|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Characterization of truncated forms of hepatitis C virus glycoproteins显示文摘 | Michalak J P Wychowski C Choukhi A | 1997 | J Gen Virol1997，78，： | 1 |
| 2 | Charac- terization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites 显示文摘 | GRAKOUI A MCCOURT D WYCHOWSKI C | 1993 | J Virol1993，67，5： | 1 |
| 3 | Expression and Identification of Hepatitis C Virus Polyprotein Cleavage Products显示文摘 | Grakoui A Wychowski C Rice C M | | 0，，03： | 1 |
| 4 | Additional Glycosylation Within a Specific Hypervariable Region of Subtype 3a of Hepatitis C Virus Protects Against Virus Neutralization显示文摘 | Sadia Anjum Ahmed Wahid Muhammad Sohail Afzal Anna Albecka Khaled Alsaleh Tahir Ahmad Thomas F. Baumert Czeslaw Wychowski Ishtiaq Qadri Fran?ois Penin Jean Dubuisson | 2013 | Journal of Infectious Diseases2013，，11： | 1 |
| 5 | Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites显示文摘 | Grakoui A McCourt D W Wychowski C | 1993 | J Virol1993，67，： | 1 |
| 6 | Induction of hepatitis C virus E1 envelope protein-specific immune response can be enhanced by mutation of N-glycosylation sites 显示文摘 | Fournillier A Wychowski C Boucreux D | 2001 | J Virol2001，75，12： | 1 |
| 7 | Highly infectious plasmids carrying poliovirus cDNA are capable of replication in transfected cells显示文摘 | Katherine M Kean Wychowski C | 1986 | Virology1986，59，2： | 1 |
| 8 | Charged residus in the transmembrane domains of hepatitis C virus glycoproteins play a key role in the processing, subcellular localization and assembly of these envelope proteins 显示文摘 | Cocquerel L Wychowski C Minner F | 2002 | J Virol2002，74，8： | 1 |
| 9 | HCV-specific immune responses induced by CIGB-230 in combination with IFN-α plus ribavirin显示文摘AIM:To analyze hepatitis C virus(HCV)-specific immune responses in chronically infected patients under triple therapy with interferon-α(IFN-α)plus ribavirin and CIGB-230.METHODS:CIGB-230 was administered in different schedules with respect to IFN-αplus ribavirin therapy.Paired serum and peripheral blood mononuclear cells(PBMC)samples from baseline and end of treatment were analyzed.The HCV-specific humoral response was tested by enzyme-linked immunosorbent assay,neutralizing antibodies were evaluated by cell culture HCV neutralization assays,PBMC proliferation was assayed by carboxyfluorescein succinimidyl ester staining and IFN-γsecretion was assessed by enzyme-linked immunospot.Data on virological and histological response and their association with immune variables are also provided.RESULTS:From week 12 to week 48,all groups of patients showed a significant reduction in mean leukocyte counts.Statistically significant reductions in antibody titers were frequent,but only individuals immunized with CIGB-230 as early add-on treatment sustained the core-IgG response,and the neutralizing antibody response was enhanced only in patients receiving CIGB-230.Cell-mediated immune responses also tended to decline,but significant reductions in IFN-γsecretion and total absence of core-specific lymphoproliferation were exclusive of the control group.Only CIGB-230-immunized individuals showed de novo induced lymphoproliferative responses against the structural antigens.Importantly,it was demonstrated that thequality of the CIGB-230-induced immune response depended on the number of doses and timing of administration in relation to the antiviral therapy.Specifically,the administration of 6 doses of CIGB-230 as late addon to therapy increased the neutralizing antibody activity and the de novo core-specific IFN-γsecretion,both of which were associated with the sustained virological response.CONCLUSION:CIGB-230,combined with IFN-α-based therapy,modifies the immune response in chronic patients.The study provides evidence for the design of more effective therapeutic vaccine interventions against HCV. | Yalena Amador-Caizares Gillian Martínez-Donato Liz lvarez-Lajonchere Claudia Vasallo Mariacarla Dausá Daylen Aguilar-Noriega Carmen Valenzuela Ivette Raíces Jean Dubuisson Czeslaw Wychowski Zurina Cinza-Estévez Marlén Castellanos Magdalys Núez Anny Armas Yaimé González Ismariley Revé Ivis Guerra ngel Pérez Aguiar Santiago Dueas-Carrera | 2014 | World Journal of Gastroenterology2014，20，1： | 1 |
| 10 | Induction of hepatitis C virus El envelope protein-specific immune response can be enhanced by mutation of N-glycosylation sites显示文摘 | Fouruillier A Wychowski C Boucreux D | 2001 | J Virol2001，75，12： | 1 |
| 11 | Cymlovirin-N inhibits hepatitis C virus entry by binding to envelope protein glycmls显示文摘 | HELLE F WYCHOWSKI C VU-DACU N | 2006 | Journal of Biological Chemistry2006，281，25： | 1 |
| 12 | Involvement of endoplasmic reticulum chaperones in the folding of hepatitis C virus glycoproteins显示文摘 | Choukhi A Ung S Wychowski C | 1998 | J Virol1998，72，： | 1 |
| 13 | Cyanovirin-N inhibitshepatitis C virus entry by binding to envelope protein glycans 显示文摘 | Helle F Wychowski C Vu-Dac N | 2006 | J Biol Chem2006，281，25： | 1 |
| 14 | Cyanovirin-N inhibits hepatitis C vires entry by binding to envelope protein glycans显示文摘 | Francois H Czeslaw Wychowski Ngoc Vu-Dac | 2006 | The Journal of Biological Chemistry2006，281，25： | 1 |
| 15 | Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment 显示文摘 | Wychowski MK Kouides PA | 2012 | Ann Pharmacother2012，46，4： | 1 |
| 16 | Role of N-linked glycans in the functions of hepatitis C virus envelope proteins incorporated into infectious virions显示文摘 | Helle F Vieyres G Elkrief L Popescu C I Wychowski C Descamps V Castelain S Roingeard P Duverlie G Dubuisson J | 2010 | J Virol2010，84，11： | 1 |
| 17 | Characterization of the hepa2titis C virus Encoded serine proteinase:determination of proteinase dependedpolyprotein cleavage sites显示文摘 | Grakoui A McCourt D W Wychowski C | 1993 | Journal of Virology1993，67，： | 1 |
| 18 | Cyanovirin-N inhibits hepatitis C virus entry by binding to envelope protein glyeans 显示文摘 | Helle F Wychowski C Vu-Dac N | 2006 | J Biol Chem2006，281，25： | 1 |
| 19 | Cyanovirin N inhibits hepatitis C virus entry by binding to envelope pro- tein glycans 显示文摘 | Helle F Wychowski C Vu-Dac N etal | 2006 | J Biol Chem2006，281，25： | 1 |
| 20 | Dabigatran-induced gas- trointestinal bleeding in an elderly patient with moderate renal impairment显示文摘 | WYCHOWSKI M K KOUIDES P A | 2012 | Ann Pharmacother2012，46，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员