|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neonatal ketamine exposure-induced hippocampal neuroapoptosis in the developing brain impairs adult spatial learning ability显示文摘Ketamine exposure can lead to selective neuroapoptosis in the developing brain.p66ShcA,the cellular adapter protein expressed selectively in immature neurons,is a known pro-apoptotic molecule that triggers neuroapoptosis when activated.Sprague-Dawley rats at postnatal day 7 were subcutaneously injected in the neck with ketamine 20 mg/kg,six times at 2-hour intervals.At 0,1,3,and 6 hours after final injection,western blot assay was used to detect the expression of cleaved caspase-3,p66ShcA,and phosphorylated p66ShcA.We found that the expression of activated p66ShcA and caspase-3 increased after ketamine exposure and peaked at 3 hours.The same procedure was performed on a different group of rats.At the age of 4 weeks,spatial learning and memory abilities were tested with the Morris water maze.Latency to find the hidden platform for these rats was longer than it was for control rats,although the residence time in the target quadrant was similar.These findings indicate that ketamine exposure resulted in p66ShcA being activated in the course of an apoptotic cascade during the neonatal period.This may have contributed to the deficit in spatial learning and memory that persisted into adulthood.The experimental protocol was approved by the Institutional Animal Care and Use Committee at the University of Texas at Arlington,USA (approval No.A13.008) on January 22,2013. | Dan Lyu Ning Tang Andrew W. Womack Yong-Jin He Qing Lin | 2020 | Neural Regeneration Research2020，15，5： | 7 |
| 2 | FGFR2, HER2 and cMet in gastric adenocarcinoma: detection, prognostic significance and assessment of downstream pathway activation显示文摘 | Guy Betts Helen Valentine Sue Pritchard Richard Swindell Victoria Williams Shethah Morgan Ewen A. Griffiths Ian Welch Catharine West Christopher Womack | 2014 | Virchows Archiv2014，，2： | 2 |
| 3 | Strategic IPO underpricing, information momentum, and lockup expiration selling显示文摘 | Rajesh K. Aggarwal Laurie Krigman Kent L. Womack | 2002 | Journal of Financial Economics2002，，1： | 2 |
| 4 | Four-premolar extraction treatment with invis-align显示文摘 | Womack WR | 2006 | J Clin Orthod2006，40，8： | 1 |
| 5 | Whey protein concentrate as a milk extender显示文摘 | McDonough F E Alford J A Womack M | 1976 | J Dairy Sci1976，59，： | 1 |
| 6 | Trans differentiation of rat hepat- ic stellate cells resuhs in leptin expression 显示文摘 | Potter JJ Womack L Mezey E | 1998 | Chem Biophys Res Commun1998，244，1： | 1 |
| 7 | Detergent effects on enzyme activity and solubilization of lipid biolayer membranes 显示文摘 | Womack M D Kendall D A MacDonald R C | 1983 | Biochim Biophys Acta1983，733，： | 1 |
| 8 | An open-label study of memantine treatment in 3 subtypes of frontotemperal lobar degeneration 显示文摘 | Boxer AL Lipton AM Womack K | 2009 | Alzheimer Dis Assoc Disord2009，23，： | 1 |
| 9 | Transdifferenti- ation of rat hepatic stellate cells results in eptin expres- sion显示文摘 | Potter J J Womack L Mezey E | 1998 | Biochem Biophys Res Commun1998，244，1： | 1 |
| 10 | Prognostic factors, re- currence and survival in transitional cell carcinoma of the upper urinary tract: A 30-year experience in 252 patients显示文摘 | Hall M C Womack S Sagalowsky A I | 1998 | Urology1998，52，4： | 1 |
| 11 | A microRNA repertoire for functional genome research in rainbow trout (Oncorhynchus mykiss) 显示文摘 | Salem M Xiao C Womack J | 2010 | Marine Biotechnology2010，12，4： | 1 |
| 12 | Aldehydes potentiate alpha(2)(I) collagen gene activity by JNK in hepatic stellate cells显示文摘 | Anania FA Womack L Jiang M Saxena NK | 2001 | Free Radic Biol Med2001，30，： | 1 |
| 13 | Strategic IPO un-derpricing, information momentum, and lockup expiration selling显示文摘 | Aggarwal R Krigman L Womack K L | 2002 | Journal of Financial Economics2002，66，6： | 1 |
| 14 | Temporoparietal hypometabolism in frontotemporal lobar degeneration and associated imaging diagnostic errors显示文摘 | Womack KB Diaz-Arrastia R Aizenstein HJ | | 0，，03： | 1 |
| 15 | A recent review of non-biological remediation of aflatoxin-contaminated crops显示文摘 | Womack E D Brown A E Sparks D L | 2014 | Journal of the Science of Food and Agriculture2014，94，9： | 1 |
| 16 | A new approach to correction of crowding 显示文摘 | William Randol Womack | 2002 | American Joural of Orthodontics and Dentofacial Orthopedics2002，122，3： | 1 |
| 17 | Assignment of five polymorphic ovine microsatellites to bovine syntenic groups 显示文摘 | Dietz AB Womack J E Swarbrick P A | 1993 | Animal Genetic1993，24，6： | 1 |
| 18 | Benefits and costs of using HPV testing to screen for cervical cancer显示文摘 | Mandelblatt JS Lawrence WE Womack SM | 2002 | JAMA2002，287，18： | 1 |
| 19 | Transdifferentiation of rat hepatic stellate ceils results in leptin expression 显示文摘 | Potter J J Womack L Mezey E | 1998 | Biochem Biophys Res Commun1998，244，1： | 1 |
| 20 | Information intermediaries and optimal informa-tion distribution显示文摘 | WOMACK R | 2002 | Library&Information Science Research2002，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员