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| 1 | In vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens of acute cholangitis显示文摘AIM: To analyze the in vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens isolated from patients with acute cholangitis. METHODS: In this prospective study a total of 65 patients with acute cholangitis due to biliary stone obstruction (n = 7), benign biliary stricture (n = 16), and malignant biliary stricture (n = 42) were investigated with regard to spectrum of bacterial infection and antibiotic resistance. Pathogens were isolated from bile cultures in all study patients. In 22 febrile patients, blood cultures were also obtained. In vitro activity of moxifloxacin and piperacillin/ sulbactam was determined by agar diffusion. RESULTS: Thirty-one out of 65 patients had positive bile and/or blood cultures. In 31 patients, 63 isolates with 17 different species were identified. The predominant strains were Enterococcus species (26/63), E.coli (13/63) and Klebsiella species (8/63). A comparable in vitro activity of moxifloxacin and piperacillin/sulbactam was observed for E.coli and Klebsiella species. In contrast, Enterococcus species had higher resistances towards moxifloxacin. Overall bacteria showed antibiotic resistances in vitro of 34.9% for piperacillin/sulbactam and 36.5% for moxifloxacin.CONCLUSION: Enterococcus species , E.coli and Klebsiella species were the most common bacteria isolated from bile and/or blood from patients with acute cholangitis. Overall, a mixed infection with several species was observed, and bacteria showed a comparable in vitro activity for piperacillin/sulbactam and moxifloxacin. | Andreas Weber Wolfgang Huber Klaus Kamereck Philipp Winkle Petra Voland Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，20： | 18 |
| 2 | Vocal fold paralysis following the anterior approach to the cervical spine 显示文摘 | Netterville J L Koriwchak M J Winkle M | 1996 | Ann Otol Rhinol Laryngol1996，105，2： | 1 |
| 3 | Inhibition of TWEAK activity as a new treatment for inflammatory and degenerative diseases显示文摘 | Yepes M Winkles JA | 2006 | Drug News Perspect2006，19，10： | 1 |
| 4 | Acetanilide-antidote combinations for weed control in corn (Zea mays) and sorghum (Sorghum bicolor)显示文摘 | Winkle M E Leavitt J R C Burnside O C | 1980 | Weed Sci1980，28，7： | 1 |
| 5 | Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries 显示文摘 | WINKLES J A ALBERTS G F CHEDID M | 1997 | Cell Physiol1997，，173： | 1 |
| 6 | Vocal fold paralysis following the anterior approach to the cervical spine显示文摘 | NETTERVILLE J L KORIWCHAK M J WINKLE M | 1996 | Ann Otol Rhinol Laryngol1996，105，： | 1 |
| 7 | Surgical management of posi:erior epistaxis: a changing paradigm显示文摘 | KLOTZDA WINKLE M R RICHMON J | 2002 | Laryngoscope2002，112，： | 1 |
| 8 | Distribution of epidermal growth factor and ligands during bronchiolar epithelial repair from naphthalene-induced Clara cell injury in the mouse显示文摘 | van WINKLE L S ISAAR J M PLOPPER C G | 1997 | Am J Pathol1997，151，2： | 1 |
| 9 | Na^+ independent transport of basic and zwitterionic amino acids in mouse blastocysts by a shared system and by processes which distinguish between these substrates显示文摘 | VAN WINKLE L J CAMPIONE A L GORMAN J M | 1988 | J Biol Chem1988，263，7： | 1 |
| 10 | Medical and surgical applications of collagen显示文摘 | Chvapil M Kronenthal L Van Winkle W Jr | 1973 | Int Rev Connect Tissue Res1973，6，： | 1 |
| 11 | Volatile Organic Compounds, Polycyclic Aromatic Hydrocarbons and Elements in the Air of Ten Urban Homes显示文摘 | Winkle M R Scheff P A | 2001 | Indoor Air2001，11，1： | 1 |
| 12 | 显示文摘 | Winkle M V | 1968 | I & EC Process Design and Development1968，7，2： | 1 |
| 13 | TWEAK - Fn14 pathway inhibition protects the integrity of the neurovascular unit during cerebral ischemia 显示文摘 | ZHANG X WINKLES J A GONGORA M C | 2007 | J Cereb Blood Flow Metab2007，27，3： | 1 |
| 14 | Activation of deltaand kappa-opioid receptors by opioid peptides protects cardiomyocytes via KATP channels显示文摘 | Cao Z Liu L Van Winkle D M | 2003 | Am J Physiol Heart Circ Physiol2003，285，3： | 1 |
| 15 | Clinical, clinicopathologic, radiographic ,and ultrasonographic abnormalities in dogs with fatal acute pancreatitis: 70 eases (1986-1995) 显示文摘 | HESS R S SAUNDERS H M Van WINKLE T J | 1998 | J Am Vet Med Assnc1998，213，5： | 1 |
| 16 | Tumor necrosis factor-like weak inducer of apoptosis stimulation of glioma cell survival is dependent on Akt2 function 显示文摘 | Fortin SP Winkles JA Symons M | 2009 | Mol Cancer Res2009，7，11： | 1 |
| 17 | Fetal exposure of rhesus macaques to bisphenol a alters cellular development of the conducting airway by changing epithelial secretory product expression 显示文摘 | Van Winkle L S Murphy S R Boetticher M V | 2013 | Environmental Health Perspectives2013，121，8： | 1 |
| 18 | Service dogs and people with physical disabilities partnerships: a systematic review 显示文摘 | Winkle M Crowe TK Hendrix I | 2012 | Oeeup Ther Int2012，19，1： | 1 |
| 19 | Vocal fold paralysis following the anterior approach to the cervical spine显示文摘 | Netterville JL Koriwchak MJ Winkle M | 1996 | Ann Otol Rhinol Laryngol1996，105，： | 1 |
| 20 | Surgical management of posterior epistaxis: a changing paradigm显示文摘 | KLOTZ D A WINKLE M R RICHMON J | 2002 | Laryngoscope2002，112，： | 1 |
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