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| 1 | Rapid eutectic growth during free fall显示文摘Rapid eutectic growth of Sb-24%Cu alloy is realized in the drop tube during the free fall under the con-tainerless condition. Based on the analysis of crystal nuclea-tion and eutectic growth in the free fall condition, it is indicated that, with the increase of undercooling, microstruc-tural transition of Sb-24%Cu eutectic alloy proceeds from lamellar to anomalous eutectic structure. Undercoolings of 0 -154 K have been obtained in experiment. The maximum undercooling exceeds to 0.19TE. Calculated results exhibit that Cu2Sb compound is the primary nucleation phase, and that the primary Sb dendrite will grow more rapidly than the eutectic structure when undercooling is larger than 40 K. The eutectic coupled zone around Sb-24%Cu eutectic alloy leads strongly to the Cu-rich side and covers a composition range from 23.0% to 32.7%Sb. | Wenjing Yao Xiujun Han Bingbo Wei | 2002 | Chinese Science Bulletin2002，47，15： | 7 |
| 2 | First Discovery and Zircon U-Pb Dating of Early Ordovician Granitoids in Lincang Batholith, Western Yunnan: Implications for the Presence of Proto-Tethyan Orogeny in the Sanjiang Region, SW China显示文摘Objective The Lincang granitic batholith,extending over 370 km from north to south with an area of more than 10000 km^2,is the major part of the Sanjiang region in western Yunnan,SW China,and is one key area to study the evolution of the Tethys.Previous studies all agreed that the Lincang batholith was formed in the Triassic。 | XIAO Qianru XIONG Fuhao ZHAO Han FENG Xiujun WANG Qiang XIAO Yuanfu | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 6 |
| 3 | High undercooling and rapid dendritic growth of Cu-Sb alloy in drop tube显示文摘Droplets of Cu-20%Sb hypoeutectic alloy has been rapidly solidified in drop tube within the containerless condition. With the decrease of droplet diameter, undercooling increases and the microstructures of primary copper dendrite refines. Undercooling up to 207 K (0.17 TL) is obtained in experiment. Theoretic analysis indicated that, because of the broad temperature range of solidification, the rapid growth of primary copper dendrite is controlled by the solutal diffusion. Judging from the calculation of T0 curve in the phase diagram, it is shown that the critical undercooling of segregationless solidification is △T0=474 K. At the maximum undercooling of 207 K, the growth velocity of primary copper phase exceeds to 37 mm/s, and the distinct solute trapping occurs. | Yao Wenjing Xiujun Han Bingbo Wei | 2002 | Chinese Science Bulletin2002，47，15： | 3 |
| 4 | Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors. | Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang | 2022 | Cell Research2022，32，11： | 2 |
| 5 | Microstructural Evolution of Rapidly Solidified Co-Mo and Ni-Mo Eutectic Alloys显示文摘Droplets of Co-37.6 wt pct Mo and Ni-47.7 wt pct Mo eutectic alloys were rapidly solidified during containerless processing in a 3 m drop tube. A kind of anomalous eutectic appears in these two eutectic alloys when undercooling is beyond 56 and 61 K, respectively. The two eutectic phases in anomalous eutectic were observed to grow in dendrite manner. The formation of anomalous eutectic is ascribed to the cooperative dendrite growth of the two independently nucleated eutectic phases. Current dendrite and eutectic growth theories are applied to describe the observed processes. | Xiujun HAN, Wenjing YAO and Bingbo WEDepartment of Applied Physics, Northwestern Polytechnical University, Xi’an 710072, China | 2003 | Journal of Materials Science & Technology2003，19，6： | 1 |
| 6 | Effect of the addition of Al-Ti-C master alloy on the microstructure and microhardness of a cast Al-10Mg alloy显示文摘The microstructure and microhardness of a cast Al-10wt%Mg (henceforth Al-10Mg) alloy with 0.2wt% addition of Al-5Ti-0.25C master alloy were compared with those of a refiner-free alloy of similar chemical composition. It was found that this level ofthe master alloy addition not only caused an effective grain refinement, but also caused a significant increase in the microhardness ofthe Al-10Mg alloy. Microchemical analysis revealed that TiC particles existed in the grain center. The relationship between the holdingtime and grain size was also studied. It shows that the grain refining efficiency is faded observably with the holding time. This is ex-plained in terms of the instability of TiC particles. | Kuibo Yin Xiufang Bian Na Han Xiujun Yao Yan Zhao Jiankun Zhou | 2006 | Journal of University of Science and Technology Beijing2006，13，2： | 0 |
| 7 | Cognitive-affective regulation process for micro-expressions based on Gaussian cloud distribution显示文摘 | Xiujun Yang Lun Xie Jing Han Zhiliang Wang | 2017 | CAAI Transactions on Intelligence Technology2017，2，1： | 0 |
| 8 | Competitive Nucleation and Rapid Growth of Co-Si Intermetallic Compounds during Eutectic Solidification under Containerless Processing Condition显示文摘The liquid-solid transitions of (Co2Si+CoSi) and (CoSi+CoSi2) eutectic alloys were realized in drop tube and the rapid eutectic growth mechanism of intermetallic compounds was examined. The experimental and calculated results indicate that with increasing Co content, the intermetallic compound prefers nucleating primarily. The eutectic microstructures experience the transitions of 'lamellar-anomalous-divorced' eutectic with undercooling. In undercooled state, the growth of CoSi intermetallic compound always lags behind others, and no matter how large the undercooling is, this intermetallic compound grows under the solutal diflusion control. The calculated coupled zone demonstrates that (Co2Si+CoSi) eutectic can form within certain undercooling regime, when the composition is in the range from 23.6% to 25.4% Si. And the calculated coupled zone of (CoSi+CoSi2) covers a composition range from 40.8% to 43.8% Si. | Wenjing Yao Zipeng Ye Nan Wang Xiujun Han Jianyuan Wang Xixing Wen | 2011 | Journal of Materials Science & Technology2011，27，11： | 0 |
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