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| 1 | The discovery of Palaeoproterozoic volcanic rocks in the Bulunkuoler Group from the Tianshuihai Massif in Xinjiang of Northwest China and its geological significance显示文摘In the Dabudaer region of the Tianshuihai Massif (Xinjiang, Northwest China), metavolcanic rocks within the mainly meta-sedimentary Bulunkuoler Group are basalt, basaltic andesite, and rhyolite. In situ zircon U-Pb LA-ICP-MS dating on rhyolite magmatic zircons yielded an age of 2481±14 Ma, interpreted as the eruption age of the Bulunkuoler Group volcanic rocks. The basalt and basaltic andesite are low-Al tholeiite series and the rhyolite is low-Al calc-alkaline series. All of rocks are charac-terized by enrichment of LREE and LILE (Rb, Th and Ba), depletion of P, Nb, Ta and Ti, and absence of Eu anomalies. The εNd(t) of basalts ranges from 3.14 to 4.88 indicating a depleted mantle source. The trace element signatures show that these magmas experienced intense crustal contamination during their ascent. Direct evidence for crustal contamination is the xenocrystic zircons in the ryholite, with ages back to ca. 3300 Ma. The primitive-mantle normalized and Zr/Y-Zr diagrams for the basic volcanic rocks show that they formed in an intra-continental tectonic setting. Combined with the previous studies and compared with North China Craton Neoarchean basic volcanic rocks, it is supposed that the Bulunkuoler Group volcanic rocks reflect the Palaeoproterozoic mantle magma underplating and interaction with felsic crust. | JI WenHua LI RongShe CHEN ShouJian HE ShiPing ZHAO ZhenMing BIAN XiaoWei ZHU HaiPing CUI JiGang REN JuanGang | 2011 | Science China Earth Sciences2011，54，1： | 22 |
| 2 | Global overview of research progress and development of precision maize planters显示文摘Maize is the most important crop for food and widely used for industrial materials,leading to its increasing demand all over the world.Precision planting is the effective method to increase maize yield.To meet the agronomic requirement of precision planting,different kinds of precision maize planters were developed.However,because of the difference of geographical environment,cropping system,farm scale and economic status among different countries,types of maize planters are various and the technologies involved are at different levels.This paper summarizes the precision maize planters currently available in the world and classifies them into four types:precision planters for tilled-land,minimum/no tilled-land,hilly&small land,and cold&arid land.Detailed characteristics have been provided for some typical precision planters and comparisons were made as to their suitability under particular working conditions.High-efficiency and high-accuracy are the main features of precision planters for tilled-land,while the ability to clean residue from seed rows and prevent planters to be blocked are the important function of precision planters for minimum/no tilled-land.To fit for hilly&small land,planters should be light-weighted and small-sized,and to warm up soil and keep moisture,planters for cold&arid land should be equipped with plastic-film mulching mechanism.Finally,developing trend of precision planting technology was analyzed and suggestions,including policy support and technical improvement,were made for developing countries to make suitable precision maize planters according to the local geographical conditions and cropping systems. | Yang Li Yan Bingxin Cui Tao Yu Yiming He Xiantao Liu Quanwei Liang Zhijie Yin Xiaowei Zhang Dongxing | 2016 | International Journal of Agricultural and Biological Engineering2016，9，1： | 17 |
| 3 | Development and application of mechanized maize harvesters显示文摘Maize harvesting is one of the most important filed operations of maize production.As the accelerating development of maize industry,mechanized maize harvesting is widely accepted and used by farmers in the world.According to the harvesting methods,maize harvesters could be classified into two types,one is maize-for-grain harvesters,including pickers and grain harvesters,the other is whole plant harvesters,including forage harvesters and combined grain-stover harvesters.Structure characteristics,appropriate areas and relative technologies of those harvesters are described in this paper,i.e.,pickers are suitable for multi-crop areas,Grain harvesters are mainly for one-crop areas when grain moisture content is lower than 25%,combined grain-stover harvesters are applicable in agro-pastoral ecotone,and forage harvesters are capable in large-scaled animal husbandry farming areas where large amount of silage are required.Meanwhile,the future development trend of the different harvesters is predicted.Big horsepower engines,enhanced working efficiency,automation and intelligence are required by large scaled farms.As maize breeding development,more varieties that are suitable for grain harvesting are put into practice,so grain combine harvesters will be popular in future. | Yang Li Cui Tao Qu Zhe Li Kehong Yin Xiaowei Han Dandan Yan Bingxin Zhao Dongyue Zhang Dongxing | 2016 | International Journal of Agricultural and Biological Engineering2016，9，3： | 13 |
| 4 | Anchor Self-Localization Algorithm Based on UWB Ranging and Inertial Measurements显示文摘Localization systems utilizing Ultra-WideBand(UWB) have been widely used in dense urban and indoor environments. A moving UWB tag can be located by ranging to fixed UWB anchors whose positions are surveyed in advance. However, manually surveying the anchors is typically a dull and time-consuming process and prone to artificial errors. In this paper, we present an accurate and easy-to-use method for UWB anchor self-localization,using the UWB ranging measurements and readings from a low-cost Inertial Measurement Unit(IMU). The locations of the anchors are automatically estimated by freely moving the tag in the environment. The method is inspired by the Simultaneous Localization And Mapping(SLAM) technique used by the robotics community. A tightly-coupled Error-State Kalman Filter(ESKF) is utilized to fuse UWB and inertial measurements, producing UWB anchor position estimates and six Degrees of Freedom(6 DoF) tag pose estimates. Simulated experiments demonstrate that our proposed method enables accurate self-localization for UWB anchors and smooth tracking of the tag. | Qin Shi Sihao Zhao Xiaowei Cui Mingquan Lu Mengdi Jia | 2019 | Tsinghua Science and Technology2019，24，6： | 11 |
| 5 | Thermal decomposition and oxidation of bastnaesite concentrate in inert and oxidative atmosphere显示文摘To clearly elucidate the oxidative roasting behaviors of the bastnaesite, the thermal decomposition and oxidation of the bastnaesite concentrate in inert and oxidative atmosphere have been investigated in detail. Experimental data indicated that the initial decomposition temperature of the concentrate under N_2 atmosphere is 150 ℃ higher than that under O_2 atmosphere,most likely because the oxidation of the cerium induces the decomposition of the concentrate. For the roasted samples under N_2 atmosphere at500 ℃ and above,the oxidation efficiency of the cerium is 19.8%-26.8% because of the fact that rareearth fluorocarbonate is first decomposed to form rare-earth oxyfluoride and CO_2, and the cerium oxyfluoride is then partially oxidized by the CO_2 gas. The rest cerium in these samples can be further oxidized in air at room temperature, with the oxidation efficiency of the cerium gradually increasing to above 80% in 7 d. This can be attributed to the obvious changes in the inner morphology of the roasted samples under N_2 atmosphere at high temperatures, which largely induce the diffusion of the air and improves the oxidation activity of CeOF, and further induces the oxidation of CeOF by the air. XRD and XPS techniques were used to further verify the significant differences in the thermal decomposition behaviors of the bastnaesite concentrate under N_2 and O_2 atmosphere. Moreover, no oxidation of Pr^(3+) to Pr^(4+) in the roasted samples under both N_2 and O_2 atmosphere is observed. This gives an overall understanding of the oxidative roasting of the bastnaesite concentrate without additives. | Longsheng Zhao Liangshi Wang Genghong Shuai Zhiqi Long Dali Cui Xiaowei Huang | 2018 | Journal of Rare Earths2018，36，7： | 10 |
| 6 | Metal-Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications显示文摘Investigation of metal–organic frameworks(MOFs)for biomedical applications has attracted much attention in recent years.MOFs are regarded as a promising class of nanocarriers for drug delivery owing to well-defined structure,ultrahigh surface area and porosity,tunable pore size,and easy chemical functionalization.In this review,the unique properties of MOFs and their advantages as nanocarriers for drug delivery in biomedical applications were discussed in the first section.Then,state-ofthe-art strategies to functionalize MOFs with therapeutic agents were summarized,including surface adsorption,pore encapsulation,covalent binding,and functional molecules as building blocks.In the third section,the most recent biological applications of MOFs for intracellular delivery of drugs,proteins,and nucleic acids,especially aptamers,were presented.Finally,challenges and prospects were comprehensively discussed to provide context for future development of MOFs as efficient drug delivery systems. | Yujia Sun Liwei Zheng Yu Yang Xu Qian Ting Fu Xiaowei Li Zunyi Yang He Yan Cheng Cui Weihong Tan | 2020 | Nano-Micro Letters2020，12，8： | 10 |
| 7 | 1,25-Dihydroxyvitamin D3 protects obese rats from metabolic syndrome via promoting regulatory T cell-mediated resolution of inflammation显示文摘Vitamin D_3 has been found to produce therapeutic effects on obesity-associated insulin resistance and dyslipidemia through its potent anti-inflammatory activity, but the precise immunomodulatory mechanism remains poorly understood. In the present study we found that 1,25-dihydroxyvitamin D_3[1,25(OH)_2D_3], the biologically active form of vitamin D_3, significantly attenuated monosodium glutamate(MSG)-induced obesity and insulin resistance as indicated by body weight reduction, oral glucose tolerance improvement, and a glucose infusion rate increase as detected with hyperinsulinemiceuglycemic clamp. Moreover, 1,25(OH)_2D_3 not only restored pancreatic islet functions but also improved lipid metabolism in insulin-targeted tissues. The protective effects of 1,25(OH)_2D_3 on glycolipid metabolism were attributed to its ability to inhibit an obesity-activated inflammatory response in insulin secretory and targeted tissues, as indicated by reduced infiltration of macrophages in pancreas islets and adipose tissue while enhancing the expression of Tgf-β1 in liver tissue, which was accompanied byincreased infiltration of Treg cells in immune organs such as spleen and lymph node as well as in insulintargeted tissues such as liver, adipose, and muscle. Together, our findings suggest that 1,25(OH)_2D_3 serves as a beneficial immunomodulator for the prevention and treatment of obesity or metabolic syndrome through its anti-inflammatory effects. | Wen Jin Bing Cui Pingping Li Fang Hua Xiaoxi Lv Jichao Zhou Zhuowei Hu Xiaowei Zhang | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 9 |
| 8 | Theoretical and numerical analysis of coal dust separated by centrifugal force for working and heading faces显示文摘In order to meet engineering needs of Chinese underground coal mines,a new dust-collecting fan,a device of dust separated by centrifugal force in driven cyclone passageway(DCCP)was designed.In centrifugal dust removal section(CDRS)of DCCP,a general equation is derived from the principle of force equilibrium.According to CDRS structure parameters and fan running parameters,the general equation is simplified,and the simplest equation is calculated numerically by MATLAB.The calculation results illustrate that increasing quantity of air current is against dust removal,but it is beneficial to dust removal by increasing the radius of driven spiral blade and increasing the particle diameter of coal dust.The conclusions show that the dust-collecting structure parameters coupled with the fan running parameters is a novel optimization approach to dust-collection fan for working and heading faces,which is especially suitable for Chinese underground mines. | Shiqiang Chen Haiqiao Wang Yiqun Li Haijiao Cui Jie Zhao Xiaowei Zhang | 2014 | International Journal of Coal Science & Technology2014，1，3： | 7 |
| 9 | Atg5 regulates late endosome and lysosome biogenesis显示文摘Autophagy is an evolutionarily conserved lysosome-based degradation process.Atg5 plays a very important role in autophagosome formation.Here we show that Atg5 is required for biogenesis of late endosomes and lysosomes in an autophagy-independent manner.In Atg5 cells,but not in other essential autophagy genes defecting cells,recycling and retrieval of late endosomal components from hybrid organelles are impaired,causing persistent hybrid organelles and defective formation of late endosomes and lysosomes.Defective retrieval of late endosomal components from hybrid organelles resulting from impaired recruitment of a component of V1-ATPase to acidic organelles blocks the pH-dependent retrieval of late endosomal components from hybrid organelles.Lowering the intracellular pH restores late endosome/lysosome biogenesis in Atg5 cells.Our data demonstrate an unexpected role of Atg5 and shed new light on late endosome and lysosome biogenesis. | PENG JunYa ZHANG Ran CUI YiTong LIU HaoDong ZHAO XiaoXin HUANG Lei HU MingXu YUAN XiaoXi MA BenYu MA XiaoWei TAKASHI Ueno MASAAKI Komatsu LIANG XingJie YU Li | 2014 | Science China(Life Sciences)2014，57，1： | 6 |
| 10 | Low-complexity method for DOA estimation based on ESPRIT显示文摘A low-complexity method for direction of arrival(DOA) estimation based on estimation signal parameters via rotational invariance technique(ESPRIT) is proposed.Instead of using the cross-correlation vectors in multistage Wiener filter(MSWF),the orthogonal residual vectors obtained in conjugate gradient(CG) method span the signal subspace used by ESPRIT.The computational complexity of the proposed method is significantly reduced,since the signal subspace estimation mainly needs two matrixvector complex multiplications at the iteration of data level.Furthermore,the prior training data are not needed in the proposed method.To overcome performance degradation at low signal to noise ratio(SNR),the expanded signal subspace spanned by more basis vectors is used and simultaneously renders ESPRIT yield redundant DOAs,which can be excluded by performing ESPRIT once more using the unexpanded signal subspace.Compared with the traditional ESPRIT methods by MSWF and eigenvalue decomposition(EVD),numerical results demonstrate the satisfactory performance of the proposed method. | Xuebin Zhuang Xiaowei Cui Mingquan Lu Zhenming Feng | 2010 | Journal of Systems Engineering and Electronics2010，21，5： | 6 |
| 11 | A Robust Graph Optimization Realization of Tightly Coupled GNSS/INS Integrated Navigation System for Urban Vehicles显示文摘This paper describes a robust integrated positioning method to provide ground vehicles in urban environments with accurate and reliable localization results. The localization problem is formulated as a maximum a posteriori probability estimation and solved using graph optimization instead of Bayesian filter. Graph optimization exploits the inherent sparsity of the observation process to satisfy the real-time requirement and only updates the incremental portion of the variables with each new incoming measurement. Unlike the Extended Kalman Filter(EKF) in a typical tightly coupled Global Navigation Satellite System/Inertial Navigation System(GNSS/INS)integrated system, optimization iterates the solution for the entire trajectory. Thus, previous INS measurements may provide redundant motion constraints for satellite fault detection. With the help of data redundancy, we add a new variable that presents reliability of GNSS measurement to the original state vector for adjusting the weight of corresponding pseudorange residual and exclude faulty measurements. The proposed method is demonstrated on datasets with artificial noise, simulating a moving vehicle equipped with GNSS receiver and inertial measurement unit. Compared with the solutions obtained by the EKF with innovation filtering, the new reliability factor can indicate the satellite faults effectively and provide successful positioning despite contaminated observations. | Wei Li Xiaowei Cui Mingquan Lu | 2018 | Tsinghua Science and Technology2018，23，6： | 5 |
| 12 | Extraction kinetics of neodymium from chloride medium using HEH/EHP saponified with magnesium bicarbonate solution显示文摘Magnesium bicarbonate solution is considered as an environmentally friendly extractant saponification agent for the solvent extraction of rare earth elements due to its advantage of minimum water pollution.In order to reveal the extraction regularity, optimize production-process and guide the use of this new extraction system, the extraction of Nd(Ⅲ) in chloride medium with HEH/EHP saponified by magnesium bicarbonate solution was investigated with the self-designed constant interfacial area cell. Besides, the effects of stirring rate, temperature, specific interfacial area and concentration of Mg-HEH/EHP on the extraction rate of Nd(Ⅲ) were systematically investigated. Results show that, the rate of extraction is governed by both diffusion and chemical reaction, and the extraction reaction takes place at the interface. The apparent activation energy of the extraction reaction is 16.88 kJ/mol. The corresponding rate equation is deduced. The mechanisms and rate-determining step are speculated based on interfacial reaction models, which is consistent with the experimental results. | Hao Lv Xiaowei Huang Zongyu Feng Meng Wang Xu Sun Xinlin Peng Dali Cui Yihanna Hu | 2019 | Journal of Rare Earths2019，37，3： | 4 |
| 13 | Recovery of rare earths and aluminum from FCC waste slag by acid leaching and selective precipitation显示文摘This paper investigated the recovery of rare earth elements(REEs) and aluminum(AI) from the waste slag discharged by FCC catalyst factory(FCC waste slag) via acid leaching and selective precipitation.Analysis methods such as ICP-AES, XRF and XRD were applied to obtain experiment data. The maximum leaching efficiency of REEs and Al was achieved at pH value of 1 and with liquid to solid ratio of 4:1,Under such conditions, 91.01%, 92.24% and 94.77% of La, Ce and Al were extracted at 20 ℃ for 2 h from the FCC waste slag, respectively. The SiO_2 content in the leaching residue was 88.3%, which can be used as an available silicon resource. The REEs can be precipitated in the form of REEs and sodium double sulfate(NaRE(SO_4)_2·xH_2 O) by adding Na_2 SO_4 to the leaching solution, while Al remained in the solution. Afterwards, the pH value of the filtrate was adjusted to 4.5, and Al was precipitated as AI(OH)_3. Finally,NaRE(SO_4)_2·xH_2 O and Al(OH)_3 were converted into RECl_3 and Al_2(SO4)_3 solution,respectively, which were recycled to manufacture zeolite. This process recovered REEs and Al from the FCC waste slag and reduced the emissions of waste slag simultaneously, which has an important economic and environment significance. | Jinyu wang Xiaowei Huang Dali Cui Liangshi Wang Zongyu Feng Bin Hu Zhiqi Long Na Zhao | 2017 | Journal of Rare Earths2017，35，11： | 4 |
| 14 | Impacts of Migration on Urban Environmental Pollutant Emissions in China: A Comparative Perspective显示文摘In recent years,researchers have devoted considerable attention to identifying the causes of urban environmental pollution.To determine whether migrant populations significantly affect urban environments,we examined the relationship between urban environmental pollutant emissions and migrant populations at the prefectural level using data obtained for 90 Chinese cities evidencing net in-migration.By dividing the permanent populations of these cities into natives and migrants in relation to the population structure,we constructed an improved Stochastic Impacts by Regression on Population,Affluence and Technology model(STIRPAT)that included not only environmental pollutant emission variables but also variables on the cities’attributes.We subsequently conducted detailed analyses of the results of the models to assess the impacts of natives and migrants on environmental pollutant emissions.The main findings of our study were as follows:1)Migrant populations have significant impacts on environmental emissions both in terms of their size and concentration.Specifically,migrant populations have negative impacts on Air Quality Index(AQI)as well as PM2.5 emissions and positive impacts on emissions of NO2 and CO2.2)The impacts of migrant populations on urban environmental pollutant emissions were 8 to 30 times weaker than that of local populations.3)Urban environmental pollutant emissions in different cities differ significantly according to variations in the industrial structures,public transportation facilities,and population densities. | WANG Guoxia SHI Xiaowei CUI Haiyan JIAO Jing | 2020 | Chinese Geographical Science2020，30，1： | 4 |
| 15 | Quantitative analysis of the performance of vector tracking algorithms显示文摘Vector tracking changes the classical structure of receivers. Combining signal tracking and navigation solution,vector tracking can realize powerful processing capabilities by the fusion technique of receiving channel and feedback correction. In this paper,we try to break through the complicated details of numerical analysis,consider the overall influencing factors of the residual in observed data,and use the intrinsic link between a conventional receiver and a vector receiver. A simple method for performance analysis of the vector tracking algorithm is proposed. Kalman filter has the same steady performance with the classic digital lock loop through the analysis of the relation between gain and band width. The theoretical analysis by the least squares model shows that the reduction of range error is the basis for the superior performance realized by vector tracking. Thus,the bounds of its performance enhancement under weak signal and highly dynamic conditions can be deduced. Simulation results verify the effectiveness of the analysis presented here. | 王前 Cui Xiaowei Liu Jing Zhao Sihao | 2017 | High Technology Letters2017，23，3： | 4 |
| 16 | Design of depth-control planting unit with single-side gauge wheel for no-till maize precision planter显示文摘No-till planters are very popular for maize seeding in fields covered with residue in annual wheat-maize double cropping system in North China Plain.However,there is no suitable depth control mechanism for existing no-till maize planters,and as a result,it is hard to obtain consistent planting depth,uniform emergence,and good passing ability at the same time.For the above reasons,a proper planting unit with a new type of depth-control mechanism was developed in this study.The mechanism consists of a single-side gauge wheel,a parallel four-bar linkage,a pair of double-disc opener,a V-shape press wheel and a depth regulator,which can adjust the planting depth from 30 mm to 90 mm to satisfy the agronomic requirement under different field conditions.Based on analysis and calculation,the width of gauge wheel was set to 50 mm while the length of parallel four-bar linkage was set to 350 mm.Field experiment was conducted and the results indicated that the newly designed planting unit with single-side gauge wheel performed well with regard to planting depth uniformity and anti-blocking ability.The planting depth uniformity and seed spacing quality were 95.45%and 91.90%,respectively,when the average height of stubble was 22.5 cm and residue amount was 0.64 kg/m^(2)in the field.It can satisfy the requirement of no-till maize planting on the cropland with residue and stubble in North China Plain. | Zhang Rui Cui Tao Han Dandan Zhang Dongxing Li Kehong Yin Xiaowei Wang Yunxia He Xiantao Yang Li | 2016 | International Journal of Agricultural and Biological Engineering2016，9，6： | 4 |
| 17 | Numerically stable method of signal subspace estimation based on multistage Wiener filter显示文摘In this paper,a numerically stable method of signal subspace estimation based on Householder multistage Wiener filter(HMSWF) is proposed.Numerical stability of the method lies on the fact that the Householder matrix in HMSWF ensures the unitary blocking operation and significantly strengthens the orthogonality of basis vectors,especially in the finite-precision implementation.In the following,we analyze the numerical stability of HMSWF and MSWF based on the correlation subtractive structure(CSS-MSWF) by establishing the equivalence between the forward recursion of MSWF and the Arnoldi algorithm in numerical linear algebra.Besides,the equivalence between HMSWF and the Householder QR decomposition(QRD) on the Krylov matrix underlying in MSWF is directly established.Based on the relationship,two theoretical upper bounds of the orthogonality error of basis vectors in signal subspace are obtained and it is demonstrated that the orthogonality of basis vectors based on HMSWF is perfectly preserved by the numerically well-behaved Householder matrix,and the corresponding signal subspace estimation is much more numerically stable than that based on CSS-MSWF.Simulations show the numerical stability of the proposed method of signal subspace estimation by HMSWF. | ZHUANG XueBin CUI XiaoWei LU MingQuan FENG ZhenMing | 2010 | Science China(Information Sciences)2010，53，12： | 4 |
| 18 | Hybrid superhydrophilic-superhydrophobic micro/nanostructures fabricated by femtosecond laserinduced forward transfer for sub-femtomolar Raman detection显示文摘Raman spectroscopy plays a crucial role in biochemical analysis.Recently,superhydrophobic surface-enhanced Raman scattering(SERS)substrates have enhanced detection limits by concentrating target molecules into small areas.However,due to the wet transition phenomenon,further reduction of the droplet contact area is prevented,and the detection limit is restricted.This paper proposes a simple method involving femtosecond laser-induced forward transfer for preparing a hybrid superhydrophilic–superhydrophobic SERS(HS-SERS)substrate by introducing a superhydrophilic pattern to promote the target molecules to concentrate on it for ultratrace detection.Furthermore,the HS-SERS substrate is heated to promote a smaller concentrated area.The water vapor film formed by the contact of the solution with the substrate overcomes droplet collapse,and the target molecules are completely concentrated into the superhydrophilic region without loss during evaporation.Finally,the concentrated region is successfully reduced,and the detection limit is enhanced.The HS-SERS substrate achieved a final contact area of 0.013mm2,a 12.1-fold decrease from the unheated case.The reduction of the contact area led to a detection limit concentration as low as 10−16 M for a Rhodamine 6G solution.In addition,the HS-SERS substrate accurately controlled the size of the concentrated areas through the superhydrophilic pattern,which can be attributed to the favorable repeatability of the droplet concentration results.In addition,the preparation method is flexible and has the potential for fluid mixing,fluid transport,and biochemical sensors,etc. | Xiaodan Ma Lan Jiang Xiaowei Li Bohong Li Ji Huang Jiaxing Sun Zhi Wang Zhijie Xu Liangti Qu Yongfeng Lu Tianhong Cui | 2019 | Microsystems & Nanoengineering2019，5，1： | 3 |
| 19 | Antagonism of toll-like receptor 2 attenuates the formation and progression of abdominal aortic aneurysm显示文摘Abdominal aortic aneurysm(AAA) is an inflammatory vascular disorder with high mortality.Accumulating evidence shows that toll-like receptor 2(TLR2) plays a critical role in the regulation of wound-repairing process after tissue injury.We wondered if TLR2 signaling contributed to the pathogenesis of AAA and that targeting TLR2 would attenuate AAA development and progression.In this study,enhanced expression of TLR2 and its ligands were observed in human AAA tissue.Neutralization of TLR2 protected against AAA development and caused established AAA to regress in mouse models of AAA.In addition,TLR2-deficient mice also failed to develop AAA.The prophylactic and therapeutic effects of blocking TLR2 were accompanied by a significant resolution of inflammation and vascular remodeling,as indicated by the decreased expression or activity of MMP-2/9,α-SMA,inflammatory cytokines,and transcription factors NF-κB,AP-1 and STAT1/3 in AAA tissue.Mechanistically,blocking TLR2 decreased the expression and interaction of TLR2 and several endogenousligands,which diminished chronic inflammation and vascular remodeling in the vascular tissue of AAA.Our studies indicate that the interactions between TLR2 and its endogenous ligands contribute to the pathogenesis of AAA and that targeting TLR2 offers great potential toward the development of therapeutic agents against AAA. | Huimin Yan Bing Cui Xiaowei Zhang Xiaoming Fu Jun Yan Xiaoxing Wang Xiaoxi Lv Zhong Chen Zhuowei Hu | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 3 |
| 20 | Effect of grain size on thermal stability and oxygen storage capacity of Ce_(0.17)Zr_(0.73)La_(0.02)Nd_(0.04)Y_(0.04)O_2 solid solutions显示文摘Nanostructured CeO_2-ZrO_2 materials are an irreplaceable constituent in catalytic systems for automobile exhaust purification due to their unique oxygen storage capacity(OSC). However, traditional CeO_2-ZrO_2 materials are easy to sinter at high temperature, which causes a sharp decrease of OSC. In this paper,La^(3+) , Nd^(3+) and Y^(3+) are chosen as dopants for CeO_2-ZrO_2 to improve anti-sintering and OSC properties.The Ce_(0.17) Zr_(0.73) La_(0.02) Nd_(0.04) Y_(0.04) O_2 powders(CZLNY) were prepared by co-precipitation method. The effects of grain sizes with different mixed chlorinated solution concentrations on performances were investigated. X-ray diffraction(XRD) and transmission electron micrograph(TEM) were performed to calculate the grain sizes of CZLNY. The specific surfaces, OSC and redox properties were investigated by N_2 adsorption/desorption and temperature programmed reduction(H2-TPR). The results show that introducing La^(3+) , Nd^(3+) and Y^(3+) into CeO_2-ZrO_2 lattice can improve the stability of phase structure and anti-sintering ability. Moreover, low concentration of mixed chlorinated solution remarkably improves structural and textural properties of CZLNY. Relatively large fresh grain exhibits superior thermal stability and OSC under the condition of being calcined at 800℃ for 3 h. The specific surface and OSC are42.37 m^2/g and 333.13 mmol/g after calcining at 1000℃ for 10 h, respectively. This is owing to the low sintered driving force of large grain and long-range migration energy of large pores during the sintering process, which are beneficial to the stability of structure in CZLNY materials. | Yuhui Zhang Meisheng Cui Yongke Hou Xiaowei Huang Yongqi Zhang Qiannan Xue | 2019 | Journal of Rare Earths2019，37，2： | 3 |
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