HK-2 房间增加了 G 2/M 拘捕, apoptosis 和 caspase-3/caspase-9 活动,而 TPG 的一样的集中没看那些特征什么时候与控制相比组织。在 I/R-treated 老鼠, TPG 管理引起了 proinflammatory cytokines 的更柔韧的下面规定(TNF-α, IL-6, IL-1, TGF-β) 并且在肾的趋化性的 cytokines (MCP-1 ) 与 TP 管理相比,建议增长的抑制和淋巴细胞的累积。并且 TPG 管理也在肾引起了更突出的抑制氧化应力和细胞内部的粘附分子的 on the levels,与 TP administration.Conclusion 相比:肾指向的 TPG 比 TP 更有效、不太有毒,在 I/R-induced 老鼠的改善肾的损害,它可以为尖锐的肾损害的处理提供一条新大街。 | Yu FU Qing LIN Tao GONG Xun SUN Zhi-rong ZHANG | 2016 | Acta Pharmacologica Sinica2016，37，11： | 9 |
| 9 | 硼作业工人配偶妊娠结局的初步研究显示文摘目的 研究硼暴露对作业工人配偶生殖健康的影响。方法 选择硼暴露组和对照组作为研究对象,进行标准问卷调查,建立相关数据库,通过χ2 检验、多元非条件Logistic回归进行分析。结果 暴露组的自然流产率和不能顺利受孕率均高于对照组。暴露组后代子女性别比低于对照组以及全国和辽宁省出生婴儿性别比。结论 硼暴露对硼作业工人配偶的妊娠结局可能有不良影响。 | 刘平 王春利 胡俊峰 Lin Xun Wendie A Robbins 吴国平 魏复盛 | 2005 | 中国公共卫生2005，21，5： | 8 |
| 10 | Analysis of the element content in poplar tree leaves by femtosecond laser-induced breakdown spectroscopy显示文摘Femtosecond laser-induced breakdown spectroscopy (fs-LIBS) is employed to analyze the element content in poplar tree leaves from four representative locations in Changchun City (Jingyue National Forest Park,JYP),Changchun University of Science and Technology (CUST),Casting Factory (CF) and Forging Factory (FF) of First Automobile Works (FAW) under identical experimental conditions.Those elements of N,P,K,Ca,Fe,Ti,Mn and Na are identified in the poplar tree leaves from the recorded spectrogram and the elemental content in the leaves is further obtained by applying free calibration method to the spectrogram.Our results show that the elements Ca and Fe in the poplar tree leaves from the CF area have the highest concentration in the four locations,which is a factor of 2.05 and 1.66 respectively to those of JYP.This experiment demon-strates that fs-LIBS can be utilized to analyze element content in a sample and find new applications in the environmental detection. | MA Shuang GAO Xun GUO KaiMin KAHSAY Medhanie LIN JingQuan | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，11： | 8 |
| 11 | Chemical vapor deposition growth of single-crystalline cesium lead halide microplatelets and heterostructures for optoelectronic applications显示文摘Organic-inorganic hybrid halide perovskites, such as CH3NH3PbI3, have emerged as an exciting class of materials for solar photovoltaic applications; however, they are currently plagued by insufficient environmental stability. To solve this issue, all-inorganic halide perovskites have been developed and shown to exhibit significantly improved stability. Here, we report a single-step chemical vapor deposition growth of cesium lead halide (CsPbX3) microcrystals. Optical microscopy studies show that the resulting perovskite crystals predominantly adopt a square-platelet morphology. Powder X-ray diffraction (PXRD) studies of the resulting crystals demonstrate a highly crystalline nature, with CsPbCl3, CsPbBr3, and CsPbI3 showing tetragonal, monoclinic, and orthorhombic phases, respectively. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) studies show that the resulting platelets exhibit well-faceted structures with lateral dimensions of the order of 10-50 μm, thickness around 1 μm, and ultra-smooth surface, suggesting the absence of obvious grain boundaries and the single-crystalline nature of the individual microplatelets. Photoluminescence (PL) images and spectroscopic studies show a uniform and intense emission consistent with the expected band edge transition. Additionally, PL images show brighter emission around the edge of the platelets, demonstrating a wave-guiding effect in high-quality crystals. With a well-defined geometry and ultra-smooth surface, the square platelet structure can function as a whispering gallery mode cavity with a quality factor up to 2,863 to support laser emission at room temperature. Finally, we demonstrate that such microplatelets can be readily grown on a variety of substrates, including silicon, graphene, and other two-dimensional materials such as molybdenum disulfide, which can readily allow the construction of heterostructure optoelectronic devices, including a graphene/perovskite/graphene vertically-stacked photodetector with photoresponsivity > 105 A/W. The extraordinary optical properties of CsPbX3 platelets, combined with their ability to be grown on diverse materials to form functional heterostructures, can lead to exciting opportunities for broad optoelectronic applications. | Yiliu Wang Xun Guan Dehui Li Hung-Chieh Cheng Xidong Duan Zhaoyang Lin Xiangfeng Duan | 2017 | Nano Research2017，10，4： | 8 |
| 12 | GENETIC ENGINEERING NEURAL STEM CELL MODIFIED BY LENTIVIRUS FOR REPAIR OF SPINAL CORD INJURY IN RATS显示文摘Objective To explore the feasibility for therapy of spinal cord injury (SCI) by genetic engineering neural stem cell (NSC) modified by lentiviral vector. Methods Following the construction of the genetic engineering NSC modified by lentivirus to secrete both neurotrophic factor-3 (NT-3) and green fluorescence protein (GFP), hemisection of spinal cord at the level of T_ 10 was performed in 56 adult Wistar rats that were randomly divided into 4 groups (n=14), namely 3 therapeutic groups and 1 control group. The therapeutic groups were dealed with NSC, genetic engineering NSC, and concentrated lentiviral supernatant which carries both GFP and NT-3, respectively. Then used fluorescence microscope to detect the transgenic expression in vitro and in vivo, migration of the grafted cells in vivo, and used the Basso, Beattie, and Bresnahan (BBB) open-field locomotor test to assess the recovery of function. Results The transplanted cells could survive for long time in vivo and migrate for long distance. The stable transgenic expression could be detected in vivo. The hindlimb function of the injured rats in 3 therapeutic groups, especially those dealed with genetic engineering NSC, improved obviously. Conclusion It is feasible to combine NSC with lentivirus for the repair of SCI. NSC modified by lentivirus to deliver NT-3, acting as a source of neurotrophic factors and function cell in vivo, has the potential to participate in spinal cord repair. | Xun Tang Pei-qiang Cai Yue-qiu Lin Martin Oudega Bas Blits Ling Xu Yun-kang Yang Tian-hua Zhou | 2006 | Chinese Medical Sciences Journal2006，21，2： | 8 |
| 13 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 14 | ntestinal absorption characteristics of imperialine: in vitro and in situ assessments显示文摘目的: Imperialine 是在在一个临床的背景被用作能止咳 / 化痰的繁体中文药 chuanbeimu (Bulbus Fritillariae Cirrhosae ) 的有效混合物。在这研究,我们基于它的物理化学的性质的评估在肠的片断调查了 imperialine 的吸收特征。 | Qing LIN Li-qin LING Ling GUO Tao GONG Xun SUN Zhi-rong ZHANG | 2015 | Acta Pharmacologica Sinica2015，36，7： | 5 |
| 15 | Multi-node CdS hetero-nanowires grown with defect-rich oxygen-doped MoS2 ultrathin nanosheets for efficient visible-light photocatalytic H2 evolution显示文摘Developing low-cost and high-efficiency photocatalysts for hydrogen production from solar water splitting is intriguing but challenging. In this study, unique one-dimensional (1D) multi-node MoS2/CdS hetero-nanowires (NWs) for efficient visible-light photocatalytic H2 evolution are synthesized via a facile hydrothermal method. Flower-like sheaths are assembled from numerous defect-rich O-incorporated {0001} MoS2 ultrathin nanosheets (NSs), and {112̅0}-facet surrounded CdS NW stems are grown preferentially along the c-axis. Interestingly, the defects in the MoS2 NSs provide additional active S atoms on the exposed edge sites, and the incorporation of O reduces the energy barrier for H2 evolution and increases the electric conductivity of the MoS2 NSs. Moreover, the recombination of photoinduced charge carriers is significantly inhibited by the heterojunction formed between the MoS2 NSs and CdS NWs. Therefore, in the absence of noble metals as co-catalysts, the 1D MoS2 NS/CdS NW hybrids exhibit an excellent H2-generation rate of 10.85 mmol·g-1·h-1 and a quantum yield of 22.0% at λ = 475 nm, which is far better than those of Pt/CdS NWs, pure MoS2 NSs, and CdS NWs as well as their physical mixtures. Our results contribute to the rational construction of highly reactive nanostructures for various catalytic applications. | Haifeng Lin Yanyan Li Haoyi Li Xun Wang | 2017 | Nano Research2017，10，4： | 5 |
| 16 | A general strategy for bimetallic Pt-based nano-branched structures as highly active and stable oxygen reduction and methanol oxidation bifunctional catalysts显示文摘The morphology and size of Pt-based bimetallic alloys are known to determine their electrocatalytic performance in reactions relevant to fuel cells.Here,we report a general approach for preparing Pt-M(M=Fe,Co and Ni)bimetallic nano-branched structure(NBs)by a simple high temperature solution-phase synthesis.As-prepared Pt-M NBs show a polycrystalline structure and are rich in steps and kinks on the surface,which promote them favorable bifunctional catalytic properties in acidic electrolytes,specifically in terms of the oxygen reduction reaction(ORR)and methanol oxidation reaction(MOR).Specially,Pt-Co NBs/C catalyst shows 6.1 and 5.3 times higher in specific activity(SA)and mass activity(MA)for ORR than state-of-the-art commercial Pt/C catalysts,respectively.Moreover,it exhibits a loss of 4.0%in SA and 14.4%in MA after 10,000 cycles of accelerated durability tests(ADTs)compared with the initial activities.In addition,we also confirmed the superior MOR activity of Pt-Co NBs/C catalyst in acidic electrolytes.For Pt-M NBs with other alloying metals,the ORR and MOR activities are both higher than commercial catalysts and are in the sequence of Pt-Co/C>Pt-Fe/C>Pt-Ni/C>commercial Pt/C(or PtRu/C).The improved activities and durability can benefit from the morphological and compositional effects.This synthesis approach may be applied to develop bifunctional catalysts with enhanced ORR and MOR properties for future fuel cells designs. | Wenjuan Lei Menggang Li Lin He Xun Meng Zijie Mu Yongsheng Yu Frances MRoss Weiwei Yang | 2020 | Nano Research2020，13，3： | 5 |
| 17 | Comparison of Two Molecular Assays For Detecting Smear Negative Pulmonary Tuberculosis显示文摘Objective To compare the performance of MTBDRplus V2 and Xpert MTB/RIF for detecting smear negative pulmonary tuberculosis(PTB). Methods Clinical PTB suspects were enrolled consecutively in Anhui Chest Hospital and Xi'an Chest Hospital from January to December in 2014. The sputum samples of smear negative PTB suspects were collected and decontaminated. The sediment was used to conduct MTBDRplus V2, Xpert MTB/RIF and drug susceptibility test(DST). All the samples with discrepant drug susceptibility result between molecular methods and phenotypic method were confirmed by DNA sequencing. Results A total of 1973 cases were enrolled in this study. The detection rates of Mycobacterium tuberculosis complex(MTBC) by MTBDRplus V2 and Xpert MTB/RIF were 27.67% and 27.98%, respectively. When setting MGIT culture result as a gold standard, the sensitivity and specificity of MTBDRplus V2 were 86.74% and 93.84%, and the sensitivity and specificity of Xpert MTB/RIF were 86.55% and 93.43%, respectively. For the detection of the resistance to rifampin, the sensitivity and specificity of MTBDRplus V2 were 94.34% and 96.62%, and the sensitivity and specificity of Xpert MTB/RIF were 88.68% and 95.96%, respectively. For the detection of the resistance to isoniazid, the sensitivity and specificity of MTBDRplus V2 were 77.38% and 98.02%, respectively. Conclusion MTBDRplus V2 and Xpert MTB/RIF can be used to detect MTBC in smear negative samples with satisfactory performance. | LI Qiang BAO Xun Di LIU Yun OU Xi Chao PANG Yu ZHAO Yan Lin | 2016 | Biomedical and Environmental Sciences2016，29，4： | 5 |
| 18 | Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Na?ve Patients with Schizophrenia显示文摘Substantial evidence supports the neurodevelopmental hypothesis of schizophrenia.Meanwhile,progressive neurodegenerative processes have also been reported,leading to the hypothesis that neurodegeneration is a characteristic component in the neuropathology of schizophrenia.However,a major challenge for the neurodegenerative hypothesis is that antipsychotic drugs used by patients have profound impact on brain structures.To clarify this potential confounding factor,we measured the cortical thickness across the whole brain using highresolution T1-weighted magnetic resonance imaging in 145 first-episode and treatment-naive patients with schizophrenia and 147 healthy controls.The results showed that,in the patient group,the frontal,temporal,parietal,and cingulate gyri displayed a significant age-related reduction of cortical thickness.In the control group,age-related cortical thickness reduction was mostly located in the frontal,temporal,and cingulate gyri,albeit to a lesser extent.Importantly,relative to healthy controls,patients exhibited a significantly smaller age-related cortical thickness in the anterior cingulate,inferior temporal,and insular gyri in the right hemisphere.These results provide evidence supporting the existence of neurodegenerative processes in schizophrenia and suggest that these processes already occur in the early stage of the illness. | Yin Lin Mingli Li Yi Zhou Wei Deng Xiaohong Ma Qiang Wang Wanjun Guo Yinfei Li Lijun Jiang Xun Hu Nanyin Zhang Tao Li | 2019 | Neuroscience Bulletin2019，35，4： | 5 |
| 19 | Uniqueness Theorems of Entire Functions with Shared-set in an Angular Domain显示文摘有关在整个复杂飞机的份额集合的全部功能的唯一理论上有大量报纸。然而,看起来,在一个尖领域的唯一理论广泛地没被调查。在这篇论文,我们在一个尖领域有关份额集合学习全部功能的唯一而不是整个复杂飞机,并且我们供应例子证明定理 1 是锋利的。 | Wei Chuan LIN Seiki MORI Hong Xun YI | 2008 | Acta Mathematica Sinica,English Series2008，24，11： | 4 |
| 20 | Characteristics of ion debris from laser-produced tin plasma and mitigation of energetic ions by ambient gas显示文摘极端紫外平版印刷术为下一代平版印刷术是很有希望的。然而,从生产激光的血浆的碎片,特别地精力充沛的离子,严重地减少极端紫外光学的一生。我们从听血浆测量了离子的特征等到有加倍频率的 Nd 的飞行方法:在 3.5O | YingBo Sun JingQuan Lin Xun Gao ZhenMing Zhao | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，3： | 4 |
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