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| 1 | Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation显示文摘apelin/apelin 受体(APJ, apelinangiotensin 像受体 1 ) 系统是一最新 deorphanized G 联合蛋白质的受体系统。是重要规章的因素的 apelin 和 APJ 在心血管的系统被表示。我们的以前的研究显著地表明了那 apelin-13 刺激脉管的光滑的肌肉房间(VSMC ) 增长。在这份报纸,我们的数据建议表明 transduction 小径的 Jagged-1/Notch3 被支持 Cyclin D1 的表示涉及 apelin-13-induced VSMC 增长。结果显示 apelin-13 在集中依赖者和时间依赖者礼貌刺激 VSMC 和 Jagged-1 和 Notch3 的表示的增长。apelin-13 导致的 Jagged-1 和 Notch3 的增加的表示能被细胞外的调整信号的蛋白质 kinase (英皇家空军之阶级最低之兵) 废除封锁。PD98059 (英皇家空军之阶级最低之兵禁止者) 能禁止 apelin-13 导致的 Jagged-1/Notch3 的激活。用小介入 RNA 的 Notch3 的下面规定禁止 Cyclin D1 的表示并且阻止 apelin-13-induced VSMC 增长。在结论, Jagged-1/Notch3 发信号 transduction 小径涉及 apelin-13 导致的 VSMC 增长。 | Lifang Li Lanfang Li Feng Xie Zidong Zhang Yu Guo Guotao Tang Deguan Lv Qixuan Lu Linxi Chen Jian Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，10： | 18 |
| 2 | Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy显示文摘Apelin 高度在左室的肥大 Sprague Dawley 老鼠建模的老鼠被表示,并且它在心血管的系统起一个关键作用。这研究是澄清 apelin-13 是否在 H9c2 老鼠 cardiomyocytes 支持肥大并且调查它的内在的机制的目的。cardiomyocyte 肥大被测量 H9c2 房间的直径,体积,和蛋白质内容观察。autophagy 的激活被由传播电子显微镜学观察 autophagosomes 的形态学评估,观察由轻显微镜学的 LC3 的 subcellular 本地化,并且由西方的污点分析检测 LC3 的联系膜的形式。表明小径的 phosphatidylinositol 3-kinase (PI3K ) 被识别,蛋白质表示用西方的污点分析被检测。结果表明 apelin-13 增加了 H9c2 房间的直径,体积,和蛋白质内容并且支持了 PI3K, Akt, ERK1/2,和 p70S6K 的 phosphorylation。Apelin-13 激活 PI3K-Akt-ERK1/2-p70S6K 小径。PI3K 禁止者 LY294002, Akt 禁止者 1701-1, ERK1/2 禁止者 PD98059 稀释了房间直径的增加,体积,蛋白质内容由 apelin-13 导致了。Apelin-13 增加了 autophagosomes 并且起来调整 beclin 的表情 1 并且 LC3-II/I 短暂地并且稳定地。autophagy 禁止者 3MA 改善了被 apelin-13 导致的房间直径,体积,和蛋白质内容的增加。这些结果建议 apelin-13 经由 PI3K-Akt-ERK1/2-p70S6K 和导致 PI3K 的 autophagy 支持 H9c2 老鼠 cardiomyocyte 肥大。 | Feng Xie Wei Liu Fen Feng Xin Li Lu He Deguan Lv Xuping Qin Lifang Li Lanfang Li Linxi Chen | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 9 |
| 3 | Autophagy, a new target for disease treatment显示文摘Since Ashford and Porter first discovered that cells 'eat themselves' in 1962, the process known as autophagy has generated intense interest in both biomedical research and clinical medicine. Autophagy is a regulated cellular pathway that transports damaged, modified or aging organelles and proteins to lysosomes/vacuoles for degradation. | XIE Feng LI LanFang CHEN LinXi | 2013 | Science China(Life Sciences)2013，56，9： | 5 |
| 4 | Meteorite classification for building the Chinese Antarctic Meteorite Depository Introduction of the classification of 500 Grove Mountains meteorites显示文摘Meteorites provide an important window into the origins and evolution of the solar system. Since the first four meteorites were recovered in Grove Mountains, Antarctica, in 1998, a further total of 12665 meteorites have been collected over seven polar seasons in the Grove Mountains. All of these meteorites are owned and managed by the Chinese Antarctic Meteorite Depository(CAMD) at the Polar Research Institute of China(PRIC). In recent years, another 500 Antarctic meteorites have been classified and characterized based on mineralogy and petrology. In this work we examine four samples that have been identified as terrestrial, and a further 496 samples that have been confirmed as meteorites. These meteorites are further divided into different types:488 ordinary chondrites, one eucrite, one ureilite, one CM2 carbonaceous chondrite, one EH4 enstatite chondrite, one mesosiderite and three iron meteorites. The classification of meteorites not only provides an abundance of fundamental scientific data, but is also significant for introducing meteorites and related scientific knowledge to the public, particularly via the website of Chinese Resource-sharing Platform of Polar Samples for scientific research and education. | XIA Zhipeng ZHANG Jie MIAO Bingkui OU Ronglin XIE Lanfang YANG Rui JING Yuan | 2016 | Advances in Polar Science2016，27，1： | 4 |
| 5 | Siderophile Element Compositions of Pyroxenes in HED Meteorites: Implications for the Differentiation of Magma Ocean on Vesta显示文摘1 Introduction The howardite,eucrite and diogenite(HED)meteorites are ultramafic and mafic igneous rocks and impact-engendered breccias derived from a thoroughly differentiated asteroid 4 Vesta.Diogenites include dunites, | CHEN Hongyi MIAO Bingkui XIE Lanfang SHAO Huimin | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 2 |
| 6 | Lunar meteorites: witnesses of the composition and evolution of the Moon显示文摘Lunar meteorites are fragments of the Moon that escaped the gravity of the Moon following high-energy impacts by asteroids,subsequently fell to Earth.An inventory of 165 lunar meteorites has been developed since the discovery and identification of the first lunar meteorite,ALHA 81005,in 1979.Although the Apollo samples are much heavier in mass than lunar meteorites,the meteorites are still an important sample supplement for scientific research on the composition and history of the Moon.Apart from a small amount of unbrecciated crystalline rocks,the majority of lunar meteorites are breccias that can be classified into three groups:highland feldspathic breccia,mare basaltic breccia,and mingled(including fledspathic and basaltic clasts)breccia.The petrography of lunar rocks suggests that there are a series of rock types of anorthosite,basalt,gabbro,troctolite,norite and KREEP in the Moon.Although KREEP is rare in lunar rocks,KREEP components have been found in the increasing number of lunar meteorites.KREEP provides important information on lunar magmatic evolution,e.g.,the VHK KREEP clasts in SaU 169 may represent the pristine lunar magma(urKREEP).Six launching pairs of lunar meteorites have been proposed now,along with ten possible lunar launching sites.In addition,symplectite is often found in lunar basalts,which is a significant record of shock metamorphism on the lunar surface.Furthermore,isotopic ages and noble gases not only provide information on crystallization processes in lunar rocks and the formation of lunar crust,but also provide insight into shock events on the lunar surface. | MIAO Bingkui CHEN Hongyi XIA Zhipeng YAO Jie XIE Lanfang NI Wenjun ZHANG Chuantong | 2014 | Advances in Polar Science2014，25，2： | 1 |
| 7 | Petrography and mineralogy of new lunar meteorite MIL090036显示文摘MIL090036 is a previously unknown meteorite(a feldspathic lunar breccia) that was discovered in Antarctica. The detailed petrography and mineralogy of this meteorite forms the subject of this paper. It has a typical clastic texture that consists of various types of rock debris(e.g. anorthosite, gabbroic anorthosite, gabbro, regolith breccia, troctolite, microporphyritic crystalline impact melt and compound clasts), mineral crystal fragments(e.g. pyroxenes, plagioclase, olivine and ilmenite) and feldspathic glass clasts. The fine-grained recrystallized minerals and mineral clasts are cemented together in a glassy groundmass. The anorthite content of plagioclase in the gabbro(An81-83) and anorthosite(An88-93) both have relatively low calcium content compared to those from other breccias(An90-98). The pyroxene composition(Fs12-35 Wo3-44 En22-79) in the rock debris, crystal mineral clasts and anorthositic glass clasts are relatively iron-deficient compared to those from gabbro debris with melt glass(Fs37-65 Wo10-29 En21-49) and groundmass(Fs18-69 Wo3-45 En14-50). In contrast, the pyroxene grains in the gabbroic anorthosite display a narrow compositional range(Fs24-27 Wo7-14 En59-69). Olivine grains in mineral fragments and the groundmass have a wider compositional range(Fo57-79) than those in the rock debris(Fo67-77). The Fe/Mn ratio in olivine is in the range of 47 to 83(average 76) and 76 to 112(average 73) in pyroxenes, and hence classify within the lunar field. The characteristics of texture, mineral assemblage and compositions suggest that MIL090036 possibly originated from a region beyond that of the Apollo and Luna samples. Further study of MIL090036 is therefore likely to lead to a better understanding of the geological processes on the Moon and the chemical composition of the lunar crust. | XIE Lanfang CHEN Hongyi MIAO Bingkui XIA Zhipeng YAO Jie | 2014 | Advances in Polar Science2014，25，1： | 1 |
| 8 | A special unbrecciated granoblastic textured basaltic eucrite meteorite显示文摘1 Introduction Generally,we can observe varying degree of ophitic texture or sub-ophitic texture in unbrecciated basaltic eucrites.However,a few unbrecciated basaltic eucritespossess the special characteristic of crystalloblastic texture by high metamorphism,which are called as granoblastic textured basaltic eucrites(Mayne et al.2009, | ZHANG Chuantong MIAO Bingkui XIE Lanfang XIA Zhipeng CHEN Hongyi | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 0 |
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