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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Mortality Associated With Atrial Fibrillation in Patients With Myocardial Infarction: A Systematic Review and Meta-Analysis显示文摘 | Patricia Jabre Véronique L. Roger Mohammad H. Murad Alanna M. Chamberlain Larry Prokop Frédéric Adnet Xavier Jouven | 2011 | Circulation2011，，15： | 2 |
| 3 | Effects of thermal and mechanical pretreatments of secondary sludge on biogas production under thermophilic conditions显示文摘 | Mavi Climent Ivet Ferrer Ma del Mar Baeza Adriana Artola Felícitas Vázquez Xavier Font | 2007 | Chemical Engineering Journal2007，，1： | 2 |
| 4 | Tautomeric enhancement of the hyperpolarizability in new acridine-benzothiazolylamine based NLO chromophers显示文摘 | Mberto M G Xavier V | 2005 | Tetrahedron2005，61，38： | 1 |
| 5 | Mineral chemistry of ore and hydrothermal alteration an the sossego oirn ox- ide-copper-gold deposit, Carajas Mineral Province, Brazil 显示文摘 | Monteiro L V S Xavier R P Hitzman M W | 2008 | Ore Geology Reviews2008，34，： | 1 |
| 6 | Phosphatidylinositol-3 kianse inhibitors block differentiation of skeletal muscle cell显示文摘 | Francesc V Xavier T | 1996 | Biol Chem1996，271，19： | 1 |
| 7 | Efficiency of crop identification based on optical and SAR image time series显示文摘 | Xavier B Laurent V Pierre D | | 0，，： | 1 |
| 8 | An Evaluation of Jacob' s Method for the Interpretation of Pumping Tests in Heterogeneous Formations 显示文摘 | PETER M M JESIJS C XAVIER S V | 1998 | Water Resources Research1998，，5： | 1 |
| 9 | Sugar sensing and Ca^2+ calmodulin requirement in vifis vinifera cells producing anthocyanins 显示文摘 | XAVIER V FABIENNE L STEPHANIE K | 2000 | Phytochemistry2000，53，6： | 1 |
| 10 | Molecular evolution and phylogeny of Sipunculan hemerythrins 显示文摘 | Stefano V Enrico N Xavier B | 2006 | Mol Evol2006，62，： | 1 |
| 11 | Quantitative structural and textural assessment of laminar pyrocarbons through Raman spectroscopy,electron diffraction and few other techniques显示文摘 | JEAN M V XAVIER B ARNAUD M | 2006 | Carbon2006，44，： | 1 |
| 12 | Pathogenesis of bovine brucellosis显示文摘 | CARVALHO NETA A V MOL J P XAVIER M N | 2010 | Vet J2010，184，2： | 1 |
| 13 | Design and development of a MEMS-IDT gyroscope显示文摘 | VARADAN V K SUH W D XAVIER P B | 2000 | Smart Materials and Structures2000，9，6： | 1 |
| 14 | Capillary electropho- resis combined with microdialysis in the human spinal cord: a new tool for monitoring rapid peroperative changes in ami- no acid neurotransmitters within the dorsal horn显示文摘 | Parrot S Sauvinet V Xavier J M | 2004 | Electropho- resis2004，25，2011： | 1 |
| 15 | Beneficial effects of endurance training on cardiac and skeletal muscle energy metabolism in heart failure显示文摘 | RENEE V C BERTRAND M XAVIER B | 2007 | Cardiovas Res2007，73，1： | 1 |
| 16 | Spectroscopic studies of gel-grown lanthanum malonate crystals显示文摘 | Mathew V Jacob S Xavier L Abraham K E | | 0，，03： | 1 |
| 17 | Destruction of contrast microbubbles by ultrasound effects on myocardial function, coronary perfusion pressure, and microvascular integrity 显示文摘 | TANIYEL A XAVIER H GUY V C | 2001 | Circulation2001，104，： | 1 |
| 18 | Quantitative structural and textural assessment of laminar pyrocarbons through Raman spectroscopy, electron diffraction and few other techniques 显示文摘 | Jean-Marie V Xavier B Arnaud M | 2006 | Carbon2006，44，： | 1 |
| 19 | Design and development of a MEMS-IDT gyroscope显示文摘 | Varadan V K Such W D Xavier P B | 2000 | Smart Malter Struct2000，9，2： | 1 |
| 20 | Design and development of a MEMS-IDT gyroscope 显示文摘 | Varadan V K Suh W D Xavier P B | 2000 | Journal of Smart Materials and Structures2000，9，6： | 1 |
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