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| 1 | Classification of Complex Reservoirs in Superimposed Basins of Western China显示文摘许多通过重叠在西方的中国的沉积的盆被形成并且混合至少二以前开发了沉积的盆,一般来说,他们能作为复杂的附加的盆被称为。这些盆和单型盆之间的不同差别是他们在地质的历史上的不连续的 stratigraphic 沉积, stratigraphic 结构和 stratigraphic 压力紧张行动。在结构的节上基于按年代先后的年龄的关联,附加的盆能在这研究被划分成五种类型:(1 ) 连续沉积类型附加了盆,(2 ) 中间、迟了的 stratigraphic 附加了盆,(3 ) 早、迟了的 stratigraphic 附加了盆,(4 ) 早、中间的 stratigraphic 附加了盆,并且(5 ) 长期的暴露的附加的盆。多重 source-reservoir-caprock 集合在如此的盆发展了。另外,多级式的烃产生和逐出,多重来源,多不的烃累积和多重类型的烃水库调整,改革和破坏发生在这些盆。在附加的盆广泛地被发现了到日期的复杂水库从这的原因正在合拢的主要水库,和根有显著地不同的地质的特征,剥光和破裂效果象联系渗出物一样在附加的盆由多相的构造事件引起了,散开,掉下,氧化,降级并且裂开。基于他们的开始特征,复杂水库被划分成五个范畴:(1 ) 主要水库,(2 ) 套住调整类型水库,(3 ) 部件变体水库,(4 ) 分阶段执行变换类型水库并且(5 ) 改革规模的水库。 | PANG Xiongqi ZHOU Xinyuan LIN Changsong HUO Zhipeng LUO Xiaorong PANG Hong | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 11 |
| 2 | Temperature dependent conductivity of Bi_4Ti_3O_(12) ceramics induced by Sr dopants显示文摘Bi_4Ti_3O_(12) is an important lead-free ferroelectric material.Doping modification of Bi_4Ti_3O_(12)has attracted great attention to improving its performances.In this work,the effect of Sr dopants on the microstructure,dielectric,and conductivity of Bi_4Ti_3O_(12) ceramic was investigated by XRD,SEM,and AC impedance spectroscopy.Substitution of 1 at%Sr for Bi decreased the grain size,suppressed the dielectric dispersion of Bi_4Ti_3O_(12) ceramic at room temperature,and resulted in different effects on the conductivity of grains and grain boundaries.The conductivity of grains in Bi_4Ti_3O_(12) ceramic was increased by the small amount of Sr dopants in the whole experimental temperature range.While the grain boundaries of 1 at%Sr-doped Bi_4Ti_3O_(12) exhibited lower conductivity than pure Bi_4Ti_3O_(12) below~380℃and higher conductivity above~380℃.The experimental phenomena were interpreted in term of compensating defects for Sr dopants. | Lin WANG Mengqi GUI Hai-Bo JIN Xinyuan HU Yongjie ZHAO Naseer Muhammad ADNAN Jing-Bo LI | 2018 | Journal of Advanced Ceramics2018，7，3： | 3 |
| 3 | Long-term variations of X-ray pulse profiles for the Crab pulsar:data analysis and modeling显示文摘The pulse profiles of the Crab pulsar(as well as some other pulsars)vary with time.They can lead to a major source of intrinsic timing noise,which lacks a detailed physical model.The phase separation?between the first left peak(P1)and the second right peak(P2)is a key parameter that shows the variations of pulse profiles for the Crab pulsar.It was found that the evolution of?has a tendency with increasing rates of 0.82?±0.25?,0.80?±0.54?,and 0.77?±0.28?per century for the 2-6,6-15,and15-60 ke V bands,respectively.Furthermore,the flux ratios(P2/P1)of X-ray pulse profiles in the three bands were calculated,and the derived flux ratios were consistent with the radio and X-ray measurements of the Insight-HXMT.In addition to discovering the physical origin of the pulse changes,the high-SNR X-ray pulse profiles were simulated in the annular gap model,and two model parameters(e.g.,the maximum emission heights of the two peaks)were observed to slightly affect the variations of peak separation.We fitted the long-term variations of emission heights of the two peaks and discovered that the emission heights showed increasing tendencies with time.Variations of these emission heights induced a characteristic period derivative,and a complete formula for both the magnetic dipole radiation and wind-particle-induced variations of the moment of inertia was used for the pulsar’s spin-down to obtain the variation rate˙αof the magnetic inclination angle,which was-1.60?per century.Intrinsic timing noise is observed to be mainly induced by the variations of pulse profiles,which might correlate with a characteristic spin period derivative arising from the fluctuations of the emission regions.This work will lay a foundation for understanding the origin of intrinsic timing noise and making high-precision timing models in the future. | LunHua Shang YuanJie Du XiangQun Cui ShiJun Dang JiGuang Lu JunTao Bai QiJun Zhi YouLi Tuo LinLi Yan LiangWei Huang XinYuan Zhang XiaoMin Bei QingQing Lin GuoJun Qiao Hua Shen RiHong Zhu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 2 |
| 4 | Effects of grain boundary diffusion of PrCu alloy on microstructure and coercivity of hot deformed(Nd,Ce)-Fe-B magnets显示文摘The technology of using high abundance rare earth element Ce in permanent magnets has attracted many concerns.In this work,the magnetic properties and microstructures of hot deformed(Nd_(1-x)Ce_(x))_(13.8)Fe_(76.1)Co_(4)Ga_(0.5)B_(5.6) magnets and a selective magnet treated with PrCu grain boundary diffusion process(GBDP) were investigated systematically.It is found that Ce is beneficial to improving the plastic deformation ability of NdFeB magnets.The strongest c-axis orientation is achieved in the HD magnets with Ce concentration of x=0.3,resulting in good comprehensive magnetic properties of B_(r)=13.00 kGs,H_(cj)=10.12 kOe,(BH)_(max)=38.42 MGOe.Based on that,the GBDP was implemented on the magnets with the best orientation using Pr_(68)Cu_(32) ribbons and the magnetic properties of B_(r)=12.87 kGs,H_(cj)=15.65 kOe,(BH)_(max)=37.48 MGOe were obtained.The results of composition distribution and Curie temperature test of the GBDPed magnets illustrate that Pr diffuses into the(Nd,Ce)_(2)(Fe,Co)_(14)B grains to substitute Ce,which not only improves the Curie temperature of the grains,but also enhances the magnetic performance of the magnets.Through GBDP,the thermal stability of magnets has also been improved. | Haijun Peng Dunbo Yu Xinyuan Bai Xiao Lin Yongjun Mao Zilong Wang Yang Luo | 2021 | Journal of Rare Earths2021，39，8： | 1 |
| 5 | Endothelial Notch activation promotes neutrophil transmigration via downregulating endomucin to aggravate hepatic ischemia/reperfusion injury显示文摘Inflammatory leukocytes infiltration is orchestrated by mechanisms involving chemokines,selectins,addressins and other adhesion molecules derived from endothelial cells(ECs),but how they respond to inflammatory cues and coordinate leukocyte transmigration remain elusive.In this study,using hepatic ischemia/reperfusion injury(HIRI)as a model,we identified that endothelial Notch activation was rapidly and dynamically induced in liver sinusoidal endothelial cells(LSECs)in acute inflammation.In mice with EC-specific Notch activation(NICeCA),HIRI induced exacerbated liver damage.Consistently,endothelial Notch activation enhanced neutrophil infiltration and tumor necrosis factor(TNF)-αexpression in HIRI.Transcriptome analysis and further qRT-PCR as well as immunofluorescence indicated that endomucin(EMCN),a negative regulator of leukocyte adhesion,was downregulated in LSECs from NICeCA mice.EMCN was downregulated during HIRI in wild-type mice and in vitro cultured ECs insulted by hypoxia/re-oxygenation injury.Notch activation in ECs led to increased neutrophil adhesion and transendothelial migration,which was abrogated by EMCN overexpression in vitro.In mice deficient of RBPj,the integrative transcription factor of canonical Notch signaling,although overwhelming sinusoidal malformation aggravated HIRI,the expression of EMCN was upregulated;and pharmaceutical Notch blockade in vitro also upregulated EMCN and inhibited transendothelial migration of neutrophils.The Notch activation-exaggerated HIRI was compromised by blocking LFA-1,which mediated leukocyte adherence by associating with EMCN.Therefore,endothelial Notch signaling controls neutrophil transmigration via EMCN to modulate acute inflammation in HIRI. | Peiran Zhang Kangyi Yue Xinli Liu Xianchun Yan Ziyan Yang Juanli Duan Congcong Xia Xinyuan Xu Mei Zhang Liang Liang Lin Wang Hua Han | 2020 | Science China(Life Sciences)2020，63，3： | 1 |
| 6 | Research on Reconfigurable Hydraulic Robot Configuration Based on Genetic Algorithm显示文摘 | Lin Jiang Hongwei Zhang Xianbao Xiang Xinyuan Chen Jie Zhao | 2011 | International Review on Computers and Software2011，，： | 1 |
| 7 | Study on the Microscopic Network Model of PVA Hydrogel Based on the Tensile Behavior显示文摘Hydrogel is an emerging material widely used in the biological field.The tensile properties of hydrogel mainly depend on its polymer network,but due to the complex microstructure of the network,some properties of the hydrogel have yet to be qua nt itatively analyzed.In this article,we built a three-dimensional random fiber net work to characterize the micros tructure of a hydrogel.The fibers were simplified as elastic beams,and the cross-links were regarded as'hinges.'Combined with the macroscopic experimental results,the influence of the change of fiber length and the relationship between the polymer content and the cross-link density were studied.The model was verified by the quasi-static tensile test results of real PVA hydrogel materials with different fiber contents.The results show that the model can well match the tensile stress-strain curve and tensile strength of the PVA hydrogels with different fiber contents.The change in micros true ture of the fiber network induces nonlinear behaviors,and although the cross-link number increases with the increase in polymer content,the cross-link density(per unit PVA chain length)of the PVA hydrogel slightly decreases as the content increases. | Kejia Xu Liqun Tang Yongrou Zhang Rong Ding Xinyuan Wang Dafei Huang Jiansheng Lin | 2019 | Acta Mechanica Solida Sinica2019，32，5： | 1 |
| 8 | Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches显示文摘Artificial intelligence(AI)models usually require large amounts of high-quality training data,which is in striking contrast to the situation of small and biased data faced by current drug discovery pipelines.The concept of federated learning has been proposed to utilize distributed data from different sources without leaking sensitive information of the data.This emerging decentralized machine learning paradigm is expected to dramatically improve the success rate of AI-powered drug discovery.Here,we simulated the federated learning process with different property and activity datasets from different sources,among which overlapping molecules with high or low biases exist in the recorded values.Beyond the benefit of gaining more data,we also demonstrated that federated training has a regularization effect superior to centralized training on the pooled datasets with high biases.Moreover,different network architectures for clients and aggregation algorithms for coordinators have been compared on the performance of federated learning,where personalized federated learning shows promising results.Our work demonstrates the applicability of federated learning in predicting drug-related properties and highlights its promising role in addressing the small and biased data dilemma in drug discovery. | Zhaoping Xiong Ziqiang Cheng Xinyuan Lin Chi Xu Xiaohong Liu Dingyan Wang Xiaomin Luo Yong Zhang Hualiang Jiang Nan Qiao Mingyue Zheng | 2022 | Science China(Life Sciences)2022，65，3： | 1 |
| 9 | Fabrication of porous scaffolds with protein nanogels显示文摘A novel type of porous scaffold was fabricated from single protein nanogels. The nanogels with single protein as core and crosslinked polymer network as shell were prepared through a two-step procedure including surface acryloylation and in situ radical polymerization. The formation of single protein nanogels was verified by matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometer, transmission electron microscopy (TEM) and dynamic light scattering (DLS) analyses. Subsequently, the porous scaffolds were fabricated through a solvent evaporating process of aqueous nanogel solutions. The porous scaffolds were characterized by Fourier transform infrared (FTIR), scanning electronic microscopy (SEM), atomic force microscopy (AFM), and fluorescence microscopy. Interestingly, the obtained porous nanogel scaffolds presented multi-level porous morphologies with macro and nano scale pores, providing better spaces and microenvironments than normal macro porous scaffolds. Cell proliferation assay of nanogels showed low cytotoxicity. Considering that both the protein species and polymer constitutes can be pre-designed and adjusted, these multi-level porous nanogel scaffolds are promising candidates for tissue culture applications. | ZHU Qi YAN Ming HE Lin ZHU XinYuan LU YunFeng YAN DeYue | 2011 | Science China Chemistry2011，54，6： | 1 |
| 10 | First Record of Petalodus Owen,1840(Chondrichthyes,Petalodontidae)in the Lower Permian(Cisuralian)of China显示文摘The Petalodontiformes are a small intriguing group of Permo–Carboniferous chondrichthyans.Petalodus is the longest known petalodont genus generally considered representative of the order.The first definite fossil record of seven well-preserved Petalodus teeth has been found in the Qianshi limestone in the Lower Permian(Cisuralian)middle–upper Taiyuan Formation in Yangquan City,Shanxi Province,North China.The specimens are characterized by petal-shaped teeth with a spade-like crown,and a long,tongue-shaped root;the crown is circled with a band or cingulum composed of imbricated ridges at the base.All seven teeth are assigned to the species P.ohioenesis because of their vertically narrow cingulum and much longer root.Petalodus is a worldwide genus,with fossil localities mainly concentrated in the Laurussia supercontinent.The occurrence of Petalodus teeth in Yangquan not only is the first fossil record in China,but also only the second record in Asia.The Yangquan fossil site was part of the paleoequatorial North China Craton during the Early Permian,and was isolated from Laurusia and East Gondwana by the Paleo-Tethys Ocean.The successful dispersal of Petalodus from Laurusia to the North China Block along Paleo-Tethys may support the possibility that Petalodus taxa were active free-swimmers rather than bottom dwellers.The new finding increases the petalodont diversity in eastern Asia,and also sheds new light on the distribution and stratigraphic range. | GAI Zhikun BAI Zhijun LIN Xianghong MENG Xinyuan ZHANG Junwen | 2021 | Acta Geologica Sinica(English Edition)2021，95，4： | 0 |
| 11 | Sensitively detecting antigen of SARS-CoV-2 by NIR-Ⅱ fluorescent nanoparticles显示文摘Early detection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection is an efficient way to prevent the spread of coronavirus disease 2019(COVID-19).Detecting SARS-CoV-2 antigen can be rapid and convenient,but it is still challenging to develop highly sensitive methods for effective diagnosis.Herein,a lateral flow assay(LFA)based on fluorescent nanoparticles emitting in the second near-infrared(NIR-II)window is developed for sensitive detection of SARS-CoV-2 antigen.Benefiting from the NIR-II fluorescence with high penetration and low autofluorescence,such NIR-II based LFA allows enhanced signal-to-background ratio,and the limit of detection is down to 0.01 ng·mL^(−1)of SARS-CoV-2 antigen.In the clinical swab sample tests,the NIR-II LFA outperforms the colloidal gold LFA with higher overall percent agreement with the polymerase chain reaction test.The clinical samples with low antigen concentrations(~0.015–~0.068 ng·mL^(−1))can be successfully detected by the NIR-II LFA,but fail for the colloidal gold LFA.The NIR-II LFA can provide a promising platform for highly sensitive,rapid,and cost-effective method for early diagnosis and mass screening of SARS-CoV-2 infection. | Ruibin Hu Tao Liao Yan Ren Wenming Liu Rui Ma Xinyuan Wang Qihui Lin Guoxin Wang Yongye Liang | 2022 | Nano Research2022，15，8： | 0 |
| 12 | Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation显示文摘Lkb1 deficiency confers the Kras-mutant lung cancer with strong plasticity and the potential for adeno-to-squamous transdifferentiation(AST).However,it remains largely unknown how Lkb1 deficiency dynamically regulates AST.Using the classical AST mouse model(Kras LSL-G12D/+;Lkb1flox/flox,KL),we here comprehensively analyze the temporal transcriptomic dynamics of lung tumors at different stages by dynamic network biomarker(DNB)and identify the tipping point at which the Wnt signaling is abruptly suppressed by the excessive accumulation of reactive oxygen species(ROS)through its downstream effector FOXO3A.Bidirectional genetic perturbation of the Wnt pathway using two different Ctnnb1 conditional knockout mouse strains confirms its essential role in the negative regulation of AST.Importantly,pharmacological activation of the Wnt pathway before but not after the tipping point inhibits squamous transdifferentiation,highlighting the irreversibility of AST after crossing the tipping point.Through comparative transcriptomic analyses of mouse and human tumors,we find that the lineage-specific transcription factors(TFs)of adenocarcinoma and squamous cell carcinoma form a“Yin-Yang”counteracting network.Interestingly,inactivation of the Wnt pathway preferentially suppresses the adenomatous lineage TF network and thus disrupts the“Yin-Yang”homeostasis to lean towards the squamous lineage,whereas ectopic expression of NKX2-1,an adenomatous lineage TF,significantly dampens such phenotypic transition accelerated by the Wnt pathway inactivation.The negative correlation between the Wnt pathway and AST is further observed in a large cohort of human lung adenosquamous carcinoma.Collectively,our study identifies the tipping point of AST and highlights an essential role of the ROS-Wnt axis in dynamically orchestrating the homeostasis between adeno-and squamous-specific TF networks at the AST tipping point. | Zhaoyuan Fang Xiangkun Han Yueqing Chen Xinyuan Tong Yun Xue Shun Yao Shijie Tang Yunjian Pan Yihua Sun Xue Wang Yujuan Jin Haiquan Chen Liang Hu Lijian Hui Lin Li Luonan Chen Hongbin Ji | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 13 | Tracing drug release process with dual-modal hyperbranched polymer-gold nanoparticle complexes显示文摘Dual-modal surface enhanced Raman spectrum(SERS)-fluorescence polymer/metal hybrid complexes have been prepared for tracing drug release process in tumor cells. Firstly, the hyperbranched poly((S-(4-vinyl) benzyl S′-propyltrithiocarbonate)-co-(poly(ethylene glycol) methacrylate))(HPVBEG) was synthesized via the combination of reversible addition-fragmentation chain-transfer(RAFT) polymerization and self-condensing vinyl polymerization(SCVP). Subsequently, the anticancer drug doxorubicin(DOX) was linked to HPVBEG via pH sensitive Schiff base bonds to form HPVBEG-g-DOX conjugates.Through aminolysis reaction, HPVBEG-g-DOX was coordinated with gold nanoparticles(GNP), resulting in the formation of HPVBEG-g-DOX/GNP complexes. In neutral condition, the HPVBEG-g-DOX/GNP complexes were stable, and DOX was bound to the surface of GNPs. Therefore, the SERS of DOX could be observed, while the fluorescence of DOX was quenched by GNPs. Under an acidic environment, DOX was released from the surface of GNPs with breakage of Schiff base bonds.Thus, the SERS signal of DOX was gradually reduced. Correspondingly, the fluorescence signal of DOX was enhanced.Through dual-modal SERS-fluorescence technique, the DOX delivery and release process was traced in tumor cells. Moreover,the viability of MCF-7 cells incubated with HPVBEG-g-DOX/GNP complexes was investigated by Cell Counting Kit-8(CCK-8) assay. The experimental results showed that HPVBEG-g-DOX/GNP complexes had similar proliferation inhibition effect compared with free DOX. Definitely, the dual-modal SERS-fluorescence complexes for tracing drug delivery and release will have promising prospects on tumor diagnosis and therapy. | Yuanyuan Zhuang Dali Wang Chunhui Yin Hongping Deng Mo Sun Lin He Yue Su Xinyuan Zhu | 2016 | Science China Chemistry2016，59，12： | 0 |
| 14 | PanGu Drug Model: learn a molecule like a human显示文摘Dear Editor,Recent achievements in large-scale pre-trained models like GPT-3 and PanGu-α have demonstrated astounding performances in many downstream tasks of natural language processing (NLP),confirming AI to be user-oriented for even industrial applications.Deep learning has been recognized as the most promising technology for pharmaceuticals,a powerful molecule pre-trained model that could economize researchers’tons of time.For the strategic application of AI capabilities to the drug discovery field,we pre-trained a model called PanGu Drug Model with 1.7 billion small molecules from ZINC20 (Irwin et al.,2020),DrugSpaceX(Yang et al.,2021),and UniChem (Chambers et al.,2013). | Xinyuan Lin Chi Xu Zhaoping Xiong Xinfeng Zhang Ningxi Ni Bolin Ni Jianlong Chang Ruiqing Pan Zidong Wang Fan Yu Qi Tian Hualiang Jiang Mingyue Zheng Nan Qiao | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 15 | Sb_(2)Se_(3) film with grain size over 10μm toward X-ray detection显示文摘Direct X-ray detectors are considered as competitive next-generation X-ray detectors because of their high spatial resolution,high sensitivity,and simple device configuration.However,their potential is largely limited by the imperfections of traditional materials,such as the low crystallization temperature of α-Se and the low atomic numbers of α-Si and α-Se.Here,we report the Sb_(2)Se_(3) X-ray thin-film detector with a p-n junction structure,which exhibited a sensitivity of 106.3 μC/(Gyair·cm^(2))and response time of<2.5 ms.This decent performance and the various advantages of Sb_(2)Se_(3),such as the average atomic number of 40.8 and μτ product(μ is the mobility,and τ is the carrier lifetime)of 1.29×1O^(-5) cm^(2)/V,indicate its potential for application in X-ray detection. | Chong WANG Xinyuan DU Siyu WANG Hui DENG Chao CHEN Guangda NIU Jincong PANG Kanghua LI Shuaicheng LU Xuetian LIN Haisheng SONG Jiang TANG | 2021 | Frontiers of Optoelectronics2021，14，3： | 0 |
| 16 | Crafting of plasmonic Au nanoparticles coupled ultrathin BiOBr nanosheets heterostructure: steering charge transfer for efficient CO_(2) photoreduction显示文摘Integrating semiconductor photocatalysts with outstanding visible light absorption and fast surface/interface charge transfer kinetics is still an enormous challenge for efficient CO_(2)photoreduction.In this work,the Au nanoparticles have been coupled with ultrathin BiOBr nanosheets,the formed heterostructure(Au/BiOBr)pos-sesses a localized surface plasmon resonance(LSPR)and enhances the visible light absorption ability,as well as forms a fast charge transport channel on the interface between Au and BiOBr.Thus,the heterostructure photo-catalyst exhibits higher photocatalytic CO_(2)to CO performance(135.3/16.43μmol g^(-1))than that of BiOBr(89.0/6.46μmol g^(-1))under 300 W Xe lamp and visible light(λ>400 nm)irradiation for 5 h,respectively.Finally,the in situ FT-IR spectroscopy revealed CO_(2)photoreduction process and found that the*COOH is the key intermediate for CO_(2)to CO.This work provides an effective method to construct multielectron transfer scheme for efficient photocatalytic CO_(2)reduction. | Gaopeng Liu Lin Wang Xin Chen Xingwang Zhu Bin Wang Xinyuan Xu Ziran Chen Wenshuai Zhu Huaming Li Jiexiang Xia | 2022 | Green Chemical Engineering2022，3，2： | 0 |
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