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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Phosphatidylinositol-3 kianse inhibitors block differentiation of skeletal muscle cell显示文摘 | Francesc V Xavier T | 1996 | Biol Chem1996，271，19： | 1 |
| 3 | Relaxed Grey-world: computational colour constancy by surface matching 显示文摘 | Francesc T Maria V | 2005 | Pattern Recognize and Intel-ligent Analysis2005，24，13： | 1 |
| 4 | Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro- exction and gas chromatography-mass detection 显示文摘 | Alfredo D Francesc V M Teresa G | 2005 | Journal of Chromatography A2005，1064，： | 1 |
| 5 | Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro-extraction and gas chromatography-mass detection 显示文摘 | ALFREDO D FRANCESC V M TERESA G | 2005 | Journal of Chromatography A2005，，97： | 1 |
| 6 | Development of a versatile, easy and rapid atmospheric monitor for ben- zene, toluene, ethylbenzene and xylenes determination in air 显示文摘 | FRANCESC A ESTEVE T SARAY L V | 2009 | Journal of Chromatography A2009，1216，48： | 1 |
| 7 | Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro-extraction and gas chromatography-mass detection 显示文摘 | Alfredo D Francesc V M Teresa G | 2005 | Journal of Chromatography A2005，1064，： | 1 |
| 8 | Effect of plant density on toxigenic fungal infection and mycotoxin contamination of maize kernels 显示文摘 | MASSIMO B AMEDEO R FRANCESC V | 2008 | Field Crops Research2008，106，3： | 1 |
| 9 | Determination of aflatoxins B1, G1, B2 and G2 in medicinal herbs by liquid chromatography- tandem mass spectrometry显示文摘 | MERITXELL V ANTONIO G IANAYA J FRANCESC B MONTSERRAT A LLU C | 2004 | J Chromatogr: A2004，1048，1： | 1 |
| 10 | Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro2extraction and gas chromatography-mass detection 显示文摘 | Alfredo D Francesc V M Teresa G | 2005 | Journal of Chromatography A2005，1064，： | 1 |
| 11 | Alkaloids from Boophane falra显示文摘 | Francesc V Jaume B Carles C | 1995 | Phytochemistry1995，40，1： | 1 |
| 12 | Association between double mutation in gyrA gene of ciprofloxacin-resistance clinical isolates of Escherichia coli 显示文摘 | Jordi V Joaquim R Francesc M | 1994 | Antimicrob Agents chemotherapy1994，38，10： | 1 |
| 13 | Passively Q-switched femtosecond-laser-written thulium waveguide laser based on evanescent field interaction with carbon nanotubes显示文摘Surface channel waveguides(WGs) were fabricated in a monoclinic Tm^(3+):KLu(WO_4)_2 crystal by femtosecond direct laser writing(fs-DLW). The WGs consisted of a half-ring cladding with diameters of 50 and 60 μm located just beneath the crystal surface. They were characterized by confocal laser microscopy and μ-Raman spectroscopy,indicating a reduced crystallinity and stress-induced birefringence of the WG cladding. In continuous-wave(CW)mode, under Ti:sapphire laser pumping at 802 nm, the maximum output power reached 171.1 mW at 1847.4 nm,corresponding to a slope efficiency η of 37.8% for the 60 μm diameter WG. The WG propagation loss was0.7 0.3 d B∕cm. The top surface of the WGs was spin-coated by a polymethyl methacrylate film containing randomly oriented(spaghetti-like) arc-discharge single-walled carbon nanotubes serving as a saturable absorber based on evanescent field coupling. Stable passively Q-switched(PQS) operation was achieved. The PQS60 μm diameter WG laser generated a record output power of 150 m W at 1846.8 nm with η = 34.6%. The conversion efficiency with respect to the CW mode was 87.6%. The best pulse characteristics(energy/duration)were 105.6 nJ/98 ns at a repetition rate of 1.42 MHz. | ESROM KIFLE PAVEL LOIKO JAVIER RODRíGUEZ VáZQUEZ DE ALDANA CAROLINA ROMERO AIRáN RóDENAS SUN YUNG CHOI JI EUN BAE FABIAN ROTERMUND VIKTOR ZAKHAROV ANDREY VENIAMINOV MAGDALENA AGUILó FRANCESC DíAZ UWE GRIEBNER VALENTIN PETROV XAVIER MATEOS | 2018 | Photonics Research2018，6，10： | 1 |
| 14 | Occurrence and removal of estrogenic short-chain ethoxy nonylphenolic compounds and their halo- genated derivatives during drinking water production 显示文摘 | MIRA P ALFREDO D FRANCESC V | 2003 | Environmental Science and Technology2003，37，19： | 1 |
| 15 | Occurrence and Removal of Estrogenic Short-Chain Ethoxy Nonylphenolic Compounds and Their Halogenated Derivatives during Drinking Water Production显示文摘 | Mira P Alfredo D Francesc V | 2003 | Environmental Science and Technology2003，37，19： | 1 |
| 16 | Investigation of Bolivian plant extracts for their radical scavenging activity and antioxidant activity显示文摘 | Irene P Francesc V Jaume B | 2003 | Life Sciences2003，73，： | 1 |
| 17 | Review of CCSDS-ILDC and JPEG2000 coding techniques for remote sensing显示文摘 | Joan Serra S Francesc Auli L Fernando Garcia V | 2004 | SPIE2004，6045，： | 1 |
| 18 | Occurrence and removal of estrogenic short-chain ethoxy nonylphenolie compounds and their halogenated derivatives during drinking water production 显示文摘 | Mira P Alfrodo D Francesc V | 2003 | Environmental Science and Technology2003，37，19： | 1 |
| 19 | BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions显示文摘 | Andrew J. Whittle Stefania Carobbio Luís Martins Marc Slawik Elayne Hondares María Jesús Vázquez Donald Morgan Robert I. Csikasz Rosalía Gallego Sergio Rodriguez-Cuenca Martin Dale Samuel Virtue Francesc Villarroya Barbara Cannon Kamal Rahmouni Miguel Lóp | 2012 | Cell2012，，4： | 1 |
| 20 | New efficent substrates semicarbazide amine oxidase/VAP-1 enzyme:analysis by SARs and computational docking显示文摘 | Francesc Y Silvia G V | | 0，，： | 1 |
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