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| 1 | Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma显示文摘Tertiary lymphoid structures(TLS)are ectopic lymphoid structures in cancers that are largely associated with favourable prognosis.However,the prognostic value of TLSs in oral squamous cell carcinoma(OSCC)is largely unknown,and the association between tumour infiltrating lymphocytes(TILs)and TLSs has been rarely explored in OSCC.In this study,associated markers of TLS,including peripheral node address(PNAd)in high endothelial venules,CD20 in B cells and CD3 in T cells,were examined in 168 OSCC patients,and survival analysis was performed between TLS-positive and TLS-negative cohorts.We detected the presence of TILs by staining CD8+cytotoxic T cells and CD57+NK cells as well.TLSs appeared as highly organized structures in 45(26.8%)cases.TLSpositive patients had a better 5-year overall survival(OS)rate(88.9%vs.56.1%,P<0.001)and relapse-free survival(RFS)rate(88.9%vs.63.4%,P=0.002).Moreover,the presence of TLS was an independent prognostic factor for both the 5-year OS rate(hazard ratio[HR]=3.784;95%confidence interval[CI],1.498–9.562)and RFS rate(HR=3.296;95%CI,1.279–8.490)in multivariate analysis.Furthermore,a higher density of CD8+T cells and CD57+NK cells was found in TLS-positive sections than in TLS-negative counterparts(P<0.001),and their combination provided a higher predictive accuracy(AUC=0.730;95%CI,0.654–0.805).In conclusion,our results suggest that TLS is an independent positive prognostic factor for OSCC patients.These findings provide a theoretical basis for the future diagnostic and therapeutic value of TLSs in OSCC treatment. | Qunxing Li Xiangqi Liu Dikan Wang Yanqiong Wang Huanzi Lu Shuqiong Wen Juan Fang Bin Cheng Zhi Wang | 2020 | International Journal of Oral Science2020，12，3： | 12 |
| 2 | Carbon materials for stable Li metal anodes: Challenges, solutions, and outlook显示文摘Lithium(Li)metal is regarded as the ultimate anode for next-generation Li-ion batteries due to its highest specific capacity and lowest electrochemical potential.However,the Li metal anode has limitations,including virtually infinite volume change,nonuniform Li deposition,and an unstable electrode-electrolyte interface,which lead to rapid capacity degradation and poor cycling stability,significantly hindering its practical application.To address these issues,intensive efforts have been devoted toward accommodating and guiding Li deposition as well as stabilizing the interface using various carbon materials,which have demonstrated excellent effectiveness,benefiting from their vast variety and excellent tunability of the structure-property relationship.This review is intended as a guide through the fundamental challenges of Li metal anodes to the corresponding solutions utilizing carbon materials.The specific functionalities and mechanisms of carbon materials for stabilizing Li metal anodes in these solutions are discussed in detail.Apart from the stabilization of the Li metal anode in liquid electrolytes,attention has also been paid to the review of anode-free Li metal batteries and solid-state batteries enabled by strategies based on carbon materials.Furthermore,we have reviewed the unresolved challenges and presented our outlook on the implementation of carbon materials for stabilizing Li metal anodes in practical applications. | Qiongqiong Lu Yulin Jie Xiangqi Meng Ahmad Omar Daria Mikhailova Ruiguo Cao Shuhong Jiao Yan Lu Yaolin Xu | 2021 | Carbon Energy2021，3，6： | 6 |
| 3 | 白细胞介素-18抑制Lewis肺癌小鼠移植瘤生长与诱导移植瘤细胞凋亡的研究(英文)显示文摘Objective:The aim of our study was to investigate the effects of interleukin-18(IL-18) on implanted Lewis lung cancer in suppressing tumor growth and inducing tumor cells apoptosis.Methods:One week after hypodermic inoculation of Lewis cells, sixteen tumor-bearing syngeneic mice were randomly divided into two groups.The mice in the treatment group were intraperitoneal injected with the IL-18, in the control group were intraperitoneal injected with normal saline.The health conditions of the mice were measured, the morphology of the tumors was studied and the apoptosis of implanted lung cancer cells was detected by TUNEL to evaluated the effects of IL-18.Results:IL-18 had no significant effects on the health conditions of the mice, but it could suppress the implanted tumor growth(inhibition rate was 75%) and induce tumor cells apoptosis.Conclusion:IL-18 can suppress the implanted Lewis lung cancer cells by way of inducing tumor cells apoptosis.It could be used as a new strategy for lung cancer. | Sheng Yang Huishan Lu Xiangqi Chen Tingyan Lin Zhiying Li Mingqiang Kang | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，3： | 1 |
| 4 | Magnetic logic inverter from crossed structures of defect-free graphene with large unsaturated room temperature negative magnetoresistance显示文摘Introducing defects into graphene has been widely utilized to realize the negative magnetoresistanee(MR)effect in graphene.However,the reported graphene negative MR exhibits only^10%under 10 T at room temperature to date,which extremely limits the resolution of future spintronics devices.Moreover,intentional defect introduction can also cause unintentional degradation in graphene's intrinsic properties.In this paper,we report a magnetic logic inverter based on a crossed structure of defect-free graphene,resulting in a substantial gain of 4.81 mV/T while exhibiting room temperature operation.This crossed structure of graphene shows large unsaturated room temperature negative MR with an enhancement of up to 1,000%at 9 T.A transition behavior between negative and positive MR is observed in this crossed structure and the transition temperature can be tuned by a ratio of the conductivity between in-plane and out-of-plane transport.Our results open an intriguing path for future two-dimensional spintronics device applications. | Chao Feng Junxiang Xiang Ping Liu Xiangqi Wang Jianlin Wang Guojing Hu Meng Huang Zhi Wang Zengming Zhang Yuan Liu Yalin Lu Bin Xiang | 2019 | Nano Research2019，12，10： | 1 |
| 5 | Roles manganese effects on the oxidation resistance of the alumina-forming austenitic steels at above 800 :C 显示文摘 | Xu Xiangqi Zhang Xiaofeng Lu Zhaoping | 2012 | Oxidat Metals2012，78，56： | 1 |
| 6 | Aldosterone may induce visfatin expression via the GR-ERK1/2 signal pathway in 3T3-L1 adipocytes显示文摘The main function of aldosterone is to regulate blood pressure and electrolytic balance;however,recent studies have also focused on the effect of aldosterone on glucose metabolism especially in adipose tissue.Aldosterone was found to inhibit insulin-induced glucose uptake in 3T3-L1 adipocytes [1] and aldosterone deficiency was found to prevent high-fat-feeding-induced hyperglycemia and adipocyte dysfunction in mice [2].Visfatin,an adipokine discovered by the team of Fukuhara,is mainly released by adipose tissue [3].Treatment of 3T3-L1 adipocytes and L6 myocytes with visfatin increased basal glucose uptake,and glucose release was suppressed in H4IIEC3 hepatocytes after visfatin treatment [3].It has also been suggested that visfatin may act as a proinflammatory cytokine [4] and produce chronic inflammation in adipocytes [5].Eyileten et al.[6] reported that treatment with angiotensin-converting enzyme inhibitor,which can reduce plasma aldosterone concentration,decreased circulating visfatin level in diabetic nephropathy patients.These findings suggest a possible interaction between the renin–angiotensin–aldosterone system(RAAS)and visfatin.Considering the important roles of aldosterone and visfatin and the association between RAAS and visfatin,we hypothesize that there may be a direct regulatory interaction between aldosterone and visfatin.To test this hypothesis,3T3-L1 adipocytes were used as the cell model and the expression of visfatin was measured by qRT-PCR and western blot analysis. | Junhua Ma Xuemei Zhao Jichen Zhang Fei Sun Jiancan Lu Hongling Zhu Mingjun Gu Jingnan Wang Xiangqi Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 1 |
| 7 | A comprehensive profile of TCF1^(+)progenitor and TCF1−terminally exhausted PD-1^(+)CD8^(+)T cells in head and neck squamous cell carcinoma:implications for prognosis and immunotherapy显示文摘The heterogeneity of exhausted T cells(Tex)is a critical determinant of immune checkpoint blockade therapy efficacy.However,few studies have explored exhausted T cell subpopulations in human cancers.In the present study,we examined samples from two cohorts of 175 patients with head and neck squamous cell cancer(HNSCC)by multiplex immunohistochemistry(mIHC)to investigate two subsets of Tex,CD8+PD1+TCF1+progenitor exhausted T cells(TCF1+Texprog)and CD8+PD1+TCF1−terminally exhausted T cells(TCF1−Texterm).Moreover,fresh tumor samples from 34 patients with HNSCC were examined by flow cytometry and immunohistochemistry to further investigate their properties and cytotoxic capabilities and their correlation with regulatory T cells(Tregs)in the tumor immune microenvironment(TIME).mIHC and flow cytometry analysis showed that TCF1−Texterm represented a greater proportion of CD8+PD1+Tex than TCF1+Texprog in most patients.TCF1+Texprog produced abundant TNFα,while TCF1−Texterm expressed higher levels of CD103,TIM-3,CTLA-4,and TIGIT.TCF1−Texterm exhibited a polyfunctional TNFα+GZMB+IFNγ+phenotype;and were associated with better overall survival and recurrence-free survival.The results also indicated that larger proportions of TCF1−Texterm were accompanied by an increase in the proportion of Tregs.Therefore,it was concluded that TCF1−Texterm was the major CD8+PD1+Tex subset in the HNSCC TIME and that these cells favor patient survival.A high proportion of TCF1−Texterm was associated with greater Treg abundance. | Dikan Wang Juan Fang Shuqiong Wen Qunxing Li Jinming Wang Lisa Yang Wenxiao Dai Huanzi Lu Junyi Guo Zhongyan Shan Wenqiang Xie Xiangqi Liu Liling Wen Jie Shen Anxun Wang Qianming Chen Zhi Wang | 2022 | International Journal of Oral Science2022，14，1： | 0 |
| 8 | Interleukin 35 protects cardiomyocytes following ischemia/reperfusion-induced apoptosis via activation of mitochondrial STAT3显示文摘Mitochondrial reactive oxygen species(mtROS)-induced apoptosis has been suggested to contribute to myocardial ischemia/reperfusion injury.Interleukin 35(IL-35),a novel anti-inflammatory cytokine,has been shown to protect the myocardium and inhibit mtROS production.However,its effect on cardiomyocytes upon exposure to hypoxia/reoxygenation(H/R)damage has not yet been elucidated.The present study aimed to investigate the potential protective role and underlying mechanisms of IL-35 in H/R-induced mouse neonatal cardiomyocyte injury.Mouse neonatal cardiomyocytes were challenged to H/R in the presence of IL-35,and we found that IL-35 dose dependently promotes cell viability,diminishes mtROS,maintains mitochondrial membrane potential,and decreases the number of apoptotic cardiomyocytes.Meanwhile,IL-35 remarkably activates mitochondrial STAT3(mitoSTAT3)signaling,inhibits cytochrome c release,and reduces apoptosis signaling.Furthermore,co-treatment of the cardiomyocytes with the STAT3 inhibitor AG490 abrogates the IL-35-induced cardioprotective effects.Our study identified the protective role of IL-35 in cardiomyocytes following H/R damage and revealed that IL-35 protects cardiomyocytes against mtROS-induced apoptosis through the mitoSTAT3 signaling pathway during H/R. | Fengyun Zhou Ting Feng Xiangqi Lu Huicheng Wang Yangping Chen Qiuxia Zhang Xinlu Zhang Jiancheng Xiu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 0 |
| 9 | Effects of trace elements on mechanical properties of the TiZrHfNb high-entropy alloy显示文摘Refractory high-entropy alloys have great potential to be utilized as high-temperature materials,and the repeatability and reproducibility of their mechanical properties are critical for practical applications.In this work,nevertheless,we found that the mechanical properties of the TiZrHfNb HEA greatly varied with the content of impurities in the samples even using high-purity raw materials.Specifically,the oxygen impurity is mainly responsible for the increment of the yield stress due to the strong interstitial hardening effect,whilst the ductility deterioration closely associates with the content of metalloid elements B,C,and Si.Our analysis reveals that the metalloid elements not only tend to segregate at grain boundaries but also enhance the aggregation of Zr and Ti.Such co-segregation induced the formation of strong(Zr,Ti)-metalloid bonds,resulting in grain boundary embrittlement and brittle fracture.Our current work demonstrates that the impurity contents in refractory HEAs need to be strictly controlled during production in order to improve their stability of mechanical performance. | Xiaoyuan Yuan Yuan Wu Meisa Zhou Xiongjun Liu Hui Wang Suihe Jiang Xiaobin Zhang Honghui Wu Xiaochun Liu Zipan Chen Xiangqi Xu Zhaoping Lu | 2023 | Journal of Materials Science & Technology2023，，21： | 0 |
| 10 | Itinerant to relocalized transition of felectrons in the Kondo insulator CeRu_(4)Sn_(6)显示文摘The three-dimensional electronic structure and the nature of Ce 4f electrons of the Kondo insulator CeRu_(4)Sn_(6)are investigated by angle-resolved photoemission spectroscopy,utilizing tunable photon energies.Our results reveal(i)the three-dimensional k-space nature of the Fermi surface,(ii)the localized-to-itinerant transition of f electrons occurs at a much high temperature than the hybridization gap opening temperature,and(iii)the“relocalization”of itinerant f-electrons below 25 K,which could be the precursor to the establishment of magnetic order. | Fan-Ying Wu Qi-Yi Wu Chen Zhang Yang Luo Xiangqi Liu Yuan-Feng Xu Dong-Hui Lu Makoto Hashimoto Hao Liu Yin-Zou Zhao Jiao-Jiao Song Ya-Hua Yuan Hai-Yun Liu Jun He Yu-Xia Duan Yan-Feng Guo Jian-Qiao Meng | 2023 | Frontiers of physics2023，18，5： | 0 |
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