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| 1 | In vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens of acute cholangitis显示文摘AIM: To analyze the in vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens isolated from patients with acute cholangitis. METHODS: In this prospective study a total of 65 patients with acute cholangitis due to biliary stone obstruction (n = 7), benign biliary stricture (n = 16), and malignant biliary stricture (n = 42) were investigated with regard to spectrum of bacterial infection and antibiotic resistance. Pathogens were isolated from bile cultures in all study patients. In 22 febrile patients, blood cultures were also obtained. In vitro activity of moxifloxacin and piperacillin/ sulbactam was determined by agar diffusion. RESULTS: Thirty-one out of 65 patients had positive bile and/or blood cultures. In 31 patients, 63 isolates with 17 different species were identified. The predominant strains were Enterococcus species (26/63), E.coli (13/63) and Klebsiella species (8/63). A comparable in vitro activity of moxifloxacin and piperacillin/sulbactam was observed for E.coli and Klebsiella species. In contrast, Enterococcus species had higher resistances towards moxifloxacin. Overall bacteria showed antibiotic resistances in vitro of 34.9% for piperacillin/sulbactam and 36.5% for moxifloxacin.CONCLUSION: Enterococcus species , E.coli and Klebsiella species were the most common bacteria isolated from bile and/or blood from patients with acute cholangitis. Overall, a mixed infection with several species was observed, and bacteria showed a comparable in vitro activity for piperacillin/sulbactam and moxifloxacin. | Andreas Weber Wolfgang Huber Klaus Kamereck Philipp Winkle Petra Voland Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，20： | 18 |
| 2 | A review of 50 children with obstructive sleep apnea syndrome显示文摘 | Guilleminnauh C Korobkin R Winkle R | 1981 | Lung1981，159，： | 1 |
| 3 | Gender roles, computer attitudes, and dyadic computer interaction performance in college students显示文摘 | Sue Winkle Williams Shirley M. Ogletree William Woodburn Paul Raffeld | | Sex Roles (-)0，，： | 1 |
| 4 | A review of 50 children with obstructive sleep apnea syndrome 显示文摘 | Guilleminault C Korebkin R Winkle R | 1981 | Lung1981，159，5： | 1 |
| 5 | Hypospadias : Duckett pedicte tube urethroplasty 显示文摘 | Dewan PA Dineen MD Winkle D | 1991 | Eur Urol1991，21，1： | 1 |
| 6 | The correlation between male age,sperm quality and sperm DNA fragmentation in 320 men attending a fertility center显示文摘 | Winkle T Rosenbusch B Gagsteiger F | 2009 | J Assist Reprod Genet2009，26，1： | 1 |
| 7 | The use of dabigatran immediately after atrial fibrillation ablation显示文摘 | Winkle RA Mead RH Engel G | 2012 | J Cardiovasc Electrophysiol2012，23，3： | 1 |
| 8 | The impact of Gelrlte and activated carbon on the elemental composition of two conifer embryogenic tissue media显示文摘 | Winkle Van S C Johnson S Pullman G S | 2003 | Plant Cell Rep2003，21，： | 1 |
| 9 | Hurnan mesenchymal stem cells respond to fibroblast growth factors 显示文摘 | Van den Bos C Mosea I Winkles I etal | 1997 | Human Cell1997，10，： | 1 |
| 10 | Hypothermia increases the threshold for ischemic preconditioning显示文摘 | Dote K Wolff RA Van Winkle DM | 1998 | J Thorac Cardiovasc Surg1998，116，2： | 1 |
| 11 | Quality by design for biopharmaceuticals显示文摘 | Rathore A S Winkle H | | 0，，01： | 1 |
| 12 | Time do main modeling of the transient asymmetric flooding of Ro-Ro ship显示文摘 | T A Santos L E Winkle C Guedes Soares | 2002 | Ocean Engineering2002，，： | 1 |
| 13 | Human mesenchymal stem cells respond to fibroblast growth factors显示文摘 | Mosca JD Winkles J | 1997 | Hum Cell1997，10，： | 1 |
| 14 | Serum antioxidant activity in diabes mellitus 显示文摘 | Jones AF Winkles JW Jennings PE | 1988 | Diabetes Res1988，7，2： | 1 |
| 15 | Vocal fold paralysis following the anterior approach to the cervical spine 显示文摘 | Netterville J L Koriwchak M J Winkle M | 1996 | Ann Otol Rhinol Laryngol1996，105，2： | 1 |
| 16 | DNA eleetrophoresis in agarose gels: A simple relation describing the length dependence of mobility electrophoresis 显示文摘 | Winkle DHV Beheshti A Rill RL | 2002 | Electrophoresis2002，23，1： | 1 |
| 17 | Inhibition of TWEAK activity as a new treatment for inflammatory and degenerative diseases显示文摘 | Yepes M Winkles JA | 2006 | Drug News Perspect2006，19，10： | 1 |
| 18 | Areview of 50 children with obstructive apnea syndrome 显示文摘 | Koroblin R Winkle R | 1981 | Lung1981，159，： | 1 |
| 19 | Transcallosal approach to the third ventr-icle:normative morphometric data based on magnetic resonance imaging scans,with special reference to the fornix and formiceal insertion显示文摘 | Winkle PA Wenger E | 1999 | Neurosurgery1999，45，2： | 1 |
| 20 | Distribution of epidermal growth factor receptor and ligands during bronchiolar epithelial repair from naphthalene-induced Clara cell injury in the mouse显示文摘 | Van Winkle LS Isaac JM Plopper CG | 1997 | Am J Pathol1997，151，2： | 1 |
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