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| 1 | Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study显示文摘AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the possibility of accurate prediction of malignancy of hepatic tumors with a positive prognostic value of 93.5% using advanced contrast-enhanced ultrasound. Contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics is a valuable tool to discriminate hepatic tumors. | EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung | 2007 | World Journal of Gastroenterology2007，13，47： | 15 |
| 2 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 3 | MR-arterioportography: A new technical approach for detection of liver lesions显示文摘AIM: To evaluate the benefit and effectiveness of MRarterioportography (MR-AP) to achieve the highest sensitivity for detection and evaluation of hepatocellular carcinoma (HCC). METHODS: Twenty liver cirrhosis patients with suspected HCC were included before transarterial chemoembolization. In all patients double-enhanced Magnetic resonance imaging (MRI) was performed. A bolus of 10 mL Magnevist was injected through a selectively placed catheter in the superior mesenteric artery and MRI of the liver was performed in arterioportographic phase. Two independent readers evaluated number, size and localization of detected lesions. Diagnostic quality was determined using a 4-point scale. Differences were analyzed for significance using a t -test. Interobserver variability was calculated. RESULTS: In all 20 patients (100%), MR-AP was feasible. Diagnostic quality was, in all cases, between 1 and2 for both modalities and readers. MR-AP detected significantly more lesions than double-enhanced MRI (102.5 vs 61, respectively, P < 0.0024). The inter-observer variability was 0.881 for MRI and 0.903 for MR-AP. CONCLUSION: Our study confirmed that the MR-AP as an additional modality for detection of HCC is beneficial, as significantly more lesions were detected compared to MRI with liver-specific contrast. | Janine Rennert Ernst-Michael Jung Andreas G Schreyer Patrick Hoffstetter Peter Heiss Stefan Feuerbach Niels Zorger | 2011 | World Journal of Gastroenterology2011，17，13： | 2 |
| 4 | Pulse cyclophosphamide for steroid-resistant focal segmental glomerulosclerosis显示文摘 | Rennert WP Kala UK Jacobs D | 1999 | PediatrNephrol1999，13，： | 1 |
| 5 | Treatment of rainbow trout farm effluents in constructed wetland with emergent plants and subsurface horizontal water flow显示文摘 | Schulz C Gelbrecht J Rennert B | | 0，，： | 1 |
| 6 | Clinical and genetic studies of Japanese homozygotes disease L444P muta- tion显示文摘 | IDA H RENNERT O M IWASAWA K | 1999 | Hum Genet1999，105，12： | 1 |
| 7 | Imaging of SeIlar and Parasellar Lesions 显示文摘 | Rennert J Doerfler A | 2007 | Clin Neurol Neurosurg2007，109，2： | 1 |
| 8 | Differentiation of cytotoxic and vasogenic edema in a patient with reversible posterior leukoencephalopathy syndrome using diffusion-weighted MRI显示文摘 | Doelken M Lanz S Rennert J | 2007 | Diagn Interv Radiol2007，13，3： | 1 |
| 9 | Treatment of rainbow trout farm effluents in constructed wetland with emergent plants and subsurface horizontal water flow显示文摘 | Schulz C Gelbrecut J Rennert B | 2003 | Aquaculture2003，217，1234： | 1 |
| 10 | Evaluation of prostate cancer characteristics in four popula- tions worldwide显示文摘 | ZEIGLER-JOHNSON CM RENNERT H MITTAL RD | 2008 | Can J Urol2008，15，3： | 1 |
| 11 | Image fusion with volume navigation of contrast enhanced ultrasound (CEUS) with computed tomography (CT) or magnetic resonance imaging (MRI) for post- interventional follow-up after transcatheter arterial chemoembolization (TACE) of hepatocellular carcinomas (HCC): Preliminary results显示文摘 | Ross C J Rennert J Schacherer D | 2010 | Clin Hemorheol Microcirc2010，46，23： | 1 |
| 12 | DNA methylation of cancer genome显示文摘 | Cheung HH Lee TL Rennert OM | 2009 | Birth Defects Res C Embryo Today2009，87，4： | 1 |
| 13 | Identification of differentially expressedmicroRNAs across the developing human brain显示文摘 | Ziats MN Rennert OM | 2014 | Mol Psychiatry2014，19，7： | 1 |
| 14 | Oxidation of ferrocyanide by birnessite显示文摘 | Rennert T Pohlmeier A Mansfeldt T | 2005 | Environmental Science & Technology2005，39，3： | 1 |
| 15 | Wound emergencies:the importance of assessment,documentation,and early treatment using a wound electronic medical record显示文摘 | Golinko M S Clark S Rennert R | 2009 | Ostomy Wound Manage2009，55，5： | 1 |
| 16 | A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL,inhibits tumor cell growth 显示文摘 | Rennert P Schneider P Cachero TG | 2000 | J Exp Med2000，192，11： | 1 |
| 17 | Constructed wetlands with free water surface for treatment of aquaculture effluents 显示文摘 | CSchulz J Gelbrecht B Rennert | 2004 | Appl- lylchthyology2004，20，： | 1 |
| 18 | Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice显示文摘 | Rennert P D Hochman P S Flavell R A | 2001 | J Exp Med2001，193，11： | 1 |
| 19 | 显示文摘 | Boirivant M Rennert PD | 1999 | J Exp Med1999，189，8： | 1 |
| 20 | Fecal DNA biomarkers for the detection of eolorectal neoplasia: attractive, but is it feasible显示文摘 | Brenner DE Rennert G | 2005 | J Natl Cancer Inst2005，97，： | 1 |
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