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| 1 | Nerve Growth Factor Prevents the Apoptosis-associated Increase in Acetylcholinesterase Activity after Hydrogen Peroxide Treatment by Activating Akt显示文摘Acetylcholinesterase (疼痛) 被认为玩结果显示出的重要角色 duringapoptosis.Our 那 H_2O_2 导致了疼痛活动,功能的标记 inapoptosis,象 neuronal 一样 PC 12 房间的增加。谷胱甘肽,涉及细胞的氧化还原作用动态平衡,禁止了疼痛活动的增加,建议在这个过程的那个反应的氧种类(ROS ) 千盐湖钥匙角色。进一步的调查证明疼痛的举起在 Akt,从进 cytosol 的线粒体的细胞色素 c 的版本,和 caspase 家庭成员的激活的降级以后被观察。神经生长因素(NGF ) 什么时候是在场的,与 Akt 水平,疼痛的举起,细胞色素 c 散开,以及 apoptosis 的维护,显著地在对待 H_2O_2 的 PC12 细胞被稀释。然而, wortmannin, PI3K/Aktpathway 的一个禁止者,加速了 apoptosis 并且增加了疼痛活动。过去表示 ofconstitutively 激活 Akt,它是 NGF receptorTrkA,推迟的 mitochondrial 倒塌和疼痛活动的禁止的举起的一个下游的发信号元素。因此, NGF preventedapoptosis 和由激活 Akt 小径并且稳定线粒体的功能的疼痛活动的举起。 | Hua JIANG~(1,3) Jingya ZHANG~(1,3) Hui ZHU~(1,3) Hong LI~2 and Xuejun ZHANG~1 ~1Laboratory of Molecular Cell Biology,Institute of Biochemistry and Cell Biology,Shangha Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China ~2DEFEMA,Faculté de Medecine et de Pharmacie,University of Rouen,Rouen 76821,France ~3Graduate school of the Chinese Academy of Sciences,Beijing 100080,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，1： | 9 |
| 2 | Pathogenic effects of biofilm with chronic pseudomonas aeruginosa lung infection in rats显示文摘Objective:To establish an animal model of P.aeruginosa biofilm associated with chronic pulmonary infection and investigate the pathogenic effects of biofilm.Methods:Experiments in vitro,measuring the MICS,MBCS of levofloxacin(LFX),ceftazidime(CAZ)in PAO579 in alginate beads and planktonic PAO579.Rats were challenged with 0.1 ml of PAO579(109CFU/ml)in alginate beads or 0.1 ml of planktonic PAO579(109 CFU/ml),3,7,14 days after challenging,bacteriological,pathological features were observed.Results:The MICS,MBCS of LFX,CAZ in PAO579 in alginate beads were higher than those in planktonic PAO579 in vitro.CFU/lung in alginate beads group was significantly higher than that in planktonic bacteria group(P = 0.002,P = 0.004,P = 0.002,respectively);macroscopic lung pathology and the inflammation in alginate beads group were significantly more severe compared to those in planktonic bacteria group in vivo.Conclusion:P.aeruginosa biofilm protected bacterium from killing of antibiotics and might mediate the host immune damage in the lung tissue and made bacterium evade the host immune defense. | Ping Yan Yiqiang Chen Zhijun Song Hong Wu Jinliang Kong Xuejun Qin | 2008 | Journal of Nanjing Medical University2008，22，1： | 7 |
| 3 | First light of the 1.8-m solar telescope–CLST显示文摘Large-aperture solar telescopes play an important role in solar observations and research,and require high temporal and spatial resolution[1].To solve some fundamental problems such as the solar dynamo,coronal heating,and the triggering of major solar eruptions,the spatial resolution for solar-atmosphere observation should reach at least 0.1 arcsec[2]. | ChangHui Rao NaiTing Gu XueJun Rao Cheng Li LanQiang Zhang JinLong Huang Lin Kong Ming Zhang YunTao Cheng Yi Pu Hua Bao YouMing Guo YangYi Liu JinSheng Yang LiBo Zhong ChangJun Wang Kai Fang XiaoJun Zhang DongHong Chen Cheng Wang XinLong Fan ZhiWu Yan KeLe Chen XiYa Wei Lei Zhu Hong Liu YongJian Wan Hao Xian WenLi Ma | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 6 |
| 4 | Numerical simulation of channel pattern changes Part Ⅰ: Mathematical model显示文摘This paper presents a computational fluid dynamics model for simulation of twodimensional (2-D) water flow, sediment transport, bank failure processes, and the subsequent channel pattern changes. Effects of secondary currents at channel bends are included in the modified momentum conservation equation of water flow. An improved bank failure model is applied to calculate bank failure due to riverbed erosion, and to simulate lateral migration and planform changes of alluvial channels. The water flow model has been validated using laboratory measurements of flow in consecutive bends designed by the authors, in addition to flume test data from the literature. | Hong WANG Gang ZHOU Xuejun SHAO | 2010 | International Journal of Sediment Research2010，25，4： | 3 |
| 5 | The R&D status of DTL for CSNS显示文摘The China Spallation Neutron Source (CSNS) is a spallation neutron research facility being built at Dongguan in Guangdong Province. The 324 MHz Alvarez-type Drift Tube Linac will be used to accelerate the H- ion beam from 3 to 80.0 MeV with peak current 15 mA. The R&D of a prototype structure at the low energy section of DTL is taking place at IHEP. The first unit tank ~2.8 m in length and 28 drift tubes containing electromagnetic quadrupoles are developed. The SAKAE coils are applied in the fabrication of the electromagnetic quadrupoles. This paper introduces the R&D status of the tank and 28 drift tubes. The fabrication process and measurement results of the electromagnetic quadrupoles of special interest are also presented. | YIN XueJun GONG KeYun PENG Jun SONG Hong XIAO YongChuan LI AHong LIU Lei FU ShiNian | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 3 |
| 6 | Adenovirus-mediated LIGHT gene modification in murine B-cell lymphoma elicits a potent antitumor effect显示文摘Here,we investigated the antitumor effect of adenovirus-mediated gene transfer of LIGHT,the tumor-necrosis factor(TNF)superfamily member also known as TNFSF14,in the murine A20 B-cell lymphoma.LIGHT gene modification resulted in upregulated expression of Fas and the accessory molecule-intercellular adhesion molecule-1(ICAM-1)on A20 cells and led to enhanced A20 cell apoptosis.LIGHT-modified A20 cells effectively stimulated the proliferation of T lymphocytes and interferon(IFN)-c production in vitro.Immunization of BALB/c mice with a LIGHT-modified A20 cell vaccine efficiently elicited protective immunity against challenge with the parental tumor cell line.Adenovirus-mediated gene transfer of LIGHT by intratumoral injection exerted a very potent antitumor effect against pre-existing A20 cell lymphoma in BALB/c mice.This adenovirus-mediated LIGHT therapy induced substantial splenic natural killer(NK)and cytotoxic T lymphocyte(CTL)activity,enhanced tumor infiltration by inflammatory cells and increased chemokine expression of CC chemokine ligand 21(CCL21),IFN-inducible protein-10(IP-10)and monokine induced by IFN-c(Mig)from tumor tissues.Thus,adenovirus-mediated LIGHT therapy might have potential utility for the prevention and treatment of B-cell lymphoma. | Guili Hu Yang Liu Hong Li Dekuang Zhao Liuqing Yang Jiangen Shen Xuejun Hong Xuetao Cao Qingqing Wang | 2010 | Cellular & Molecular Immunology2010，7，4： | 3 |
| 7 | Numerical simulation of turbulent flow in helically coiled open-channels with compound cross-sections显示文摘Turbulence structure in a helically coiled open channel flow is numerically simulated using three different turbulence models--the Launder and Ying model, the Naot and Rodi model, and the nonlinear k-ε Model (SY model). Simulation results were compared with observation of (i) turbulent flows in alternating point-bar type channel bends with rectangular sections, and (ii) straight open channel flows with compound cross-sections. Based on calculations of the impact of various channel curvatures on turbulence characteristics, accuracy of the three turbulence models was analyzed with observed data as a qualitative reference. It has been found out that the Launder and Ying model and the nonlinear k-ε Model are able to predict the same general trend as measured data, and the simulation of the effect of the centrifugal force on the formation of secondary currents produces a correct pattern. | SHAO Xuejun WANG Hong CHEN Zhi | 2004 | Science China(Technological Sciences)2004，47，1： | 3 |
| 8 | Plant Resistance to Pest and Research Progress of Its Genetic Improvement显示文摘Pest damage is a significant factor that cuts agricultural production,and cultivation of pest-resistant varieties is the most economic and effective approach of controlling pest damage. Plant pest resistance includes antixenosis,antibiosis,and tolerance. Current popular methods for the genetic improvement of crop pest resistance are traditional breeding method,transgenic breeding,and molecular mark-assisted breeding. This paper introduced major mechanisms and genetic bases of plant pest resistance,and reviewed research progress of domestic and international genetic improvement of plant pest resistance,analyzed the problems and its development prospects. | Chen Manfeng Wang Xuejun Ge Hong Miao Yamei Wang Kaihua Gu Chunyan Meng Lingyang | 2015 | Plant Diseases and Pests2015，6，1： | 2 |
| 9 | Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor γ显示文摘Peroxisome 激活 proliferator 的受体(PPAR ) 属于 ligand 依赖的抄写因素的原子荷尔蒙受体总科。最近的结果证明了 PPAR 纬的收缩筋例如 troglitazone (TGZ ) ,能禁止房间增长并且支持独立于 PPAR 纬的房间区别。在现在的学习,我们提供 TGZ 可以直接绑在 EGFR 并且触发它发信号和 PPAR 纬的成为主观独立人士的证据。详细研究表明有 TGZ 的延长孵化有效地稀释了由指向受体到 endo-lysosomal 降级机械发信号的 EGFR。尽管细胞外的调整信号的发信号 kinase 小径被 TGZ 短暂地在 EGFR overexpressing 癌症细胞激活,导致 EGF 的 Akt phosphorylation 的抑制很可能说明了 TGZ 在 pharmacologically 可完成的集中引起的肿瘤细胞的生长拘捕。因此,我们提供了显示 TGZ 由支持 EGFR 降级和 attenuating Akt phosphorylation 禁止房间增长的证据的一根新线。 | Xiaoqi Li Xuanming Yang Youli Xu Xuejun Jiang Xin Li Fajun Nan Hong Tang | 2009 | Cell Research2009，19，6： | 2 |
| 10 | Simulation of turbulence structure and secondary flow of compound section open channel with spiral descending shape 显示文摘 | Shao Xuejun Wang Hong Chen Zhi | 2004 | Science in China Series E :Technological Sciences2004，34，1： | 1 |
| 11 | Hepatocyte growth factor protects endothelial progenitor cell from damage of low-density lipoprotein cholesterol via the PI3K/Akt signaling pathway显示文摘 | XueJun Yu MingBao Song JianFei Chen GuangXu Zhu Gang Zhao Hong Wang Lan Hunag | 2010 | Molecular Biology Reports2010，，5： | 1 |
| 12 | Novel anion exchange method for exact antimony doping control of stannic oxide nanocrystal powder显示文摘 | ZHANG Xuejun LIANG Hong bo GAN Fu-xing | 2006 | Am Ceram Soc2006，89，3： | 1 |
| 13 | Clinical and laboratory profiles of refractory Mycoplasma pneumoniae pneumonia in children显示文摘 | Meijuan Wang Yuqing Wang Yongdong Yan Canhong Zhu Li Huang Xuejun Shao Jun Xu Hong Zhu Xiangle Sun Wei Ji Zhengrong Chen | 2014 | International Journal of Infectious Diseases2014，，： | 1 |
| 14 | Numeical modeling of turbulent flow in curved channels of compound crosssection显示文摘 | SHAO Xuejun WANG Hong CHEN Zhi | 2003 | Advances in Water Resources2003，，26： | 1 |
| 15 | Three-dimensional modeling of bank erosion and morphological changers in the Shishou bend of the middle Yangtze River显示文摘 | Jia Dongdong Shao Xuejun Wang Hong | 2010 | Advances in Wetter Resources2010，33，： | 1 |
| 16 | Numerical model for sediment transport and bed degradation in the Yangtze River channel downstream of Three Gorges reservoir 显示文摘 | ZHOU Gang WANG Hong SHAO Xuejun | 2009 | Journal of Hydraulic Engineering ASCE2009，135，9： | 1 |
| 17 | Three-dimensional modeling of bank erosion and morphological changes in the Shishou bend of the middle Yangtze River 显示文摘 | Jia Dongdong Shao Xuejun Wang Hong | 2010 | Advances in Water Resources2010，33，3： | 1 |
| 18 | Numerical modeling of turbulent flow in curved channels of compound cross-section显示文摘 | Xuejun Shao Hong Wang Zhi Chen | 2003 | Advances in Water Resources2003，26，5： | 1 |
| 19 | 显示文摘 | Yue Xuejun Hong Tiansheng Xiang Wei | 2012 | Chinese Physics Letters2012，29，12： | 1 |
| 20 | Three-dimensional modeling of bank erosion and morphological changes in the Shishou bend of the middle Yangtze River显示文摘 | Dongdong Jia Xuejun Shan Hong Wang Gang Zhou | 2010 | Advance in Water resources2010，，33： | 1 |
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