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| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | Negative-strand RNA viruses:genetic engineering and applications 显示文摘 | PALESE P ZHENG H Y ENGEL O G | 1996 | Proc Natl Acad Sci USA1996，，11： | 1 |
| 4 | Crystal structure of the BTBdomain from PLZF显示文摘 | Ahmad K F Engel C K Prive G G | 1998 | Biochemistry1998，95，12： | 1 |
| 5 | Thalassaemia 显示文摘 | Higgs DR Engel JD Stamatoyannopoulos G | 2012 | Lancet2012，379，9813： | 1 |
| 6 | Influence of sex on lung cancer histology, stage, and survival in a midwestern United Statestumor registry 显示文摘 | Ringer G Smith JM Engel AM | 2005 | Clin Lung Cancer2005，7，3： | 1 |
| 7 | Continuous/discontinuous finite element approximations of fourth-order elliptic problems in structural and continuum mechanics with applications to thin beams and plates, and strain gradient elasticity显示文摘 | Garikipati K Hughes T J R | 2002 | Comput Methods Appl Mech Engng2002，191，： | 1 |
| 8 | Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event显示文摘 | Essmann F Engels IH Totzke G | 2004 | Cancer Res2004，64，19： | 1 |
| 9 | Chilling pig carcasses:effects on temperature,weight loss and ultimate meat quality显示文摘 | VANDERWAL P G ENGEL B BEEK G V | 1995 | Meat Science1995，40，： | 1 |
| 10 | More about the polymerization of lactides in the presence of stannous oc- toate 显示文摘 | Schwach G Coudane J Engel R | 1997 | Journal of Polymer Science: Part A: Polymer Chemistry1997，35，16： | 1 |
| 11 | Cardiac arrest in pregnancy and perimortem cesarean delivery: case report and discussion显示文摘 | Engels PT Caddy SC Jiwa G | 2011 | CJEM2011，13，： | 1 |
| 12 | Predictors and variability of repeat measurements of urinary phenols and parabens in a cohort of Shanghai women and men显示文摘 | Engel L S Buckley J P Yang G | 2014 | Environmental Health Perspectives2014，122，7： | 1 |
| 13 | The HLA-G genotype is potentially associated with idiopathic recurrent spontaneous abortion显示文摘 | Pfeiffer KA Fimmers R Engels G | 2001 | Mol Hum Reprod2001，7，4： | 1 |
| 14 | Residual spinothalamic tract pathways predict development of central pain after spinal cord injury显示文摘 | Wasner G Lee BB Engel S | 2008 | Brain2008，131，9： | 1 |
| 15 | Surface discharge switch design:the critical factor显示文摘 | Engel T G Kristiansen M Baker M C | 1991 | IEEE Trans on Electron Devices1991，38，4： | 1 |
| 16 | Recent Advances in Cys-loop Receptor Structure and Function 显示文摘 | SINE S M ENGEL A G | 2006 | Nature2006，440，： | 1 |
| 17 | Mutations of the multi-drug resistance-associated protein ABC transporter gene 5 result in reduction of phytic acid in rice seeds 显示文摘 | Xu X H Zhao H J Liu Q L Frank T Engel K H An G Shu Q Y | 2009 | Theoretical and Applied Genetics2009，119，： | 1 |
| 18 | Nitrendipine vs captopril in essential hypertension:Effect on circadian blood pressure and left ventricular hypertrophy显示文摘 | Henneke KH Engels G | 1994 | Cardiology1994，85，： | 1 |
| 19 | Predictive value of serum SlOOp for monitoring patients with metastatic melanoma during chemotherapy adn/or immunotherapy 显示文摘 | Hauschild A Engel G Brenner W | 2003 | Br J Demratol2003，11，： | 1 |
| 20 | Epidemiology of sepsis in Germany:results from a national prospective multicenter study显示文摘 | Engel C Brunkhorst F M Bone H G | | 0，，4： | 1 |
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