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| 1 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 2 | Synthesis of Multiester-appended and Multicarboxylic-appended Imidazolium Ionic Liquids显示文摘Multiester-appended imidazolium ionic liquids were synthesized in a quaternizationreaction between the imidazole derivatives carrying single or double esters and ethyl chloroacetateor bromoethane. Multicarboxylic-appended imidazolium ionic liquids were achieved from thehydrolysis of the corresponding ionic liquids. The influences of multifunctional groups on thetransition temperatures and viscosity of these new ionic liquids were investigated. | Wei Guo GENG Xuc Hui LI Le Fu WANG Hong Li DUAN Wei Ping PAN | 2006 | Chinese Chemical Letters2006，17，2： | 4 |
| 3 | Two-photon absorption and two- photon excited fluorescence of triphenylamine-based multibranched chromophores 显示文摘 | Wang X M Yang P Xuc G B | 2005 | Synth Met2005，155，： | 1 |
| 4 | In vitro Susceptibilitics to and bactericidal activitics garenoxacin (BM S-284756) and other antimicrobial agent against human mycoplasmas and ureaplasmas 显示文摘 | Wakes KB Crabb DM Xuc B | 2003 | Antimicrob Agents Chemother2003，47，1： | 1 |
| 5 | Pituitrin com- bined nitroglycerin treatment of esophageal gastric variccs rupture hemorrhage of cost-effectiveness analysis显示文摘 | Xuc Cui-ying Wang Xiao-hua Song Hui-fang ct al | 2012 | Journal of China pharm- aceutical industry2012，21，12： | 1 |
| 6 | Prevalenceofprehypertension,hypertensionand,associatedriskfactorsinMongolianandHanChinesepopulationsinNortheastChina显示文摘 | SunZ ZhengL XuC LiJ ZhangX LiuS etal | 2008 | IntJCardiol2008，128，25： | 1 |
| 7 | PolyanilineGfunctionalizedcarbonnanotubesupportedplatinumcatalysts显示文摘 | HeDP ZengC XuC etal | 2011 | LangGmuir2011，27，9： | 1 |
| 8 | Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventrieular eardiomyoeytes: insights into the development of cell-based pacemaker显示文摘 | Xuc T Cho HC Akar FG | 2005 | Circulation2005，111，1： | 1 |
| 9 | In vitro susceptibilitics to bac tericidal activitis garenoxacin (BM S-284756) and other antimicrobial agent against human mycoplasmas and ureaplasmas显示文摘 | Waites KB Crabb DM Xuc B | 2003 | An timicrob Agents Chemother2003，47，1： | 1 |
| 10 | Transurethralseminalvesiculoscopyusinga6Fvesiculoscopeforejaculatoryductobstruction:Initialexperience显示文摘 | WANGH YEH XUC etal | 2012 | JAndrol2012，33，4： | 1 |
| 11 | Energy conservation of electrolytic alumin -urn industry in China 显示文摘 | Boqiang Lin Lin Xuc | 2015 | Renewable and Sustainable Energy Rev -iews2015，43，67： | 1 |
| 12 | Endobronchial tuberculosis:an overview显示文摘 | Xue Q Wang N Xuc X | 2011 | Eur J Clin Microbiol Infect Dis2011，30，9： | 1 |
| 13 | Synthesis of N - caprolactam chlorides as cationic bleach activators for low - temperature bleaching of cotton fabric under near - neutral pH conditions 显示文摘 | WeiD SunC WangM DuJ XuC | 2014 | Coloration Technology2014，130，6： | 1 |
| 14 | Biological pretreatment of com stover byIrpex lacteus for enzymatic hydrolysis 显示文摘 | XuC Ma F Zhang X | 2010 | Journal of Agricultural andFood Chemistry2010，58，10： | 1 |
| 15 | Aripiprazole a novel antipsychoic, is a high affinity prrtial, agonist at humun dopine D2 receptors 显示文摘 | Burris KD Molski TF Xuc | 2002 | T phamacol Exp Ther2002，302，1： | 1 |
| 16 | Rational behavior and cooperation degree in competitive situation 显示文摘 | Xuc | 1999 | International of System Science1999，30，4： | 1 |
| 17 | MicrostructuresandpropertiesofsilverbasedcontactmaterialfabricatedbyhotextrusionofinternaloxidizedAg! Sn! Sballoypowders显示文摘 | XuC YiD WuC etal | 2012 | MaterialsScienceandEngineering:A2012，538，： | 1 |
| 18 | Fibroblast growth factors are translocated to the nucleus of human endothelial cells in a microtubule-and lysosome-independent pathway显示文摘 | HUG KIMH XUC | 2000 | Biochem Biophys Res Commun2000，273，2： | 1 |
| 19 | Study on the synthesis and photoconductivity of bisazo compounds having 1,3,4-oxadiazole 显示文摘 | Jinqiang Xuc Shirong Wang Limei Zhang | 2007 | Dyes and Pigments2007，75，： | 1 |
| 20 | AuniqueModepositassociatedwithcarbonatitesintheQinlingorogenicbelt,centralChina显示文摘 | XUC KYNICKYJ CHAKHMOURADIANAR etal | 2010 | Lithos2010，118，12： | 1 |
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