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| 1 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 2 | Situation Awareness of Active Distribution Network:Roadmap,Technologies,and Bottlenecks显示文摘With the rapid development of local generation and demand response,the active distribution network(ADN),which aggregates and manages miscellaneous distributed resources,has moved from theory to practice.Secure and optimal operations now require an advanced situation awareness(SA)system so that operators are aware of operation states and potential risks.Current solutions in distribution supervisory control and data acquisition(DSCADA)as well as the distribution automation system(DAS)generally are not able to meet the technology requirements of SA.In this paper,the authors’participation in the project of developing an SA system as the basic component of a practical active distribution management system(ADMS)deployed in Beijing,China,is presented.This paper reviews the ADN’s development roadmap by illustrating the changes that are made in elements,topology,structure,and control scheme.Taking into consideration these hardware changes,a systematic framework is proposed for the main components and the functional hierarchy of an SA system for the ADN.The SA system’s implementation bottlenecks are also presented,including,but not limited to issues in big data platform,distribution forecasting,and security evaluation.Potential technology solutions are also provided. | Jin Lin Can Wan Yonghua Song Renle Huang Xiaoshuang Chen Wanfang Guo Yi Zong You Shi | 2016 | CSEE Journal of Power and Energy Systems2016，2，3： | 13 |
| 3 | Large-field high-resolution two-photon digital scanned light-sheet microscopy显示文摘 | Weijian Zong Jia Zhao Xuanyang Chen Yuan Lin Huixia Ren Yunfeng Zhang Ming Fan Zhuan Zhou Heping Cheng Yujie Sun Liangyi Chen | 2015 | Cell Research2015，25，2： | 12 |
| 4 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 5 | A 12-year cohort study on the efficacy of plasmaderived hepatitis B vaccine in rural newborns显示文摘AIM To understand the anti-HBs persistenceand the long-term preventive efficacy in ruralnewborns after vaccination with plasma-derivedhepatitis B vaccine.METHODS In the time of expanded program onimmunization(EPI),the newborns werevaccinated with 10μg×3 doses of hepatitis Bvaccine and 762 newborns who were HBsAgnegative after primary immunization wereselected for cohort observation from 1986 to1998.Their serum samples were detectedqualitatively and quantitatively for hepatitis Binfecting markers,including HBsAg,anti-HBsand anti-HBc by SPRIA Kits.The annual HBsAgpositive conversion rate was counted by life-table method.RESULTS①The anti-HBs positive rate was94.44% for the babies born to HBsAg negativemothers and 84.21% for those born to HBsAgpositive mothers in the 1st year afterimmunization,and dropped to 51.31% and52.50% in the 12th year respectively.GMT valuewas dropped from 31.62 to 3.13 and 23.99 to 3.65in the 2nd to the 12th year respectively.Therewas a marked drop in GMT at the 3rd to the 5thyear,and in anti-HBs positive rate at the 9th tothe 10th year.②In the period of 12 yearsobservation,the person-year HBsAg positive conversion rates were 0.12%(5/4150.0)innewborns born to HBsAg negative mothers and0.20%(1/508.0)in those born to HBsAgpositive mothers,and none of the HBsAgpositive converted children became HBsAgchronic carriers.Compared with the baselinebefore immunization,the protective rates were97.19% and 95.32% respectively.CONCLUSION The protective efficacy ofplasma-derived hepatitis B vaccine persisted atleast 12 years,and a booster dose seems notnecessary within at least 12 years after theprimary three-doses immunization to newbornsborn to HBsAg negative mothers. | Hong Bin Liu Zong Da Meng Jing Chen Ma Chang Quan Han Ying Lin Zhang Zhan Chun Xing Yu Wei Zhang Yu Zhong Liu Hui Lin Cao | 2000 | World Journal of Gastroenterology2000，6，3： | 11 |
| 6 | Expert consensus on the evaluation and diagnosis of combat injuries of the Chinese People's Liberation Army显示文摘The accurate assessment and diagnosis of combat injuries are the basis for triage and treatment of combat casualties. A consensus on the assessment and diagnosis of combat injuries was made and discussed at the second annual meeting of the Professional Committee on Disaster Medicine of the Chinese People's Liberation Army(PLA). In this consensus agreement, the massive hemorrhage, airway, respiration, circulation and hypothermia(MARCH) algorithm, which is a simple triage and rapid treatment and field triage score, was recommended to assess combat casualties during the first-aid stage, whereas the abbreviated scoring method for combat casualty and the MARCH algorithm were recommended to assess combat casualties in level Ⅱ facilities. In level Ⅲ facilities, combined measures, including a history inquiry, thorough physical examination, laboratory examination, X-ray, and ultrasound examination, were recommended for the diagnosis of combat casualties. In addition, corresponding methods were recommended for the recognition of casualties needing massive transfusions, assessment of firearm wounds, evaluation of mangled extremities, and assessment of injury severity in this consensus. | Zhao-wen Zong Lian-yang Zhang Hao Qin Si-xu Chen Lin Zhang Lei Yang Xiao-xue Li Quan-wei Bao Dao-cheng Liu Si-hao He Yue Shen Rong Zhang Yu-feng Zhao Xiao-zheng Zhong representing the PLA Professional Committee and Youth Committee on Disaster Medicine | 2018 | Military Medical Research2018，5，3： | 10 |
| 7 | Finite element model validation of bridge based on structural health monitoring——Part I: Response surface-based finite element model updating显示文摘In the engineering practice, merging statistical analysis into structural evaluation and assessment is a tendency in the future. As a combination of mathematical and statistical techniques, response surface(RS) methodology has been successfully applied to design optimization, response prediction and model validation. With the aid of RS methodology,these two serial papers present a finite element(FE) model updating and validation method for bridge structures based on structural health monitoring. The key issues to implement such a model updating are discussed in this paper, such as design of experiment,parameter screening, construction of high-order polynomial response surface model,optimization methods and precision inspection of RS model. The proposed procedure is illustrated by a prestressed concrete continuous rigid-frame bridge monitored under operational conditions. The results from the updated FE model have been compared with those obtained from online health monitoring system. The real application to a full-size bridge has demonstrated that the FE model updating process is efficient and convenient.The updated FE model can relatively reflect the actual condition of Xiabaishi Bridge in the design space of parameters and can be further applied to FE model validation and damage identification. | Zhouhong Zong Xiaosong Lin Jie Niu | 2015 | Journal of Traffic and Transportation Engineering(English Edition)2015，2，4： | 9 |
| 8 | 17β-estradiol attenuates homocysteine-induced oxidative stress and inflammatory response as well as MAPKs cascade via activating PI3-K/Akt signal transduction pathway in Raw 264,7 cells显示文摘氧化应力,煽动性的反应,和激活 mitogen 的蛋白质 kinases (MAPK ) 串联是骨质疏松症的重要病原的因素。提高的 homocysteine (Hcy ) 可以在绝经后的骨质疏松症激活氧化应力和还原剂骨头矿物质密度,这被报导了。而且,荷尔蒙代替治疗广泛地在诊所被使用了与骨质疏松症阻止并且对待绝经后的女人, osteoporotic 骨折和位于 Hcy 的行动下面的相关信号 transduction 小径仍然保持不清楚。在这研究,我们调查了 17-estradiol 的效果(导致 Hcy 的氧化压力,煽动性的反应和 MAPK 串联,以及内在的信号 transduction 小径在上的 17-E 2) 鼠科未加工 264.7 个房间。反应的氧种类(ROS ) 被 fluorospectrophotometry 估计。proinflammatory cytokines 肿瘤坏死因素 --(TNF-) 并且 interleukin (IL )-1 被 double-immunofluorescence 标记和反向的 transcriptase 聚合酶链反应试金分析分别地。而且, MAPK 串联的 phosphorylation 层次被西方的污点分析测量。一个特定的 phosphatidylinositol 3-kinase (PI3-K ) 禁止者, Wortmannin (1 M ) 被采用决定 PI3-K/Akt 发信号小径是否调停了 17-E 2 的效果在上未加工 264.7 个房间。17-E 2 显著地减少了 ROS 生产由 Hcy 导致了,在蛋白质和 mRNA 的 TNF-1 和 IL-1 的表示铺平,并且下面调整 MAPK (ERK1/2, JNK 和 p38 ) 的 phosphorylation。导致 Hcy 的变化上的 17-E 2 的这些压制的效果被预告的处理与 PI3-K 禁止者 Wortmannin 颠倒。结果显示那 17-estradiol 可以稀释 MAPK 的导致 Hcy 的氧化应力,煽动性的反应和起来规定在未加工经由 PI3-K/Akt 的 264.7 个房间表明 transduction 小径。 | Ying Zhang Ying He Yi Zong Jiazhi Guo Lin Sun Yunbing Ma Wei Dong Li Gui | 2015 | Acta Biochimica et Biophysica Sinica2015，47，2： | 9 |
| 9 | A polyoxometalate-functionalized two-dimensional titanium carbide composite MXene for effective cancer theranostics显示文摘作为一个新家庭二维(2D ) nanomaterials,因为高效, MXenes 最近包括精力在万用的应用吸引了许多注意存储和电气化学,而是他们到 biomedicine 的特定的申请很少被报导了特别为 theranostic nanomedicine,即,并发的诊断成像和治疗。这研究第一次显示出表面设计和 2D Ti 3 由 GdW 10-based polyoxometalates (POM ) 的集成的 C 2 MXene nanosheets。这些多功能的 GdW 10@Ti3 C 2 合成 nanosheets 向过高热的治疗提供磁性的回声(先生) 或计算断层摄影术(CT ) 向肿瘤房间或异种皮移植的成像指导。没有进一步的出现,一个肿瘤有效地在观察时期期间被根除。是综合的到 Ti 310 nanoclusters > C 2 nanosheets 被表明基于他们的唯一的作文为提高对比的 CT 和先生成像用作一个对比代理人,因此为诊断成像的指导显示出潜力并且为肿瘤过高热 nanotherapy 监视。在 GdW 10@Ti3 C 2 合成 nanosheets 被表明保证他们的随后的翻译进医疗。这研究为由表面工程和 multifunctionalization 拓宽 MXenes 的生物医学的应用提供新奇策略,它被期望在 nanotheranostics 支持 MXenes 的生物医学的应用的进一步的探索。 | Luyan Zong Huixia Wu Han Lin Yu Chen | 2018 | Nano Research2018，11，8： | 9 |
| 10 | Radial propagation of magnetospheric substorm-injected energetic electrons observed using a BD-IES instrument and Van Allen Probes显示文摘In cases where substorm injections can be observed simultaneously by multiple spacecraft,they can help elucidate the potential mechanisms of particle transport and energization,of great importance to understanding and modeling the magnetosphere.In this paper,using data returned from the BeiDa-IES(BD-IES) instrument onboard a satellite in an inclined(55°) geosynchronous orbit(IGSO),in combination with two geo-transfer orbiting(GTO) satellite Van Allen Probes(A and B),we analyze a substorm injection event that occurred on the 16 th of October 2015.During this substorm injection,the IGSO onboard BD-IES was outbound,while both Van Allen Probe satellites(A and B) were inbound,a configuration of multiple trajectories that provides a unique opportunity to simultaneously investigate both the inward and outward radial propagation of substorm injection.Indicated by AE/AL indices,this substorm was closely related to an IMF/solar wind discontinuity that showed a sharp change in IMF Bz direction to the north.The innermost signature of this substorm injection was detected by Van Allen Probes A and B at L-3.7,while the outermost signature was observed by the onboard BD-IES instrument at L~\0.These data indicate that the substorm had a global,rather than just local,effect.Finally,we suggest that electric fields carried by fast-mode compressional waves around the substorm injection are the most likely candidate mechanism for the electron injection signatures observed in the inner- and outermost inner magnetosphere. | ZONG QiuGang HAO YiXin ZOU Hong FU SuiYan ZHOU XuZhi REN Jie WANG LingHua YUAN ChongJing LIU ZhiYang JIA XiangHong QUAN Lin LIU Ying WANG YongFu | 2016 | Science China Earth Sciences2016，59，7： | 8 |
| 11 | Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress显示文摘AMPK, a master regulator of metabolic homeostasis, is activated by both AMP-dependent and AMP-independent mechanisms. The conditions under which these different mechanisms operate, and their biological implications are unclear. Here, we show that, depending on the degree of elevation of cellular AMP, distinct compartmentalized pools of AMPK are activated, phosphorylating different sets of targets. Low glucose activates AMPK exclusively through the AMP-independent, AXIN-based pathway in lysosomes to phosphorylate targets such as ACC1 and SREBP1c, exerting early anti-anabolic and pro-catabolic roles. Moderate increases in AMP expand this to activate cytosolic AMPK also in an AXIN-dependent manner. In contrast, high concentrations of AMP, arising from severe nutrient stress, activate all pools of AMPK independently of AXIN. Surprisingly, mitochondrion-localized AMPK is activated to phosphorylate ACC2 and mitochondrial fission factor (MFF) only during severe nutrient stress. Our findings reveal a spatiotemporal basis for hierarchical activation of different pools of AMPK during differing degrees of stress severity. | Yue Zong Chen-Song Zhang Mengqi Li Wen Wang Zhichao Wang Simon A. Hawley Teng Ma Jin-Wei Feng Xiao Tian Qu Qi Yu-Qing Wu Cixiong Zhang Zhiyun Ye Shu-Yong Lin Hai-Long Piao D. Grahame Hardie Sheng-Cai Lin | 2019 | Cell Research2019，29，6： | 8 |
| 12 | Development of the detonation-driven expansion tube for orbital speed experiments显示文摘The hypersonic flow at orbital speeds is a fundamental issue for the ground tests of aerospace crafts.The detonation-driven high-enthalpy expansion tube(JF16 expansion tube)was developed to investigate re-entry physics.A forward detonation cavity(FDC)driver was applied in the JF16 expansion tube to create stable driving flows.The sound speed ratio of the detonated to test gas was examined to minimize the magnitude of test flow perturbations.The acceleration section length,incident shock decay and diaphragms thickness were investigated in detail to obtain optimal operation parameters.Flow visualization was also carried out with schlieren system to demonstrate the test flow stability and the effective test duration.Experimental data showed that the test flow with a velocity of 8.3 km/s and a total enthalpy up to 40 MJ/kg can be generated successfully and the test duration lasts for more than 50μs. | JIANG Zong Lin WU Bo GAO Yun Liang ZHAO Wei HU Zong Min | 2015 | Science China(Technological Sciences)2015，58，4： | 8 |
| 13 | Oscillation analysis of a DFIG-based wind farm interfaced with LCC-HVDC显示文摘With the increasing capacity of wind farm, HVDC technology has become a promising transmission scheme for long distance transportation of large-scale wind power. However oscillation caused by this system will have a great influence on the security and stability of power system operation. In this paper, the oscillation of a doubly-fed induction generator(DFIG)-based wind farm interfaced with line commutated converter(LCC) based HVDC is discussed. Low-frequency oscillation and subsynchronous oscillation(SSO) are studied since these two oscillations are the particularly concerned oscillations in the stability study of power system in recent years. The model of a DFIG-based wind farm interconnected with LCC-HVDC is developed. The impact of drive train model's structure and parameters on the oscillation characteristics is analyzed. Eigenvalue and participation factor analysis are used to identify the three main modes, which include controller mode, electromechanical mode, and shaft mode. The effects of DFIG controller's parameters, wind speed and operating conditions of HVDC on those modes are studied. Electromagnetic transient simulations are performed to verify the results of the eigenvalue analysis. | YANG Lin XIAO Xiang Ning PANG Cheng Zong | 2014 | Science China(Technological Sciences)2014，57，12： | 7 |
| 14 | Study of retinal vessel oxygen saturation in ischemic and non-ischemic branch retinal vein occlusion显示文摘AIM:To explore how oxygen saturation in retinal blood vessels is altered in ischemic and non-ischemic branch retinal vein occlusion(BRVO).·METHODS:Fifty BRVO eyes were divided into ischemic(n=26)and non-ischemic(n=24)groups,based on fundus fluorescein angiography.Healthy individuals(n=52 and n=48,respectively)were also recruited as controls for the two groups.The mean oxygen saturations of the occluded vessels and central vessels were measured by oximetry in the BRVO and control groups.·RESULTS:In the ischemic BRVO group,the occluded arterioles oxygen saturation(Sa O2-A,106.0%±14.3%),instead of the occluded venule oxygen saturation(Sa O2-V,60.8%±9.4%),showed increases when compared with those in the same quadrant vessels(Sa O2-A,86.1%±16.5%)in the contralateral eyes(P<0.05).The oxygen saturations of the central vessels showed similar trends with those of the occluded vessels.In the non-ischemic BRVO group,the occluded and central Sa O2-V and Sa O2-A showed no significant changes.In both the ischemic and non-ischemic BRVOs,the central Sa O2-A was significantly increased when compared to healthy individuals.·CONCLUSION:Obvious changes in the occluded and central Sa O2-A were found in the ischemic BRVO group,indicating that disorders of oxygen metabolism in the arterioles may participate in the pathogenesis of ischemic BRVO. | Lei-Lei Lin Yan-Min Dong Yao Zong Qi-Shan Zheng Yue Fu Yong-Guang Yuan Xia Huang Garrett Qian Qian-Ying Gao | 2016 | International Journal of Ophthalmology(English edition)2016，9，1： | 7 |
| 15 | Anti-proton contamination design of the imaging energetic electron spectrometer based on Geant4 simulation显示文摘The measurement of energetic particles plays an important role in the space environment monitoring and space weather forecasting.The accuracy of the energetic electron measurement is seriously influenced by the proton contamination.An anti-proton contamination design for the sensor of imaging energetic electron spectrometer is introduced in this paper.According to the electron and proton spectrum on the typical satellite orbits calculated by the radiation belt models,the efficiency of the anti-proton contamination design is estimated by the Geant4 simulation and the design is optimized based on the simulation results. | LUO Lin ZOU Hong ZONG QiuGang WANG LingHua CHEN HongFei SHI WeiHong YU XiangQian | 2015 | Science China(Technological Sciences)2015，58，8： | 7 |
| 16 | Influence of polymers on the stability of Gudao crude oil emulsions显示文摘The influence of different types and concentrations of polymers on the stability of Gudao crude oil emulsion was investigated by measuring the volume of water separated from the emulsions and the interfacial shear viscosity of the oil/water interfacial film.Experimental results indicate that the simulated water-in-oil emulsion with 40 mg/L of partially hydrolyzed polyacrylamide(HPAM)3530S could be easily broken by adding demulsifier C and was readily separated into two layers.However, HPAM AX-74H and hydrophobically associating water-soluble polymer(HAP)could stabilize the crude oil emulsion.With increasing concentration of AX-74H and HAP,crude oil emulsions became more stable.Water droplets were loosely packed in the water-in model oil emulsion containing HPAM 3530S, but water droplets were smaller and more closely packed in the emulsion containing AX-74H or HAP.The polymers could be adsorbed on the oil/water interface,thereby increasing the strength of the interfacial film and enhancing the emulsion stability. | Lin Meiqin Zhang Chunling Zong Hua Li Mingyuan Fang Hongbo Guo Jixiang | 2008 | Petroleum Science2008，5，2： | 6 |
| 17 | Leaf photosynthesis and yield components of mung bean under fully open-air elevated[CO_2]显示文摘Mung bean(Vigna radiata L.) has the potential to establish symbiosis with rhizobia,and symbiotic association of soil micro flora may facilitate the photosynthesis and plant growth response to elevated[CO_2].Mung bean was grown at either ambient CO_2 400 μmol mol^(-1) or[CO_2]((550+17) μmol mol^(-1)) under free air carbon dioxide enrichment(FACE) experimental facility in North China.Elevated[CO_2]increased net photosynthetic rate(P_n),water use efficiency(WUE) and the non-photochemical quenching(NPQ) of upper most fully-expanded leaves,but decreased stomatal conductance(G_s),intrinsic efficiency of PSII(F_v '/F_m'),quantum yield of PSII(φ_(PSll)) and proportion of open PSII reaction centers(q_p).At elevated[CO_2],the decrease of F_v'/F_m',φ_(PSII),q_p at the bloom stage were smaller than that at the pod stage.On the other hand,P_n was increased at elevated[CO_2]by 18.7 and 7.4%at full bloom(R2) and pod maturity stages(R4),respectively.From these findings,we concluded that as a legume despite greater nutrient supply to the carbon assimilation at elevated[CO_2],photosynthetic capacity of mung bean was still suppressed under elevated[CO_2]particularly at pod maturity stage but plant biomass and yield was increased by 11.6 and 14.2%,respectively.Further,these findings suggest that even under higher nutrient acquisition systems such as legumes,nutrient assimilation does not match carbon assimilation under elevated[CO_2]and leads photosynthesis down-regulation to elevated[CO_2]. | GAO Ji HAN Xue Saman Seneweera LI Ping ZONG Yu-zheng DONG Qi LIN Er-da HAO Xing-yu | 2015 | Journal of Integrative Agriculture2015，14，5： | 6 |
| 18 | Early Biomarkers in 1H Nuclear Magnetic Resonance Spectroscopy of Striatal Pathological Mechanisms after Acute Carbon Monoxide Poisoning in Rats显示文摘Objective In vivo Proton Magnetic Resonance Spectroscopy(1H-MRS) can be used to evaluate the levels of specific neurochemical biomarkers of pathological mechanisms in the brain. Methods We conducted T2-Weighted Magnetic Resonance Imaging(MRI) and 1H-MRS with a 3.0-Tesla animal MRI system to investigate the early microstructural and metabolic profiles in vivo in the striatum of rats following carbon monoxide(CO) poisoning. Results Compared to baseline, we found significant cortical surface deformation, cerebral edema changes, which were indicated by the unclear gray/white matter border, and lateral ventricular volume changes in the brain. A significant reduction in the metabolite to total creatine(Cr) ratios of N-acetylaspartate(NAA) was observed as early as 1 h after the last CO administration, while the lactate(Lac) levels increased marginally. Both the Lac/Cr and NAA/Cr ratios leveled off at 6 h and showed no subsequent significant changes. In addition, compared to the control, the choline(Cho)/Cr ratio was slightly reduced in the early stages and significantly increased after 6 h. In addition, a pathological examination revealed mild cerebral edema on cessation of the insult and more severe cerebral injury after additional CO poisoning. Conclusion The present study demonstrated that 1H-MRS of the brain identified early metabolic changes after CO poisoning. Notably, the relationship between the increased Cho/Cr ratio in the striatum and delayed neuropsychologic sequelae requires further research. | GUAN Li LI Zong Yang ZHANG Yan Lin CONG Cui Cui ZHAO Jin Yuan | 2015 | Biomedical and Environmental Sciences2015，28，10： | 6 |
| 19 | cAMP elevators inhibit LPS-induced IL-12 p40 expression by interfering with phosphorylation of p38 MAPK in Murine Peritoneal Macrophages显示文摘cAMP mediated signaling may play a suppressive role in immune response. We previously found that the cAMP-elevators (CTx and 8-Br-cAMP) inhibited IL-12, IL-la, IL-6 gene expression, but increased the transcriptional levels of IL-10 and IL-1Ra in LPS-treated murine peritoneal macrophages. The present study examined a possible molecular mechanism involved in cAMP elevators-induced inhibition of IL-12 p40 expression in response to LPS. Our data demonstrated that cAMP elevators downregulated IL-12 p40 mRNA expression and IL-12 pT0 production in murine peritoneal macrophages. Subsequent studies revealed that cAMP-elevators blocked phosphorylation of p38 MAPK, but did not affect the activity of NF-κB binding to IL-12 promoter (-136/-112). This is the first report that cAMP elevators inhibit LPS-induced IL-12 production by a mechanism that is associated, at least in part, with p38-dependent inhibition by cAMP signaling pathways. | WEI Guo FENG, YI BING WANG, JIN SONG ZHANG, XING Yu WANG, CHANG LIN LI, ZONG LIANG CHANGLaboratory of Immune Signaling Transduction, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China | 2002 | Cell Research2002，12，5： | 6 |
| 20 | Chinese expert consensus on the treatment of modern combat-related spinal injuries显示文摘The battlefield treatments of spinal and spinal cord injury vary from civilian settings. However, there is no unified battlefield treatment guidelines for spine trauma in PLA. An expert consensus is reached, based on spine trauma epidemiology and the concepts of battlefield treatment combined with the existing levels of military medical care in modern warfare. Since the specialized treatment for spine trauma are no significant difference between civilian settings and modern war, the first aid, emergency treatment and early treatment of spine trauma are introduced separately in three levels in this consensus. In Level I facilities, the fast and accurate evaluation of spine trauma followed by fixation and stabilization are recommended during the first-aid stage. Re-evaluation, further treatment for possible hemorrhagic shock, dyspnea and infection are recommended at Level II facilities. At Level III facilities, it is recommended to strengthen the intensive care and the prevention of urinary system and lung infection for the wounded with severe spinal injury, however, spinal surgery is not recommended in a battlefield hospital. The grading standard for evidence evaluation and recommendation was used to reach this expert consensus. | Zhao-Wen Zong Hao Qin Si-Xu Chen Jia-Zhi Yang Lei Yang Lin Zhang Wen-Qiong Du Xin Zhong Ren-Jie Zhou Dan Tan Hao Wu | 2019 | Military Medical Research2019，6，2： | 5 |
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