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| 1 | Cellulose synthesis genes CESA6 and CSI1 are important for salt stress tolerance in Arabidopsis显示文摘Soil salinity is a widespread abiotic stress constraint threatening agricultural production,as it severely inhibits growth and development of crops.Several salt stress signaling pathways have been discovered in the model plant Arabidopsis thaliana,which include components for sensing the stress,transmitting the signal and regulating the downstream genes(Deinlein et al.2014;Julkowska | Shuang-Shuang Zhang Le Sun Xinran Dong Sun-Jie Lu Weidong Tian Jian-Xiang Liu | 2016 | Journal of Integrative Plant Biology2016，58，7： | 9 |
| 2 | Simultaneous Curvature and Temperature Sensing Based on a Novel Mach-Zehnder Interferometer显示文摘A novel fiber inline Mach-Zehnder interferometer(MZI)is proposed for simultaneous measurement of curvature and temperature.The sensor composes of single mode-multimode-dispersion compensation-multimode-single mode fiber(MMF-DCF-MMF)structure,using the direct fusion technology.The experimental results show curvature sensitivities of−12.82 nm/m^(−1) and−14.42 nm/m^(−1) in the range of 0−0.65 m^(−1) for two resonant dips,as well as temperature sensitivities of 57.6 pm/and 74.3℃pm/within the range of 20℃℃−150.In addition,℃the sensor has unique advantages of easy fabrication,low cost,high fringe visibility of 24 dB,and high sensitivity,which shows a good application prospect in dual-parameters of sensing of curvature and temperature. | Xiaoyan SUN Haifeng DU Xinran DONG Youwang HU Ji’an DUAN | 2020 | Photonic Sensors2020，10，2： | 4 |
| 3 | Short-Term and Continuing Stresses Differentially Interplay with Multiple Hormones to Regulate Plant Survival and Growth显示文摘压力植物激素, abscisic 酸(骆驼毛的织物) ,在便于植物熬过并且成长 undera 很好起重要作用压力条件的宽范围。主要集中于对短期的骆驼毛的织物处理的植物回答的以前的基因表示研究,而是持续骆驼毛的织物处理和他们的差别的效果糟糕被学习。这里,我们为 1h 或 9 d 与骆驼毛的织物对待植物,并且我们的染色体宽的分析显示差别在二个条件下面调整了基因是 tremendouslydifferent。我们分析了由把他们已知的应答的基因的整个集合用作集成他们的生合成的反馈规定的 reportersand 表明变化的另外的荷尔蒙。我们发现了那,在短期的骆驼毛的织物处理下面,表明 outputsof 支持生长的荷尔蒙, brassinosteroids 和赤霉素,和关於生命的压力应答的荷尔蒙, jasmonic 酸, weresignificantly 禁止了,当表明产量的植物生长素和乙烯被支持时。然而,支撑了骆驼毛的织物处理 repressedcytokinin 并且赤霉素发信号,但是刺激了植物生长素发信号。用荷尔蒙相关的异种的几个集合,我们包括受体或抄写管理者,在相应神经质的发信号小径的 foundcandidates 是到骆驼毛的织物的必要 inresponding。我们的调查结果显示骆驼毛的织物依赖者的相互作用在植物在不同层次 areinvolved 与荷尔蒙强调信号在短暂应力下面幸存并且适应继续紧张的 environments.Key 词: | Cangjing Yang Jingjing Liu Xinran Dong Zhenying Cai Weidong Tian Xuelu Wang | 2014 | Molecular Plant2014，7，5： | 4 |
| 4 | Wind tunnel experiments on dust emissions from different landform types显示文摘The measurement and assessment of dust emissions from different landforms are important to understand the atmospheric loading of PM10(particulate matter ≤10 μm aerodynamic diameter) and to assess natural sources of dust; however, the methodology and technique for determining the dust still present significant research challenges. In the past, specialized field observation and field wind tunnel studies have been used to understand the dust emission. A series of wind tunnel tests were carried out to identify natural sources of dust and measure the magnitudes of dust emissions from different landforms. The method used in this study allowed the measurement of the PM10 emission rate using a laboratory based environmental boundary layer wind tunnel. Results indicated that PM10 emissions demonstrated strong temporal variation and were primarily driven by aerodynamic entrainment. Sand dunes, playa, and alluvial fans had the largest dust emission rates(0.8–5.4 mg/(m^2·s)) while sandy gravel, Gobi desert and abandoned lands had the lowest emission rates(0.003–0.126 mg/(m^2·s)). Dust emissions were heavily dependent on the surface conditions, especially the availability of loose surface dust. High dust emissions were a result of the availability of dustparticle materials for entrainment while low dust emissions were a result of surface crusts and gravel cover. Soil surface property(surface crusts and gravel cover) plays an important role in controlling the availability of dust-sized particles for entrainment. The dust emission rate depended not only on the surface conditions but also on the friction velocity. The emission rate of PM10 varies as a power function of the friction velocity. Although dynamic abrasion processes have a strong influence on the amount of dust entrainment, aerodynamic entrainment may provide an important mechanism for dust emissions. Large volumes of dust entrained by aerodynamic entrainment cannot only occur at low shear velocity without saltation, but may dominate the entrainment process in many arid and semi-arid environments. So it may also be responsible for large magnitude dust storms. Playa and alluvial fan landforms, prior to developing a surface crust, may be the main sources of dust storms in Qinghai Province. | WU Wei YAN Ping WANG Yong DONG Miao MENG Xiaonan JI Xinran | 2018 | Journal of Arid Land2018，10，4： | 3 |
| 5 | Integrating remotely sensed water stress factor with a crop growth model for winter wheat yield estimation in the North China Plain during 2008–2018显示文摘Accurate estimation of regional-scale crop yield under drought conditions allows farmers and agricultural agencies to make well-informed decisions and guide agronomic management. However, few studies have focused on using the crop model data assimilation(CMDA) method for regional-scale winter wheat yield estimation under drought stress and partial-irrigation conditions. In this study, we developed a CMDA framework to integrate remotely sensed water stress factor(MOD16 ET PET) with the WOFOST model using an ensemble Kalman filter(En KF) for winter wheat yield estimation at the regional scale in the North China Plain(NCP) during 2008–2018. According to our results, integration of MOD16 ET PETwith the WOFOST model produced more accurate estimates of regional winter wheat yield than open-loop simulation. The correlation coefficient of simulated yield with statistical yield increased for each year and error decreased in most years, with r ranging from 0.28 to 0.65 and RMSE ranging from 700.08 to1966.12 kg ha. Yield estimation using the CMDA method was more suitable in drought years(r = 0.47, RMSE = 919.04 kg ha) than in normal years(r = 0.30, RMSE = 1215.51 kg ha). Our approach performed better in yield estimation under drought conditions than the conventional empirical correlation method using vegetation condition index(VCI). This research highlighted the potential of assimilating remotely sensed water stress factor, which can account for irrigation benefit, into crop model for improving the accuracy of winter wheat yield estimation at the regional scale especially under drought conditions, and this approach can be easily adapted to other regions and crops. | Wen Zhuo Shibo Fang Dong Wu Lei Wang Mengqian Li Jiansu Zhang Xinran Gao | 2022 | The Crop Journal2022，10，5： | 3 |
| 6 | High-risk phenotypes of genetic disease in a Neonatal Intensive Care Unit population显示文摘To the Editor: Genetic diseases contribute to 35% of deaths during the first year of life and are a significant cause of intensive care.[1] A previous study based on the China Neonatal Genomes Project investigated the genetic causes of early infant deaths and found that >25% of deceased neonates with genetic diagnoses can be cured if diagnosed in time.[2] Therefore, it is crucial to target and diagnose neonates with genetic diseases as early as possible. According to our experience, the typical phenotypes, such as special facial features or multiple congenital anomalies (MCAs), indicate a high risk of genetic disease and lead physicians to perform genetic testing in neonates as early as possible. However, in practice, infants without typical phenotypes typically undergo a long and costly diagnostic process before genetic diagnoses are confirmed. Moreover, a recent survey by the American College of Medical Genetics and Genomics (ACMG) and other national professional organizations indicated that there are insufficient numbers of qualified geneticists to fulfil genetic service needs.[3] The ACMG published the general clinical features for genetic testing indications. For example, patients with phenotypes or family history data that strongly implicate a genetic cause may undergo genetic testing.[1] However, the study indicated that many genetic conditions arise de novo or are inherited with no family history.[1] A previous study attempted to apply the non-phenotype-driven panel approach in neonates admitted to the neonate intensive care unit (NICU).[4] However, at present, the diagnostic yield is only 3.45% (1/29).[4] In addition, the economic and ethical issues associated with genomic screening remain challenging. Therefore, the available indications for genetic testing may improve the management of genetic diseases. | Tiantian Xiao Qi Ni Huiyao Chen Huijun Wang Lin Yang Bingbing Wu Yun Cao Guoqiang Cheng Laishuan Wang Liyuan Hu Hongfang Mei Yulan Lu Mengchun Gong Xinran Dong Wenhao Zhou | 2022 | Chinese Medical Journal2022，，5： | 2 |
| 7 | Kidney injury molecule-1 is a potential receptor for SARS-CoV-2显示文摘COVID-19 patients present high incidence of kidney abnormalities,which are associated with poor prognosis and mortality.The identification of SARS-CoV-2 in the kidney of COVID-19 patients suggests renal tropism of SARS-CoV-2.However,whether there is a specific target of SARS-CoV-2 in the kidney remains unclear.Herein,by using in silico simulation,coimmunoprecipitation,fluorescence resonance energy transfer,fluorescein isothiocyanate labeling,and rational design of antagonist peptides,we demonstrate that kidney injury molecule-1(KIM1),a molecule dramatically upregulated upon kidney injury,binds with the receptor-binding domain(RBD)of SARS-CoV-2 and facilitates its attachment to cell membrane,with the immunoglobulin variable Ig-like(Ig V)domain of KIM1 playing a key role in this recognition.The interaction between SARS-CoV-2 RBD and KIM1 is potently blockaded by a rationally designed KIM1-derived polypeptide AP2.In addition,our results also suggest interactions between KIM1 Ig V domain and the RBDs of SARS-CoV and MERS-CoV,pathogens of two severe infectious respiratory diseases.Together,these findings suggest KIM1 as a novel receptor for SARS-CoV-2 and other coronaviruses.We propose that KIM1 may thus mediate and exacerbate the renal infection of SARS-CoV-2 in a‘vicious cycle’,and KIM1 could be further explored as a therapeutic target. | Chen Yang Yu Zhang Xia Zeng Huijing Chen Dong Yang Yuchen Chen Ziwei Shen Xiaomu Wang Xinran Liu Mingrui Xiong Hong Chen Kun Huang | 2021 | Journal of Molecular Cell Biology2021，13，3： | 2 |
| 8 | Protective humoral immunity in SARS-CoV-2 infected pediatric patients显示文摘After the rapid spread of SARS-CoV-2 in Wuhan,China,at the beginning of 2020,about 1.5 million confirmed cases and over 80,000 deaths have been reported around 200 countries and territories all over the world and the number continues to increase.However,we still have limited knowledge of this new coronavirus,especially the interaction between SARS-CoV-2 and our immune system. | Yaguang Zhang Jin Xu Ran Jia Chunyan Yi Wangpeng Gu Pengcheng Liu Xinran Dong Hao Zhou Bo Shang Shipeng Cheng Xiaoyu Sun Jing Ye Xuezhen Li Jia Zhang Zhiyang Ling Liyan Ma Bingbing Wu Mei Zeng Wenhao Zhou Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，7： | 2 |
| 9 | NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis显示文摘Lung cancer,which is exacerbated by environmental pollution and tobacco use,has become the most common cause of cancer-related deaths worldwide,with a five-year overall survival rate of only 19%(Siegel et al.,2020;Yang et al.,2020;Yu and Li,2020).Nearly 85%of lung cancers are non-small cell lung cancers,of which lung adenocarcinoma is the most common subtype accounting for 50%of non-small cell lung cancer cases.At present,radiotherapy is the primary therapeutic modality for lung cancer at different stages,with significant prolongation of survival time(Hirsch et al.,2017;Bai et al.,2019;Shi et al.,2020). | Lisha ZHOU Changsheng DONG Zhuoming XU Xinran WANG Luyi ZHANG Siyuan CHEN Jiahao CHEN Yingying ZHU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 2 |
| 10 | High Sensitive Refractive Index Sensor Based on Cladding Etched Photonic Crystal Fiber Mach-Zehnder Interferometer显示文摘A high sensitive refractive index sensor based on the cladding etched photonic crystal fiber (PCF) Mach-Zehnder interferometer (MZI) is proposed, which is spliced a section of photonic crystal fiber between two single modes fibers (SMFs).The interference fringe of the MZI shifts with the variation of the ambient refractive index (RI). It is found that the RI sensitivity slightly decrease with an increase in the interference length. The sensitivities of MZI with 35inm PCF, 40mm PCF, and 45mm PCF are 106.19nm/RIU, 93.33nm/RIU, and 73.64nm/RIU, respectively, in the range of 13.33 to 1.381. After etched, the RI sensitivity of the MZI could be improved obviously. The RI sensitivities of the MZI with 35 mm PCF are up to 211.53nm/RIU and 359.37nm/RIU when the cladding diameter decreases to 112(im and 91 pm, respectively. Moreover, the sensor is insensitive to temperature, and the measured sensitivity is only 9.21 pm/℃ with the range from 20℃ to 500℃. In addition, the sensor has advantage of simple fabrication, low cost, and high RI sensitivity. | Haifeng DU Xiaoyan SUN Youwang HU Xinran DONG Jianhang ZHOU | 2019 | Photonic Sensors2019，9，2： | 2 |
| 11 | Deletion of CHD8 in cerebellar granule neuron progenitors leads to severe cerebellar hypoplasia,ataxia,and psychiatric behavior in mice显示文摘CHD8 is a candidate gene for autism spectrum disorders and neurological development delay.It has been reported to be essential for neurogenesis in the cerebral cortex,but the function of CHD8 in cerebellum has not been comprehensively investigated.The potential relationship of cerebellum dysplasia with psychiatric disorders in patients with CHD8 mutations is still not clear.In this study,we establish different conditional knockout mouse models to investigate the roles of CHD8 in cerebellar development.Mice with neural stem cell-specific Chd8 deletion exhibit significant reduction of cerebellum volume and no layering structure is detected.Genetic deletion of Chd8 in cerebellar granule neuron progenitors(GNPs)leads to cerebellar hypoplasia,absent of proliferation layer and ectopic of Purkinje neuron.However,no substantial cerebellar dysplasia is detected in mice with Purkinje neuron-or oligodendrocyte-specific Chd8 ablation.Single-cell RNA sequencing indicates that ribosome-related genes and pathways are most significantly disrupted in GNPs,indicating the potential mechanism.Importantly,in addition to the ataxia phenotype,mice with GNPspecific Chd8 ablation present a neuropsychiatric phenotype in three-chamber and light/dark tests.Taken together,our results provide insights not only into the function of CHD8 in cerebellar development,but also the pathogenesis of neuropsychiatric disorders in patients with CHD8 mutations. | Xiang Chen Tong Chen Chen Dong Huiyao Chen Xinran Dong Lin Yang Liyuan Hu Huijun Wang Bingbing Wu Ye Yao Yu Xiong Man Xiong Yifeng Lin Wenhao Zhou | 2022 | Journal of Genetics and Genomics2022，49，9： | 1 |
| 12 | Spectral and biodistributional engineering of deep near-infrared chromophore显示文摘Fluorescence-guided surgery calls for development of near-infrared fluorophores.Despite the wide-spread application and a safe clinical record of Indocyanine Green(ICG),its maximal absorption wavelength at780 nm is rather short and longer-wavelength dyes are desired to exploit such benefits as low phototoxicity and deep penetration depth.Here,we report ECY,a stable deep near-infrared(NIR)fluorochromic scaffold absorbing/emitting at 836/871 nm with a fluorescence quantum yield of 16%in CH_(2)Cl_(2).ECY was further rationally engineered for biological distribution specificity.Analogous bearing different numbers of sulfonate group or a polyethylene glycol chain were synthesized.By screening this focused library upon intravenous injection to BALB/c mice,ECYS2 was identified to be a suitable candidate for bioimaging of organs involved in hepatobiliary excretion,and ECYPEG was found to be a superior candidate for vasculature imaging.They have potentials in intraoperative imaging. | Yan Dong Xicun Lu Yi Li Weichao Chen Lei Yin Jie Zhao Xinru Hu Xinran Li Zuhai Lei Yuyang Wu Hao Chen Xiao Luo Xuhong Qian Youjun Yang | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 13 | Morphological and heterojunctional engineering of two-dimensional porous Mo-Ni based catalysts for highly effective catalytic reduction of aromatic nitro compounds显示文摘Hydrogenation reactions play crucial roles on chemical synthesis and pollutant elimination.The improvement of the ability to activate reactants and increase of the contact probability between the catalysts and reactants are positive to improve the catalytic performance.Herein,we have reported the design of two-dimensional porous Ni-Ni_(3)N-Ni Mo N heterojunction sheets(2D Mo-Ni based nanosheets)for efficient catalytic hydrogenation of the aromatic nitro-compounds.The heterojunction interfaces provide plentiful active sites to improve the activating ability of the catalyst on the reactants.Additionally,the 2D porous structure facilitates not only the contact of catalytic sites with reactants but also mass transfer and diffusion,both of which are favorable to accelerating the hydrogenation process.As a result,the optimized sample of 2D Mo-Ni sheet exhibits good activity for the hydrogenation of aromatic nitro-compounds by converting 0.2 mmol/L(30 mL)of p-nitrophenol to p-aminophenol within 45 s with good recyclability.The activation energy and the reaction rate at 25℃ is 31.11 k J/mol and 0.0796 s^(-1),respectively,both of which surpass most of reported non-noble metal catalysts and rivals with most noble metal-based catalysts.The combination of late and early transition metals provides an innovative way to obtain outstanding catalysts for the hydrogenation. | Zexu Fang Ying Gu Xinran Dong Gen Zhang Lin Li Xiaoguang Zhou Chungui Tian | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 14 | Two-dimensional porous Cu-CuO nanosheets: Integration of heterojunction and morphology engineering to achieve high-effective and stable reduction of the aromatic nitro-compounds显示文摘The morphology and heterojunction engineering are effective ways to boost the performance of Cubased catalysts. Herein, we have reported the designed synthesis of two-dimensional Cu-Cu O heterojunction nanosheets(2D Cu-Cu O NS) based on 3-aminopropyl-triethoxysilane(APTES, KH550) aided synthetic strategy. The APTES can act as both the ligand and alkali(-OH) source to guide the large-scale synthesis of 2D Cu-based precursor, which can transform into 2D Cu-Cu O NS by the controllable post-treatment.The Si species from APTES can protect the particles from the severe aggregation and growth, guaranteeing the formation of 2D sheets composed of small-sized Cu-Cu O heterojunction(about 20 nm). The heterojunction interfaces can provide plentiful active sites to boost the catalytic ability. The 2D sheets can provide large accessible surface, being conducive to the contact of the catalyst and reactants. Benefiting from above virtues, the 2D Cu-Cu O NS showed the superior catalytic performance for the reduction of a series of nitro compounds, being superior to most reported non-noble metal-based catalysts. Notably,it exhibited good re-cycled performance with no obvious performance degradation after 10 consecutive catalysis. The present study will be promising to promote the application of the Cu-based catalysts, due to its ability to control the morphology and potential for the large-scale synthesis. | Xinran Dong Zexu Fang Ying Gu Xiaoguang Zhou Chungui Tian | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 15 | CYP2C9^(*)3 Increases the Ibuprofen Response of Hemodynamically Significant Patent Ductus Arteriosus in the Infants with Gestational Age of More Than 30 Weeks显示文摘Hemodynamically significant patent ductus arteriosus(hsPDA)is a severe condition in newborns.Ibuprofen is an effective treatment to reduce the severe complications and the need for surgical treatment.Several single-nucleotide polymorphisms(SNPs)were related to the ibuprofen metabolism,treatment effects,and the onset of side effects.The effects of SNPs on hsPDA response after ibuprofen treatment are unknown.Therefore,in this study,we recruited hsPDA patients with standard ibuprofen treatment.Those patients had participated in China Neonatal Genomes Project(CNGP,ClinicalTrials.gov Identifier:NCT03931707)with next-generation sequencing data.We reanalyzed the sequencing data and compared the allele frequencies of known ibuprofen-related SNPs between ibuprofen Responder and Non-responder groups.In total,185 hsPDA patients were recruited with gestational age(GA)ranging from 24 to 40 weeks.No significant differences were detected in the basic information,period of ibuprofen treatment,rate of conservative treatment,complications,and side effects between ibuprofen Responder group and Non-responder group.Totally,17 hsPDA carried CYP2C9^(*)3 and one with CYP2C9^(*)2 were detected.In the GA group of more than 30 GA weeks(GA>30 wks group),we found higher allele frequency of CYP2C9^(*)3 in Responder group than in Non-responder group(16%vs.0,p=0.0391).In the GA group of less than 30 GA weeks(GA≤30 wks group),the sum allele frequency of CYP2C9^(*)3 and CYP2C9^(*)2 had no stastical difference between two groups(Responder group vs.Non-responder group,13%vs.11%,p=0.768).Therefore,we came to conclude that genetic tests of CYP2C9^(*)3 site may benefit the prediction of ibuprofen treatment outcome for hsPDA patients with gestational age of more than 30 weeks. | Xiang Chen Yuxi Chen Tiantian Xiao Xinran Dong Yulan Lu Yanyan Qian Huijun Wang Wenhao Zhou | 2022 | Phenomics2022，2，1： | 0 |
| 16 | PICOTEES:a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants from Chinese children cohorts显示文摘The growth in biomedical data resources has raised potential privacy concerns and risks of genetic information leakage. For instance, exome sequencing aids clinical decisions by comparing data through web services, but it requires significant trust between users and providers. To alleviate privacy concerns, the most commonly used strategy is to anonymize sensitive data. Unfortunately, studies have shown that anonymization is insufficient to protect against reidentification attacks. Recently, privacy-preserving technologies have been applied to preserve application utility while protecting the privacy of biomedical data. We present the PICOTEES framework, a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants (http://gffzz63bc6e6362d14768svbpnbqv0v6c06xnq.ffgz.tsg.suse.edu.cn/). PICOTEES enables privacy-preserving queries of the phenotype spectrum for a single variant by utilizing trusted execution environment technology, which can protect the privacy of the user's query information, backend models, and data, as well as the final results. We demonstrate the utility and performance of PICOTEES by exploring a bioinformatics dataset. The dataset is from a cohort containing 20,909 genetic testing patients with 3,152,508 variants from the Children's Hospital of Fudan University in China, dominated by the Chinese Han population (>99.9%). Our query results yield a large number of unreported diagnostic variants and previously reported pathogenicity. | Xinran Dong Yulan Lu Lanting Guo Chuan Li Qi Ni Bingbing Wu Huijun Wang Lin Yang Songyang Wu Qi Sun Hao Zheng Wenhao Zhou Shuang Wang | 2024 | Journal of Genetics and Genomics2024，51，2： | 0 |
| 17 | High‑Resolution and Multidimensional Phenotypes Can Complement Genomics Data to Diagnose Diseases in the Neonatal Population显示文摘Advances in genomic medicine have greatly improved our understanding of human diseases.However,phenome is not well understood.High-resolution and multidimensional phenotypes have shed light on the mechanisms underlying neonatal diseases in greater details and have the potential to optimize clinical strategies.In this review,we first highlight the value of analyzing traditional phenotypes using a data science approach in the neonatal population.We then discuss recent research on high-resolution,multidimensional,and structured phenotypes in neonatal critical diseases.Finally,we briefly introduce current technologies available for the analysis of multidimensional data and the value that can be provided by integrating these data into clinical practice.In summary,a time series of multidimensional phenome can improve our understanding of disease mechanisms and diagnostic decision-making,stratify patients,and provide clinicians with optimized strategies for therapeutic intervention;however,the available technologies for collecting multidimensional data and the best platform for connecting multiple modalities should be considered. | Tiantian Xiao Xinran Dong Yulan Lu Wenhao Zhou | 2023 | Phenomics2023，3，2： | 0 |
| 18 | The Information Efficiency of QFII's Investment in China's Capital Market显示文摘This paper takes stock price synchronization and price delay as indicators of information efficiency, and uses mixed cross-sectional data of listed companies into which Qualified Foreign Institutional Investors(QFII) have made investments, to study the impact of QFII's investment behaviors on the information efficiency of China's stock market. The results show that QFII's investments can improve the information efficiency of China's stock market, but its impact is varied. The impact of QFII's investments on market information efficiency is more significant in bear markets than in bull markets, the impact on private enterprises is more significant than on state-owned enterprises, and the impact on Small and Medium Enterprises(SME) market is more significant than in main board market. Further research also finds that QFII has a certain threshold effect on the information efficiency of China's stock market. This research paper provides a problem-solving perspective for China's capital markets to achieve information efficiency through opening up, and at the same time warns against financial risks. | Sun Xianchao Zhao Xiaolei Liu Xinran Dong Jianming | 2021 | Contemporary Social Sciences2021，6，2： | 0 |
| 19 | Precision medicine via the integration of phenotype-genotype information in neonatal genome project显示文摘The explosion of next-generation sequencing(NGS)has enabled the widespread use of genomic data in precision medicine.Currently,several neonatal genome projects have emerged to explore the advantages of NGS to diagnose or screen for rare genetic disorders.These projects have made remarkable achievements,but still the genome data could be further explored with the assistance of phenotype collection.In contrast,longitudinal birth cohorts are great examples to record and apply phenotypic information in clinical studies starting at the neonatal period,especially the trajectory analyses for health development or disease progression.It is obvious that efficient integration of genotype and phenotype benefits not only the clinical management of rare genetic disorders but also the risk assessment of complex diseases.Here,we first summarize the recent neonatal genome projects as well as some longitudinal birth cohorts.Then,we propose two simplified strategies by integrating genotypic and phenotypic information in precision medicine based on current studies.Finally,research collaborations,sociological issues,and future perspectives are discussed.How to maximize neonatal genomic information to benefit the pediatric population remains an area in need of more research and effort. | Xinran Dong Tiantian Xiao Bin Chen Yulan Lu Wenhao Zhou | 2022 | Fundamental Research2022，2，6： | 0 |
| 20 | Genomic diversity and ecological distribution of marine Pseudoalteromonas phages显示文摘Pseudoalteromonas,with a ubiquitous distribution,is one of the most abundant marine bacterial genera.It is especially abundant in the deep sea and polar seas,where it has been found to have a broad metabolic capacity and unique co-existence strategies with other organisms.However,only a few Pseudoalteromonas phages have so far been isolated and investigated and their genomic diversity and distribution patterns are still unclear.Here,the genomes,taxonomic features and distribution patterns of Pseudoalteromonas phages are systematically analyzed,based on the microbial and viral genomes and metagenome datasets.A total of 143 complete or nearly complete Pseudoalteromonas-associated phage genomes(PSAPGs)were identifed,including 34 Pseudoalteromonas phage isolates,24 proviruses,and 85 Pseudoalteromonas-associated uncultured viral genomes(UViGs);these were assigned to 47 viral clusters at the genus level.Many integrated proviruses(n=24)and flamentous phages were detected(n=32),suggesting the prevalence of viral lysogenic life cycle in Pseudoalteromonas.PSAPGs encoded 66 types of 249 potential auxiliary metabolic genes(AMGs)relating to peptidases and nucleotide metabolism.They may also participate in marine biogeochemical cycles through the manipulation of the metabolism of their hosts,especially in the phosphorus and sulfur cycles.Siphoviral and flamentous PSAPGs were the predominant viral lineages found in polar areas,while some myoviral and siphoviral PSAPGs encoding transposase were more abundant in the deep sea.This study has expanded our understanding of the taxonomy,phylogenetic and ecological scope of marine Pseudoalteromonas phages and deepens our knowledge of viral impacts on Pseudoalteromonas.It will provide a baseline for the study of interactions between phages and Pseudoalteromonas in the ocean. | Kaiyang Zheng Yue Dong Yantao Liang Yundan Liu Xinran Zhang Wenjing Zhang Ziyue Wang Hongbing Shao Yeong Yik Sung Wen Jye Mok Li Lian Wong Andrew McMinn Min Wang | 2023 | Marine Life Science & Technology2023，5，2： | 0 |
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