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| 1 | Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes显示文摘The objective was to investigate the effect of kinsenoside(Kin) treatments on macrophage polarity and evaluate the resulting protection of chondrocytes to attenuate osteoarthritis(OA) progression.RAW264.7 macrophages were polarized to M1/M2 subtypes then administered with different concentrations of Kin. The polarization transitions were evaluated with quantitative real-time polymerase chain reaction(q RT-PCR), confocal observation and flow cytometry analysis. The mechanism of Kin repolarizing M1 macrophages was evaluated by Western blot. Further, macrophage conditioned medium(CM) and IL-1β were administered to chondrocytes. Micro-CT scanning and histological observations were conducted in vivo on anterior cruciate ligament transection(ACLT) mice with or without Kin treatment. We found that Kin repolarized M1 macrophages to the M2 phenotype. Mechanistically, Kin inhibited the phosphorylation of IκBα, which further reduced the downstream phosphorylation of P65 in nuclear factor-κB(NF-κB) signaling. Moreover, Kin inhibited mitogen-activated protein kinases(MAPK) signaling molecules p-JNK, p-ERK and p-P38. Additionally, Kin attenuated macrophage CM and IL-1β-induced chondrocyte damage. In vivo, Kin reduced the infiltration of M1 macrophages,promoted M2 macrophages in the synovium, inhibited subchondral bone destruction and reduced articular cartilage damage induced by ACLT. All the results indicated that Kin is an effective therapeutic candidate for OA treatment. | Feng Zhou Jingtian Mei Xiuguo Han Hanjun Li Shengbing Yang Minqi Wang Linyang Chu Han Qiao Tingting Tang | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 35 |
| 2 | Degradation of chlorpyrifos in laboratory soil and its impact on soil microbial functional diversity显示文摘Degradation of chlorpyrifos at different concentrations in soil and its impact on soil microbial functional diversity were investigated under laboratory condition.The degradation half-live of chlorpyrifos at levels of 4,8,and 12 mg/kg in soil were calculated to be 14.3,16.7,and 18.0 d,respectively.The Biolog study showed that the average well color development(AWCD) in soils was significantly(P < 0.05) inhibited by chlorpyrifos within the first two weeks and thereafter recovered to a similar level as the control.A similar variation in the diversity indices(Simpson index 1/D and McIntosh index U) was observed,but no significant difference among the values of the Shannon-Wiener index H was found in chlorpyrifos-treated soils.With an increasing chlorpyrifos concentration,the half-life of chlorpyrifos was significantly(P 0.05) extended and its inhibitory effect on soil microorganisms was aggravated.It is concluded that chlorpyrifos residues in soil had a temporary or short-term inhibitory effect on soil microbial functional diversity. | FANG Hua YU Yunlong CHU Xiaoqiang WANG Xiuguo YANG Xiaoe YU Jingquan | 2009 | Journal of Environmental Sciences2009，21，3： | 25 |
| 3 | Carbendazim induces a temporary change in soil bacterial community structure显示文摘The effect of carbendazim applications on the diversity and structure of a soil bacterial community was studied under field conditions using temperature gradient gel electrophoresis (TGGE) and partial sequence analysis of PCR-amplified 16S rRNA gene. After four successive introductions of carbendazim at a level of 0.94 kg active ingredient (a.i.)/ha, the genetic diversity (expressed as Shannon index, H ) decreased from 1.43 in the control to 1.29 in treated soil. This harmful effect seems to increase with the concentration of carbendazim. The value of H in the soil treated with carbendazim at 4.70 kg a.i./ha was reduced to 1.05 (P 0.05). The structure of soil bacterial community was also affected after four repeated applications of carbendazim at levels of 0.94, 1.88 and 4.70 kg a.i./ha, as seen in the relative intensities of the individual band. However, the bacterial community in carbendazim-treated soil recovered to that in the control 360 d after the first treatment. The results indicated that repeated applications of carbendazim could reduce soil microbial diversity and alter the bacterial community structure temporarily. | WANG Xiuguo, SONG Min, GAO Chunming, DONG Bin, ZHANG Qun, FANG Hua, YU Yunlong Department of Plant Protection, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310029, China. | 2009 | Journal of Environmental Sciences2009，21，12： | 3 |
| 4 | Treatment of Enzymolysis Wastewater by Centrifugation- Coagulation- Fenton Reagent Oxidation- Adsorption Process显示文摘[Objective]The study aimed to discuss the optimal conditions for the treatment of enzymolysis wastewater by centrifugation-coagulation-Fenton reagent oxidation-adsorption process.[Method]According to the water-quality characteristics of wastewater from a heparin sodium production factory of Jiangsu Province,enzymolysis wastewater was segregated from intestinal lavage wastewater and treated through centrifugation-coagulation-Fenton reagent oxidation-adsorption process,and the optimal technical parameters were determined.[Result]After enzymolysis wastewater was centrifuged at a speed of 4 000 rpm,0.6 g/L CTS as the coagulant was added to the supernatant.Hereafter,pH of the coagulated effluent was adjusted to 3,and then 1.5%(V/V)H2O2was added to the coagulated effluent;a certain amount of ferrous sulfate(n H2O2∶n FeSO4·7H2O=8∶1)was added to the mixture;the reaction conducted for 30 min,and then solution pH was adjusted to about9.Finally,the oxidized effluent flowed through a resin red until the adsorptive capacity reached 240 BV,and COD of the effluent water was lower than 100 mg/L,meeting the Grade-I standard of Comprehensive Discharge Standard of Sewage(GB8978-1996).[Conclusion]The research could provide a new process for the treatment of enzymolysis wastewater. | Jian Zhai Chunhua Jiang Guoqing Cao Xiuguo Lu | 2013 | Meteorological and Environmental Research2013，4，9： | 3 |
| 5 | Highly Efficient Photoelectrocatalytic Reduction of CO2 to Methanol by a p–n Heterojunction CeO2/CuO/Cu Catalyst显示文摘Photoelectrocatalytic reduction of CO2 to fuels has great potential for reducing anthropogenic CO2 emissions and also lessening our dependence on fossil fuel energy.Herein,we report the successful development of a novel photoelectrocatalytic catalyst for the selective reduction of CO2 to methanol,comprising a copper catalyst modified with flower-like cerium oxide nanoparticles(CeO2 NPs)(a n-type semiconductor)and copper oxide nanoparticles(CuO NPs)(a p-type semiconductor).At an applied potential of−1.0 V(vs SCE)under visible light irradiation,the CeO2 NPs/CuO NPs/Cu catalyst yielded methanol at a rate of 3.44μmol cm^−2 h^−1,which was approximately five times higher than that of a CuO NPs/Cu catalyst(0.67μmol cm^−2 h^−1).The carrier concentration increased by^108 times when the flower-like CeO2 NPs were deposited on the CuO NPs/Cu catalyst,due to synergistic transfer of photoexcited electrons from the conduction band of CuO to that of CeO2,which enhanced both photocatalytic and photoelectrocatalytic CO2 reduction on the CeO2 NPs.The facile migration of photoexcited electrons and holes across the p–n heterojunction that formed between the CeO2 and CuO components was thus critical to excellent light-induced CO2 reduction properties of the CeO2 NPs/CuO NPs/Cu catalyst.Results encourage the wider application of composite semiconductor electrodes in carbon dioxide reduction. | Zhengbin Pan Ershuan Han Jingui Zheng Jing Lu Xiaolin Wang Yanbin Yin Geoffrey INWaterhouse Xiuguo Wang Peiqiang Li | 2020 | Nano-Micro Letters2020，12，2： | 3 |
| 6 | Treatment of Intestinal Lavage Wastewater by Coagulation-ASBR-SBR Process显示文摘[Objective]The study aimed to discuss the optimal conditions for the treatment of intestinal lavage wastewater by coagulation-ASBR-SBR process.[Method]According to the water-quality characteristics of wastewater from a heparin sodium production factory of Jiangsu Province,intestinal lavage wastewater was segregated from enzymolysis wastewater and treated using coagulation-ASBR-SBR process,and the effects of PFS dosage,HRT of ASBR and SBR reactor on the removal rate of COD and NH+4-N were analyzed.[Result]The best dosage of PFS was 0.15 g/L,and the optimal HRT of ASBR reactor was 36 h,while the best HRT of SBR reactor was 15 h.Under the optimal conditions above,the removal rate of COD and NH+4-N reached 99.1%and 97.3%respectively,and the quality of the effluent water could reach the first standard of Comprehensive Discharge Standard of Sewage(GB8978-1996).[Conclusion]The research could provide a new process for the treatment of intestinal lavage wastewater. | Jian Zhai Chunhua Jiang Guoqing Cao Xiuguo Lu | 2013 | Meteorological and Environmental Research2013，4，8： | 2 |
| 7 | Advanced Mueller matrix ellipsometry:Instrumentation and emerging applications显示文摘Mueller matrix ellipsometry(MME)provides the 4×4 Mueller matrix of a sample under test,which determines how the state of polarization is changed as light interacts with the sample.Due to the redundant information contained in the Mueller matrix,MME has gained more and more extensive applications in the characterization of surfaces,interfaces,thin films,and nanostructures.In addition,the instrumentation of MME has also achieved great developments since its advent in the 1970 s.In this paper,we will first review the basic principle as well as the common system layouts of MME for the full Mueller matrix measurement.Then,the basic procedure of ellipsometry data analysis is reviewed.After that,some new developments in MME in our lab for different applications are introduced,including the broadband MME,the high-resolution imaging MME,and the high-speed MME.Some emerging applications of the developed MMEs are also presented.Conclusions and perspectives of the advanced ellipsometry are finally drawn and discussed. | CHEN XiuGuo GU HongGang LIU JiaMin CHEN Chao LIU ShiYuan | 2022 | Science China(Technological Sciences)2022，65，9： | 2 |
| 8 | Apparent ages of suspended sediment and soil erosion of the Pearl River (Zhujiang) drainage basin显示文摘The carbon isotopic composition (Δ 14 C,δ 13 C) and apparent ages of suspended sediment were determined in the Pearl River in the years 1998,2000 and 2005.These results indicate that suspended POC consists mostly of young carbon and some 'old carbon'.Apparent ages of suspended POC range from 540 to 2050 a BP.The apparent ages are older in the Xijiang and Beijiang Rivers,while these values are variable in the Dongjiang River,including old and young samples.The suspended POCδ 13 C values increase with increasing Δ 14 C in the Pearl River,indicating that its source is soil and bedrock from depths under 15 30 cm.Since the organic carbon of the surface soil is quickly decomposed when it enters the rivers,its carbon isotopic characteristics are insignificant in suspended sediment.In the Pearl River drainage basin,there are areas with more severe soil erosion than others.For example,erosion is much more severe in the Xijiang River drainage basin when compared to the light soil erosion in the Dongjiang River drainage basin. | WEI XiuGuo SHEN ChengDe LI NingLi WANG FuShun DING Ping WANG Ning GUO ZhiXing LIU KeXin | 2010 | Chinese Science Bulletin2010，55，15： | 2 |
| 9 | Preparation, morphology and properties of muhilamellar barrier materials based on blends of high-density polyethylene and copolyester显示文摘 | Cui Xiuguo Wang Xiaodong | 2006 | J Appl Polym Sci2006，101，6： | 1 |
| 10 | Desoxyepothilone B: An efficacious microtubule-targeted antitumor ag ent with a promising in vivo profile relative to epothilone B显示文摘 | Xiuguo Zhang Balog-Aaron | 1998 | Proceeding s of the National Academy of Sciences of the United States of America1998，95，16： | 1 |
| 11 | The effect of verapamil on the pharmacokineues of paclitaxel in rats显示文摘 | Jun-Shik Choia Xiuguo Lia | 2005 | European Journal of Pharmaceutical Sciences2005，24，： | 1 |
| 12 | Estimation of the convergence order of rigorous coupled-wave analysis for OCD metrology显示文摘 | Ma Yuan Liu Shiyuan Chen Xiuguo | | 0，，： | 1 |
| 13 | ~4C as a tool for evaluating riverine POC sources and erosion of the Zhujiang (Pearl River) drainage basin, South China 显示文摘 | Wei Xiuguo Yi Weixi Shen Chengde Yechieli Y Li Ningli Ding Ping Wang Ning Liu Kexin | 2010 | Nucl Instrum Methods Phys Res Sect B2010，268，7： | 1 |
| 14 | Formal Verification for CCML Based Web Service Composition显示文摘 | Zhang Xiuguo Liu Hongbo | 2011 | Information Technology Journal2011，10，9： | 1 |
| 15 | Techni- cal and Professional Skills Development in Practice Course fur Advance Manufacturing Technology with Modern Information Technology 显示文摘 | DongMin Zhang YanYun Wu XiuGuo Shen | 2011 | Advances in Computer Science Environment Ecoinformatics and Education Communications in Computer and Information Science 20112011，，217： | 1 |
| 16 | Enhanced bioavail- ability of tamoxifen after oral administration of tamoxifen with quereetin in rats显示文摘 | Sang-Chul Shin JunShik Choi Xiuguo Li | 2006 | Int J Pharm2006，313，12： | 1 |
| 17 | Effect of ionomers on mechanical properties, morphology, and rheology of polyoxymethylene and its blends with methyl methacrylate-styrene-butadiene copolymer 显示文摘 | Wang Xiaodong Cui Xiuguo | 2005 | European Polymer Journal2005，41，4： | 1 |
| 18 | Remote Absolute Roll-Angle Measurement in Range of 180°Based on Polarization Modulation显示文摘Remote measurement of object orientation is often required in many applications.Out of the six degrees of freedom(DoF)that determine object orientation in space,the roll angle is the most difficult to measure using optical methods.In this letter,we propose a remote Stokes roll-angle sensor that measures roll angles from the detected Stokes vectors of modulated polarized light retroreflected from a sensing unit comprised simply of a retarder and a planar reflection mirror.Experimental results have shown that the proposed sensor can realize absolute roll angle measurement in an unprecedented range of 180°with a maximum absolute error of less than 0.25°and a measurement resolution of better than 0.01°.The proposed sensor adopts a coaxial design and takes the advantages of compactness,simplicity and low cost,and moreover,can be further expanded to a three-DoF angle sensor due to the sensitivity of the sensing unit to other two kinds of angles(pitch and yaw). | Xiuguo Chen Jinbao Liao Honggang Gu Chuanwei Zhang Hao Jiang Shiyuan Liu | 2020 | Nanomanufacturing and Metrology2020，3，3： | 1 |
| 19 | Synthesis and morphological investigation of ordered SBA-15-type mesoporous silica with an amphiphilic triblock copolymer template under various conditions显示文摘 | Jin Zhengwei Wang Xiaodong Cui Xiuguo | 2008 | Colloids and Surfaces A:Physicochem Engineering Aspects2008，316，13： | 1 |
| 20 | Contents and sources of polycyclic aromatic hydrocarbons and organochlorine pesticides in vegetable soils of Guangzhou, China显示文摘 | Laiguo Chen Yong Ran Baoshan Xing Bixian Mai Jianghua He Xiuguo Wei Jiamo Fu Guoying Sheng | 2005 | Chemosphere2005，，7： | 1 |
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