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| 1 | Liuwei Dihuang pill suppresses metastasis by regulating the wnt pathway and disrupting β-catenin/T cell factor interactions in a murine model of triple-negative breast cancer显示文摘OBJECTIVE:To investigate if the Liuwei Dihuang pill(LWDHP)can inhibit metastasis to the liver and lungs in mice bearing triple-negative breast cancer(TNBC),and the molecular mechanism underpinning this action.METHODS:Ninety-nine TNBC bearing-mice were distributed randomly to five groups:control(Con),paclitaxel(PTX),low-dose LWDHP(LLP,2.3 g·kg^-1·d^-1),middle-dose LWDHP(MLP,4.6 g·kg^-1·d^-1)and high-dose LWDHP(HLP,9.2 g·kg^-1·d^-1).The LWDHP were administered(p.o.)to the agonal stage.The morphology of BC cells was observed by hematoxylin&eosin staining.Expression of axin-2,β-catenin,T cell factor(TCF),cyclin-D1 and vascular endothelial growth factor(VEGF)was detected by western blotting or immunofluorescence.β-catenin/TCF-1 interaction was measured using a co-immunoprecipitation assay.RESULTS:After LWDHP treatment,metastasis of BC cells to the lungs and liver was inhibited,expression of axin-2 was increased,expression of TCF-1,β-catenin,cyclin-D1 and VEGF was decreased,andβ-catenin/TCF-1 interaction was disrupted.CONCLUSION:The LWDHP could inhibit metastasis of BC cells to the liver and lungs.The molecular mechanism underlying this action may be regulation of protein expression andβ-catenin/TCF-1 interactions in the Wnt pathway. | Zheng Lixiang Zheng Qing Yu Zhipeng Wang Jian Ren Xiaoying Gong Yan Yang Xue Hunag Ping Weng Meizhi Liu Hongning Liu Haizhou | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 9 |
| 2 | 显示文摘The phase formation regularities in nanometer powders of ternary alloys prepared by gas evaporation process with induction current as the heating source were investigated. Al-Cu-Mn and Al-Cu-Cr were chosen as the samples in this study. The experimental results show that the necessary conditions for forming ternary compound phases in a ternary alloy nanometer powder are that they must be able to form in a conventional bulk alloy. To obtain a ternary compound phase in nanometer powders, composition of the master alloy must be in a certain range. Changing the composition of the master alloy and evaporation temperature can control the kinds of the phases and their relative amount in the alloy nanometer powders. In present study, AlMn, Al8Mn5 and AlCu2Mn phases formed in as-prepared nanometer powders of Al-Cu-Mn alloy, and the highest relative amount of AlCu2Mn phase is about 99%. In nanometer powders of Al-Cu-Cr alloy,Cu9Al4, Al2Cu3, AlCr2 and Al13Cr2 phases formed without any ternary compound phase. | Yan, HG Chen, ZH Kang, ZT Chen, G Hunag, PY | 2001 | 中国有色金属学会会刊:英文版2001，11，6： | 3 |
| 3 | Uplift differential of active fold zones during the late Quaternary, northern piedmonts of the Tianshan Mountains, China显示文摘On the north piedmont of Tianshan Mountains, China, the Kuytun River and Manas River transverse the Dushanzi and Manas folds, resulted in 7-level and 6-level pedestal terraces, respectively, which are the tectonomorphic marks of folding and uplift of the Dushanzi and Manas anticlines since the late Quaternary. We have collected samples from deposits of all terraces for OSL (optically stimulated luminescence) geological dating using the SMAR (single-multiple-aliquot-regeneration) method on fine grains. We have also performed dating using the 14 C method on the samples from the deposit of terrace T1 along the Kuytun River. The results show that all these deposits are of the later phase of the late Pleistocene. Comparison of terrace dating and climate change since 200 ka suggests that the terraces T1, T2, T3, T4 and T5 along the Manas River formed in 6, 8.5, 10, 14 and 32 ka, respectively. The incision time of Kuitun River's T1, T2, T3, T4, T5, T6 and T7 terraces were 1.7, 14, 20, 25, 32, 50 and 100 ka years ago, respectively. The terrace T4 along the Manas River and T2 along the Kuytun River were formed during the late part of the late Pleistocene, i.e., 14 ka. Since 14 ka, the incision of the Manas River has generated three levels of pedestal terraces, while that of the Kuytun River has only produced one level of such terraces. The latest folding and uplift of the Dushanzi anticline took place in 1.7 ka, while that of the Manas anticline occurred in 5 ka. Since 14ka or the later time of the late Pleistocene, the Dushanzi and Manas anticlines have risen by 40 and 95 m, respectively, implying uplift rates 2.7 and 6.8 mm/a for each. | YANG XiaoPing LI An HUNAG WeiLiang | 2013 | Science China Earth Sciences2013，56，5： | 3 |
| 4 | Crystal and Molecular Structure of Hexahydro-2-(Nitro-Benzoylmethylene)Pyrimidine显示文摘Compound C13H14Cl3N3O3, Mr = 366. 42, monoclinic, space groupP21/n, a=9. 649(1), b= 17. 315(2), c= 9. 715(1) A, β=96. 30(1)°. V= 1613. 3(3) A3, Z=4, De= 1. 509 g/cm3, μ= 0. 582 mm-1, F(000) = 752, R=0. 049, wR(F2) = 0. 095. Its unit cell is composed of four hexahydro-2- (nitrobenzoylmethylene)pyrimidine (1 ) molecules and four chloroform molecules (solvent). Both phenyl andheterocyclic rings in moiecule 1 are twisted to some degree to form a big conjugate sys-tem. The oxygen atoms of nitro and carbonyl groups in one molecule 1 form hydrogenbonds with the NH groups of the heterocyclic rings in other molecules which enhancethe stability of molecular packing. | LI Zhan-Jiang CHEN Xiao-Min REN Zhong-Xu LI Yan CHEN Xue-An HUNAG Zhi-Tang(Institute of Chemistry, the Chinese Academy of Schoces, Beijing 100080) | 1997 | Chinese Journal of Structural Chemistry1997，16，4： | 2 |
| 5 | Pyramiding of bacterial blight resistance genes in rice:marker-assisted selection using RFLP and PCR显示文摘 | Hunag N Angeles ER Domingo J | 1997 | Theor Appl Genet1997，95，： | 1 |
| 6 | Simulation of Dynamic Load for Bridges显示文摘 | HUNAG E S NOWAK A S | 1991 | Journal of Structural Engineering1991，117，5： | 1 |
| 7 | In vivo expression of GLP-1/IgG-Fc fusion protein enhances beta-cell mass and protects against streptozotocin-induced diabetes 显示文摘 | Kumar M Hunag Y Glinka Y | 2007 | Gene Ther2007，14，： | 1 |
| 8 | Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice显示文摘 | Kumar M Hunag Y Glinka Y | 2007 | Gene Ther2007，14，2： | 1 |
| 9 | JWA, a novel signaling molecule, involved in the induction of diefferentation of human myeloid leukemia cells显示文摘 | Hunag S Shen Q Mao WG | 2006 | Biochem Biophys Res Commu2006，341，： | 1 |
| 10 | Gene therapy of diabetes 195 using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db 196 mice显示文摘 | Kumar M Hunag Y Glinka Y | 2007 | Gene Therapy2007，14，： | 1 |
| 11 | Desulfurization of gasoline by extraction with new ionic liquids 显示文摘 | Hunag C Chen B Zhang J | 2004 | Energy&Fuels2004，18，： | 1 |
| 12 | Exploring the sensitive indicators of uterotrophic assay in immature SD rats exposed to para-nonylphenol显示文摘 | Hunag Y N Cheng W B Xu P Y | 2004 | Sichuan Da Xue Xue Bao Yi Xue Ban2004，35，1： | 1 |
| 13 | Mechanism- based strain gradient plasticity(I):Theory显示文摘 | GAO H HUNAG Y NIX W D | 1999 | Jour- nal of Mechanical Pyhsical Solids1999，47，6： | 1 |
| 14 | Profile likelihood Inferences on semiparametric Varying-Coefficient partially linear models 显示文摘 | FAN J HUNAG T | 2005 | Bernoulli2005，，11： | 1 |
| 15 | Enhanced energy conversion efficiency of the Sr^(2+)-modified nanoporous TiO2 electrode sensitized with a ruthenium complex显示文摘 | Yang S Huang Y Hunag C | 2002 | Chem Mater2002，14，： | 1 |
| 16 | Feasible instantaneous motion and kinematic characteristics of a special 3-DOF 3-UPU parallel manipulator显示文摘 | Li Shihua Hunag zhen Zuo Rongguo | 2004 | Mechanism and Machine Theory2004，39，9： | 1 |
| 17 | Effects of two dust storms on solar radiation in the Beijing - Tianjin area显示文摘 | Zhou M Y Chen Z Hunag R | 1994 | Geophys ResLett1994，21，24： | 1 |
| 18 | The numerical bifurcation method of nonlinear lateral stability analysis of a locomotive显示文摘 | HUNAG Cheng-rong ZHAN Fei-sheng | 1994 | Vehicle System Dynamics1994，23，1： | 1 |
| 19 | A confidence limit for the empirical mode decomposition and hilbert spectral analysis 显示文摘 | HUNAG N E WU Manli LONG S R | 2003 | Proc R Soc Lond A2003，，459： | 1 |
| 20 | Vision-based measurement of temperature distribution in a 500-kW model furnace using the two colour method显示文摘 | HUNAG Y YAN Y RILEY G | 2000 | Measurement2000，28，3： | 1 |
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