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| 1 | Diagnosis of Helicobacter pylori infection: Current options and developments显示文摘Accurate diagnosis of Helicobacter pylori(H. pylori) infection is a crucial part in the effective management of many gastroduodenal diseases. Several invasive and non-invasive diagnostic tests are available for the detection of H. pylori and each test has its usefulness and limitations in different clinical situations. Although none can be considered as a single gold standard in clinical practice,several techniques have been developed to give the more reliable results. Invasive tests are performed via endoscopic biopsy specimens and these tests include histology,culture,rapid urease test as well as molecular methods. Developments of endoscopic equipment also contribute to the real-time diagnosis of H. pylori during endoscopy. Urea breathingtest and stool antigen test are most widely used noninvasive tests,whereas serology is useful in screening and epidemiological studies. Molecular methods have been used in variable specimens other than gastric mucosa. More than detection of H. pylori infection,several tests are introduced into the evaluation of virulence factors and antibiotic sensitivity of H. pylori,as well as screening precancerous lesions and gastric cancer. The aim of this article is to review the current options and novel developments of diagnostic tests and their applications in different clinical conditions or for specific purposes. | Yao-Kuang Wang Fu-Chen Kuo Chung-Jung Liu Meng-Chieh Wu Hsiang-Yao Shih Sophie SW Wang Jeng-Yih Wu Chao-Hung Kuo Yao-Kang Huang Deng-Chyang Wu | 2015 | World Journal of Gastroenterology2015，21，40： | 66 |
| 2 | Dual specimens increase the diagnostic accuracy and reduce the reaction duration of rapid urease test显示文摘AIM:To evaluate the influence of multiple samplings during esophagogastr oduodenoscopy(EGD) on the accuracy of the rapid urease test,and the validity of newly developed rapid urease tests,HelicotecUT plus test and HelicotecUT test,CLO test and ProntoDry test.METHODS:A total of 355 patients undergoing EGD for dyspepsia were included.Their Helicobacter pylori(H.pylori) treatment status was either nave or eradicated.Six biopsy specimens from antrum and gastric body,respectively,were obtained during EGD.Single antral specimens and dual(antrum+body) specimens were compared.Infection status of H.pylori was evaluated by three different tests:culture,histology,and four different commercially available rapid urease tests(RUTs)-including the newly developed HelicotecUT plus test and HelicotecUT test,and established CLO test and ProntoDry test.H.pylori status was defined as positive when the culture was positive or if there were concordant positive results among histology,CLO test and ProntoDry test.RESULTS:When dual specimens were applied,sensitivity was enhanced and RUT reaction time was signif icantly reduced,regardless of their treatment status.Thirty minutes were enough to achieve an agreeable positive rate in all the RUTs.Both newly developed RUTs showed comparable sensitivity,specif icity and accuracy to the established RUTs,regardless of patient treatment status,RUT reaction duration,and EGD biopsy sites.CONCLUSION:Combination of antrum and body biopsy specimens greatly enhances the sensitivity of rapid urease test and reduces the reaction duration to 30 min. | Wen-Hung Hsu Sophie SW Wang Chiao-Yun Chen Ching-Wen Chang Jaw-Yuan Wang Yuan-Chieh Yang Deng-Chyang Wu Ming-Tsang Wu | 2010 | World Journal of Gastroenterology2010，16，23： | 13 |
| 3 | Low effect‐site concentration of propofol target‐controlled infusion reduces the risk of hypotension during endoscopy in a T aiwanese population显示文摘 | Wen‐Hung Hsu Sophie SW Wang Hsiang‐Yao Shih Meng‐Chieh Wu Yi‐Yu Chen Fu‐Chen Kuo Hui‐Ying Yang Shun‐Li Chiu Koung‐Shing Chu Kuang‐I Cheng Deng‐Chyang Wu I‐Cheng Lu | 2013 | Journal of Digestive Diseases2013，，3： | 3 |
| 4 | Delayed cardioprotection of aged rat myocytes is associated with activation of mitogenactivated protein kinase 显示文摘 | Liu XH Wang SW Wu XD | 2000 | Chinese Medical Journal2000，113，1： | 2 |
| 5 | A GA-based mobile RFIDlocalization scheme for internet of things 显示文摘 | Wu T Y Liaw G H Huang SW | 2012 | Personal and Ubiquitous Computing2012，16，3： | 1 |
| 6 | D-ct-tocopherol polyethylene glycol succinate-based derivative nanoparticles as a novel carrier for paelitaxel delivery 显示文摘 | Wu YP Chu Q Tan SW | 2015 | Intern J Nano med2015，10，5： | 1 |
| 7 | Radiographic and clinical results of posterior dynamic stabilization for the treatment of multisegrnent degenerative disc disease with a minimum follow-up of 3 years显示文摘 | Yu SW Yen CY Wu CH | 2012 | Arch Orthop Trauma Surg2012，132，5： | 1 |
| 8 | Excitatory repetitive transcranial magnetic stimulation induces improvements in chronic poststroke aphasia显示文摘 | Szaflarski JP Vannest J Wu SW | 2011 | Med Sci Monit2011，17，3： | 1 |
| 9 | Lercanidipine inhibits vascular smooth muscle cell proliferation and neointimal formation via reducing intracellular reactive oxygen species and inactivating Ras-ERK1/2 signaling显示文摘 | Wu JR Liou SF Lin SW | | 0，，： | 1 |
| 10 | Portable preimpact fall detector with iner- tial sensors 显示文摘 | Wu G Xue SW | 2008 | IEEE Transaction on Neural System and Re- habilitation Engineering2008，16，： | 1 |
| 11 | Prevalence of Significant Carotid Stenosis in Chinese Patients with Peripheral and Coronary Artery Disease显示文摘 | Cheng SW Wu LL Lau H | 1999 | Aust NZ J Surg1999，69，1： | 1 |
| 12 | Hepatitis E virus: neutralizing sites, diagnosis, and protective immunity 显示文摘 | Zhang J Li SW Wu T | 2012 | Rev Med Virol2012，22，5： | 1 |
| 13 | Transcranial magnetic stimulation measures in attention-deficit/hyperactivity disorder显示文摘 | Wu SW Gilbert DL Shahana N | 2012 | Pediatr Neurol2012，47，3： | 1 |
| 14 | Staged external and intemal less-invasive stabilisation system plating for open proximal tibia显示文摘 | Ma CH Wu CH Yu SW | 2010 | Injury2010，41，： | 1 |
| 15 | Radiographic and clinical results of posterior dynamic stabilization for the treatment of multisegment degenerative disc disease with a minimum follow-up of 3 years显示文摘 | Yu SW Yen CY Wu CH | 2012 | Arch Orthop Trauma Surg2012，132，5： | 1 |
| 16 | Hepatitis C virus F protein up-regulates c-myc and down-regulates p53 in human hepatoma hepG(2)cells显示文摘 | WU WB SHAO SW ZHAO LJ | 2007 | Intervirology2007，50，5： | 1 |
| 17 | Changes in venous hemodynamics after superficial venous surgery for mixed superficial and deep venous insufficiency显示文摘 | Ting AC Cheng SW Wu LL | 2001 | World J Surg2001，25，2： | 1 |
| 18 | Identication of inhibitors of the HIV-1 gp41 six helix bundle fornation from extracts of Chinese medicinal herbs Prunella Vulgaris and Rhizoma Cibtte显示文摘 | Liu SW Jiang SB Wu ZH | 2002 | Life Sciences2002，71，15： | 1 |
| 19 | Enforced expression of MCAM/ MUC18 increases in vitro motility and invasiveness and in vivo metastasis of two mouse melanoma K1735 sublines in a syngeneic mouse model显示文摘 | Wu GJ Fu P Wang SW | | 0，，11： | 1 |
| 20 | 4- (Methylnitrosamino) - 1 - (3-pyridyl) - 1 -b utanone from cigarette smoke stimulates colon cancer growth via beta- adrenoeeptors 显示文摘 | WU WK WONG HP LUO SW | 2005 | Cancer Res2005，65，12： | 1 |
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