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| 1 | Influence of Ren and Du meridian electro-acupuncture on neural stem cell proliferation and extracellular signal-regulated kinase pathway in a rat model of focal cerebral ischemia injury显示文摘BACKGROUND:Studies have shown that electro-acupuncture at the Ren meridian could improve proliferation of subventricular zone neural stem cells in cerebral-ischemic rats. However,there are few reports on the influence of electro-acupuncture at the Du meridian on neural stem cell proliferation. OBJECTIVE:To observe the influence of electro-acupuncture at Ren and Du meridians on neural stem cell proliferation in the subventricular zone and altered signal transduction in cerebral ischemia rats. DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at the Laboratory of Human Anatomy,Medical College of Sun Yat-sen University from May 2006 to February 2008. MATERIALS:Mouse anti-rat bromodeoxyuridine (BrdU) monoclonal antibody was provided by Sigma,USA; mouse anti-rat nestin monoclonal antibody and extracellular signal-regulated protein kinase (ERK) specific inhibitor PD98059 were provided by Calbiochem,Germany; acupuncture needle was provided by Suzhou Acupuncture Supplies,China. METHODS:A total of 126 rats were randomly assigned to four groups:model (n = 36),Du meridian (n = 36),Ren/Du meridian (n = 36),and Ren/Du meridian + PD98059 (n = 18). Rats in the Ren /Du meridian + PD98059 group were observed on days 7 (n = 6) and 14 (n = 12) after cerebral ischemia injury. Rats in the model,Du meridian,and Ren/Du meridian groups were observed on days 7,14,and 28 after cerebral ischemia injury,with 12 rats per group at each time point. Thread occlusion was used to establish middle cerebral artery occlusion models. Electro-acupuncture was performed at Renzhong (DU 26) and Baihui (DU 20) acupoints in the Du meridian group,as well as Chengjiang (RN 24),Guanyuan (RN 4),Renzhong,and Baihui acupoints in the Ren/Du meridian and Ren/Du meridian + PD98059 groups 2 days after model establishment. In addition,electro-acupuncture stimulation with disperse-dense waves was performed,with 30 Hz disperse wave,100 Hz dense wave,and 5 V intensity for 20 minutes. Rats in the Ren/Du meridian + PD98059 group were treated with 0.2 μg PD98059 injection into the subventricular zone,2 μL per rat. Rats in the model group were not treated with electro-acupuncture. MAIN OUTCOME MEASURES:BrdU/nestin immunofluorescent staining was used to detect proliferating neural stem cells in the subventricular zone of cerebral ischemia rats; Western blot was used to determine phosphorylated ERK1 and 2 (pERK1/2) expression in the subventricular zone. RESULTS:On days 14 and 28 after cerebral ischemia,there were significantly more BrdU-positive and BrdU/nestin-positive cells in the Ren /Du meridian group compared with the Du meridian group (P < 0.05). PD98059 decreased the number of BrdU-positive and BrdU/nestin-positive cells induced by electro-acupuncture at the Ren and Du meridians (P < 0.05). On days 7,14,and 28 after treatment,pERK1/2 expression was significantly greater in the Du meridian and Ren/Du meridian groups compared with the model group (P < 0.05). The promoting effect of electro-acupuncture at Ren and Du meridians on ERK1/2 phosphorylation was superior to electro-acupuncture at the Du meridian alone on day 14 after model induction (P < 0.05). However,PD98059 completely abolished the promoting effect of electro-acupuncture at Ren/Du meridians on pERK1/2 expression (P < 0.05). CONCLUSION:Electro-acupuncture at Ren and Du meridians increased proliferation of subventricular zone neural stem cells,which was related to activation of the ERK pathway in a rat model of cerebral ischemia injury. | Wenshu Luo Haibo Yu Zhuoxin Yang Min Pi Lihong Diao Xiaodan Rao | 2010 | Neural Regeneration Research2010，5，6： | 14 |
| 2 | Species-dependent neuropathology in transgenic SOD' aigs显示文摘 | Huaqiang Yang Guohao Wang Haitao Sun Runzhe Shu Tao Liu Chuan-En Wang Zhaoming Liu Yu Zhao Bentian Zhao Zhen Ouyang Dongshan Yang Jiao Huang Yueling Zhou Shihua Li Xiaodan Jiang Zhicheng Xiao Xiao-Jiang Li Liangxue Lai | 2014 | Cell Research2014，24，4： | 13 |
| 3 | A novel colloidal gold immunochromatography assay strip for the diagnosis of schistosomiasis japonica in domestic animals显示文摘Background:Schistosomiasis remains a major public health concern in China and an epidemiological survey has revealed that schistosome-infected bovines and goats are the main transmission sources for the disease.Therefore,development of a sensitive technique for the diagnosis of schistosomiasis in domestic animals is necessary.Method:A novel colloidal gold immunochromatography assay(GICA)strip was developed for detecting Schistosoma japonicum in domestic animals.The colloidal gold was conjugated with recombinant streptococcal protein G(rSPG).As the test and control lines,the schistosome soluble egg antigen and rSPG,respectively,were blotted on nitrocellulose membrane.Results:The lowest detectable serum dilution was 1∶640 for schistosome-infected buffaloes.The cross-reaction rate of GICA was 14.29%with Paramphistomum sp.in buffaloes,16.67%with Haemonchus sp.in goats,and 33.33%with Orientobilharzia sp.in goats.These results were slightly lower and similar to those obtained through ELISA.Moreover,the strips for detecting S.japonicum in mice,rabbits,buffaloes,and goats showed high sensitivity(100.00%,100.00%,100.00%,and 100.00%,respectively)and specificity(100.00%,100.00%,94.23%,and 88.64%,respectively).And the sensitivity or specificity of the GICA strips did not present any significant differences after storage for 12 months at room temperature.When compared with ELISA,the GICA strips exhibited similar sensitivity and specificity in the diagnosis of schistosomiasis in mice,rabbits,buffaloes,and goats.Besides,only 5μl of serum are required for the test and the detection can be completed within 5 min.Conclusion:This study is the first to develop a GICA strip using gold-rSPG conjugate for the diagnosing of schistosomiasis in domestic animals,and preliminary results showed that the developed strip may be suitable for large-scale screening of schistosomiasis in endemic areas. | Rui Xu Jintao Feng Yang Hong Chao Lv Dengyun Zhao Jiaojiao Lin Ke Lu Hao Li Jinming Liu Xiaodan Cao Tao Wang Jinli Zai Zhaozhe Wang Bingguang Jia Qian Han Chuangang Zhu | 2017 | Infectious Diseases of Poverty2017，6，1： | 12 |
| 4 | Triage for management of cervical high-grade squamous intraepithelial lesion patients with positive margin by conization: a retrospective analysis显示文摘这研究的目的是为颈的高级有鳞的 intraepithelial 的管理指导 triage 有由 conization 的积极边缘的损害(HSIL ) 病人。有由 conization 的积极边缘的 HSIL 病人的 Clinico 病理学的数据回顾地从 2009 年 1 月被收集到 2014 年 12 月。所有病人在 6 个月以内经历了第二等的 conization 或子宫切除。剩余损害的率被计算,并且与剩余损害联系的因素被 univariate 和 multivariate 分析分析。在 119 个病人的一个总数之中, 56 (47.06%) 病人们在他们的随后的外科的标本介绍了剩余 HSIL,包括侵略的颈的癌(3 阶段 IA1 和 1 个阶段 IA2 病人) 的 4 个盒子。Univariate 分析显示出那耐心的年龄 > 35 年(P=0.005 ) , menopausal 时期 > 5 年(P=0.0035 ) ,和多重象限的参与(P=0.001 ) 显著地与剩余疾病被相关;然而, multivariate 分析揭示了那多重象限的参与(P=0.001;或, 3.701;95%CI, 1.4969.154 ) 是为剩余疾病的一个独立风险因素。将近有由 conization 的积极边缘的 HSIL 病人的一半与多重积极边缘在随后的外科的标本,和那些是没有疾病的可以考虑 re-conization 或重新评价。 | Yuya Dou Xiaodan Zhang Yang Li Fenfen Wang Xing Xie Xinyu Wang | 2017 | Frontiers of Medicine2017，11，2： | 12 |
| 5 | Effect of quercetin on the expression of Bcl-2/Bax apoptotic proteins in endometrial cells of lipopolysaccharide-induced-abortion mice显示文摘OBJECTIVE: To explore the effect of quercetin on the expressions of Bcl-2/Bax apoptotic proteins in endometrial cells in mice with abortion induced by lipopolysaccharide.METHODS: For in vivo experiment, twenty five Kunming mice were randomly divided into five groups at day 4 of pregnancy, with 5 mice per group. The mice were treated with lipopolysaccharide(LPS)through tail vein intravenous injection at day 4 of pregnancy, followed by different concentrations of quercetin by oral gavage consecutively at days 5 to6 of pregnancy. On day 7 of gestation, the mice were sacrificed and the histopathological changes of the uterus tissues were observed. Immunohistochemical staining was applied to the detection of Bcl-2/Bax apoptotic proteins in the endometrial cells. For in vitro experiment, the primary endometrial cells werecultured using a uterus tissue mass culturing method sampled at day 4.5 of pregnancy. The cells were treated with LPS with or without different dosages of quercetin, respectively, for 12 h after 80% confluence. The expression of Bcl-2/Bax apoptotic proteins were detected by western blotting.RESULTS: Both the in vivo and in vitro experiments showed decreased expression of Bcl-2 and enhanced expression of Bax after LPS treatment, leading to a decreased Bcl-2/Bax ratio. The expression of Bcl-2 significantly increased while the expression of Bax was significantly elevated, in the LPS plus quercetin group compared to the LPS only group.CONCLUSION: These results suggest that quercetin has protective effect by partially regulating the expression of Bcl-2/Bax proteins, which in turn inhibits endometrial cell apoptosis and benefits the embryo implantation. | Wang Xiaodan Yan Yongping Yang Liu Li Mu Zhong Xiuhui | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 7 |
| 6 | Hydrochlorination of Acetylene Using SiC Foam Supported Structured C/Au Catalysts显示文摘AUCI_3 loaded structured catalysts were prepared on SiC foam supported with pre-coated activated carbon layers.The catalytic properties of the structured catalysts towards hydrochlorination of acetylene were tested in a fixedbed reactor with the AuCI_3 loaded on activated carbon pellets as a reference.For isopyknic catalysts,the structured catalyst with only one fifth of the Au amount as that was used on the reference catalyst exhibited even a little higher acetylene conversion and much better stability than the latter no matter what the gas hourly space velocities of acetylene were used.The results indicated that the more homogeneous distribution of AUCI_3 particles and better heat transfer along the fixed-bed reactor originated from the low pressure drop and high thermal conductivity of the SiC foam supported structured catalysts might be able to account for their improved efficiency and stability.It is believed that these novel structured C/Au catalysts can be potentially applied in VCM industrialization in view of their greatly reduced cost and much prolonged life. | Xiaodan Yang Chunhai Jiang Zhenming Yang Jinsong Zhang | 2014 | Journal of Materials Science & Technology2014，30，5： | 6 |
| 7 | A neurotrophic peptide-functionalized self-assembling peptide nanofiber hydrogel enhances rat sciatic nerve regeneration显示文摘神经指导水管(NGC ) 是为外部神经新生的自体同源的神经的一种潜在的选择。有希望的治疗学的策略是用物理或化学的指导暗示修改神经指导水管 intraluminal 微型环境。在这研究,神经营养的 peptide-functionalized 能在 vitro 支持 PC12 细胞粘附,增长,和 neuronal 区别的自我装配的肽 nanofiber hydrogel 是在一个空 chitosan 试管(hCST ) 的腔的 prefilled 在一只老鼠加速 axonal 新生臀部的神经缺点模型。functionalized 自我装配的肽被介绍神经营养的肽开发(RGI, RGIDKRHWNSQ ) 源于导出大脑的神经营养的因素(BDNF ) 到自我装配的肽 RADA16 的 C 终点 -- 我(交流 --(RADA )4-CONH2) 。词法,组织学, electrophysiological,和功能的分析证明 RGI-functionalized,自我装配,肽 nanofiber hydrogel RAD/RGI 能生产显著地与提高的 re-myelination 和马达改进了 axonal 新生的神经营养的微型环境功能的恢复。 | Jiaju Lu Xun Sun Heyong Yin Xuezhen Shen Shuhui Yang Yu Wang Wenli Jiang Yue Sun Lingyun Zhao Xiaodan Sun Shibi Lu Antonios G. Mikos Jiang Peng Xiumei Wang | 2018 | Nano Research2018，11，9： | 6 |
| 8 | Could CMIP6 climate models reproduce the early-2000s global warming slowdown?显示文摘The unexpected global warming slowdown during 1998–2013 challenges the existing scientific understanding of global temperature change mechanisms,and thus the simulation and prediction ability of state-of-the-art climate models since most models participating in phase 5 of the Coupled Model Intercomparison Project(CMIP5)cannot simulate it.Here,we examine whether the new-generation climate models in CMIP6 can reproduce the recent global warming slowdown,and further evaluate their capacities for simulating key-scale natural variabilities which are the most likely causes of the slowdown.The results show that although the CMIP6 models present some encouraging improvements when compared with CMIP5,most of them still fail to reproduce the warming slowdown.They considerably overestimate the warming rate observed in 1998–2013,exhibiting an obvious warming acceleration rather than the observed deceleration.This is probably associated with their deficiencies in simulating the distinct temperature change signals from the human-induced long-term warming trend and/or the three crucial natural variabilities at interannual,interdecadal,and multidecadal scales.In contrast,the 4 models that can successfully reproduce the slowdown show relatively high skills in simulating the long-term warming trend and the three keyscale natural variabilities.Our work may provide important insight for the simulation and prediction of near-term climate changes. | Meng WEI Qi SHU Zhenya SONG Yajuan SONG Xiaodan YANG Yongqing GUO Xinfang LI Fangli QIAO | 2021 | Science China Earth Sciences2021，64，6： | 5 |
| 9 | Seasonal Variations of Several Main Water Masses in the Southern Yellow Sea and East China Sea in 2011显示文摘The seasonal variations of several main water masses in the southern Yellow Sea (SYS) and East China Sea (ECS) in 2011 were analyzed using the in-situ data collected on four cruises.There was something special in the observations for the Yellow Sea Warm Current (YSWC) ,the Yellow Sea Cold Water Mass (YSCWM) and the Changjiang Diluted Water (CDW) during that year.The YSWC was confirmed to be a seasonal current and its source was closely associated with the Kuroshio onshore intrusion and the northerly wind.It was also found that the YSCWM in the summer of 2011 occupied a more extensive area in comparison with the climatologically-mean case due to the abnormally powerful wind prevailing in the winter of 2010 and decaying gradually thereafter.Resulting from the reduced Changjiang River discharge,the CDW spreading toward the Cheju Island in the summer of 2011 was weaker than the long-term mean and was confined to flow southward in the other seasons.The other water masses seemed normal without noticeable anomalies in 2011.The Yellow Sea Coastal Current (YSCC) water,driven by the northerly wind,flowed southeastward as a whole except for its northeastward surface layer in summer.The Taiwan Warm Current (TWC) was the strongest in summer and the weakest in winter in its northward movement.The Kuroshio water with an enhanced onshore intrusion in autumn was stable in hydrographic features apart from the seasonal variation of its surface layer. | QUAN Qi MAO Xinyan YANG Xiaodan HU Yingying ZHANG Haiyan JIANG Wensheng | 2013 | Journal of Ocean University of China2013，12，4： | 5 |
| 10 | Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes:a pilot study显示文摘Mesenchymal stem cells(MSC)have been used in clinical trials for severe diabetes,a chronic disease with high morbidity and mortality.Bone marrow is the traditional source of human MSC,but human term placenta appears to be an alternative and more readily available source.Here,the therapeutic effect of human placenta-derived MSC(PD-MSC)was studied in type 2 diabetes patients with longer duration,islet cell dysfunction,high insulin doses as well as poor glycemic control in order to evaluate the safety,efficacy and feasibility of PD-MSC treatment in type 2 diabetes(T2D).Ten patients with T2D received three intravenous infusions of PDSC,with one month interval of infusion.The total number of PDSC for each patient was(1.22–1.51)×10^(6)/kg,with an average of 1.35×10^(6)/kg.All of the patients were followed up after therapy for at least 3 months.A daily mean dose of insulin used in 10 patients was decreased from 63.7±18.7 to 34.7±13.4 IU(P<0.01),and the C-peptide level was increased from 4.1±3.7 ng/mL to 5.6±3.8 ng/mL(P<0.05)respectively after therapy.In 4 of 10 responders their insulin doses reduced more than 50%after infusion.The mean levels of insulin and C-peptide at each time point in a total of 10 patients was higher after treatment(P<0.05).No fever,chills,liver damage and other side effects were reported.The renal function and cardiac function were improved after infusion.The results obtained from this pilot clinical trial indicate that transplantation of PD-MSC represents a simple,safe and effective therapeutic approach for T2D patients with islet cell dysfunction.Further large-scale,randomized and well-controlled clinical studies will be required to substantiate these observations. | Ranhua JIANG Zhibo HAN Guangsheng ZHUO Xiaodan QU Xue LI Xin WANG Yuankang SHAO Shimin YANG Zhong Chao HAN | 2011 | Frontiers of Medicine2011，5，1： | 5 |
| 11 | Distributed Control of Thermostatically Controlled Loads in Distribution Network with High Penetration of Solar PV显示文摘High penetration of solar energy can result in voltage rise in midday,while growth in residential air conditioning is the main contributor of overloading and voltage drop issues during peak demand time.This paper provides a hierarchical control scheme to coordinate multiple groups of aggregated thermostatically controlled loads to regulate network loading and voltage in a distribution network.Considering the limited number of messages that can be exchanged in a realistic communication environment,an event-triggered distributed control strategy is proposed in this paper.Through intermittent on and off toggling of air conditioners,the required active power adjustment is shared among participating aggregators to solve the issue.A case study is conducted and simulation results are presented to demonstrate the performance of the proposed control scheme. | Ke Meng Dongxiao Wang Zhao Yang Dong Xiaodan Gao Yu Zheng Kit Po Wong | 2017 | CSEE Journal of Power and Energy Systems2017，3，1： | 4 |
| 12 | Active loading liposomal irinotecan hydrochloride:Preparation,in vitro and in vivo evaluation显示文摘The aim of the present study was to investigate the effect of various transmembrane ammonium salt gradients and different lipid composition on the loading efficiency of liposomal formulations of irinotecan hydrochloride(CPT-11),their behavior in vivo and cytotoxicity.Among ammonium salts studied,ammonium sulfate was successfully used to load CPT-11 into liposomes with the highest encapsulation efficiency.Subsequently,liposomal CPT-11 with different lipid composition was prepared by ammonium sulfate gradient method.CPT-11 can be loaded to a level over 90%into liposomes composed of soybean phospholipids/cholesterol(SPC-L)or hydrogenated natural soybean phospholipids/cholesterol(HSPC-L).In vitro release profiles were also investigated,indicating that HSPC-L had a lower release than that in SPC-L.In vivo,encapsulation of CPT-11 in both liposomal formulations showed higher area under the curve(AUC),a lower rate of clearance(CL)and smaller volume of distribution for CPT-11 than those of irinotecan hydrochloride solution(CPT-11-S).However,CL and AUC of 7-ethyl-10-hydroxycamptothecin(SN-38)were moderately improved in HSPC-L group.Based on the results of comparative pharmacokinetics of liposomal CPT-11 with different lipid composition,the in vitro cytotoxicity of HSPC-L was evaluated with human tumor cell.The result indicated that liposomal CPT-11 showed a great enhancement in vitro cytotoxicity.The results suggested that entrapment of CPT-11 in liposomes especially in those with high phase-transition temperature lipid by ammonium sulfate gradient would be a promising formulation with a better in vivo behavior. | Hongyan Wei Juan Song Hao Li Yang Li Shanshan Zhu Xiaodan Zhou Xiwen Zhang Li Yang | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，5： | 3 |
| 13 | An Active De-anonymizing Attack Against Tor Web Traffic显示文摘Tor is pervasively used to conceal target websites that users are visiting. A de-anonymization technique against Tor, referred to as website fingerprinting attack, aims to infer the websites accessed by Tor clients by passively analyzing the patterns of encrypted traffic at the Tor client side. However, HTTP pipeline and Tor circuit multiplexing techniques can affect the accuracy of the attack by mixing the traffic that carries web objects in a single TCP connection. In this paper, we propose a novel active website fingerprinting attack by identifying and delaying the HTTP requests at the first hop Tor node. Then, we can separate the traffic that carries distinct web objects to derive a more distinguishable traffic pattern. To fulfill this goal, two algorithms based on statistical analysis and objective function optimization are proposed to construct a general packet delay scheme. We evaluate our active attack against Tor in empirical experiments and obtain the highest accuracy of 98.64%, compared with 85.95% of passive attack. We also perform experiments in the open-world scenario. When the parameter k of k-NN classifier is set to 5, then we can obtain a true positive rate of 90.96% with a false positive rate of 3.9%. | Ming Yang Xiaodan Gu Zhen Ling Changxin Yin Junzhou Luo | 2017 | Tsinghua Science and Technology2017，22，6： | 3 |
| 14 | Anti-oxidant and anti-inflammatory activities of ultrasonicassistant extracted polyphenol-rich compounds from Sargassum muticum显示文摘Polypehnol is an important,potentially bioactive component of Sargassum muticum.In this study,ultrasonic assisted extraction of polyphenol-rich substances was performed using a 38%ethanol solution at a solid:liquid ratio of 1:30 at 68℃ for 32min,determined by single-factor and response surface methodology(RSM)optimization.The content of polyphenol was 5.66mg/g in the crude extract.Further extraction showed that the polyphenol mainly distributed in ethyl acetate(SKEE)and water phases(SKEW).The anti-oxidation test by electron spin resonance(ESR)spectrum showed that the SKEE had the strongest scavenging activity on DPPH(1,1-diphenyl-2-picrylhydrazyl)and alkyl radicals.SKEE was shown noncytotoxic but could inhibit the generation of cellular ROS,showing protective effects in H2O2 and AAPHinduced Vero cells and UV-B irradiated HaCaT cells.SKEE also signifi cantly inhibited the release of NO of LPS-induced RAW 264.7 cells.Therefore,the polyphenol-rich extracts in ethanol and ethyl acetate showed excellent anti-oxidant and anti-infl ammatory activities,which is beneficial to the development of high-value bio-substances. | YU Yuan WANG Le FU Xiaoting WANG Lei FU Xiaodan YANG Min HAN Zhenlian MOU Haijin JEON You-Jin | 2019 | Journal of Oceanology and Limnology2019，37，3： | 3 |
| 15 | Glycomolecules in Echinococcus granulosus cyst fluid inhibit TLR4-mediated inflammatory responses via c-Raf显示文摘Cystic echinococcosis,which is caused by larval infection of Echinococcus granulosus(E.granulosus)sensu lato,is a widespread chronic cyst-forming helminthic disease that affects up to 3 million people.1 E.granulosus can actively divert the host immune response towards anergy and anti-inflammatory pathways.2 Previous studies have shown that E.granulosus can escape host immunosurveillance by modulating the maturation of dendritic cells(DCs).3,4 Nevertheless,how E.granulosus,an extracellular pathogen,modulates the inflammatory response in DCs remains poorly understood.In this study,we investigated the effects of E.granulosus cyst fluid(EgCF)on bone marrow-derived DCs(BMDCs)exposed to LPS,an inflammatory stimulus,and the mechanisms involved in the EgCF–DCs immune modulation. | Jun Hou Linlin Li Dan Dong Lianghai Wang Xian Wang Kun Yang Xiaodan Xu Congzhe Chen Xiangwei Wu Xueling Chen | 2020 | Cellular & Molecular Immunology2020，17，4： | 3 |
| 16 | Tailoring mesoporous-silica nanoparticles for robust immobilization of lipase and biocatalysis显示文摘nano 搬运人的合理设计为为先进 biocatalysis 的现代的酶固定是批评的。此处,我们与一个高 C18 内容报导修改 octadecylalkyl 的 mesoporous 硅石 nanoparticles (C18-MSNs ) 的合成(~ 19 wt.%) 并且悦耳的毛孔尺寸(1.6-13 nm ) 。增加的恐水病的内容和一个定制的毛孔缩放,这被表明(比脂肪分解酵素的尺寸稍微大) 为使不能调动的脂肪分解酵素的高效负责。优化 C18-MSNs 展览 711 mg/g 和比免费的酶的高 5.23 倍的一项特定的活动的一个装载能力。另外, 93% 起始的活动在复用以后被保留五次,它比性能迄今为止报导了的最好好。我们的调查结果为 biocatalytic 应用为脂肪分解酵素的柔韧的固定铺平道路。 | Mohammad Kalantari Meihua Yu Yannan Yang Ekaterina Strounina Zhengying Gu Xiaodan Huang Jun Zhang Hao Song Chengzhong Yu | 2017 | Nano Research2017，10，2： | 3 |
| 17 | Oomycetes Seek Help from the Plant:Phytophthora infestans Effectors Target Host Susceptibility Factors显示文摘 | Petra C. Boevink Hazel McLellan Eleanor M. Gilroy Shaista Naqvi Qin He Lina Yang Xiaodan Wang Dionne Turnbull Miles R. Armstrong Zhendong Tian Paul R.J. Birch | 2016 | Molecular Plant2016，9，5： | 2 |
| 18 | Targeting of anti-microbial proteins to the hyphal surface amplifies protection of crop plants against Phytophthora pathogens显示文摘Phytophthora pathogens are a persistent threat to the world's commercially important agricultural crops,including potato and soybean.Current strategies aim at reducing crop losses rely mostly on disease-resistance breeding and chemical pesticides,which can be frequently overcome by the rapid adaptive evolution of pathogens.Transgenic crops with intrinsic disease resista nee offer a promising alternative and con tinue to be developed.Here,we explored Phytophthora-derived PI3P(phosphatidylinositol 3-phosphate)as a novel control target,using proteins that bind this lipid to direct secreted anti-microbial peptides and proteins(AMPs)to the surface of Phytophthora pathogens.In transgenic Nicotiana benthamiana,soybean,and potato plants,significantly enhanced resistance to different pathogen isolates was achieved by expression of two AMPs(GAFP1 or GAFP3 from the Chinese medicinal herb Gastrodia elata)fused with a PI3P-specific binding domain(FYVE).Using the soybean pathogen P.sojae as an example,we demonstrated that the FYVE domain could boost the activities of GAFPs in multiple independent assays,including those performed in vitro,in vivo,and in planta.Mutational analysis of P.sojae PI3K1 and PI3K2 genes of this pathogen confirmed that the enhanced activities of the targeted GAFPs were correlated with PI3P levels in the pathogen.Collectively,our study provides a new strategy that could be used to confer resistance not only to Phytophthora pathogens in many plants but also potentially to many other kinds of plant pathogens with unique targets. | Yang Zhou Kun Yang Qiang Yan Xiaodan Wang Ming Cheng Jierui Si Xue Xue Danyu Shen Maofeng Jing Brett M.Tyler Daolong Dou | 2021 | Molecular Plant2021，14，8： | 2 |
| 19 | Clinical Experience in the Treatment of Vulvovaginal Candida Disease with Integrated Traditional Chinese and Western Medicine显示文摘Summarizing two cases of vaginal candidiasis,cured by integrated traditional Chinese and western medicine in clinical work,it is found that the combination of traditional Chinese and western medicine has a significant effect on the treatment of this disease.The curative effect is outstanding,and the recurrence rate is significantly reduced,which can be used as a reference for gynecological medical workers. | Xiaodan Yang Jie Wang Zhenzhen Jia Lihong Zhu | 2021 | Journal of Clinical and Nursing Research2021，5，4： | 2 |
| 20 | Strongly coupled Te-SnS_(2)/MXene superstructure with self-autoadjustable function for fast and stable potassium ion storage显示文摘Potassium-ion batteries(PIBs)are a promising candidate for next-generation electric energy storage applications because of the abundance and low cost of potassium.However,the development of PIBs is limited by sluggish kinetics and huge volume expansion of anodes,leading to poor rate capability and cycling stability.Herein,an advanced superstructure anode,including Te-doped SnS_(2) nanosheets uniformly anchored on MXene surface(Te-SnS_(2)/MXene),is rationally designed for the first time to boost K^(+)storage performance.Featuring with strong interface interaction and self-autoadjustable interlayer spacings,the Te-SnS_(2)/MXene can efficiently accelerate electron/ion transfer,accommodate volume expansion,inhibit crack formation,and improve pseudocapacitive contribution during cycling.Thus,the novel Te-SnS_(2)/MXene anode delivers a high reversible capacity(343.2 mAh g^(-1) after 50 cycles at0.2 A g^(-1)),outstanding rate capability(186.4 mAh g^(-1) at 20 A g^(-1)),long cycle stability(165.8 mAh g^(-1)after 5000 cycles at 10 A g^(-1) with a low electrode swelling rate of only 15.4%),and reliable operation in flexible full battery.The present Te-SnS_(2)/MXene becomes among the best transition metal-based anode materials for PIBs reported to date. | Hongyang Sun Yelong Zhang Xiaodan Xu Jianwen Zhou Fan Yang Hao Li Hao Chen Yucheng Chen Zheng Liu Zhenping Qiu Da Wang Lipo Ma Jiawei Wang Qingguang Zeng Zhangquan Peng | 2021 | Journal of Energy Chemistry2021，30，10： | 2 |
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