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| 1 | Novel immunological and nutritional-based prognostic index for gastric cancer显示文摘AIM: To assess the prognostic significance of immunological and nutritional-based indices, including the prognostic nutritional index(PNI), neutrophillymphocyte ratio(NLR), and platelet-lymphocyte ratio in gastric cancer.METHODS: We retrospectively reviewed 632 gastric cancer patients who underwent gastrectomy between1998 and 2008. Areas under the receiver operating characteristic curve were calculated to compare the predictive ability of the indices, together with estimating the sensitivity, specificity and agreement rate.Univariate and multivariate analyses were performed to identify risk factors for overall survival(OS). Propensity score analysis was performed to adjust variables to control for selection bias.RESULTS: Each index could predict OS in gastric cancer patients in univariate analysis, but only PNI had independent prognostic significance in multivariate analysis before and after adjustment with propensity scoring(hazard ratio, 1.668; 95% confidence interval:1.368-2.035). In subgroup analysis, a low PNI predicted a significantly shorter OS in patients with stage Ⅱ-Ⅲ disease(P = 0.019, P < 0.001), T3-T4 tumors(P <0.001), or lymph node metastasis(P < 0.001). Canton score, a combination of PNI, NLR, and platelet, was a better indicator for OS than PNI, with the largest area under the curve for 12-, 36-, 60-mo OS and overall OS(P = 0.022, P = 0.030, P < 0.001, and P = 0.024,respectively). The maximum sensitivity, specificity, and agreement rate of Canton score for predicting prognosis were 84.6%, 34.9%, and 70.1%, respectively.CONCLUSION: PNI is an independent prognostic factor for OS in gastric cancer. Canton score can be a novel preoperative prognostic index in gastric cancer. | Kai-Yu Sun Jian-Bo Xu Shu-Ling Chen Yu-Jie Yuan Hui Wu Jian-Jun Peng Chuang-Qi Chen Pi Guo Yuan-Tao Hao Yu-Long He | 2015 | World Journal of Gastroenterology2015，21，19： | 18 |
| 2 | Investigating the dynamic mechanical behaviors of polyurea through experimentation and modeling显示文摘Polyurea is widely employed as a protective coating in many fields because of its superior ability to improve the anti-blast and anti-impact capability of structures.In this study,the mechanical properties of polyurea XS-350 were investigated via systematic experimentation over a wide range of strain rates(0.001-7000 s^-1)by using an MTS,Instron VHS,and split-Hopkinson bars.The stress-strain behavior of polyurea was obtained for various strain rates,and the effects of strain rate on the primary mechanical properties were analyzed.Additionally,a modified rate-dependent constitutive model is proposed based on the nine-parameter Mooney-Rivlin model.The results show that the stress-strain curves can be divided into three distinct regions:the linear-elastic stage,the highly elastic stage,and an approximate linear region terminating in fracture.The mechanical properties of the polyurea material were found to be highly dependent on the strain rate.Furthermore,a comparison between model predictions and the experimental stress-strain curves demonstrated that the proposed model can characterize the mechanical properties of polyurea over a wide range of strain rates. | Hao Wang Ximin Deng Haijun Wu Aiguo Pi Jinzhu Li Fenglei Huang | 2019 | Defence Technology(防务技术)2019，15，6： | 13 |
| 3 | Electro-acupuncture at Conception and Governor vessels and transplantation of umbilical cord bloodderived mesenchymal stem cells for treating cerebral ischemia/reperfusion injury显示文摘Mesenchymal stem cell transplantation is a novel means of treating cerebral ischemia/reperfusion,and can promote angiogenesis and neurological functional recovery.Acupuncture at Conception and Governor vessels also has positive effects as a treatment for cerebral ischemia/reperfusion.Therefore,we hypothesized that electro-acupuncture at Conception and Governor vessels plus mesenchymal stem cell transplantation may have better therapeutic effects on the promotion of angiogenesis and recovery of neurological function than either treatment alone.In the present study,human umbilical cord blood-derived mesenchymal stem cells were isolated,cultured,identified and intracranially transplanted into the striatum and subcortex of rats at24 hours following cerebral ischemia/reperfusion.Subsequently,rats were electro-acupunctured at Conception and Governor vessels at 24 hours after transplantation.Modified neurological severity scores and immunohistochemistry findings revealed that the combined interventions of electro-acupuncture and mesenchymal stem cell transplantation clearly improved neurological impairment and up-regulated vascular endothelial growth factor expression around the ischemic focus.The combined intervention provided a better outcome than mesenchymal stem cell transplantation alone.These findings demonstrate that electro-acupuncture at Conception and Governor vessels and mesenchymal stem cell transplantation have synergetic effects on promoting neurological function recovery and angiogenesis in rats after cerebral ischemia/reperfusion. | Haibo Yu Pengdian Chen Zhuoxin Yang Wenshu Luo Min Pi Yonggang Wu Ling Wang | 2014 | Neural Regeneration Research2014，9，1： | 13 |
| 4 | Predictive value of serum uric acid on cardiovascular disease and all-cause mortality in urban Chinese patients显示文摘背景在尿酸(SUA ) 铺平的增加的浆液和心血管的风险之间的协会被辩论十年了。几大研究规定了在心血管的疾病(CVD ) 或脑血管的疾病关于提高的 SUA 层次的临床的意义冲突结果。这研究的目的从 56 ~ 95 年在年龄的 3570 个住院病人是调查在 SUA 和 CVD 和所有原因死亡和他们的潜在的诊断 value.Methods A 之间的关系全部的(平均数(67. | WU Yong-quan LI Jue XU Yuan-xi WANG Yong-liang LUO Ying-yi HU Da-yi LIU Wei-jing YANG Ming PI Lin WANG Ming-sheng WANG Ji-yun ZHAO Shu-mei LI Mei-jing | 2010 | Chinese Medical Journal2010，，11： | 11 |
| 5 | Addictive evaluation of cholic acid-verticinone ester, a potential cough therapeutic agent with agonist action of opioid receptor显示文摘 | Jiu-liang ZHANG Hui WANG Chang CHEN Hui-fang PI Han-li RUAN Peng ZHANG Ji-zhou WU | 2009 | Acta Pharmacologica Sinica2009，30，5： | 7 |
| 6 | Rare Earth Element Geochemistry of Phosphatic Rocks in Neoproterozoic Ediacaran Doushantuo Formation in Hushan Section from the Yangtze Gorges Area, South China显示文摘Phosphatic rocks are widely distributed in Neoproterozoic Ediacaran Doushantuo Formation in Yangtze Gorges Area, South China. In this study, rare earth element geochemistry of eight phosphatic rock samples from the Hushan Section has been studied. All the samples display typical hat-shaped REE patterns, moderate negative Ce anomalies(Ce/Ce*=0.55 to 0.67), slightly positive Eu anomalies(Eu/Eu*=1.05 to 1.22) and low Y/Ho ratios(38.2±5.6). The hat-shaped REE patterns indicate diagenetic alteration of the primary REE signatures, which coincides with detrital siliciclastic sources of REE based on the Y/Ho ratios. The degree of Negative Ce anomalies and positive Eu anomalies may have recorded the redox features of diagenetic fluids, suggesting an anoxic environment during the phosphogenesis processes in Neoproterozoic Ediacaran Doushantuo Formation, South China. The geochemical comparison between the Lower Phosphorite Layer and Upper Phosphorite Layer at Hushan indicates a greater degree of diagenesis occurred in the Upper Layer than the Lower one. Besides the terrigenous sources of REE, organic materials could have also played a role on the REE characteristics. | Hong Xin Shaoyong Jiang Jinghong Yang Heping Wu Daohui Pi | 2016 | Journal of Earth Science2016，27，2： | 7 |
| 7 | Cytotoxic Diarylheptanoids from Pericarps of Juglans Cathayensis Dode显示文摘A novel diarylheptanoid,named Jugcathanin(1),along with two known diarylheptanoids(2,3),were isolated from the fresh pericarps of Juglans Cathayensis Dode. A known triterpene(4) and a known aphthaoquinone(5) were also isolated from the plant. Their structures were elucidated on the basis of spectroscopic studies. All the compounds exhibited moderate cytotoxicities against human Hela,HepG2,and HL-60 cell lines. | LI Yi-xiu RUAN Han-li ZHOU Xue-feng ZHANG Yong-hui PI Hui-fang WU Ji-zhou | 2008 | Chemical Research in Chinese Universities2008，24，4： | 7 |
| 8 | Polypropylene Separators with Robust Mussel-inspired Coatings for High Lithium-ion Battery Performances显示文摘The performances of lithium-ion batteries(LIBs)are dependent on the wettability and stability of porous separators.Musselinspired coatings seem to be useful to improve the surface wettability of commercialized polyolefin separators.However,it is still a challenge to guarantee their stability under polar electrolytes.Herein,we report a facile and versatile way to enhance the wettability and stability of polypropylene separators by constructing robust polydopamine(PDA)coatings triggered with CuSO4/H2O2.These coatings were conveniently deposited on the polypropylene separator surfaces and the PDA-coated separators exhibited the improved surface wettability and thermal stability.The electrolyte uptake increased nearly two folds from the pristine separator to the modified ones.Correspondingly,the ionic conductivity also rose from 0.82 mS·cm^-1 to 1.30 mS·cm^-1.Most importantly,the CuSO4/H2O2-triggered PDA coatings were very stable under strong polar electrolytes,endowing the cells with excellent cycle performance and enhanced C-rate capacity.Overall,the results unequivocally demonstrate that application of PDA coatings on polyolefin separator triggered by CuSO4/H2O2 is a facile and efficient method for improving the wettability and stability of separators for high LIBs performance. | Chao Zhang Hong-Qing Liang Jun-Ke Pi Guang-Peng Wu Zhi-Kang Xu | 2019 | Chinese Journal of Polymer Science2019，37，10： | 5 |
| 9 | Combinatorial effects of conception and governor vessel electroacu-puncture and human umbilical cord blood-derived mesenchymal stem cells on pathomorphologic lesion and cellular apoptosis in rats with cerebral ischemia/reperfusion显示文摘OBJECTIVE: To investigate the combinatorial effects of conception and governor vessel electroacupuncture(EA) and human umbilical cord blood-derived mesenchymal stem cells(HUCB-MSCs) on pathomorphologic lesion and cellular apoptosis in rats with cerebral ischemia/reperfusion. METHODS: With the HUCB-MSCs isolated, cultured and identified and the models of cerebral ischemia-reperfusion established, the HUCB-MSCs of passage three were intracranially transplanted and the EA at conception and governor vessels was applied. The pathomorphologic lesion by hematoxylin-eosin staining and the cellular apoptosis by terminal deoxynucleotidyl transferase-mediated nick-end labeling method around the ischemic focus were observed. RESULTS: The cultured adherent HUCB-MSCs exhibited a spindle shape and expressed MSC-specific markers, with the cell purity and proliferation rate significantly increasing after the primary passage. HE staining showed that there were no pathological changes observed in the sham surgery group. However, in the PBS transplantation group, degeneration and necrosis of a great number of nerve cells were seen. In both the HUCB-MSCs transplantation group and the HUCB-MSCs transplantation + EA group, reparative changes of the pathomorphism of the tissue were found. Both combination treatment and simple MSCs treatment were able to improve the pathomorphorlogic lesion following cerebral ischemia and reduce the abnormal TUNEL-positive numbers, with former better than latter. CONCLUSION: HUCB-MSCs improve pathological lesions and inhibit the cellular apoptosis around the cerebral ischemic area. EA at conception and governor vessels also improve pathological lesion and inhibit the cellular apoptosis in rats treated with HUCB-MSCs transplantation, which effects were superior to that of simple HUCB-MSCs transplantation. | Zhuoxin Yang Pengdian Chen Haibo Yu Wenshu Luo Min Pi Yonggang Wu Ling Wang Fuxia Yang Yanhua Gou | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 5 |
| 10 | Formation of willow leaf-like structures composed of NH2-MIL68(In) on a multifunctional multiwalled carbon nanotube backbone for enhanced photocatalytic reduction of Cr(VI)显示文摘photogenerated 电子 / 洞以及提高的可见轻吸收的有效分离和转移在 photocatalytic 反应起必要作用。支持 Cr (VI ) 的 photocatalytic 减小,一个有毒的重金属离子, multiwalled 碳 nanotube (MWCNT ) 作为一个电子领受人被介绍进 NH 2-MIL-68(In) 。这导致了一棵柳树的生长形成 MWCNT/NH 2-MIL-68(In)(PL-1 ) 的一根 MWCNT 脊梁上的像叶子的金属器官的框架(MOF ) ,它显示出 photogenerated 搬运人的高度有效的转移。而且, MWCNT 加入为 Cr (VI ) 散开介绍了更多的 mesopores 并且没有降低传导乐队位置,提高了可见轻吸附。作为结果, PL-1 的运动常数被发现是几乎三的 photocatalytic 比父母 NH 2-MIL-68(In) 的高预定。因此,在 MWCNT 上种 MOF 由利用太阳能为环境污染的有效补习提供一个灵巧、有希望的答案。这个工作提供为 photocatalytic 反应使用 MWCNT/MOF composites 的第一个例子。 | Yunhong Pi Xiyi Li Qibin Xia Junliang Wu Zhong Li Yingwei Li Jing Xiao | 2017 | Nano Research2017，10，10： | 5 |
| 11 | Industrial Poverty Alleviation Model in Southwestern High-altitude Mountainous Areas of China——A Case Study of Industrial Poverty Alleviation of Xueshan Township in Luquan County of Yunnan Province through Planting Codonopsis pilosula显示文摘Due to the severe restrictions of natural conditions and ecological environment,high-altitude mountainous areas usually become the ' hard bones' in the battle against poverty. Xueshan Township,Luquan Yi and Miao Autonomous County of Yunnan Province,located in the alpine valley of Jinsha River,is a major township with wide and deep poverty,and the incidence of poverty is up to 45. 00%. In recent years,Xueshan Township has insisted on the battle against poverty,made effort to develop the Codonopsis pilosula industry,and successfully developed a road to poverty alleviation through C. pilosula industry,and formed a unique industrial poverty alleviation model by the end of 2018,the incidence of poverty dropped to 0. 74%. Based on field survey and interview,this paper analyzes and summarizes the specific practices,main results,practical experience and promotion and application measures of the poverty alleviation model of C. pilosula planting industry in Xueshan Township,in the hope of providing certain reference for the targeted poverty alleviation in similar areas in Yunnan Province and other provinces of China. | Zisheng YANG Renyi YANG Yanbo HE Chonghui LU En ZHU Yaohan PI Mingxin WU Ying XIONG | 2019 | Asian Agricultural Research2019，11，3： | 4 |
| 12 | A new alkaloid from Lycoris aurea显示文摘新碱从 Lycoris 的灯泡被孤立脲(L’ Herit ) 植物。它的结构包括 2D NMR 通过化学、分光镜的研究作为 3-o-ethyltazettinol 被建立。 | Hui Fang Pi Peng Zhang Han Li Ruan Yong Hui Zhang Han Dong Sun Ji Zhou Wu | 2009 | Chinese Chemical Letters2009，20，11： | 4 |
| 13 | Green Tea Polyphenols Alleviate Autophagy Inhibition Induced by High Glucose in Endothelial Cells显示文摘Bovine aortic endothelial cells(BAECs)were cultured with high glucose(33 mmol/L),4 mg/L green tea polyphenols(GTPs)or 4 mg/L GTPs co-treatment with high glucose for 24 h in the presence or absence of Bafilomycin-A1(BAF).We observed that high glucose increased the accumulation of LC3-II.Treatment with BAF did not further increase the accumulation of LC3-II.Results also showed an increased level of p62 | ZHANG Pi Wei TIAN Chong XU Fang Yi CHEN Zhuo Raynard BURNSIDE YI Wei Jie XIANG Si Yun XIE Xiao WU Nan Nan YANG Hui ZHAO Na Na YE Xiao Lei YING Chen Jiang | 2016 | Biomedical and Environmental Sciences2016，29，7： | 3 |
| 14 | Acute Cerebellar Infarction Complicated with Multiple Intracerebral Hemorrhage Treated by An Integrated Chinese and Western Medicine Approach:A Case Report显示文摘Cerebellar infarction accounts for almost 3%of all ischemic strokes,with 27,400 new cases each year in the USA alone.^(1)Since the computerized tomography(CT)scan is often negative in the early hours after onset,it is difficult to diagnose。 | CHEN Peng SHEN Qin-xuan SHEN Lin-yan WU Zhi-bing PI Li-hong GE Wen-hua QI Wei | 2017 | Chinese Journal of Integrative Medicine2017，23，3： | 3 |
| 15 | Altitude-related shift of relative abundance from insect to sunbird pollination in Elaeagnus umbellata(Elaeagnaceae)显示文摘The evolution of floral traits has been thought to be influenced by local,effective pollinators.However,little attention has been paid to the possibility that altitudinal variation in floral traits could be mediated by local pollinator functional groups,particularly a shift from bees to birds.Plant size,floral traits,pollinators and their pollination roles were investigated in the spring-flowering shrub Elaeagnus umbellata(Elaeagnaceae)at three altitudes(1160,1676,and 2050 m)in Minshan,Sichuan Province,on the northern rim of the Hengduan Mountains,southwest China.Compared to lower altitudes,higher-altitude plants were smaller but the floral tubes were longer,with a larger volume of nectar of lower sugar concentration but with a greater proportion of sucrose.The visitation frequency of bees decreased with altitude,whereas the sunbirds did the opposite.Birds and bees foraged for nectar but not pollen,and birds deposited more pollen grains per visit relative to bees and least were syrphid flies.Excluding birds decreased seed set at high but not at mid-or low altitude.Our study of E.umbellata revealed an association between altitudinal variation in floral traits and a change in the relative abundance of the major pollinators with altitude from majority bees to majority sunbirds.Although abiotic factors also tend to vary with altitude and can affect floral traits,nectar properties of“pro-bird”pollination were observed at high altitude. | Hua-Qiang Pi Qiu-Mei Quan Bo Wu Xiao-Wen Lv Li-Min Shen Shuang-Quan Huang | 2021 | Journal of Systematics and Evolution2021，59，6： | 3 |
| 16 | Synthesis and antitussive evaluation of verticinone-cholic acid salt,a novel and potential cough therapeutic agent显示文摘瞄准:基于 Shedan-Chuanbei 粉末寻求新奇、有势力的能止咳的药,为咳嗽的繁体中文药准备的建筑群治疗。方法:Verticinone 胆酸酸(Ver-CA ) 盐,一篇小说, verticinone 和胆酸的 salifying 衍生物,哪个是在 Shedan-Chuanbei 粉末的主要简历有功成分,被综合。我们然后评估了能止咳的活动和盐的尖锐毒性。结果:与水里的好溶解度,新混合物有与一样比较的能止咳的活动单个 verticinone 和单个胆酸开的更多有势力。管理 Ver-CA 的 3 mg/kg 能导致柠檬性的导致酸的咳嗽的超过 50% 减小。有 naloxone 的预告的处理(0.8 mg/kg, ip ) 能仅仅部分反对它的能止咳的效果。在另一方面, glybenclamide (3 mg/kg, ip ) , ATP 敏感的 K+ 隧道 blocker,能显著地也减少 Ver-CA 的能止咳的效果。进一步尖锐的毒性研究证明 Ver-CA 的 LD (50 ) 价值是乘 verticinone 的的 3。结论:基于药理学和尖锐毒性的研究,盐与单个 verticinone 和胆酸相比有协作、稀释的毒性。而且,现在的学习也建议那 Ver-CA,一个潜在的新奇能止咳的代理人,可以经由两个施加它的能止咳的效果外设(由 ATP 敏感的 K+ 隧道调制了) 并且中央机制(由 opioid 受体调制了) 。 | Fang-zhou XU Chang CHEN Yong-hui ZHANG Han-li RUAN Hui-fang PI Pong ZHANG Ji-zhou WU | 2007 | Acta Pharmacologica Sinica2007，28，10： | 2 |
| 17 | NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy显示文摘Oral squamous cell carcinoma(OSCC)is the most common type of oral malignancy,and metastasis accounts for the poor prognosis of OSCC.Autophagy is considered to facilitate OSCC development by mitigating various cellular stresses;nevertheless,the mechanisms of autophagy in OSCC cell proliferation and metastasis remain unknown.In our study,high-sensitivity label-free quantitative proteomics analysis revealed nuclear protein 1(NUPR1)as the most significantly upregulated protein in formalin-fixed paraffin-embedded tumour samples derived from OSCC patients with or without lymphatic metastasis. | Tengfei Fan Xiaoning Wang Sheng Zhang Ping Deng Yi Jiang Yidan Liang Sheng Jie Qing Wang Chuwen Li Guocai Tian Zhen Zhang Zhenhu Ren Bo Li Yanrong Chen Zhijing He Yan Luo Mingliang Chen Hanjiang Wu Zhengping Yu Huifeng Pi Zhou Zhou Zhiyuan Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 18 | Two new ent-kaurane diterpenoids from the aerial parts of Isodon excisoides显示文摘Two new ent-kaurane diterpenoids, ent-7a,14b-dihydroxykaur-16-en-15-one-20-oic acid(1) and 1,7a,12b,14b-tetrahydroxy-1,10-seco-ent-kaur-10,16-dien-15-one(2), together with six known ones(3–8), were isolated from the EtOAc extract of the aerial parts of Isodon excisoides. Their structures were elucidated on the basis of 1D NMR and 2D NMR analyses as well as HR-ESI-MS experiments. | Ke Jiao Huo-Yun Li Peng Zhang Hui-Fang Pi Han-Li Ruan Ji-Zhou Wu | 2014 | Chinese Chemical Letters2014，25，1： | 2 |
| 19 | Peptide NGR Modified TiO_(2) Nanofiber Substrate for Circulating Tumor Cells Capture显示文摘The analysis of circulating tumor cells(CTCs)allows a noninvasive method of“real-time liquid biopsy”from the blood samples of cancer patients for the diagnosis of early-stage cancer,prognosis,and monitoring therapeutic response.In this study,we develop a simple,inexpensive,and reliable method that utilizes a small molecule peptide,the asparagine-glycine-arginine(NGR),as a capture probe for the selective enrichment and isolation of circulating tumor cells(CTCs).The multiscale TiO_(2) nanofibers are obtained by electrospinning and calcination.Bovine serum albumin(BSA)is decorated onto TiO_(2) nanofiber surfaces to inhibit non-target cell adhesion,while NGR peptides are conjugated onto the TiO_(2)-BSA surface through the glutaraldehyde(GA)to specifically capture the target cells.The TiO_(2)-BSA-NGR substrate exhibits a high capture sensitivity and efficiency from the mimical blood samples with PC-3 cancer cells as low as 10 cells/mL.The TiO_(2) nanofiber substrate can be a promising strategy for the capture and enumeration of CTCs in cancer progression monitoring. | Changchong Chen Zeen Wu Pi Ding Na Sun Hui Liu Yong Chen Zhili Wang Renjun Pei | 2020 | Advanced Fiber Materials2020，2，4： | 2 |
| 20 | Numerical simulation and inversion of offshore area depth based on x-band microwave radar显示文摘A detection method of offshore area depth utilizing the x-band microwave radar is proposed. The method is based on the sea clutter imaging mechanism of microwave radar, and combined with dispersion equation of the liner wave theorem and least square method(LSM), consequently get the inversion results of water depth in the detected region. The wave monitoring system OSMAR-X exploited by the Ocean State Laboratory, Wuhan University, based on a microwave radar has proven to be a powerful tool to monitor ocean waves in time and space. Numerical simulation and inversion of offshore area depth are carried out here; since JONSWAP model can give description of stormy waves in different growth phase, it is suitable for simulation. Besides, some results from measured data detected by OSMAR-X x-band radar located at Longhai of Fujian Province, China, validates this method. The tendency of the average water depths inferred from the radar images is in good agreement with the tide level detected by Xiamen tide station. These promising results suggest the possibility of using OSMAR-X to monitor operationally morphodynamics in coastal zones. This method can be applied to both shore-based and shipborne x-band microwave radar. | WANG Li WU Xiongbin PI Xiaoshan MA Ketao LIU Jianfei TIAN Yun | 2015 | Acta Oceanologica Sinica2015，34，3： | 2 |
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