| 1 | Integrated histopathological,lipidomic,and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is transmitted on mink farms between minks and humans in many countries.However,the systemic pathological features of SARS-CoV-2-infected minks are mostly unknown.Here,we demonstrated that minks were largely permissive to SARS-CoV-2,characterized by severe and diffuse alveolar damage,and lasted at least 14 days post inoculation(dpi).We first reported that infected minks displayed multiple organ-system lesions accompanied by an increased inflammatory response and widespread viral distribution in the cardiovascular,hepatobiliary,urinary,endocrine,digestive,and immune systems.The viral protein partially co-localized with activated Mac-2+macrophages throughout the body.Moreover,we first found that the alterations in lipids and metabolites were correlated with the histological lesions in infected minks,especially at 6 dpi,and were similar to that of patients with severe and fatal COVID-19.Particularly,altered metabolic pathways,abnormal digestion,and absorption of vitamins,lipids,cholesterol,steroids,amino acids,and proteins,consistent with hepatic dysfunction,highlight metabolic and immune dysregulation.Enriched kynurenine in infected minks contributed to significant activation of the kynurenine pathway and was related to macrophage activation.Melatonin,which has significant anti-inflammatory and immunomodulating effects,was significantly downregulated at 6 dpi and displayed potential as a targeted medicine.Our data first illustrate systematic analyses of infected minks to recapitulate those observations in severe and fetal COVID-19 patients,delineating a useful animal model to mimic SARS-CoV-2-induced systematic and severe pathophysiological features and provide a reliable tool for the development of effective and targeted treatment strategies,vaccine research,and potential biomarkers. | Zhiqi Song Linlin Bao Wei Deng Jiangning Liu Erjun Ren Qi Lv Mingya Liu Feifei Qi Ting Chen Ran Deng Fengdi Li Yunpeng Liu Qiang Wei Hong Gao Pin Yu Yunlin Han Wenjie Zhao Junjun Zheng Xujian Liang Fuhe Yang Chuan Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 5 | PTB7-Th based organic solar cell with a high V_(oc) of 1.05 V by modulating the LUMO energy level of benzotriazole-containing non-fullerene acceptor显示文摘The open-circuit voltage(V_(oc))of classical photovoltaic polymers,such as P3HT and PTB7-Th,are always restricted when combining with fullerene derivatives,due to the difficulty of modulating the energy levels of fullerene derivatives.Thus,design of new non-fullerene small molecule acceptor(NFSMA)is very significant to match with these mature polymer donors and improve the V_(oc)and power conversion efficiency(PCE).Here,a new benzotriazole(BTA)-based NFSMA,BTA7 was synthesized by adopting A_2@A_1ADAA_1@A_2type molecular backbone.By using a strong electron-accepting unit of malononitrile(M)as terminal segment A_2,BTA7 demonstrates strong crystallinity,red-shifted absorption spectrum and down-shifted lowest unoccupied molecular orbital(LUMO)energy levels in comparison with BTA_1and BTA_2.Organic solar cells(OSCs)based on PTB7-Th:BTA7 realized a high V_(oc)of 1.05 V with a moderate PCE of 4.60%.The energy loss(E_(loss)=E_gàe V_(oc))of 0.53 e V is lower than the experiential minimum value of0.6 e V,which indicates PTB7-Th still has large potential to improve the V_(oc)and photovoltaic performance after the development of novel electron acceptors. | Bo Xiao Yingjie Zhao Ailing Tang Haiqiao Wang Jing Yang Erjun Zhou | 2017 | Science Bulletin2017，62，18： | 1 |
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