|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Selective COX-2 inhibitor,NS-398,suppresses cellular proliferation in human hepatocellular carcinoma cell lines via cell cycle arrest显示文摘AIM: To investigate the growth inhibitory mechanism of NS-398, a selective cyclooxygenase-2 (COX-2) inhibitor, in two hepatocellular carcinoma (HCC) cell lines (HepG2 and Huh7). METHODS: HepG2 and Huh7 cells were treated with NS-398. Its effects on cell viability, cell proliferation, cell cycles, and gene expression were respectively evaluated by water-soluble tetrazolium salt (WST-1) assay, 4’-6-diamidino-2-phenylindole (DAPI) staining, flow cytometer analysis, and Western blotting, with dimethyl sulfoxide (DMSO) as positive control. RESULTS: NS-398 showed dose- and time-dependent growth-inhibitory effects on the two cell lines. Proliferating cell nuclear antigen (PCNA) expressions in HepG2 and Huh7 cells, particularly in Huh7 cells were inhibited in a time- and dose-independent manner. NS-398 caused cell cycle arrest in the G1 phase with cell accumulation in the sub-G1 phase in HepG2 and Huh7 cell lines. No evidence of apoptosis was observed in two cell lines. CONCLUSION: NS-398 reduces cell proliferation by inducing cell cycle arrest in HepG2 and Huh7 cell lines, and COX-2 inhibitors may have potent chemoprevention effects on human hepatocellular carcinoma. | Ji Yeon Baek Wonhee Hur Jin Sang Wang Si Hyun Bae Seung Kew Yoon | 2007 | World Journal of Gastroenterology2007，13，8： | 27 |
| 2 | 船舶升沉运动监测系统的设计与基本试验验证显示文摘随着海上航运和海洋资源开发的快速发展,船舶及一些浮式海洋工程结构在海上的运动状态越来越受人们的关注,对姿态测量与监测系统的开发逐渐成为研究热点。近年来MEMS惯性器件的发展,为捷联系统打下了基础。文中在分析了微机电系统(MEMS)加速度传感器工作原理的基础上,设计了一种基于MEMS加速度传感器和陀螺仪的船舶海上升沉运动监测系统,并在试验平台上验证了系统的可行性。该系统具有大量程、高分辨率、小型化、集成化、实时性等特点,具有广泛的应用前景。 | 李俣菡 喻言 Zhang Chunwei 杜忠诚 Kang Wonhee 田勇 | 2014 | 仪表技术与传感器2014，，8： | 2 |
| 3 | CD133 + liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma显示文摘 | Lian Shu Piao Wonhee Hur Taek-Kyun Kim Sung Woo Hong Sung Woo Kim Jung Eun Choi Pil Soo Sung Myeong Joon Song Byeong-Chel Lee Daehee Hwang Seung Kew Yoon | 2011 | Cancer Letters2011，，2： | 2 |
| 4 | Disturbance observer based position tracking controller in the presence of biased sinusoidal dis- turbance for electrohydraulic actuators 显示文摘 | WONHEE K SHIN D WON D | 2013 | IEEE Transactions on Control Systems Technology2013，21，6： | 1 |
| 5 | Adenoviral delivery of IL-1 receptor antagonist abrogates disease activity during the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice 显示文摘 | Wonhee Hur Mi-La Cho Seung Kew Yoon | 2006 | Immunology letters2006，106，2： | 1 |
| 6 | Studying for multi-primary LCD 显示文摘 | Wonhee Choe Seong-Deok | 2005 | SPIE-IS& T2005，5667，： | 1 |
| 7 | A QTL resource and comparison tool for pigs: PigQTLDB显示文摘 | Zhi-Liang Hu Svetlana Dracheva Wonhee Jang Donna Maglott John Bastiaansen Max F. Rothschild James M. Reecy | 2005 | Mammalian Genome2005，，10： | 1 |
| 8 | Output feedback nonlinear control for electro-hydraulic systems 显示文摘 | Wonhee Kim Daehee Won Donghoon Shin | 2012 | Mechatronics2012，22，6： | 1 |
| 9 | Effect of Mg Content in Cu(Mg)/SiOJSi Multilayers on the Resistiv- ity After Annealing in an Oxygen Ambient显示文摘 | Lee Wonhee Cho Heunglyul Cho Bumseok | 2000 | J Vac Sci Technol2000，18，6： | 1 |
| 10 | Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease显示文摘 | Rhee Yong-Hee Ko Ji-Yun Chang Mi-Yoon Yi Sang-Hoon Kim Dohoon Kim Chun-Hyung Shim Jae-Won Jo A-Young Kim Byung-Woo Lee Hyunsu Lee Suk-Ho Suh Wonhee Park Chang-Hwan Koh Hyun-Chul Lee Yong-Sung Lanza Robert Kim Kwang-Soo Lee Sang-Hun | 2011 | Journal of Clinical Investigation2011，，6： | 1 |
| 11 | CD133 + liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma显示文摘 | Lian Shu Piao Wonhee Hur Taek-Kyun Kim Sung Woo Hong Sung Woo Kim Jung Eun Choi Pil Soo Sung Myeong Joon Song Byeong-Chel Lee Daehee Hwang Seung Kew Yoon | 2011 | Cancer Letters2011，，2： | 1 |
| 12 | Output feedback nonlinear control for electro-hydraulic systems显示文摘 | Wonhee Kim Daehee Won Donghoon Shin Chung Choo Chung | 2012 | Mechatronics2012，，6： | 1 |
| 13 | Formation mechanism of titanium silicide by mechanical alloying显示文摘 | Chang Sop Byun Sang Bopark Dong Kwan Kim Wonhee Lee Chang Yong Hyun P. J. Reucroft | 2001 | Journal of Materials Science2001，，2： | 1 |
| 14 | CD133 + liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma显示文摘 | Lian Shu Piao Wonhee Hur Taek-Kyun Kim Sung Woo Hong Sung Woo Kim Jung Eun Choi Pil Soo Sung Myeong Joon Song Byeong-Chel Lee Daehee Hwang Seung Kew Yoon | 2011 | Cancer Letters2011，，2： | 1 |
| 15 | Adenoviral delivery of IL-1 receptor antagonist abrogates disease activity during the development of autoirmnune arthritis in IL-1 receptor antagonist-deficient mice 显示文摘 | WONHEE HUR MI-LA CHO SEUNG KEW YOON | 2006 | Immunol Lett2006，106，2： | 1 |
| 16 | Target Specific Systemic Delivery of TGF-,8 SiRNA/(PEI-SS)-g-HA Complex for the Treatment of Liver Cirrhosis显示文摘 | Kitae Park Sung Woo Hong Wonhee Hur | 2011 | Biomaterials2011，，32： | 1 |
| 17 | Interactions between Transmembrane Helices within Monomers of the Aquaporin AtPIP2;1 Play a Crucial Role in Tetramer Formation显示文摘Aquaporin (AQP ) 是在原核生物、真核细胞的房间的各种各样的 subcellular 膜发现的水隧道蛋白质。AQP 的生理的功能在许多有机体被阐明了。然而,理解他们的生物的续生说留下逃犯,特别地考虑他们怎么集合进 tetramers。这里,我们调查了涉及 Arabidopsis 血浆膜 AQP AtPIP2 的 tetramer 形成的氨基酸残余; 1 使用的广泛的氨基酸替换 mutagenesis。变异的蛋白质 V41A/E44A, F51A/L52A, F87A/I91A, F92A/I93A, V95A/Y96A,和 H216A/L217A,在 transmembrane (TM ) 怀有丙氨酸替换 AtPIP2 的 helices; 1 polymerized 进有比四大的子单元的一个可变数字的多重 oligomeric 建筑群。而且,这些变异的蛋白质失败了到交通到血浆膜,而不是在 endoplasmic 蜂窝胃积累(嗯) 。基于结构的建模表明这些残余大部分在单体以内涉及在 TM helices 之间的相互作用。这些结果建议在以内并且在单体之间发生的 inter-TM 相互作用在 AtPIP2 在 tetramer 形成起关键作用; 1 建筑群。而且, AtPIP2 的集会; 1 tetramers 为他们从 ER 的 trafficking 是批评的到血浆膜,以及水渗透。 | Yun-Joo Yoo Hyun Kyung Lee Wonhee Han Dae Heon Kim Myoung Hui Lee Jouhyun Jeon Dong Wook Lee Junho Lee Yongjik Lee Juhun Lee Jin Seok Kim Yunje Cho Jin-Kwan Han Inhwan Hwang | 2016 | Molecular Plant2016，9，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员