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| 1 | Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells显示文摘尽管有非酒精的脂肪肝疾病是良性的混乱的起始的信仰,纤维变性前进发生在病人的一个重要数字,这现在被认出。而且,肝的脂肪变性在大量其它为肝的纤维变性的前进作为一个风险因素被识别了肝疾病。这里,我们建立了一在里面在肝的星形的房间(HSC ) 上学习肝的类脂化合物累积的效果的 vitro 模型,肝 fibrogenesis 的中央调停人。主要人的 hepatocytes 与浸透的丰满的酸 palmitate 被孵化导致细胞内部的类脂化合物累积。随后,人的 HSC 从 steatotic 或控制 hepatocytes 与调节媒介(厘米) 被孵化。在 hepatocytes 的类脂化合物累积导致了加速了 HSC 的激活和增长的因素的版本,并且提高了他们的抵抗到 apoptosis,大部分经由 PI-3-kinase 小径的激活调停了。而且,从 steatotic hepatocytes 的厘米导致了 profibrogenic 基因 TGF- 尾, metallo-proteinase-1 (TIMP-1 ) 的织物禁止者, TIMP-2 和 matrix-metallo-proteinase-2 的表示,以及在 HSC 的原子因素的魏 B 依赖者 MCP-1 表示。在摘要,我们的在里面 vitro 数据在 vivo 为在肝的脂肪变性和 fibrogenesis 之间的 pathophysiological 连接显示潜在的机制。附此,这研究提供一在 vitro 吸引人学习导致脂肪变性的 fibrogenesis 的分子的机制,并且识别并且测试小说的模型在脂肪肝为 antifibrotic 指向治疗疾病。 | Hella Wobser Christoph Dora Thomas S Weiss Thomas Amann Cornelius Bollheimer Roland Btittner Juergen Schoelmerich Claus Helterbrand | 2009 | Cell Research2009，19，8： | 16 |
| 2 | Complete remission of liver metastasis of pancreatic cancer under vaccination with a HLA-A2 restricted peptide derived from the universal tumor antigen Survivin显示文摘 | Wobser M Keikavoussi P Kunzmann V | 2006 | Cancer Immunol Immunother2006，55，10： | 1 |
| 3 | Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death 显示文摘 | Wobser H Dussmann H K? gel D | 2002 | J Biol Chem2002，277，8： | 1 |
| 4 | Primary hypertrophic osteoarthropathy with digital clubbing and palmoplantar hyperhidrosis caused by 15-PGHD/HPGD loss-of- function mutations显示文摘 | Bergmann C Wobser M Morbach H | 2011 | Exp Dermatol2011，20，6： | 1 |
| 5 | Frequency and significance of the novel single nueleotide missense polymorphism Vall09Asp in the human gene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases显示文摘 | Sch(a)ffler A Zeitoun M Wobser H | | 0，，： | 1 |
| 6 | Monitoring w?hrend hepatischer Radiofrequenzablation (RFA): Vergleich der Real-Time-Ultraschall-Elastografie (RTE) mit der Kontrastmittelsonografie (CEUS). Erste klinische Ergebnisse bei 25 Patienten显示文摘 | P. Wiggermann K. Brünn J. Rennert M. Loss H. Wobser A. Schreyer C. Stroszczynski E. Jung | 2013 | Ultraschall in Med2013，，： | 1 |
| 7 | Dendritic cell based antitumor vaccination : impact of functional indoleamine 2,3-dioxygenase expression 显示文摘 | Wobser M Voigt H Houben R | 2007 | Cancer Immunol Immunother2007，56，7： | 1 |
| 8 | Prevalence of ultrasound-diagnosed non-alcoholic fatty liver disease in a hospital cohort and its association with anthropometric,biochemical and sonographic characteristics显示文摘 | Kirovski G Schacherer D Wobser H | 2010 | Int J Clin Exp Med2010，3，3： | 1 |
| 9 | Expression pattern of thelymphatic and vascular markers VEGFR-3 and CD31 does not pre-dict regional lymph node metastasis in cutaneous melanoma显示文摘 | Wobser M Siedel C Schrama D | 2006 | ArchDermatol Res2006，297，8： | 1 |
| 10 | Dendritic cell based antitumor vaccination: impact of functional in- doleamine 2, 3-dioxygenase expression显示文摘 | Wobser M Voigt H Houben R | 2007 | Cancer Immu- nol Immunother2007，56，7： | 1 |
| 11 | Complete remission of liver metastasis of pancreatic cancer under vaccination with a HLA-A2 restricted peptide derived from the universal tumor antigen survivin显示文摘 | Wobser M keikavoussi P kunzmann V | 2006 | Cancer Immunol Immunother2006，55，： | 1 |
| 12 | Eaely loss of mammalian target of rapamycin complex 1 ( mTORCI ) signaling and reducting in cell siza during dominant-negative suppression of hepatic nuclear factor 1-alpha (HNF1A) fanction in INS-1 insulinoma cells 显示文摘 | Farrelly AM Wobser H Bonnet C | 2009 | Diabetologia2009，52，1： | 1 |
| 13 | Major response to paclitaxel combined with irradiation as sccond-line therapy in metastatic angiosarcoma of the face and scapl显示文摘 | HOFMANN UB WOBSER M KNEITZ H | 2009 | British Journal of Dermatology2009，169，： | 1 |
| 14 | Complete remission of liver metastasis of pancreatic cancer under vaccination with a HLA-A2 restricted peptide derived from the universal tumor antigen survivin显示文摘 | Marion Wobser Petra Keikavoussi Volker Kunzmann Markus Weininger Mads H. Andersen Juergen C. Becker | 2006 | Cancer Immunology, Immunotherapy2006，，10： | 1 |
| 15 | Frequecy and significance of the novel single nucleotide missense poly- morphism Vall09Asp in the human gene encoding omen- tin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases显示文摘 | Schiffler A Zeitoun M Wobser H | 2007 | Cardiovasc Dia- betol2007，13，6： | 1 |
| 16 | Complete remission of liver metastasis of pancreatic cancer under vaccination with a HLA-A2 restricted peptide derived from the universal tumor antigen survivin显示文摘 | Wobser M Keikavoussi P Kunzmann V | 2006 | Cancer Immunol Immunother2006，55，10： | 1 |
| 17 | Microvessel density and expression of vascular endothelial growth factor and its receptors in different subtypes of primary cutaneous B-cell lymphoma显示文摘 | Wobser M Siedel C Kneitz H | 2013 | Acta Derm Venereol2013，93，6： | 1 |
| 18 | Survivin-specific T-cell reactivity correlates with tumor response and patient survival: a phase-Ⅱpeptide vaccination trial in metastatic melanoma显示文摘 | Becker J C Andersen M H Hofmeister-Muller V Wobser M Frey L Sandig C | 2012 | Cancer Immunol Immunother2012，61，： | 1 |
| 19 | Frequency and significance of the novel single nucleotide missense polymerp-hism Vall 09 Asp in the human gene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflamematory bowel diseases显示文摘 | Schaffler A Zeitoun M Wobser H | 2007 | Cardiovasc Diabetol2007，6，3： | 1 |
| 20 | Frequency and significance of the novel sinOe nucleotide missense polymorphism Vall09Asp in the human gene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases显示文摘 | Schaffller A Zeitoun M Wobser H | 2007 | Cardiovasc Diabetol2007，6，： | 1 |
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