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| 1 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 2 | Effect of acupotomy on nitric oxide synthase and beta-endorphin in third lumbar vertebrae transverse process syndrome model rats显示文摘OBJECTIVE: To explore the long-term effects and pain relief mechanism of acupotomy by observing changes in nitric oxide synthase(NOS) and beta-endorphin(β-EP) in the hypothalamus, spinal cord,and peripheral blood of rats with third lumbar vertebrae(L3) transverse process syndrome.METHODS:Twenty-eight SD rats were randomly assigned to normal, model, electroacupuncture(EA),and acupotomy group. The last three groups were put through an operation to emulate L3transverse process syndrome. Fourteen days after the simulation operation, EA and acupotomy treatments were applied to the respective groups. Fifty-six days afterthe simulation operation, biochemistry tests and enzyme-linked immunosorbent assay were used to measure NOS and β-EP in the hypothalamus, spinal cord, and peripheral blood.RESULTS: Rats with the simulation operation showed significantly higher levels of NOS and β-EP in the hypothalamus, spinal cord, and peripheral blood than those in the normal group. The EA and acupotomy groups had significantly lower levels of NOS and β-EP than those in the model group.There was no statistical difference between the EA and acupotomy groups.CONCLUSION: EA and acupotomy treatments significantly lowered NOS and β-EP levels in the hypothalamus, spinal cord, and peripheral blood and alleviated L3transverse process syndrome. | Changqing Guo Naigang Liu Xiaohong Li Hongmei Sun Bo Hu Jing Lu Yan Guo Chuxi Liang Hong Xu Haixia Wu | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 15 |
| 3 | Elemental compositions of PM_(2.5) and TSP in Lijiang,southeastern edge of Tibetan Plateau during pre-monsoon period显示文摘推迟的微粒(TSP ) 取样的 PM2.5 和总数在丽江被收集,东南的西藏的高原,中国。十六个元素(艾尔, Si, S, K, Ca, Cr, Mn, Ti, Fe, Ni, Zn,同样 Br, Sb, Pb 和 Cu ) 被分析在季风前时期期间调查他们的元素的作文。结果证明 Ca 是在 PM2.5 和 TSP 样品的最丰富的元素。Si, Ti, Ca, Fe, K 和 Mn 的丰富因素(EF ) 都为 PM2.5 和 TSP 低于 10,并且这些元素也有更低的 PM2.5/TSP 比率(0.320.34 ) ,建议他们主要从外壳的来源被导出。元素 Cu, Zn, S, Br 和 Sb 在 PM2.5 和 TSP 样品显示出强壮的丰富,与他们从 0.66 ~ 0.97 的 PM2.5/TSP 比率,显示他们在好部分被充实并且由人为的来源影响了。在背轨道的 500 hPa 和计算的风地的分析显示艾尔, Si , Ca , Ti , Cr , Mn 和 Fe 能被运输在灰尘暴风雨季节,和那 S 期间从西北的中国影响, K , Ni , Br 和 Pb 从南亚在西的运输期间到达了高集中。与原则部件分析和关联分析结合了, PM2.5 样品的元素主要来自外壳的来源,生物资源燃烧排出物和地区性的交通相关的来源。 | Ningning Zhang Junji Cao Hongmei Xu Chongshu Zhu | 2013 | Particuology2013，11，1： | 14 |
| 4 | Genomic survey of bZIP transcription factor genes related to tanshinone biosynthesis in Salvia miltiorrhiza显示文摘Tanshinones are a class of bioactive components in the traditional Chinese medicine Salvia miltiorrhiza, and their biosynthesis and regulation have been widely studied. Current studies show that basic leucine zipper(bZIP) proteins regulate plant secondary metabolism, growth and developmental processes. However, the b ZIP transcription factors involved in tanshinone biosynthesis are unknown.Here, we conducted the first genome-wide survey of the b ZIP gene family and analyzed the phylogeny,gene structure, additional conserved motifs and alternative splicing events in S. miltiorrhiza. A total of 70 Smb ZIP transcription factors were identified and categorized into 11 subgroups based on their phylogenetic relationships with those in Arabidopsis. Moreover, seventeen Smb ZIP genes underwent alternative splicing events. According to the transcriptomic data, the Smb ZIP genes that were highly expressed in the Danshen root and periderm were selected. Based on the prediction of b ZIP binding sites in the promoters and the co-expression analysis and co-induction patterns in response to Ag^+ treatment via quantitative real-time polymerase chain reaction(qRT-PCR), we concluded that Smb ZIP7 and Smb ZIP20 potentially participate in the regulation of tanshinone biosynthesis. These results provide a foundation for further functional characterization of the candidate Smb ZIP genes, which have the potential to increase tanshinone production. | Yu Zhang Zhichao Xu Aijia Ji Hongmei Luo Jingyuan Song | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 14 |
| 5 | Incidence and mortality of primary bone cancers in China, 2014显示文摘Objective: In this study, we aimed to estimate the updated incidence and mortality of primary bone cancers based on population-based cancer registration data in 2014, collected by the National Central Cancer Registry of China(NCCRC).Methods: In 2017, 339 registries' data were qualified based on data quality criteria set down by the NCCRC.Cases of primary bone cancers were retrieved from the national database. We estimated numbers of primary bone cancer cases and deaths in China using age-specific rates and corresponding national population stratified by area,sex, age-group(0, 1-4, 5-9, 10-14, …, 85+). Chinese standard population in 2000 and Segi's World population were applied for the calculation of age-standardized incidence and mortality rates.Results: In 2014, 24,000 primary bone cancer cases and 17,200 deaths attributable to primary bone cancers were estimated to have occurred in China. The crude incidence rate of primary bone cancers was 1.76/100,000, with agestandardized incidence rate by Chinese standard population(ASIRC) and by World standard population(ASIRW)being 1.35/100,000 and 1.32/100,000, respectively. The crude mortality rate of primary bone cancers was1.26/100,000, with age-standardized mortality rate by Chinese standard population(ASMRC) and by World standard population(ASMRW) being 0.88/100,000 and 0.86/100,000, respectively. Age-specific incidence curve was bimodally distributed with age, with the first peak occurring in the second decade of the life and the second peak in the elderly. Males had higher crude and age-standardized rates for both incidence and mortality compared with females. Both crude and age-standardized incidence rates were higher in rural areas than in urban areas, so were the crude and age-standardized mortality rates.Conclusions: This population-based study presents the most recently available estimates on primary bone cancers in China, revealing that the males are 1.34 times as much as females suffering from primary bone cancers and the adolescents in puberty and the elderly are predominantly affected groups by these cancers. High-quality cancer registration data are a prerequisite for undertaking further study for gaining insight into the causes and risk factors for primary bone cancers in China. | Liang Xia Rongshou Zheng Yanjun Xu Xiaojun Xu Siwei Zhang Hongmei Zeng Lifeng Lin Wanqing Chen | 2019 | Chinese Journal of Cancer Research2019，31，1： | 13 |
| 6 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 7 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 8 | Noble metal nanoclusters and their in situ calcination to nanocrystals: Precise control of their size and interface with Ti02 nanosheets and their versatile catalysis applications显示文摘 | Anwer Shoaib Muwei Ji Hongmei Qian Jiajia Liu Meng Xu Jiatao Zhang | 2016 | Nano Research2016，9，6： | 10 |
| 9 | Distribution and deposition of polycyclic aromatic hydrocarbons in precipitation in Guangzhou, South China显示文摘Polycyclic aromatic hydrocarbons (PAHs) were measured in precipitation from March to August 2005 in Guangzhou, South China. Fourteen PAHs were studied, and their total concentrations varied from 616.6 to 3486.7 ng/L in dissolved phase and from 403.8 to 3125.5 ng/L in particulate phase. The estimated deposition loading of PAHs was 3568 μg/m2 during the monitoring period. The deposition of PAHs was a potential source for Pearl River comparing with the contents of surface water. In addition, the high concentration in precipitation here implied that PAHs pollution was a potential environmental problem in Guangzhou. Most precipitation concentrations of PAHs in March (the last month in winter in Guangzhou) were higher than in the other months (in rainy season). PAHs inclined to be adsorbed to particulate phase with the increase of molecular weight in rainwater. Combustion of fossil fuel and biomass might be the major source of PAHs, while the direct leakage or volatilization from petroleum products might be insignificant. | HUANG Deyin PENG Ping'an XU Yigang DENG Yunyun DENG Hongmei | 2009 | Journal of Environmental Sciences2009，21，5： | 9 |
| 10 | MoSi_2 oxidation resistance coatings for Mo_5Si_3/MoSi_2 composites显示文摘In order to improve the oxidation resistance properties of 30 at.% Mo5Si3/MoSi2 composite at high temperature in air, a molybdenum disilicide coating was prepared on its surface by a molten salt technology. XRD and SEM analysis showed that only tetragonal MoSi2 phase existed in the coating after being siliconized for 5 h at 900°C. The oxidation film formed on the uncoated sample was not dense, so that oxygen diffused easily through it. The volatilization of MoO3 resulted in the oxidation film separating from the substrate. The MoSi2 coating was proved to be an effective method to prevent 30 at.% Mo5Si3/MoSi2 composites from being oxidized at 1200°C. A dense glassy SiO2 film was formed on the MoSi2 coating surface, which acted as a barrier layer for the diffusion of oxygen atoms to the substrate. The 30at.% Mo5Si3/MoSi2 composites with a MoSi2 coating showed much better oxidation resistance at high temperature. | YAN Jianhui XU Hongmei ZHANG Houan TANG Siwen | 2009 | Rare Metals2009，28，4： | 8 |
| 11 | The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis显示文摘 | Fang Wang Wei Song Hongmei Zhao Yanni Ma Yuxia Li Di Zhai Jingnan Pi Yanmin Si Jiayue Xu Lei Dong Rui Su Mengmeng Zhang Yong Zhu Xiaoxia Ren Fei Miao Wenjie Liu Feng Li Junwu Zhang Aibin He Ge Shan Jingyi Hui Linfang Wang Jia Yu | 2017 | Cell Research2017，27，3： | 7 |
| 12 | Variation of culturable bacteria along depth in the East Rongbuk ice core,Mt.Everest显示文摘冰从从东方 Rongbuk 冰河被钻的 22.27 m 冰核心融化水,埃韦雷斯特山是以二个孵化方法的孵化:板直接融化水并且丰富融化水优先的板分别地。许多可耕种的细菌与 1385 的一个总数在二孵化从 0295 CFU mL1 到 01720 CFU mL1 孤立获得。比较指导耕作,丰富耕作恢复了更多的细菌。生产颜料的细菌说明了因为 84.9% 总数的一般水准孤立。如此的高百分比建议那颜料生产可以是为在冰核心的细菌的一个适应生理的特征在冰河上应付强壮的紫外放射。许多可耕种的细菌并且生产颜料孤立沿着深度同时地变化了:在中间的更高的丰富并且在顶和底部更低。它显示冰核心的中间的部分为微生物引起的幸存是好客的。基于殖民地的生理的性质, 89 孤立为种系发生的分析被选择。获得的 16S rRNA 基因序列掉进四个组:Firmicutes, Alpha-Proteobacteria, Gamma-Proteobacteria,和 Actinobacteria,与是主导的 Firmicutes。微生物引起的作文源于直接并且丰富耕作没被重叠。我们建议探索 culturable 是一个更好的方法在由联合途径的冰核心的微生物引起的差异直接并且丰富耕作。 | Liang Shen Tandong Yao Baiqing Xu Hongmei Wang Nianzhi Jiao Shichang Kang Xiaobo Liu Yongqin Liu | 2012 | Geoscience Frontiers2012，3，3： | 7 |
| 13 | Morphological, cytological and molecular analyses of a synthetic hexaploid derived from an interspecific hybrid between Gossypium hirsutum and Gossypium anomalum显示文摘Gossypium anomalum represents an inestimable source of genes that could potentially be transferred into the gene pool of cultivated cotton. To resolve interspecific hybrid sterility problems, we previously treated triploid hybrids derived from a cross between Gossypium hirsutum and G. anomalum with 0.15% colchicine and obtained a putative fertile hexaploid. In this study, we performed morphological, molecular and cytological analyses to assess the hybridity and doubled status of putative interspecific hybrid plants. Most of the morphological characteristics of the putative hexaploid plants were intermediate between G. hirsutum and G.anomalum. Analysis of mitotic metaphase plates revealed 78 chromosomes, confirming the doubled hybrid status of the hexaploid. Genome-wide molecular analysis with different genome-derived SSR markers revealed a high level of polymorphism(96.6%) between G. hirsutum and G. anomalum. The marker transferability rate from other species to G. anomalum was as high as 98.0%. The high percentage of polymorphic markers with additive banding profiles in the hexaploid indicates the hybridity of the hexaploid on a genome-wide level. A-genome-derived markers were more powerful for distinguishing the genomic differences between G. hirsutum and G. anomalum than D-genome-derived markers. This study demonstrates the hybridity and chromosomally doubled status of the(G. anomalum × G. hirsutum)2hexaploid using morphological, cytological and molecular marker methods. The informative SSR markers screened in the study will be useful marker resources for tracking the flow of G. anomalum genetic material among progenies that may be produced by future backcrosses to G. hirsutum. | Xia Zhang Caijiao Zhai Linchi He Qi Guo Xianggui Zhang Peng Xu Hongmei Su Yuanyong Gong Wanchao Ni Xinlian Shen | 2014 | The Crop Journal2014，2，5： | 5 |
| 14 | Induction of jasmonic acid biosynthetic genes inhibits Arabidopsis growth in response to low boron显示文摘The essential micronutrient boron(B) has key roles in cell wall integrity and B deficiency inhibits plant growth. The role of jasmonic acid(JA) in plant growth inhibition under B deficiency remains unclear. Here,we report that low B elevates JA biosynthesis in Arabidopsis thaliana by inducing the expression of JA biosynthesis genes. Treatment with JA inhibited plant growth and, a JA biosynthesis inhibitor enhanced plant growth, indicating that the JA induced by B deficiency affects plant growth. Furthermore,examination of the JA signaling mutants jasmonate resistant1, coronatine insensitive1-2, and myc2 showed that JA signaling negatively regulates plant growth under B deficiency. We identified a low-B responsive transcription factor, ERF018, and used yeast one-hybrid assays and transient activation assays in Nicotiana benthamiana leaf cells to demonstrate that ERF018 activates the expression of JA biosynthesis genes. ERF018 overexpression(OE)lines displayed stunted growth and up-regulation of JA biosynthesis genes under normal B conditions,compared to Col-0 and the difference between ERF018 OE lines and Col-0 diminished under low B.These results suggest that ERF018 enhances JA biosynthesis and thus negatively regulates plant growth. Taken together, our results highlight the importance of JA in the effect of low B on plant growth. | Yupu Huang Sheliang Wang Chuang Wang Guangda Ding Hongmei Cai Lei Shi Fangsen Xu | 2021 | Journal of Integrative Plant Biology2021，63，5： | 5 |
| 15 | Molecular distribution and seasonal variation of hydrocarbons in PM_(2.5) from Beijing during 2006显示文摘正常(n) 链烷和多不的芳香的烃(哼) 在 2006 从北京在 PM2.5 被收集并且分析了使用一种热 desorption-GC/MS 技术。n 链烷的年度平均集中并且哼 282 是 ????????????? ? ㈠ ?? 朠洯″ ???? ?? | Yushan Li Junji Cao Jianjun Li Jiamao Zhou Hongmei Xu Renjian Zhang Zhiyun Ouyang | 2013 | Particuology2013，11，1： | 5 |
| 16 | Characteristics and origin of mafic and ultramafic xenoliths in trachyandesite lavas from Heikongshan volcano,Tengchong,Yunnan Province,China显示文摘The trachyandesite lavas from Heikongshan volcano of the Tengchong volcanic cluster, Yunnan Province contain relatively abundant mafic and ultramafic small xenoliths comprising mainly gabbro, pyroxenite and rare lherzolites, all less than 2.5 cm in size. Gabbro xenoliths are characterized by 'open' texture represented by relatively abundant vesicles and ground-mass fillings, while pyroxenite xenoliths are characterized by equigranular and poikilitic texture. Their mineral compositions (clinopyroxene ± orthopyroxene ± plagioclase) are similar to those of phenocrysts in lavas, and their equilibration temperature (1000-1125°C) is consistent with the crystallization temperature of the phenocrysts (998-1108°C). Thus, the textures and compositions of these xenoliths are different from those of lower crustal and mantle xenoliths, and were derived from the magma chamber. Among them, the gabbroic xenoliths come from the crystal-bubble-liquid zone at the top of the magma reservoir, while the pyroxenite xenoliths come from the cumulates in the bottom of magma reservoir. The studied single lherzolite xenolith with porphyroclastic texture has similar mineral compositions to the mantle xenoliths from eastern China, and is considered to be of upper mantle origin. It was brought into magma reservoir by replenishment magma, and might have experienced a cooling event before eruption. The formation of xenoliths in trachyandesite flows largely reflects the ascent, storage, evolution and eruption processes of magma. | YU HongMei, LIN ChuanYong, SHI LanBin, XU JianDong & CHEN XiaoDe Institute of Geology, China Earthquake Administration, Beijing 100029, China | 2010 | Science China Earth Sciences2010，53，9： | 5 |
| 17 | Expert consensus on early childhood caries management显示文摘Early childhood caries(ECC)is a significant chronic disease of childhood and a rising public health burden worldwide.ECC may cause a higher risk of new caries lesions in both primary and permanent dentition,affecting lifelong oral health.The occurrence of ECC has been closely related to the core microbiome change in the oral cavity,which may be influenced by diet habits,oral health management,fluoride use,and dental manipulations.So,it is essential to improve parental oral health and awareness of health care,to establish a dental home at the early stage of childhood,and make an individualized caries management plan.Dental interventions according to the minimally invasive concept should be carried out to treat dental caries.This expert consensus mainly discusses the etiology of ECC,caries-risk assessment of children,prevention and treatment plan of ECC,aiming to achieve lifelong oral health. | Jing Zou Qin Du Lihong Ge Jun Wang Xiaojing Wang Yuqing Li Guangtai Song Wei Zhao Xu Chen Beizhan Jiang Yufeng Mei Yang Huang Shuli Deng Hongmei Zhang Yanhong Li Xuedong Zhou | 2022 | International Journal of Oral Science2022，14，3： | 5 |
| 18 | Surface micro/nanostructure evolution of Au-Ag alloy nanoplates: Synthesis, simulation, plasmonic photothermal and surface-enhanced Raman scattering applications显示文摘 | Hongmei Qian Meng Xu Xiaowei Li Muwei Ji Lei Cheng Anwer Shoaib Jiajia Liu Lan Jiang Hesun Zhu Jiatao Zhang | 2016 | Nano Research2016，9，3： | 5 |
| 19 | Relationship between chronic diarrhea with normal colonoscopy findings and terminal ileum lesions显示文摘 | LI Hongling WANG Changcheng LIU Shuqing XU Dongsheng ZHANG Ju CHEN hongmei | 2014 | Chinese Medical Journal2014，，16： | 4 |
| 20 | Multicenter phaseⅡstudy of apatinib single or combination therapy in HER2-negative breast cancer involving chest wall metastasis显示文摘Objective:Breast cancer(BC)with chest wall metastasis(CWM)usually shows rich neovascularization.This trial explored the clinical effect of apatinib on human epidermal growth factor receptor 2(HER2)-negative advanced BC involving CWM.Methods:This trial involved four centers in China and was conducted from September 2016 to March 2020.Patients received apatinib 500 mg/d[either alone or with endocrine therapy if hormone receptor-positive(HR+)]until disease progression or unacceptable toxicity.Progression-free survival(PFS)was the primary endpoint.Results:We evaluated 26 patients for efficacy.The median PFS(mPFS)and median overall survival(mOS)were4.9[range:2.0-28.5;95%confidence interval(95%CI):2.1-8.3]months and 18(range:3-55;95%CI:12.9-23.1)months,respectively.The objective response rate(ORR)was 42.3%(11/26),and the disease-control rate was76.9%(20/26).In the subgroup analysis,HR+patients compared with HR-negative patients had significantly improved mPFS of 7.0(95%CI:2.2-11.8)months vs.2.3(95%CI:1.2-3.4)months,respectively(P=0.001);and mPFS in patients without or with chest wall radiotherapy was 6.4(95%CI:1.6-19.5)months vs.3.0(95%CI:1.3-4.6)months,respectively(P=0.041).In the multivariate analysis,HR+status was the only independent predictive factor for favorable PFS(P=0.014).Conclusions:Apatinib was highly effective for BC patients with CWM,especially when combined with endocrine therapy.PFS improved significantly in patients with HR+status who did not receive chest wall radiotherapy.However,adverse events were serious and should be carefully monitored from the beginning of apatinib treatment. | Huiping Li Cuizhi Geng Hongmei Zhao Hanfang Jiang Guohong Song Jiayang Zhang Yaxin Liu Xinyu Gui Jing Wang Kun Li Zhongsheng Tong Fangyuan Zhao Junlan Yang Guoliang Chen Qianyu Liu Xu Liang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 4 |
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