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| 1 | Grade classification of neuroepithelial tumors using high-resolution magic-angle spinning proton nuclear magnetic resonance spectroscopy and pattern recognition显示文摘Clinical data have shown that survival rates vary considerably among brain tumor patients,according to the type and grade of the tumor.Metabolite profiles of intact tumor tissues measured with high-resolution magic-angle spinning proton nuclear magnetic resonance spectroscopy (HRMAS 1H NMRS) can provide important information on tumor biology and metabolism.These metabolic fingerprints can then be used for tumor classification and grading,with great potential value for tumor diagnosis.We studied the metabolic characteristics of 30 neuroepithelial tumor biopsies,including two astrocytomas (grade I),12 astrocytomas (grade II),eight anaplastic astrocytomas (grade III),three glioblastomas (grade IV) and five medulloblastomas (grade IV) from 30 patients using HRMAS 1H NMRS.The results were correlated with pathological features using multivariate data analysis,including principal component analysis (PCA).There were significant differences in the levels of N-acetyl-aspartate (NAA),creatine,myo-inositol,glycine and lactate between tumors of different grades (P<0.05).There were also significant differences in the ratios of NAA/creatine,lactate/creatine,myo-inositol/creatine,glycine/creatine,scyllo-inositol/creatine and alanine/creatine (P<0.05).A soft independent modeling of class analogy model produced a predictive accuracy of 87% for high-grade (grade III-IV) brain tumors with a sensitivity of 87% and a specificity of 93%.HRMAS 1H NMR spectroscopy in conjunction with pattern recognition thus provides a potentially useful tool for the rapid and accurate classification of human brain tumor grades. | CHEN WenXue LOU HaiYan ZHANG HongPing NIE Xiu LAN WenXian YANG YongXia XIANG Yun QI JianPin LEI Hao TANG HuiRu CHEN FenEr DENG Feng | 2011 | Science China(Life Sciences)2011，54，7： | 5 |
| 2 | Thermochemical Sulfate Reduction in the Tazhong District,Tarim Basin,Northeast China:Evidence from Formation Water and Natural Gas Geochemistry显示文摘形成水和天然气地球化学在的系统的分析中央在迟了的阶段的煤气的侵略被天然气的 H2S 和 CO2 的内容的增加伴随的 Tarim 盆( CUTB )表演高举,由形成高全部的溶解固体形成流水,由 HCO 的内容的增加? 3 ,相对 Cl ?,由第二家庭离子的增加(Ca2+,Mg2+,Sr2+和Ba2+)并且由 SO2 的内容的减少? 4 ,相对 Cl ?。上述现象能仅仅由 thermochemical 硫酸盐减小(TSR ) 的方法被解释。TSR 经常发生在油和水的转变地区并且经常在下列反应公式被描述:CH+CaSO4+H-2OH2S+CO2+CaCO3。(1 ) 溶解了 SO2 ? 当 H2S 和 CO2 被产生时, 4 在上述反应在形成水里被消费,导致 SO2 的减少 ? 4 在形成水和在天然气的 H2S 和 CO2 的增加里。如果形成水存在,产生 CO2 将继续与碳酸盐反应形成酸式碳酸盐,它能在形成水里被溶解,因此导致 Ca2+ 和 HCO 的丰富 ? 3。上述反应能被下列方程描述:CO2+H2O+CaCO3Ca2++2HCO ? 3。在 CUTB 的寒武纪、更低的奥陶纪的 stratigraphic 温度超过了 120 整瑣湯捩栠獩潴祲漠?桚橥慩杮?畆楪湡?湡?楊湡硧?牰癯湩散?景猠畯桴?楨慮椠?浩潰瑲湡?潦?湵敤獲慴摮湩?桴?整瑣湯捩攠潶畬楴湯漠?潓瑵?桃湩?畢?瑩?慭浧瑡捩愠瑣癩瑩?瀠瑥潲敧敮楳?猠牴瑡杩慲桰捩猠煥敵据?景琠敨?浡慩獮慨?片畯?獩猠楴汬猠牴湯汧?潣瑮潲敶獲慩??牥?敷瀠敲敳瑮渠睥猠湥楳楴敶栠杩?敲潳畬楴湯椠湯洠捩潲瀭潲敢???偍??A稠物潣?敧'覡睖珱K杯捩污搠瑡?潦?桴?慍業湡桳湡?潲灵愠摮瀠瑥潲牧灡楨慣?慤慴琠?潣獮牴楡?桴?...桴? | XIANG Caifu PANG Xiongqi WANG Jianzhong LI Qiming WANG Hongping ZHOU Changqian YANG Haijun | 2010 | Acta Geologica Sinica(English Edition)2010，84，2： | 4 |
| 3 | Surgical treatment of hepato-pancreato-biliary disease in China:the Tongji experience显示文摘Hepato-pancreato-biliary(HPB) tumors are common in China. However, these tumors are often diagnosed at intermediate/advanced stages because of the lack of a systemic surveillance program in China. This situation creates many technical challenges for surgeons and increases the incidence of postoperative complications. Therefore, Dr. Xiao-Ping Chen has made many important technical improvements, such as Chen's hepatic portal occlusion method, the anterior approach for liver resection of large HCC tumors, the modified technique of Belghiti's liver-hanging maneuver, inserting biliary-enteric anastomosis technique, and invaginated pancreaticojujunostomy with transpancreatic U-sutures. These techniques are simple, practical, and easy to learn. Owing to these advantages, complicated surgical procedures can be simplified, and the curative effects are greatly improved. These improved techniques have been widely applied in China and will benefit many additional patients. In this review, we introduce our experience of surgically treating intermediate/advanced hepatocellular carcinoma(HCC), hilar cholangiocarcinoma(HC), and pancreatic carcinoma, mainly focusing on technical innovations established by Dr. Chen in HPB surgery. | binhao zhang wei dong hongping luo xuanru zhu lin chen changhai li wei zhang shuai xiang wanguang zhang zhiyong huang xiao-ping chen | 2016 | Science China(Life Sciences)2016，59，10： | 2 |
| 4 | Crystal struc- tures and elastic properties of superhard IrN2 and IrN3 from first principles显示文摘 | Wu Zhijian Zhao Erjun Xiang Hongping | 2007 | Phys Rev B2007，76，5： | 1 |
| 5 | Synthesis and characterization of titania MQ silicone resin hybrid nanocomposite via sol- gel process显示文摘 | Hongping Xiang Jianfeng Ge Shaohui Cheng | 2011 | Journal of Sol- Gel Science and Technology2011，59，3： | 1 |
| 6 | Theoretical Reinvestigation of the Electronic Structure of CuNCN: the Influence of Packingon the Magnetic Properties 显示文摘 | Hongping Xiang Xiaohui Liu Riehard Dronskowski | 2009 | The Journal of Physical Chemistry C2009，113，18： | 1 |
| 7 | Crystal Structures and Elastic Properties of Superhard IrN2and IrN3 from First-Principles 显示文摘 | WU Zhijian ZHAO Erjun XIANG Hongping | 2007 | Phys Rev B2007，76，05： | 1 |
| 8 | Cell osteogenic bioactivity mediated precisely by varying scaled micro-pits on ordered micro/nano hierarchical structures of titanium显示文摘Hierarchical surface structures with micro–nano scale play a crucial role in regulation of cell proliferation and osteogenic differentiation.It has been proven that cells are extremely sensitive to the nanoscaled structure and show multifarious phenotypes.Though a vital function of microstructure on osseointegration has been confirmed,the cell performances response to different microscaled structure is needed to be further dissected and in depth understood.In this work,the ordered micro–nano hierarchical structures with varying micro-scaled pits were precisely fabricated on titanium successfully by the combination of electrochemical,chemical etching and anodization as well.In vitro systematical assessments indicated that the micro–nano multilevel structures on titanium exhibited excellent cells adhesion and spreading ability,as well as steerable proliferation and osteogenic differentiation behaviors.It is shown that smaller micro-pits and lower roughness of the hierarchical structures enabled faster cell propagation.Despite cell growth was delayed on micro–nano titanium with relatively larger cell-match-size micro-pits and roughness,osteogenic-specific genes were significantly elevated.Furthermore,the alkaline phosphatase activity,collagen secretion and extracellular matrix mineralization of MC3T3-E1 on multiscaled titanium were suppressed by a large margin after adding IWP-2(an inhibitor of Wnt/b-catenin signal pathway),indicating this pathway played a crucial part in cell osteogenic differentiation modulated by micro–nano structures. | Yanmei Zhang Xiankuan Wang Yaxian Li Jianhe Liang Pinliang Jiang Qiaoling Huang Yun Yang Hongping Duan Xiang Dong Gang Rui Changjian Lin | 2022 | Regenerative Biomaterials2022，9，1： | 1 |
| 9 | Potent antifouling compounds produced by marine Streptomyces显示文摘 | Ying Xu Hongping He Stefan Schulz Xin Liu Nobushino Fusetani Hairong Xiong Xiang Xiao Pei-Yuan Qian | 2009 | Bioresource Technology2009，，4： | 1 |
| 10 | Towrard-target precision pesticide application and its system design 显示文摘 | Zheng Jiaqiang Zhou Hongping Xu Youlin Zhao Maocheng Zhang Huichun Ge Yufeng Xiang Haitao Chen Yong | 2005 | Transactions of the CSAE2005，21，11： | 1 |
| 11 | Synthesis and characterization of titania/MQ silicone resin hybrid nanocomposite via sol-gel process显示文摘 | Xiang Hongping Ge Jianfeng Cheng Shaohui | 2011 | J Sol-Gel Sci Techn2011，59，： | 1 |
| 12 | Methane Adsorption on Montmorillonite, Kaolinite and Illite at High Pressures显示文摘Shale gas, which is derived from organic matters in shale and stored in shale deposits, is an important unconventional gas resource and attracts attention due to its significant requirement in the hydrocarbon production. Methane (CH4) is the dominant component of shale gas, and adsorbed gas is an important reservoir form. Many studies have investigated the adsorption capacities and adsorption mechanisms of CH4 in shale. Organic matters and clay minerals have been proposed to be the two major components for CH4 adsorption. Adsorption of CH4 in organic matters, such as the adsorption capacity and effects of characteristics of the organic matters, has been well investigated. However, studies on CH4 adsorption on clay minerals have mainly focused on evaluating the adsorption capacity, and very little information about the adsorption mechanism has been provided. For example, the adsorption sites and factors influencing CH4 adsorption on clay minerals remain unclear. Three main reasons account for this: (1) the co-existence of organic matters in samples affects the evaluation of CH4 adsorption on clay minerals; (2) the pressures used during adsorption are not representative of actual reservoir pressures; and (3) the clay minerals selected have low swelling capacity and a smaller interlayer distances than a CH4 size, resulting in the misunderstanding of the CH4 adsorption sites. | LIU Dong YUAN Peng LIU Hongmei TAN Daoyong YUAN Weiwei ZHOU Xiang HE Hongping | 2013 | 矿物学报2013，33，S1： | 0 |
| 13 | Role of the Interlayer Space of Montmorillonite in Hydrocarbon Generation: A Combined Study by TG-FTIR and High Temperature-Pressure Pyrolysis显示文摘The interlayer clay-organic complex is an important clay-organic association in sedimentary environments. The interlayer region of clay minerals not only provides storage space for organic matter, but also possesses solid acid sites; and these acid sites were proposed to be involved with the transformation of organic matter into liquid and gaseous hydrocarbons. However, the effect of the organic matter storage in the interlayer space of clay minerals on the hydrocarbons generation has not been made clear. In this study, the interlayer complex of 12-aminolauric acid (ALA) and Na+-montmorillonite (Na+-Mt), labeled as ALAinter-Mt (Na), was synthesized to investigate the role of the interlayer space of montmorillonite in hydrocarbon generation. Simply mixed ALA-Mt complex [ALA-Mt (Na)] was also prepared for comparison. The pyrolysis of ALA and ALA-Mt complexes was studied using thermogravimetry coupled with Fourier transform infrared spectroscopy (TG-FTIR) and a high temperature-pressure system (a confined gold capsule-autoclave system). | LIU Hongmei YUAN Peng LIU Dong ZHOU Xiang HE Hongping ZHU Jianxi | 2013 | 矿物学报2013，33，S1： | 0 |
| 14 | APPLICATION OF CASE-BASED REASONING IN FORECASTING INSECT PESTS显示文摘XiaLuping;Zhulei;XiangHongping(AnhuiInstituteofAchitecture)APPLICATIONOFCASE-BASEDREASONINGINFORECASTINGINSECTPESTS￥XiaLuping... | Xia Luping Zhulei Xiang Hongping(Anhui Institute of Achitecture) | 1995 | 安徽建筑工业学院学报(自然科学版)1995，3，2： | 0 |
| 15 | Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation显示文摘Currently,human health due to corona virus disease 2019(COVID-19)pandemic has been seriously threatened.The coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)spike(S)protein plays a crucial role in virus transmission and several S-based therapeutic approaches have been approved for the treatment of COVID-19.However,the efficacy is compromised by the SARS-CoV-2 evolvement and mutation.Here we report the SARS-CoV-2 S protein receptor-binding domain(RBD)inhibitor licorice-saponin A3(A3)could widely inhibit RBD of SARS-CoV-2 variants,including Beta,Delta,and Omicron BA.1,XBB and BQ1.1.Furthermore,A3 could potently inhibit SARS-CoV-2 Omicron virus in Vero E6 cells,with EC50 of 1.016μM.The mechanism was related to binding with Y453 of RBD determined by hydrogen-deuterium exchange mass spectrometry(HDX-MS)analysis combined with quantum mechanics/molecular mechanics(QM/MM)simulations.Interestingly,phosphoproteomics analysis and multi fluorescent immunohistochemistry(mIHC)respectively indicated that A3 also inhibits host inflammation by directly modulating the JNK and p38 mitogen-activated protein kinase(MAPK)pathways and rebalancing the corresponding immune dysregulation.This work supports A3 as a promising broad-spectrum small molecule drug candidate for COVID-19. | Yang Yi Wenzhe Li Kefang Liu Heng Xue Rong Yu Meng Zhang Yang-Oujie Bao Xinyuan Lai Jingjing Fan Yuxi Huang Jing Wang Xiaomeng Shi Junhua Li Hongping Wei Kuanhui Xiang Linjie Li Rong Zhang Xin Zhao Xue Qiao Hang Yang Min Ye | 2024 | Journal of Pharmaceutical Analysis2024，14，1： | 0 |
| 16 | Distribution, evolution and structural properties of Wushenqi paleo-uplift in Ordos Basin, NW China显示文摘This paper depicts the distribution of the Wushenqi paleo-uplift in the Ordos Basin by using the latest drilling and seismic data, and analyzes the tectonic evolution of the paleo-uplift with the support of Bischke curve and balanced section. The compressional Wushenqi paleo-uplift which developed in the Early Caledonian orogeny(Huaiyuan orogeny) is approximately a ellipse extending in S-N direction. Its long axis is about 194 km and short axis is about 55-94 km in nearly W-E direction. The denudation thickness and area of the Cambrian in the core are 170-196 m and 11 298 km^(2), respectively. It was mainly formed during the Huaiyuan orogeny according to the chronostratigraphic framework. It was in the embryonic stage in the Middle-Late Cambrian, denuded after developed obviously at the end of Late Cambrian. The paleo-uplift of the 3rd member of the Ordovician Majiagou Formation was reactivated and reduced in area. In the sedimentary period of the Ma 4 Member-pre-Carboniferous, the paleo-uplift experienced non-uniform uplift and denudation. It entered the stable period of burial and preservation in the Carboniferous and later period. The Wushenqi paleo-uplift was formed on the weak area of the basement and tectonic belts, into an compressional structure with irregular morphology, under the control of the non-coaxial compression in the south and north and the stress transmitted by the uplift in the basin. The Wushenqi paleo-uplift has a controlling effect on the sedimentary reservoirs and hydrocarbon accumulation. | MAO Danfeng HE Dengfa BAO Hongping WEI Liubin XU Yanhua CHENG Xiang GOU Junyi WU Saijun | 2023 | Petroleum Exploration and Development2023，50，4： | 0 |
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