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| 1 | KIF2C:a novel link between Wnt/β-catenin and mTORCI signaling in the pathogenesis of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and is the fourth-leading cause of cancer-related deaths worldwide.HCC is refractory to many standard cancer treatments and the prognosis is often poor,highlighting a pressing need to identify biomarkers of aggressiveness and potential targets for future treatments.Kinesin family member 2C(KIF2C)is reported to be highly expressed in several human tumors.Nevertheless,the molecular mechanisms underlying the role of KIF2C in tumor development and progression have not been investigated.In this study,we found that KIF2C expression was significantly upregulated in HCC,and that KIF2C up-regulation was associated with a poor prognosis.Utilizing both gain and loss of function assays,we showed that KIF2C promoted HCC cell proliferation,migration,invasion,and metastasis both in vitro and in vivo.Mechanistically,we identified TBC1D7 as a binding partner of KIF2C,and this interaction disrupts the formation of the TSC complex,resulting in the enhancement of mammalian target of rapamycin complexl(mTORCI)signal transduction.Additionally,we found that KIF2C is a direct target of the Wnt/β-catenin pathway,and acts as a key factor in mediating the crosstalk between Wnt/β-catenin and mTORCI signaling.Thus,the results of our study establish a link between Wnt/β-catenin and mTORCI signaling,which highlights the potential of KIF2C as a therapeutic target for the treatment of HCC. | Shi Wei Miaomiao Dai Chi Zhang Kai Teng Fengwei Wang Hongbo Li Weipeng Sun Zihao Feng Tiebang Kang Xinyuan Guan Ruihua Xu Muyan Cai Dan Xie | 2021 | Protein & Cell2021，12，10： | 8 |
| 2 | An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression显示文摘 | Jerome Barbier Xin Chen Gabriel Sanchez Muyan Cai Marion Helsmoortel Takuma Higuchi Pierre Giraud Xavier Contreras Gangjun Yuan Zihao Feng Rima Nait-Saidi Olivier Deas Lisa Bluy Jean-Gabriel Judde Sylvie Rouquier William Ritchie Shuji Sakamoto Dan Xie Rosemary Kiernan | 2018 | Cell Research2018，28，5： | 3 |
| 3 | High expression of trimethylated histone H3 lysine 4 is associated with poor prognosis in hepatocellular carcinoma显示文摘 | Chuanchao He Junyao Xu Jianlong Zhang Dan Xie Hua Ye Zhiyu Xiao Muyan Cai Kang Xu Yunjie Zeng Haigang Li Jie Wang | 2012 | Human Pathology2012，，9： | 3 |
| 4 | Loss/Down-Regulation of Tumor Suppressor in Lung Cancer 1 Expression Is Associated With Tumor Progression and Is a Biomarker of Poor Prognosis in Ovarian Carcinoma显示文摘 | Guofen Yang Weipeng He Muyan Cai Fei Luo Hsiangfu Kung Xinyuan Guan Yixin Zeng Dan Xie | 2011 | International Journal of Gynecological Cancer2011，，3： | 1 |
| 5 | Loss/Down-Regulation of Tumor Suppressor in Lung Cancer 1 Expression Is Associated With Tumor Progression and Is a Biomarker of Poor Prognosis in Ovarian Carcinoma显示文摘 | Guofen Yang Weipeng He Muyan Cai Fei Luo Hsiangfu Kung Xinyuan Guan Yixin Zeng Dan Xie | 2011 | International Journal of Gynecological Cancer2011，，3： | 1 |
| 6 | Golgi phosphoprotein 3 ( GOLPH3 ) promotes hepatocellular carcinoma cell aggressiveness by activating the NF ‐κ B pathway显示文摘 | Ting Dai Dongsheng Zhang Muyan Cai Chanjuan Wang Zhiqiang Wu Zhe Ying Jueheng Wu Mengfeng Li Dan Xie Jun Li Libing Song | 2015 | Pathol2015，，3： | 1 |
| 7 | Early Differential Diagnosis and Nursing for Acute Aortic Dissection 显示文摘 | YANG Xiaowen WANG Hong XIE Muyan | 2009 | Journal of Nursing Science2009，24，2： | 1 |
| 8 | Three lactic acid bacteria with anti-obesity properties:In vitro screening and probiotic assessment显示文摘The worldwide obesity epidemic has imposed human being a huge burden and attention had been drawn to manipulating the lactic acid bacteria (LAB) to improve obesity symptoms.In this study,a more comprehensive and reliable in vitro method was established to screen LAB with greater potential against obesity.Firstly,twenty-eight human feces-derived LAB strains were selected by assessing bile salt-acid tolerance and cholesterol lowering capacity.Subsequently,the triglyceride lowering capacity,bile salt hydrolase (BSH) activity,α-glucosidase activity inhibition capacity and Enterobacter cloacae (E.cloacae) growth inhibition capacity were tested for further evaluating the anti-obesity properties of LAB strains.Principal component analysis (PCA) of these results indicated that Limosilactobacillus reuteri (L.reuteri) NCUH003,Lactiplantibacillus plantarum (L.plantarum) NCUH046 and Limosilactobacillus fermentum (L.fermentum) NCUH068 exhibited favorable anti-obesity properties.Besides,the LAB displayed good gastrointestinal adaptability and antioxidant activity but no hemolytic activity,and they were sensitive to various antibiotics.These results indicated that L.reuteri NCUH003,L.plantarum NCUH046 and L.fermentum NCUH068 are potential for application in obesity treatment. | Benliang Wei Zhen Peng Muyan Xiao Tao Huang Wendi Zheng Mingyong Xie Tao Xiong | 2022 | Food Bioscience2022，47，3： | 0 |
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